GREMLIN Database
GCH31 - GTP cyclohydrolase III 1
UniProt: Q9HQT7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 255 (236)
Sequences: 111 (72)
Seq/√Len: 4.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
145_I219_R7.9481.00
43_A74_V4.0190.88
43_A89_S3.2250.73
151_Y164_I3.1120.71
53_F56_F2.8800.64
86_A145_I2.7730.61
7_T63_T2.6770.58
156_D159_A2.6650.58
91_G123_L2.3890.49
117_D201_G2.2720.46
74_V89_S2.1870.43
135_D201_G2.0020.37
142_F220_V1.9160.35
166_A173_R1.9030.35
242_A246_D1.8860.34
94_S212_D1.8480.33
142_F232_G1.8290.32
93_G102_G1.8250.32
180_D219_R1.7940.31
43_A121_T1.7440.30
9_V86_A1.7240.30
36_L137_V1.7190.29
156_D176_H1.7180.29
225_G230_D1.7120.29
27_V89_S1.7110.29
51_V71_H1.7060.29
16_P185_F1.6770.28
59_M238_A1.6770.28
27_V43_A1.6710.28
15_G185_F1.6710.28
27_V74_V1.6630.28
10_Q87_S1.6500.28
146_D215_D1.6310.27
37_Y41_S1.6280.27
117_D131_E1.6130.27
95_T181_S1.6130.27
37_Y157_A1.6080.27
16_P29_L1.5980.26
95_T224_R1.5920.26
15_G29_L1.5850.26
9_V109_Q1.5740.26
35_R76_E1.5720.26
159_A176_H1.5660.26
66_L70_A1.5290.25
48_D200_D1.5240.25
124_G168_Y1.5080.24
29_L185_F1.5030.24
41_S121_T1.4820.24
42_Q168_Y1.4670.23
63_T71_H1.4450.23
66_L93_G1.4400.23
50_Y210_V1.4310.23
137_V181_S1.4140.22
78_I216_V1.3990.22
71_H218_L1.3810.22
24_R246_D1.3800.21
116_A200_D1.3610.21
132_R173_R1.3570.21
66_L205_D1.3450.21
199_S202_D1.3440.21
124_G144_V1.3360.21
116_A123_L1.3330.21
5_Q64_N1.3230.20
92_T125_Q1.3220.20
72_A164_I1.3090.20
137_V157_A1.3010.20
49_G227_S1.2990.20
63_T218_L1.2970.20
8_L78_I1.2950.20
5_Q184_F1.2920.20
24_R229_H1.2830.20
180_D199_S1.2790.19
166_A207_I1.2660.19
76_E151_Y1.2650.19
7_T71_H1.2540.19
163_H225_G1.2450.19
35_R45_G1.2390.19
53_F162_T1.2340.19
50_Y192_I1.2320.19
19_V29_L1.2270.18
41_S154_E1.2240.18
156_D183_S1.2110.18
146_D149_G1.2060.18
61_A184_F1.2040.18
27_V181_S1.2030.18
9_V174_H1.2020.18
50_Y232_G1.1920.18
164_I214_A1.1840.18
13_N240_E1.1810.18
139_I183_S1.1800.18
18_T55_R1.1790.18
42_Q182_L1.1780.18
91_G131_E1.1760.17
98_D215_D1.1650.17
122_L125_Q1.1600.17
78_I90_I1.1590.17
27_V37_Y1.1530.17
165_E169_A1.1370.17
40_L61_A1.1360.17
175_M183_S1.1340.17
35_R216_V1.1290.17
13_N77_S1.1240.17
69_E107_L1.1190.16
121_T145_I1.1060.16
105_G117_D1.0950.16
182_L207_I1.0940.16
9_V244_E1.0860.16
119_R154_E1.0820.16
170_A181_S1.0780.16
39_D153_D1.0780.16
126_P134_D1.0770.16
86_A200_D1.0650.16
91_G200_D1.0610.16
117_D200_D1.0590.15
56_F180_D1.0520.15
6_V109_Q1.0510.15
16_P52_F1.0500.15
32_L138_Q1.0450.15
27_V41_S1.0440.15
23_P61_A1.0430.15
44_I192_I1.0390.15
53_F203_Y1.0330.15
73_R162_T1.0270.15
6_V74_V1.0210.15
117_D126_P1.0120.15
19_V185_F1.0030.15
91_G213_T1.0010.15
9_V61_A0.9980.15
61_A71_H0.9890.14
27_V219_R0.9850.14
183_S191_I0.9770.14
70_A98_D0.9760.14
150_T157_A0.9740.14
66_L226_A0.9720.14
11_L126_P0.9720.14
13_N36_L0.9710.14
6_V95_T0.9700.14
27_V229_H0.9670.14
43_A229_H0.9660.14
75_Q218_L0.9660.14
104_T175_M0.9650.14
16_P19_V0.9640.14
181_S219_R0.9610.14
5_Q71_H0.9580.14
40_L104_T0.9480.14
12_D80_N0.9470.14
9_V122_L0.9310.13
219_R229_H0.9290.13
21_P236_K0.9290.13
158_F162_T0.9250.13
34_S64_N0.9240.13
66_L133_T0.9230.13
105_G224_R0.9170.13
27_V121_T0.9150.13
13_N104_T0.9150.13
52_F75_Q0.9120.13
15_G19_V0.9100.13
40_L78_I0.9070.13
5_Q63_T0.9060.13
40_L51_V0.9010.13
95_T134_D0.9000.13
55_R239_L0.8900.13
55_R243_R0.8900.13
18_T243_R0.8900.13
18_T239_L0.8900.13
75_Q185_F0.8890.13
164_I169_A0.8890.13
69_E234_G0.8820.13
8_L86_A0.8800.13
124_G169_A0.8800.13
76_E216_V0.8770.13
239_L243_R0.8770.13
20_T77_S0.8700.13
213_T228_A0.8670.13
174_H178_A0.8670.13
234_G242_A0.8660.13
5_Q61_A0.8640.13
142_F168_Y0.8580.12
135_D164_I0.8540.12
241_V244_E0.8530.12
20_T197_G0.8520.12
167_G194_V0.8520.12
24_R45_G0.8500.12
7_T61_A0.8390.12
144_V206_A0.8330.12
126_P200_D0.8300.12
102_G125_Q0.8290.12
82_Y240_E0.8280.12
160_S166_A0.8270.12
162_T172_M0.8240.12
25_R174_H0.8200.12
202_D225_G0.8190.12
44_I61_A0.8190.12
109_Q202_D0.8150.12
20_T62_V0.8040.12
117_D150_T0.8040.12
28_D80_N0.7960.12
27_V180_D0.7910.12
86_A226_A0.7890.12
229_H246_D0.7860.12
49_G96_P0.7850.11
44_I160_S0.7800.11
150_T168_Y0.7770.11
11_L138_Q0.7770.11
6_V205_D0.7760.11
7_T184_F0.7760.11
163_H197_G0.7680.11
74_V121_T0.7680.11
219_R242_A0.7620.11
34_S145_I0.7530.11
45_G140_A0.7510.11
109_Q205_D0.7470.11
48_D211_Q0.7460.11
117_D154_E0.7440.11
15_G75_Q0.7430.11
64_N184_F0.7410.11
69_E79_R0.7370.11
90_I126_P0.7360.11
91_G116_A0.7340.11
117_D228_A0.7260.11
9_V158_F0.7250.11
34_S60_I0.7240.11
216_V237_H0.7210.11
68_L94_S0.7150.11
220_V236_K0.7130.11
162_T165_E0.7120.11
74_V181_S0.7090.11
58_N171_L0.7090.11
90_I93_G0.7080.11
159_A162_T0.7020.10
144_V220_V0.7000.10
58_N240_E0.6980.10
212_D226_A0.6980.10
110_Q242_A0.6970.10
98_D106_A0.6950.10
34_S37_Y0.6940.10
31_T162_T0.6880.10
124_G155_L0.6880.10
31_T175_M0.6850.10
75_Q240_E0.6820.10
126_P199_S0.6810.10
100_L242_A0.6810.10
51_V218_L0.6760.10
32_L194_V0.6760.10
78_I95_T0.6740.10
44_I208_A0.6740.10
77_S138_Q0.6740.10
16_P32_L0.6740.10
138_Q182_L0.6730.10
16_P82_Y0.6690.10
236_K240_E0.6690.10
78_I175_M0.6690.10
191_I225_G0.6680.10
181_S195_C0.6660.10
232_G242_A0.6650.10
105_G212_D0.6650.10
15_G96_P0.6640.10
49_G148_T0.6640.10
186_V236_K0.6630.10
69_E216_V0.6630.10
125_Q131_E0.6600.10
73_R173_R0.6600.10
12_D58_N0.6580.10
135_D154_E0.6580.10
195_C229_H0.6520.10
58_N140_A0.6510.10
86_A215_D0.6510.10
68_L226_A0.6470.10
60_I247_T0.6400.10
142_F192_I0.6350.10
32_L185_F0.6350.10
56_F138_Q0.6310.10
105_G217_A0.6290.10
54_T60_I0.6260.10
89_S164_I0.6230.10
15_G87_S0.6210.10
154_E202_D0.6200.10
41_S74_V0.6200.10
98_D244_E0.6160.10
107_L226_A0.6140.09
54_T200_D0.6100.09
22_S229_H0.6060.09
15_G52_F0.6040.09
66_L203_Y0.6010.09
132_R169_A0.6000.09
72_A133_T0.5990.09
59_M78_I0.5980.09
13_N71_H0.5980.09
153_D171_L0.5970.09
44_I224_R0.5970.09
208_A227_S0.5950.09
108_Q157_A0.5940.09
68_L170_A0.5930.09
88_L160_S0.5910.09
114_Q120_E0.5910.09
45_G65_G0.5900.09
34_S77_S0.5890.09
37_Y74_V0.5850.09
50_Y236_K0.5730.09
25_R48_D0.5730.09
170_A199_S0.5730.09
39_D82_Y0.5680.09
60_I146_D0.5670.09
25_R164_I0.5660.09
6_V91_G0.5650.09
46_T135_D0.5620.09
168_Y183_S0.5590.09
95_T226_A0.5570.09
206_A216_V0.5560.09
199_S224_R0.5540.09
99_A223_G0.5540.09
94_S199_S0.5510.09
37_Y89_S0.5430.09
69_E205_D0.5420.09
78_I109_Q0.5420.09
21_P85_T0.5400.09
154_E164_I0.5400.09
97_A193_A0.5390.09
115_D119_R0.5360.09
11_L156_D0.5360.09
21_P240_E0.5360.09
140_A220_V0.5330.09
93_G105_G0.5330.09
4_T197_G0.5320.09
31_T158_F0.5310.09
16_P75_Q0.5290.09
201_G217_A0.5260.09
80_N118_R0.5230.09
9_V247_T0.5220.09
109_Q212_D0.5220.09
121_T125_Q0.5220.09
61_A64_N0.5210.09
42_Q124_G0.5210.09
170_A213_T0.5190.09
68_L202_D0.5170.08
124_G214_A0.5170.08
98_D178_A0.5160.08
53_F172_M0.5160.08
208_A225_G0.5150.08
11_L218_L0.5140.08
11_L32_L0.5120.08
101_V226_A0.5100.08
5_Q8_L0.5100.08
63_T225_G0.5090.08
21_P118_R0.5080.08
131_E200_D0.5070.08
173_R183_S0.5070.08
27_V107_L0.5070.08
45_G237_H0.5050.08
19_V153_D0.5040.08
122_L140_A0.5030.08
36_L211_Q0.5030.08
164_I205_D0.5030.08
206_A246_D0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qv6A 4 0.9765 100 0.14 Contact Map
3i5cA 2 0.6863 97 0.931 Contact Map
3hvaA 1 0.5686 96.9 0.932 Contact Map
3tvkA 1 0.5765 96.7 0.934 Contact Map
3hvwA 1 0.5255 96.5 0.935 Contact Map
3qyyA 1 0.5608 96.5 0.935 Contact Map
4urgA 1 0.5529 95.9 0.939 Contact Map
3mtkA 2 0.5725 95.9 0.939 Contact Map
4iobA 1 0.5529 95.9 0.939 Contact Map
3ignA 1 0.5843 95.8 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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