GREMLIN Database
Q9HQT5 - Htr13 transducer
UniProt: Q9HQT5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 423 (363)
Sequences: 25072 (19241)
Seq/√Len: 1009.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_A116_T2.6371.00
94_A99_L2.6021.00
250_H316_N2.4431.00
94_A102_G2.4291.00
123_A126_M2.1971.00
250_H320_E2.1621.00
89_T117_A2.1251.00
103_D130_R2.0471.00
246_T320_E2.0441.00
253_A256_D2.0261.00
249_D252_E2.0191.00
215_L351_E1.9261.00
78_L82_S1.9151.00
259_E263_D1.8981.00
57_V61_T1.8781.00
221_E225_A1.8781.00
340_E344_S1.8621.00
93_T117_A1.8601.00
113_E116_T1.8561.00
236_G330_E1.8461.00
88_F119_A1.8211.00
95_I126_M1.8001.00
89_T121_V1.7581.00
93_T97_S1.7571.00
197_Q200_A1.7541.00
214_S218_D1.7471.00
248_Q325_A1.7331.00
92_V125_D1.7311.00
343_T347_D1.7121.00
54_D58_E1.7121.00
243_Q323_N1.7051.00
93_T124_E1.7041.00
79_A83_A1.6991.00
337_D340_E1.6921.00
336_E340_E1.6891.00
358_G361_T1.6711.00
218_D221_E1.6521.00
225_A341_A1.6291.00
173_L390_K1.6281.00
204_E207_D1.6241.00
225_A228_E1.6051.00
245_A249_D1.5931.00
246_T249_D1.5891.00
211_E214_S1.5891.00
250_H253_A1.5871.00
386_E389_R1.5701.00
311_E315_E1.5661.00
232_A334_E1.5631.00
92_V122_V1.5581.00
407_A410_Q1.5551.00
249_D253_A1.5551.00
406_H410_Q1.5531.00
224_V228_E1.5511.00
53_V57_V1.5501.00
207_D211_E1.5491.00
244_T324_A1.5441.00
333_T337_D1.5411.00
123_A127_S1.5361.00
130_R134_A1.5331.00
93_T121_V1.5281.00
210_D214_S1.5241.00
262_N311_E1.5171.00
256_D259_E1.5091.00
45_L49_P1.5031.00
74_L78_L1.5001.00
235_D239_E1.4881.00
379_E382_M1.4871.00
89_T93_T1.4861.00
103_D123_A1.4731.00
347_D351_E1.4631.00
255_D318_Q1.4621.00
233_I338_S1.4571.00
227_V346_L1.4561.00
126_M130_R1.4521.00
207_D210_D1.4461.00
308_E312_E1.4421.00
95_I125_D1.4391.00
248_Q252_E1.4311.00
305_T309_E1.4281.00
60_Y64_L1.4241.00
180_N386_E1.4231.00
196_E200_A1.4191.00
414_A417_S1.4131.00
322_R326_D1.4111.00
86_D89_T1.4071.00
203_T207_D1.4031.00
301_E305_T1.3971.00
103_D126_M1.3971.00
103_D127_S1.3961.00
53_V56_C1.3831.00
52_I56_C1.3831.00
242_H246_T1.3821.00
217_T221_E1.3811.00
189_S193_S1.3751.00
357_T361_T1.3721.00
117_A120_R1.3641.00
333_T336_E1.3491.00
106_T111_A1.3431.00
347_D350_E1.3421.00
158_E162_E1.3351.00
298_S301_E1.3351.00
344_S347_D1.3311.00
205_V363_L1.3291.00
229_Q337_D1.3281.00
305_T308_E1.3271.00
92_V121_V1.3211.00
371_E375_E1.3211.00
213_Q217_T1.3181.00
228_E232_A1.3171.00
220_Y353_K1.3141.00
179_D182_D1.3081.00
222_R344_S1.3071.00
151_A155_E1.2991.00
410_Q414_A1.2971.00
243_Q324_A1.2971.00
56_C60_Y1.2961.00
168_E172_R1.2961.00
350_E354_D1.2951.00
148_D151_A1.2911.00
253_A316_N1.2841.00
236_G334_E1.2831.00
165_Q169_E1.2811.00
99_L102_G1.2761.00
245_A329_V1.2761.00
253_A309_E1.2731.00
329_V333_T1.2641.00
351_E354_D1.2631.00
221_E224_V1.2601.00
214_S217_T1.2531.00
239_E242_H1.2501.00
200_A204_E1.2451.00
220_Y224_V1.2421.00
46_A50_D1.2411.00
251_T321_T1.2411.00
303_S307_A1.2351.00
88_F118_H1.2261.00
238_T242_H1.2241.00
385_D389_R1.2231.00
354_D358_G1.2181.00
61_T65_P1.2171.00
242_H245_A1.2101.00
231_E235_D1.2101.00
198_I370_T1.2071.00
304_K308_E1.2051.00
175_A179_D1.1991.00
169_E172_R1.1961.00
382_M386_E1.1911.00
225_A344_S1.1911.00
235_D238_T1.1901.00
294_D297_K1.1861.00
368_S371_E1.1831.00
154_A158_E1.1811.00
389_R393_T1.1781.00
361_T365_E1.1781.00
179_D183_N1.1761.00
44_V48_H1.1681.00
399_A403_D1.1631.00
203_T371_E1.1571.00
396_D399_A1.1531.00
243_Q327_T1.1521.00
127_S131_G1.1501.00
91_A104_G1.1491.00
182_D186_A1.1461.00
58_E61_T1.1441.00
72_G76_A1.1411.00
260_V306_Q1.1401.00
413_E417_S1.1391.00
396_D400_S1.1361.00
244_T328_L1.1351.00
128_A131_G1.1341.00
238_T332_E1.1341.00
382_M385_D1.1341.00
183_N186_A1.1341.00
176_Q179_D1.1331.00
400_S403_D1.1331.00
326_D329_V1.1311.00
378_E382_M1.1291.00
237_V335_T1.1181.00
87_A105_P1.1161.00
312_E316_N1.1111.00
245_A248_Q1.1071.00
368_S372_R1.1031.00
48_H52_I1.1011.00
172_R176_Q1.0991.00
389_R392_D1.0981.00
330_E333_T1.0971.00
49_P52_I1.0971.00
94_A97_S1.0961.00
220_Y350_E1.0961.00
200_A203_T1.0931.00
326_D330_E1.0931.00
341_A344_S1.0891.00
315_E319_V1.0861.00
217_T357_T1.0851.00
262_N307_A1.0811.00
241_R329_V1.0751.00
57_V60_Y1.0701.00
49_P53_V1.0661.00
44_V49_P1.0641.00
219_G349_F1.0621.00
215_L218_D1.0611.00
131_G134_A1.0601.00
232_A235_D1.0601.00
248_Q322_R1.0581.00
161_R165_Q1.0571.00
365_E368_S1.0551.00
216_A353_K1.0481.00
393_T396_D1.0451.00
88_F122_V1.0451.00
253_A313_R1.0411.00
403_D407_A1.0401.00
276_S294_D1.0381.00
75_L79_A1.0301.00
403_D406_H1.0291.00
416_Q420_D1.0251.00
190_D193_S1.0181.00
124_E128_A1.0171.00
236_G239_E1.0161.00
50_D54_D1.0161.00
92_V118_H1.0151.00
309_E312_E1.0121.00
162_E165_Q1.0121.00
228_E231_E1.0111.00
392_D396_D1.0101.00
172_R175_A1.0081.00
219_G352_I1.0051.00
417_S420_D1.0031.00
84_D111_A1.0021.00
106_T119_A1.0011.00
91_A94_A1.0001.00
308_E311_E0.9951.00
230_V338_S0.9951.00
186_A190_D0.9951.00
241_R332_E0.9941.00
45_L48_H0.9851.00
361_T364_D0.9801.00
87_A91_A0.9801.00
302_E305_T0.9771.00
234_H336_E0.9761.00
375_E379_E0.9721.00
346_L350_E0.9711.00
208_R358_G0.9701.00
411_K414_A0.9691.00
153_V156_L0.9661.00
90_A94_A0.9651.00
246_T250_H0.9601.00
334_E337_D0.9601.00
418_E421_Q0.9581.00
204_E362_S0.9541.00
234_H238_T0.9541.00
232_A236_G0.9531.00
87_A90_A0.9521.00
106_T123_A0.9511.00
210_D364_D0.9501.00
97_S124_E0.9471.00
312_E315_E0.9461.00
238_T336_E0.9401.00
234_H339_L0.9391.00
227_V231_E0.9391.00
91_A102_G0.9381.00
176_Q180_N0.9351.00
233_I335_T0.9341.00
71_Y75_L0.9321.00
105_P123_A0.9301.00
273_L281_R0.9291.00
226_V342_S0.9281.00
90_A93_T0.9271.00
153_V157_I0.9271.00
213_Q360_S0.9231.00
151_A154_A0.9231.00
372_R375_E0.9221.00
88_F92_V0.9221.00
388_A392_D0.9191.00
364_D368_S0.9181.00
171_D175_A0.9171.00
206_N210_D0.9161.00
115_V119_A0.9151.00
100_L133_V0.9141.00
410_Q413_E0.9141.00
193_S197_Q0.9141.00
196_E378_E0.9121.00
211_E215_L0.9091.00
161_R409_L0.9021.00
150_A154_A0.8971.00
177_Q181_T0.8941.00
319_V323_N0.8931.00
229_Q334_E0.8921.00
263_D302_E0.8921.00
218_D222_R0.8921.00
226_V345_S0.8901.00
340_E343_T0.8881.00
239_E327_T0.8881.00
323_N326_D0.8851.00
86_D90_A0.8821.00
125_D129_L0.8821.00
354_D357_T0.8801.00
80_A84_D0.8801.00
213_Q357_T0.8791.00
212_A356_V0.8771.00
353_K357_T0.8731.00
124_E127_S0.8731.00
119_A123_A0.8731.00
358_G362_S0.8731.00
66_N70_A0.8661.00
82_S86_D0.8661.00
251_T317_I0.8651.00
148_D414_A0.8641.00
332_E336_E0.8641.00
222_R225_A0.8641.00
155_E158_E0.8631.00
44_V47_D0.8621.00
276_S297_K0.8571.00
409_L413_E0.8551.00
231_E343_T0.8511.00
294_D298_S0.8511.00
106_T120_R0.8501.00
218_D351_E0.8501.00
104_G123_A0.8491.00
215_L355_L0.8461.00
266_D277_I0.8461.00
252_E256_D0.8441.00
120_R123_A0.8431.00
193_S196_E0.8381.00
246_T323_N0.8371.00
375_E378_E0.8361.00
51_H55_C0.8351.00
218_D344_S0.8291.00
89_T118_H0.8281.00
258_V311_E0.8251.00
191_I377_S0.8201.00
406_H409_L0.8191.00
269_N297_K0.8191.00
186_A189_S0.8091.00
191_I373_Q0.8081.00
78_L81_T0.8071.00
390_K394_I0.8051.00
158_E161_R0.8021.00
165_Q168_E0.8021.00
54_D57_V0.8011.00
257_I306_Q0.7991.00
257_I313_R0.7981.00
85_A115_V0.7951.00
262_N266_D0.7941.00
64_L68_T0.7941.00
240_V328_L0.7931.00
241_R245_A0.7841.00
102_G106_T0.7811.00
46_A49_P0.7791.00
252_E322_R0.7791.00
397_E400_S0.7761.00
225_A337_D0.7751.00
258_V262_N0.7711.00
379_E383_M0.7711.00
95_I122_V0.7671.00
247_L317_I0.7651.00
223_A345_S0.7611.00
96_Q124_E0.7601.00
224_V346_L0.7581.00
176_Q386_E0.7561.00
157_I161_R0.7521.00
217_T220_Y0.7521.00
47_D51_H0.7491.00
45_L52_I0.7481.00
349_F352_I0.7441.00
351_E355_L0.7431.00
372_R376_S0.7431.00
128_A421_Q0.7421.00
256_D309_E0.7421.00
262_N308_E0.7401.00
297_K301_E0.7371.00
225_A229_Q0.7361.00
76_A79_A0.7351.00
122_V126_M0.7331.00
208_R211_E0.7331.00
266_D304_K0.7321.00
243_Q320_E0.7311.00
84_D115_V0.7291.00
237_V331_L0.7251.00
70_A74_L0.7231.00
254_I314_V0.7231.00
240_V331_L0.7211.00
152_A156_L0.7171.00
96_Q121_V0.7161.00
85_A118_H0.7151.00
216_A219_G0.7141.00
102_G126_M0.7141.00
247_L324_A0.7141.00
116_T120_R0.7131.00
180_N383_M0.7071.00
184_L383_M0.7061.00
319_V322_R0.7061.00
153_V160_A0.7051.00
154_A416_Q0.7051.00
211_E355_L0.7031.00
91_A126_M0.7021.00
318_Q322_R0.6991.00
263_D266_D0.6981.00
44_V51_H0.6981.00
180_N183_N0.6961.00
148_D418_E0.6961.00
83_A87_A0.6951.00
396_D403_D0.6951.00
91_A122_V0.6931.00
343_T346_L0.6931.00
239_E243_Q0.6881.00
111_A115_V0.6881.00
229_Q341_A0.6881.00
100_L129_L0.6861.00
229_Q232_A0.6841.00
184_L384_I0.6841.00
404_A407_A0.6831.00
58_E62_N0.6801.00
166_N397_E0.6801.00
240_V327_T0.6801.00
170_I174_A0.6791.00
205_V362_S0.6781.00
407_A411_K0.6771.00
315_E318_Q0.6751.00
339_L343_T0.6741.00
316_N320_E0.6721.00
181_T387_A0.6711.00
56_C59_Y0.6711.00
107_D111_A0.6691.00
381_T385_D0.6681.00
104_G119_A0.6671.00
223_A342_S0.6641.00
189_S381_T0.6631.00
201_S365_E0.6601.00
149_E419_S0.6591.00
218_D348_T0.6571.00
51_H54_D0.6531.00
206_N364_D0.6511.00
177_Q391_A0.6511.00
86_D117_A0.6511.00
81_T84_D0.6511.00
80_A83_A0.6491.00
52_I55_C0.6481.00
112_Q116_T0.6471.00
149_E153_V0.6441.00
98_P132_R0.6431.00
224_V350_E0.6431.00
169_E173_L0.6401.00
91_A95_I0.6371.00
223_A226_V0.6371.00
98_P125_D0.6371.00
187_E190_D0.6371.00
192_S381_T0.6361.00
157_I416_Q0.6361.00
337_D341_A0.6331.00
182_D388_A0.6321.00
88_F91_A0.6321.00
256_D260_V0.6311.00
210_D213_Q0.6281.00
257_I260_V0.6271.00
231_E339_L0.6251.00
188_I384_I0.6221.00
195_I370_T0.6211.00
48_H51_H0.6201.00
267_Q295_E0.6201.00
378_E381_T0.6191.00
244_T325_A0.6191.00
187_E376_S0.6181.00
414_A418_E0.6161.00
321_T324_A0.6111.00
237_V240_V0.6091.00
44_V52_I0.6091.00
209_S356_V0.6091.00
84_D113_E0.6071.00
300_A303_S0.6061.00
94_A125_D0.6061.00
232_A330_E0.6051.00
252_E255_D0.6041.00
408_Q422_S0.6021.00
92_V95_I0.5991.00
239_E330_E0.5991.00
302_E309_E0.5971.00
264_I303_S0.5971.00
44_V55_C0.5961.00
190_D376_S0.5961.00
217_T353_K0.5961.00
320_E323_N0.5951.00
83_A86_D0.5941.00
122_V125_D0.5911.00
184_L380_L0.5901.00
316_N319_V0.5891.00
401_M404_A0.5861.00
113_E119_A0.5861.00
212_A355_L0.5851.00
222_R341_A0.5831.00
408_Q412_L0.5811.00
259_E262_N0.5781.00
68_T72_G0.5761.00
223_A349_F0.5741.00
257_I314_V0.5721.00
84_D114_S0.5711.00
231_E234_H0.5701.00
152_A155_E0.5701.00
189_S192_S0.5691.00
106_T116_T0.5691.00
149_E152_A0.5681.00
201_S362_S0.5641.00
167_M398_V0.5631.00
178_S392_D0.5631.00
89_T115_V0.5621.00
197_Q365_E0.5621.00
87_A106_T0.5601.00
82_S115_V0.5551.00
192_S377_S0.5551.00
155_E407_A0.5541.00
415_Y422_S0.5511.00
171_D399_A0.5501.00
167_M401_M0.5501.00
267_Q302_E0.5501.00
241_R328_L0.5491.00
413_E416_Q0.5441.00
104_G107_D0.5431.00
222_R348_T0.5421.00
329_V332_E0.5411.00
230_V233_I0.5371.00
196_E374_T0.5361.00
125_D128_A0.5351.00
385_D388_A0.5351.00
88_F115_V0.5331.00
128_A132_R0.5311.00
129_L132_R0.5281.00
219_G348_T0.5261.00
97_S128_A0.5251.00
366_I369_G0.5231.00
209_S359_V0.5201.00
49_P56_C0.5191.00
169_E393_T0.5141.00
219_G223_A0.5141.00
417_S421_Q0.5131.00
59_Y63_T0.5111.00
195_I373_Q0.5101.00
405_N409_L0.5101.00
220_Y346_L0.5081.00
204_E358_G0.5061.00
408_Q415_Y0.5061.00
81_T85_A0.5051.00
72_G75_L0.5041.00
374_T377_S0.5021.00
120_R124_E0.5001.00
393_T397_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zx6A 2 0.7139 100 0.255 Contact Map
2ch7A 2 0.6974 100 0.403 Contact Map
1qu7A 2 0.5272 100 0.407 Contact Map
3g67A 2 0.4941 100 0.5 Contact Map
4i3mA 2 0.3546 99.9 0.7 Contact Map
4cq4A 4 0.2033 99 0.834 Contact Map
2f95B 2 0.1182 98.9 0.839 Contact Map
4gycB 2 0.1395 98.8 0.844 Contact Map
3zccA 2 0.2577 98.6 0.855 Contact Map
4i5sA 2 0.6879 98.1 0.875 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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