GREMLIN Database
Q9HQT2 - Uncharacterized protein
UniProt: Q9HQT2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 367 (333)
Sequences: 53488 (46641)
Seq/√Len: 2555.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
200_V275_S4.9921.00
229_T258_T3.8601.00
157_R178_T3.4021.00
278_G294_Y3.3031.00
198_R231_T3.1871.00
231_T260_E2.9351.00
220_A328_V2.9021.00
105_V361_V2.8381.00
201_V211_T2.8291.00
216_D247_V2.7191.00
222_R256_Y2.5241.00
166_A170_E2.4061.00
210_R213_D2.3591.00
216_D324_V2.3501.00
196_A229_T2.3311.00
305_D310_V2.1751.00
330_A333_A2.1721.00
231_T258_T2.1681.00
233_V271_L2.1621.00
247_V251_A2.1521.00
35_A99_S2.1411.00
35_A101_Y2.1171.00
314_D317_D2.0891.00
198_R229_T2.0631.00
198_R274_R2.0601.00
32_H358_R2.0371.00
239_A245_A2.0361.00
199_I277_Y2.0231.00
218_V230_C2.0011.00
220_A325_A1.9961.00
313_L318_D1.9891.00
340_Q344_P1.9701.00
333_A337_D1.8961.00
352_R356_A1.8751.00
163_A166_A1.8291.00
219_D251_A1.8081.00
157_R360_Q1.8021.00
166_A179_V1.7911.00
214_A230_C1.7881.00
278_G299_M1.7861.00
163_A311_D1.7601.00
202_L268_I1.7521.00
249_A254_R1.7501.00
333_A339_L1.7451.00
105_V120_Y1.7251.00
319_V330_A1.7121.00
210_R283_P1.6961.00
358_R362_A1.6871.00
119_Q155_D1.6841.00
160_A177_P1.6771.00
332_A336_D1.6681.00
197_D335_I1.6681.00
218_V228_L1.6661.00
197_D276_R1.6571.00
183_P350_R1.6561.00
225_G332_A1.6431.00
27_A354_A1.6371.00
264_P267_R1.6321.00
163_A179_V1.6221.00
238_A243_Y1.5951.00
166_A177_P1.5931.00
235_A239_A1.5851.00
22_V26_A1.5701.00
326_G330_A1.5611.00
214_A279_L1.5601.00
269_T297_S1.5561.00
213_D324_V1.5361.00
233_V260_E1.5341.00
323_G326_G1.5291.00
208_D284_I1.5011.00
198_R276_R1.4981.00
263_V267_R1.4861.00
212_L247_V1.4831.00
319_V333_A1.4821.00
303_A309_Q1.4811.00
339_L342_S1.4661.00
275_S299_M1.4571.00
221_L332_A1.4531.00
231_T271_L1.4431.00
170_E174_D1.4371.00
267_R270_E1.4231.00
160_A166_A1.4231.00
225_G336_D1.4171.00
231_T275_S1.4051.00
27_A351_D1.4041.00
200_V233_V1.3871.00
205_I232_I1.3811.00
30_A355_D1.3771.00
201_V214_A1.3741.00
217_V327_A1.3671.00
159_L357_I1.3611.00
324_V328_V1.3531.00
220_A324_V1.3521.00
106_S117_S1.3411.00
159_L360_Q1.3401.00
247_V250_A1.3341.00
199_I331_I1.3341.00
265_R268_I1.3321.00
211_T232_I1.3221.00
199_I279_L1.2961.00
356_A359_R1.2911.00
30_A358_R1.2881.00
246_D250_A1.2801.00
20_V289_M1.2801.00
352_R355_D1.2731.00
287_F292_A1.2691.00
273_G297_S1.2641.00
321_F330_A1.2471.00
35_A58_P1.2451.00
326_G329_D1.2401.00
318_D321_F1.2341.00
280_N291_V1.2271.00
163_A167_D1.2261.00
6_V28_L1.2161.00
328_V332_A1.2121.00
194_A197_D1.2041.00
167_D170_E1.2021.00
350_R353_F1.1891.00
349_G352_R1.1861.00
268_I272_L1.1841.00
291_V309_Q1.1731.00
245_A249_A1.1671.00
198_R275_S1.1561.00
213_D304_P1.1561.00
213_D322_E1.1541.00
281_L327_A1.1521.00
161_N165_T1.1511.00
282_K285_E1.1491.00
280_N290_A1.1481.00
353_F356_A1.1461.00
219_D223_A1.1371.00
213_D216_D1.1361.00
339_L343_L1.1351.00
307_G310_V1.1351.00
235_A262_D1.1291.00
6_V107_T1.1271.00
122_H289_M1.1201.00
213_D283_P1.1171.00
315_G330_A1.1141.00
212_L216_D1.1061.00
161_N182_P1.0981.00
272_L297_S1.0901.00
206_A237_P1.0871.00
199_I218_V1.0841.00
260_E271_L1.0811.00
231_T274_R1.0761.00
204_R208_D1.0761.00
242_D246_D1.0741.00
269_T273_G1.0691.00
160_A169_F1.0641.00
202_L272_L1.0641.00
341_P344_P1.0621.00
242_D245_A1.0571.00
200_V271_L1.0541.00
288_G309_Q1.0531.00
27_A30_A1.0501.00
222_R225_G1.0491.00
216_D251_A1.0471.00
353_F357_I1.0461.00
212_L243_Y1.0451.00
291_V303_A1.0391.00
295_V301_A1.0391.00
329_D333_A1.0331.00
186_P349_G1.0311.00
298_G345_R1.0291.00
106_S119_Q1.0211.00
202_L233_V1.0191.00
182_P289_M1.0181.00
23_H26_A1.0171.00
278_G290_A1.0161.00
334_A343_L1.0131.00
213_D327_A1.0101.00
304_P321_F1.0061.00
214_A281_L1.0051.00
233_V263_V1.0051.00
95_R99_S1.0031.00
25_C36_L1.0011.00
23_H350_R0.9971.00
248_R259_V0.9971.00
161_N286_H0.9921.00
248_R253_S0.9881.00
308_G311_D0.9811.00
15_G18_D0.9791.00
160_A165_T0.9771.00
117_S155_D0.9731.00
221_L228_L0.9711.00
341_P345_R0.9701.00
178_T360_Q0.9601.00
155_D158_Y0.9591.00
355_D359_R0.9571.00
58_P62_P0.9561.00
201_V232_I0.9551.00
217_V328_V0.9541.00
183_P353_F0.9511.00
19_A23_H0.9501.00
35_A56_S0.9461.00
218_V256_Y0.9461.00
291_V301_A0.9441.00
319_V343_L0.9421.00
168_A172_S0.9401.00
236_A239_A0.9391.00
294_Y299_M0.9351.00
25_C29_A0.9341.00
285_E288_G0.9331.00
303_A320_L0.9291.00
58_P61_A0.9281.00
303_A313_L0.9281.00
221_L331_I0.9271.00
167_D171_A0.9271.00
229_T256_Y0.9251.00
260_E263_V0.9231.00
168_A171_A0.9231.00
118_V159_L0.9211.00
197_D277_Y0.9171.00
321_F327_A0.9161.00
20_V122_H0.9121.00
220_A223_A0.9111.00
263_V271_L0.9091.00
243_Y247_V0.9081.00
277_Y334_A0.9051.00
221_L328_V0.9021.00
319_V334_A0.8971.00
299_M344_P0.8921.00
272_L299_M0.8921.00
6_V25_C0.8901.00
221_L335_I0.8861.00
219_D222_R0.8851.00
222_R226_H0.8851.00
201_V281_L0.8831.00
164_W167_D0.8821.00
280_N309_Q0.8791.00
340_Q343_L0.8721.00
355_D358_R0.8721.00
196_A227_D0.8711.00
228_L335_I0.8701.00
279_L331_I0.8661.00
291_V312_V0.8651.00
306_S309_Q0.8631.00
265_R269_T0.8621.00
283_P322_E0.8611.00
209_K285_E0.8571.00
243_Y246_D0.8541.00
187_I190_V0.8471.00
35_A39_I0.8461.00
150_A154_P0.8461.00
170_E177_P0.8441.00
245_A248_R0.8431.00
217_V324_V0.8411.00
246_D249_A0.8401.00
170_E173_Y0.8361.00
107_T122_H0.8321.00
116_P156_T0.8311.00
302_F330_A0.8311.00
23_H185_D0.8281.00
248_R251_A0.8281.00
197_D228_L0.8261.00
219_D253_S0.8231.00
277_Y331_I0.8231.00
350_R354_A0.8221.00
96_R101_Y0.8211.00
54_D57_V0.8191.00
209_K290_A0.8181.00
200_V272_L0.8161.00
161_N289_M0.8141.00
270_E274_R0.8121.00
123_F208_D0.8111.00
189_G192_W0.8081.00
180_C360_Q0.8071.00
215_I248_R0.8061.00
23_H27_A0.8051.00
209_K282_K0.8041.00
178_T356_A0.8031.00
56_S59_V0.7981.00
95_R98_A0.7961.00
271_L274_R0.7961.00
216_D220_A0.7941.00
337_D340_Q0.7921.00
201_V278_G0.7921.00
207_P212_L0.7911.00
270_E273_G0.7911.00
292_A348_F0.7891.00
159_L180_C0.7881.00
288_G291_V0.7861.00
216_D219_D0.7841.00
349_G353_F0.7821.00
300_L334_A0.7791.00
319_V339_L0.7791.00
20_V182_P0.7791.00
315_G319_V0.7781.00
197_D227_D0.7761.00
325_A329_D0.7741.00
122_H161_N0.7731.00
55_V59_V0.7731.00
21_C107_T0.7721.00
202_L278_G0.7711.00
118_V157_R0.7701.00
201_V230_C0.7701.00
31_A358_R0.7651.00
164_W168_A0.7641.00
19_A265_R0.7631.00
302_F321_F0.7621.00
357_I361_V0.7611.00
29_A34_V0.7581.00
181_H356_A0.7571.00
15_G204_R0.7571.00
181_H311_D0.7531.00
280_N288_G0.7531.00
329_D332_A0.7531.00
203_G211_T0.7501.00
20_V120_Y0.7451.00
110_E113_V0.7401.00
351_D355_D0.7331.00
239_A242_D0.7201.00
321_F326_G0.7181.00
244_V247_V0.7161.00
300_L344_P0.7141.00
181_H348_F0.7091.00
186_P296_A0.7091.00
325_A328_V0.7081.00
30_A351_D0.7081.00
210_R322_E0.7051.00
19_A22_V0.7011.00
85_A88_V0.7011.00
103_V361_V0.7001.00
178_T181_H0.7001.00
302_F334_A0.7001.00
86_R90_L0.6991.00
8_H17_A0.6991.00
347_R352_R0.6981.00
24_T357_I0.6971.00
333_A336_D0.6951.00
304_P327_A0.6921.00
6_V34_V0.6921.00
20_V357_I0.6901.00
29_A32_H0.6901.00
105_V357_I0.6831.00
334_A340_Q0.6821.00
199_I228_L0.6811.00
110_E117_S0.6801.00
25_C34_V0.6731.00
180_C356_A0.6701.00
359_R362_A0.6691.00
8_H21_C0.6681.00
342_S345_R0.6671.00
210_R281_L0.6651.00
217_V331_I0.6641.00
305_D320_L0.6631.00
215_I257_V0.6631.00
287_F348_F0.6621.00
180_C357_I0.6621.00
187_I191_P0.6611.00
118_V361_V0.6581.00
193_G196_A0.6571.00
226_H336_D0.6571.00
313_L320_L0.6571.00
278_G301_A0.6561.00
120_Y159_L0.6541.00
279_L327_A0.6521.00
87_S91_R0.6521.00
174_D177_P0.6521.00
248_R257_V0.6521.00
221_L225_G0.6501.00
338_G341_P0.6491.00
59_V62_P0.6471.00
271_L275_S0.6471.00
276_R340_Q0.6471.00
140_N143_W0.6461.00
86_R89_L0.6451.00
354_A358_R0.6431.00
203_G209_K0.6401.00
69_A72_L0.6381.00
165_T168_A0.6381.00
281_L304_P0.6331.00
142_V145_R0.6321.00
138_R141_G0.6311.00
23_H289_M0.6241.00
205_I211_T0.6241.00
96_R99_S0.6221.00
188_D191_P0.6191.00
294_Y301_A0.6191.00
277_Y302_F0.6191.00
213_D217_V0.6171.00
218_V221_L0.6131.00
107_T120_Y0.6131.00
101_Y104_A0.6131.00
199_I335_I0.6091.00
37_F95_R0.6091.00
20_V24_T0.6071.00
163_A181_H0.6061.00
207_P238_A0.6061.00
292_A312_V0.6061.00
55_V58_P0.6051.00
245_A259_V0.6041.00
181_H287_F0.6031.00
198_R271_L0.6011.00
30_A354_A0.5981.00
164_W310_V0.5981.00
302_F331_I0.5951.00
32_H362_A0.5931.00
310_V320_L0.5931.00
272_L290_A0.5931.00
103_V118_V0.5921.00
77_P81_P0.5911.00
10_T18_D0.5901.00
17_A108_A0.5901.00
84_A87_S0.5901.00
162_S165_T0.5901.00
144_S148_A0.5891.00
165_T286_H0.5871.00
227_D256_Y0.5851.00
84_A88_V0.5851.00
24_T27_A0.5841.00
27_A350_R0.5841.00
212_L283_P0.5821.00
210_R304_P0.5811.00
233_V268_I0.5781.00
160_A179_V0.5771.00
204_R209_K0.5771.00
222_R228_L0.5761.00
146_L150_A0.5761.00
150_A153_R0.5751.00
120_Y357_I0.5741.00
122_H182_P0.5741.00
295_V344_P0.5731.00
138_R142_V0.5731.00
200_V278_G0.5721.00
263_V268_I0.5721.00
205_I239_A0.5721.00
26_A29_A0.5711.00
282_K288_G0.5701.00
200_V299_M0.5661.00
166_A174_D0.5651.00
265_R271_L0.5641.00
221_L226_H0.5631.00
215_I244_V0.5631.00
214_A218_V0.5621.00
272_L278_G0.5611.00
185_D350_R0.5611.00
20_V107_T0.5601.00
290_A294_Y0.5591.00
248_R254_R0.5591.00
316_D333_A0.5571.00
217_V279_L0.5551.00
306_S310_V0.5521.00
54_D58_P0.5521.00
149_P153_R0.5521.00
111_L154_P0.5481.00
124_P127_R0.5461.00
98_A101_Y0.5451.00
137_G140_N0.5421.00
81_P84_A0.5421.00
244_V259_V0.5421.00
282_K290_A0.5401.00
313_L317_D0.5381.00
31_A34_V0.5371.00
207_P283_P0.5361.00
207_P243_Y0.5351.00
104_A115_L0.5351.00
200_V231_T0.5331.00
121_V165_T0.5321.00
222_R227_D0.5321.00
157_R161_N0.5321.00
288_G292_A0.5321.00
141_G144_S0.5321.00
46_A49_A0.5321.00
11_L22_V0.5321.00
77_P80_G0.5311.00
217_V221_L0.5291.00
140_N144_S0.5271.00
21_C36_L0.5261.00
145_R149_P0.5261.00
96_R100_A0.5251.00
57_V61_A0.5251.00
225_G228_L0.5241.00
164_W311_D0.5241.00
181_H353_F0.5211.00
298_G344_P0.5211.00
322_E327_A0.5191.00
117_S156_T0.5181.00
184_V296_A0.5181.00
14_R262_D0.5181.00
272_L294_Y0.5161.00
23_H183_P0.5151.00
328_V331_I0.5151.00
219_D254_R0.5141.00
123_F126_F0.5121.00
332_A335_I0.5111.00
216_D250_A0.5111.00
334_A337_D0.5081.00
230_C257_V0.5081.00
268_I271_L0.5071.00
300_L340_Q0.5071.00
70_A73_S0.5051.00
277_Y335_I0.5041.00
170_E176_R0.5041.00
157_R176_R0.5041.00
169_F173_Y0.5041.00
121_V124_P0.5021.00
234_G261_T0.5001.00
202_L290_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r60A 1 0.9782 100 0.247 Contact Map
4n9wA 1 0.8801 100 0.257 Contact Map
3froA 3 0.9837 100 0.261 Contact Map
3okpA 1 0.9046 100 0.262 Contact Map
3c48A 2 0.9428 100 0.264 Contact Map
1rzuA 1 0.9782 100 0.278 Contact Map
3oy2A 2 0.8992 100 0.294 Contact Map
2qzsA 1 0.97 100 0.296 Contact Map
2x6qA 1 0.9128 100 0.298 Contact Map
3s28A 4 0.9891 100 0.304 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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