Q9HQT2 - HALSA - GREMLIN Contacts

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Q9HQT2 - Uncharacterized protein

UniProt:	Q9HQT2	Sequences: MARVAVLHNTLDFRGGADAVCVHTCAALAAAHDVALFTISETTPDAVGAQFDVDVSVPVVAPPGASNVAAALSAAAPTVGPQLAARSVLLRAFFRRHASAYDVAVSTANELAVPLPSVQYVHFPQFRCDTTPTADPGRLNGVWSRLAAPAADRPDTRYLANSAWTADAFEASYDRRPTVCHPPVDPIDGVPWGARADRIVVLGRIAPDKRTLDAIDVVDALRARGHDLTCTIVGAAPAAYRDYVADVRAAADSRPYVTVETDVPRGRITELLGRSRYGLNLKPIEHFGMAVAEYVASGMLAFAPDSGGQVDVLDGDDDVLFEGVAGAVDAIAAAIDDGLQPSLPRDRFGRDRFADAIRRQVAAVCPD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	367 (333)
Sequences:	53488 (46641)
Seq/√Len:	2555.9

ECOLI - WCAL WBBK GLGA WCAI RFAG RFAB WCAC
BACSU - YQGM YPJH EPSF GLGA YTCC TUAH COTSA TUAC EPSD YKVP CGEB TAGE
HALSA - Q9HQT2 Q9HSW1 Q9HQQ0 Q9HS45 Q9HRP8 Q9HSV2 Q9HSV4 Q9HRP9
SULSO - Q980C8 Q97XT7 Q97UU3 Q97XT9 Q97V80 Q97UM0 Q97VL4 Q97XT8 Q97V61 Q97XT6 Q97XF6 Q7LXI2 Q7LXM9 Q97XT1 Q97XT5 Q97ZD3 Q97XU2 Q7LXF8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
200_V	275_S	4.992	1.00
229_T	258_T	3.860	1.00
157_R	178_T	3.402	1.00
278_G	294_Y	3.303	1.00
198_R	231_T	3.187	1.00
231_T	260_E	2.935	1.00
220_A	328_V	2.902	1.00
105_V	361_V	2.838	1.00
201_V	211_T	2.829	1.00
216_D	247_V	2.719	1.00
222_R	256_Y	2.524	1.00
166_A	170_E	2.406	1.00
210_R	213_D	2.359	1.00
216_D	324_V	2.350	1.00
196_A	229_T	2.331	1.00
305_D	310_V	2.175	1.00
330_A	333_A	2.172	1.00
231_T	258_T	2.168	1.00
233_V	271_L	2.162	1.00
247_V	251_A	2.152	1.00
35_A	99_S	2.141	1.00
35_A	101_Y	2.117	1.00
314_D	317_D	2.089	1.00
198_R	229_T	2.063	1.00
198_R	274_R	2.060	1.00
32_H	358_R	2.037	1.00
239_A	245_A	2.036	1.00
199_I	277_Y	2.023	1.00
218_V	230_C	2.001	1.00
220_A	325_A	1.996	1.00
313_L	318_D	1.989	1.00
340_Q	344_P	1.970	1.00
333_A	337_D	1.896	1.00
352_R	356_A	1.875	1.00
163_A	166_A	1.829	1.00
219_D	251_A	1.808	1.00
157_R	360_Q	1.802	1.00
166_A	179_V	1.791	1.00
214_A	230_C	1.788	1.00
278_G	299_M	1.786	1.00
163_A	311_D	1.760	1.00
202_L	268_I	1.752	1.00
249_A	254_R	1.750	1.00
333_A	339_L	1.745	1.00
105_V	120_Y	1.725	1.00
319_V	330_A	1.712	1.00
210_R	283_P	1.696	1.00
358_R	362_A	1.687	1.00
119_Q	155_D	1.684	1.00
160_A	177_P	1.677	1.00
332_A	336_D	1.668	1.00
197_D	335_I	1.668	1.00
218_V	228_L	1.666	1.00
197_D	276_R	1.657	1.00
183_P	350_R	1.656	1.00
225_G	332_A	1.643	1.00
27_A	354_A	1.637	1.00
264_P	267_R	1.632	1.00
163_A	179_V	1.622	1.00
238_A	243_Y	1.595	1.00
166_A	177_P	1.593	1.00
235_A	239_A	1.585	1.00
22_V	26_A	1.570	1.00
326_G	330_A	1.561	1.00
214_A	279_L	1.560	1.00
269_T	297_S	1.556	1.00
213_D	324_V	1.536	1.00
233_V	260_E	1.534	1.00
323_G	326_G	1.529	1.00
208_D	284_I	1.501	1.00
198_R	276_R	1.498	1.00
263_V	267_R	1.486	1.00
212_L	247_V	1.483	1.00
319_V	333_A	1.482	1.00
303_A	309_Q	1.481	1.00
339_L	342_S	1.466	1.00
275_S	299_M	1.457	1.00
221_L	332_A	1.453	1.00
231_T	271_L	1.443	1.00
170_E	174_D	1.437	1.00
267_R	270_E	1.423	1.00
160_A	166_A	1.423	1.00
225_G	336_D	1.417	1.00
231_T	275_S	1.405	1.00
27_A	351_D	1.404	1.00
200_V	233_V	1.387	1.00
205_I	232_I	1.381	1.00
30_A	355_D	1.377	1.00
201_V	214_A	1.374	1.00
217_V	327_A	1.367	1.00
159_L	357_I	1.361	1.00
324_V	328_V	1.353	1.00
220_A	324_V	1.352	1.00
106_S	117_S	1.341	1.00
159_L	360_Q	1.340	1.00
247_V	250_A	1.334	1.00
199_I	331_I	1.334	1.00
265_R	268_I	1.332	1.00
211_T	232_I	1.322	1.00
199_I	279_L	1.296	1.00
356_A	359_R	1.291	1.00
30_A	358_R	1.288	1.00
246_D	250_A	1.280	1.00
20_V	289_M	1.280	1.00
352_R	355_D	1.273	1.00
287_F	292_A	1.269	1.00
273_G	297_S	1.264	1.00
321_F	330_A	1.247	1.00
35_A	58_P	1.245	1.00
326_G	329_D	1.240	1.00
318_D	321_F	1.234	1.00
280_N	291_V	1.227	1.00
163_A	167_D	1.226	1.00
6_V	28_L	1.216	1.00
328_V	332_A	1.212	1.00
194_A	197_D	1.204	1.00
167_D	170_E	1.202	1.00
350_R	353_F	1.189	1.00
349_G	352_R	1.186	1.00
268_I	272_L	1.184	1.00
291_V	309_Q	1.173	1.00
245_A	249_A	1.167	1.00
198_R	275_S	1.156	1.00
213_D	304_P	1.156	1.00
213_D	322_E	1.154	1.00
281_L	327_A	1.152	1.00
161_N	165_T	1.151	1.00
282_K	285_E	1.149	1.00
280_N	290_A	1.148	1.00
353_F	356_A	1.146	1.00
219_D	223_A	1.137	1.00
213_D	216_D	1.136	1.00
339_L	343_L	1.135	1.00
307_G	310_V	1.135	1.00
235_A	262_D	1.129	1.00
6_V	107_T	1.127	1.00
122_H	289_M	1.120	1.00
213_D	283_P	1.117	1.00
315_G	330_A	1.114	1.00
212_L	216_D	1.106	1.00
161_N	182_P	1.098	1.00
272_L	297_S	1.090	1.00
206_A	237_P	1.087	1.00
199_I	218_V	1.084	1.00
260_E	271_L	1.081	1.00
231_T	274_R	1.076	1.00
204_R	208_D	1.076	1.00
242_D	246_D	1.074	1.00
269_T	273_G	1.069	1.00
160_A	169_F	1.064	1.00
202_L	272_L	1.064	1.00
341_P	344_P	1.062	1.00
242_D	245_A	1.057	1.00
200_V	271_L	1.054	1.00
288_G	309_Q	1.053	1.00
27_A	30_A	1.050	1.00
222_R	225_G	1.049	1.00
216_D	251_A	1.047	1.00
353_F	357_I	1.046	1.00
212_L	243_Y	1.045	1.00
291_V	303_A	1.039	1.00
295_V	301_A	1.039	1.00
329_D	333_A	1.033	1.00
186_P	349_G	1.031	1.00
298_G	345_R	1.029	1.00
106_S	119_Q	1.021	1.00
202_L	233_V	1.019	1.00
182_P	289_M	1.018	1.00
23_H	26_A	1.017	1.00
278_G	290_A	1.016	1.00
334_A	343_L	1.013	1.00
213_D	327_A	1.010	1.00
304_P	321_F	1.006	1.00
214_A	281_L	1.005	1.00
233_V	263_V	1.005	1.00
95_R	99_S	1.003	1.00
25_C	36_L	1.001	1.00
23_H	350_R	0.997	1.00
248_R	259_V	0.997	1.00
161_N	286_H	0.992	1.00
248_R	253_S	0.988	1.00
308_G	311_D	0.981	1.00
15_G	18_D	0.979	1.00
160_A	165_T	0.977	1.00
117_S	155_D	0.973	1.00
221_L	228_L	0.971	1.00
341_P	345_R	0.970	1.00
178_T	360_Q	0.960	1.00
155_D	158_Y	0.959	1.00
355_D	359_R	0.957	1.00
58_P	62_P	0.956	1.00
201_V	232_I	0.955	1.00
217_V	328_V	0.954	1.00
183_P	353_F	0.951	1.00
19_A	23_H	0.950	1.00
35_A	56_S	0.946	1.00
218_V	256_Y	0.946	1.00
291_V	301_A	0.944	1.00
319_V	343_L	0.942	1.00
168_A	172_S	0.940	1.00
236_A	239_A	0.939	1.00
294_Y	299_M	0.935	1.00
25_C	29_A	0.934	1.00
285_E	288_G	0.933	1.00
303_A	320_L	0.929	1.00
58_P	61_A	0.928	1.00
303_A	313_L	0.928	1.00
221_L	331_I	0.927	1.00
167_D	171_A	0.927	1.00
229_T	256_Y	0.925	1.00
260_E	263_V	0.923	1.00
168_A	171_A	0.923	1.00
118_V	159_L	0.921	1.00
197_D	277_Y	0.917	1.00
321_F	327_A	0.916	1.00
20_V	122_H	0.912	1.00
220_A	223_A	0.911	1.00
263_V	271_L	0.909	1.00
243_Y	247_V	0.908	1.00
277_Y	334_A	0.905	1.00
221_L	328_V	0.902	1.00
319_V	334_A	0.897	1.00
299_M	344_P	0.892	1.00
272_L	299_M	0.892	1.00
6_V	25_C	0.890	1.00
221_L	335_I	0.886	1.00
219_D	222_R	0.885	1.00
222_R	226_H	0.885	1.00
201_V	281_L	0.883	1.00
164_W	167_D	0.882	1.00
280_N	309_Q	0.879	1.00
340_Q	343_L	0.872	1.00
355_D	358_R	0.872	1.00
196_A	227_D	0.871	1.00
228_L	335_I	0.870	1.00
279_L	331_I	0.866	1.00
291_V	312_V	0.865	1.00
306_S	309_Q	0.863	1.00
265_R	269_T	0.862	1.00
283_P	322_E	0.861	1.00
209_K	285_E	0.857	1.00
243_Y	246_D	0.854	1.00
187_I	190_V	0.847	1.00
35_A	39_I	0.846	1.00
150_A	154_P	0.846	1.00
170_E	177_P	0.844	1.00
245_A	248_R	0.843	1.00
217_V	324_V	0.841	1.00
246_D	249_A	0.840	1.00
170_E	173_Y	0.836	1.00
107_T	122_H	0.832	1.00
116_P	156_T	0.831	1.00
302_F	330_A	0.831	1.00
23_H	185_D	0.828	1.00
248_R	251_A	0.828	1.00
197_D	228_L	0.826	1.00
219_D	253_S	0.823	1.00
277_Y	331_I	0.823	1.00
350_R	354_A	0.822	1.00
96_R	101_Y	0.821	1.00
54_D	57_V	0.819	1.00
209_K	290_A	0.818	1.00
200_V	272_L	0.816	1.00
161_N	289_M	0.814	1.00
270_E	274_R	0.812	1.00
123_F	208_D	0.811	1.00
189_G	192_W	0.808	1.00
180_C	360_Q	0.807	1.00
215_I	248_R	0.806	1.00
23_H	27_A	0.805	1.00
209_K	282_K	0.804	1.00
178_T	356_A	0.803	1.00
56_S	59_V	0.798	1.00
95_R	98_A	0.796	1.00
271_L	274_R	0.796	1.00
216_D	220_A	0.794	1.00
337_D	340_Q	0.792	1.00
201_V	278_G	0.792	1.00
207_P	212_L	0.791	1.00
270_E	273_G	0.791	1.00
292_A	348_F	0.789	1.00
159_L	180_C	0.788	1.00
288_G	291_V	0.786	1.00
216_D	219_D	0.784	1.00
349_G	353_F	0.782	1.00
300_L	334_A	0.779	1.00
319_V	339_L	0.779	1.00
20_V	182_P	0.779	1.00
315_G	319_V	0.778	1.00
197_D	227_D	0.776	1.00
325_A	329_D	0.774	1.00
122_H	161_N	0.773	1.00
55_V	59_V	0.773	1.00
21_C	107_T	0.772	1.00
202_L	278_G	0.771	1.00
118_V	157_R	0.770	1.00
201_V	230_C	0.770	1.00
31_A	358_R	0.765	1.00
164_W	168_A	0.764	1.00
19_A	265_R	0.763	1.00
302_F	321_F	0.762	1.00
357_I	361_V	0.761	1.00
29_A	34_V	0.758	1.00
181_H	356_A	0.757	1.00
15_G	204_R	0.757	1.00
181_H	311_D	0.753	1.00
280_N	288_G	0.753	1.00
329_D	332_A	0.753	1.00
203_G	211_T	0.750	1.00
20_V	120_Y	0.745	1.00
110_E	113_V	0.740	1.00
351_D	355_D	0.733	1.00
239_A	242_D	0.720	1.00
321_F	326_G	0.718	1.00
244_V	247_V	0.716	1.00
300_L	344_P	0.714	1.00
181_H	348_F	0.709	1.00
186_P	296_A	0.709	1.00
325_A	328_V	0.708	1.00
30_A	351_D	0.708	1.00
210_R	322_E	0.705	1.00
19_A	22_V	0.701	1.00
85_A	88_V	0.701	1.00
103_V	361_V	0.700	1.00
178_T	181_H	0.700	1.00
302_F	334_A	0.700	1.00
86_R	90_L	0.699	1.00
8_H	17_A	0.699	1.00
347_R	352_R	0.698	1.00
24_T	357_I	0.697	1.00
333_A	336_D	0.695	1.00
304_P	327_A	0.692	1.00
6_V	34_V	0.692	1.00
20_V	357_I	0.690	1.00
29_A	32_H	0.690	1.00
105_V	357_I	0.683	1.00
334_A	340_Q	0.682	1.00
199_I	228_L	0.681	1.00
110_E	117_S	0.680	1.00
25_C	34_V	0.673	1.00
180_C	356_A	0.670	1.00
359_R	362_A	0.669	1.00
8_H	21_C	0.668	1.00
342_S	345_R	0.667	1.00
210_R	281_L	0.665	1.00
217_V	331_I	0.664	1.00
305_D	320_L	0.663	1.00
215_I	257_V	0.663	1.00
287_F	348_F	0.662	1.00
180_C	357_I	0.662	1.00
187_I	191_P	0.661	1.00
118_V	361_V	0.658	1.00
193_G	196_A	0.657	1.00
226_H	336_D	0.657	1.00
313_L	320_L	0.657	1.00
278_G	301_A	0.656	1.00
120_Y	159_L	0.654	1.00
279_L	327_A	0.652	1.00
87_S	91_R	0.652	1.00
174_D	177_P	0.652	1.00
248_R	257_V	0.652	1.00
221_L	225_G	0.650	1.00
338_G	341_P	0.649	1.00
59_V	62_P	0.647	1.00
271_L	275_S	0.647	1.00
276_R	340_Q	0.647	1.00
140_N	143_W	0.646	1.00
86_R	89_L	0.645	1.00
354_A	358_R	0.643	1.00
203_G	209_K	0.640	1.00
69_A	72_L	0.638	1.00
165_T	168_A	0.638	1.00
281_L	304_P	0.633	1.00
142_V	145_R	0.632	1.00
138_R	141_G	0.631	1.00
23_H	289_M	0.624	1.00
205_I	211_T	0.624	1.00
96_R	99_S	0.622	1.00
188_D	191_P	0.619	1.00
294_Y	301_A	0.619	1.00
277_Y	302_F	0.619	1.00
213_D	217_V	0.617	1.00
218_V	221_L	0.613	1.00
107_T	120_Y	0.613	1.00
101_Y	104_A	0.613	1.00
199_I	335_I	0.609	1.00
37_F	95_R	0.609	1.00
20_V	24_T	0.607	1.00
163_A	181_H	0.606	1.00
207_P	238_A	0.606	1.00
292_A	312_V	0.606	1.00
55_V	58_P	0.605	1.00
245_A	259_V	0.604	1.00
181_H	287_F	0.603	1.00
198_R	271_L	0.601	1.00
30_A	354_A	0.598	1.00
164_W	310_V	0.598	1.00
302_F	331_I	0.595	1.00
32_H	362_A	0.593	1.00
310_V	320_L	0.593	1.00
272_L	290_A	0.593	1.00
103_V	118_V	0.592	1.00
77_P	81_P	0.591	1.00
10_T	18_D	0.590	1.00
17_A	108_A	0.590	1.00
84_A	87_S	0.590	1.00
162_S	165_T	0.590	1.00
144_S	148_A	0.589	1.00
165_T	286_H	0.587	1.00
227_D	256_Y	0.585	1.00
84_A	88_V	0.585	1.00
24_T	27_A	0.584	1.00
27_A	350_R	0.584	1.00
212_L	283_P	0.582	1.00
210_R	304_P	0.581	1.00
233_V	268_I	0.578	1.00
160_A	179_V	0.577	1.00
204_R	209_K	0.577	1.00
222_R	228_L	0.576	1.00
146_L	150_A	0.576	1.00
150_A	153_R	0.575	1.00
120_Y	357_I	0.574	1.00
122_H	182_P	0.574	1.00
295_V	344_P	0.573	1.00
138_R	142_V	0.573	1.00
200_V	278_G	0.572	1.00
263_V	268_I	0.572	1.00
205_I	239_A	0.572	1.00
26_A	29_A	0.571	1.00
282_K	288_G	0.570	1.00
200_V	299_M	0.566	1.00
166_A	174_D	0.565	1.00
265_R	271_L	0.564	1.00
221_L	226_H	0.563	1.00
215_I	244_V	0.563	1.00
214_A	218_V	0.562	1.00
272_L	278_G	0.561	1.00
185_D	350_R	0.561	1.00
20_V	107_T	0.560	1.00
290_A	294_Y	0.559	1.00
248_R	254_R	0.559	1.00
316_D	333_A	0.557	1.00
217_V	279_L	0.555	1.00
306_S	310_V	0.552	1.00
54_D	58_P	0.552	1.00
149_P	153_R	0.552	1.00
111_L	154_P	0.548	1.00
124_P	127_R	0.546	1.00
98_A	101_Y	0.545	1.00
137_G	140_N	0.542	1.00
81_P	84_A	0.542	1.00
244_V	259_V	0.542	1.00
282_K	290_A	0.540	1.00
313_L	317_D	0.538	1.00
31_A	34_V	0.537	1.00
207_P	283_P	0.536	1.00
207_P	243_Y	0.535	1.00
104_A	115_L	0.535	1.00
200_V	231_T	0.533	1.00
121_V	165_T	0.532	1.00
222_R	227_D	0.532	1.00
157_R	161_N	0.532	1.00
288_G	292_A	0.532	1.00
141_G	144_S	0.532	1.00
46_A	49_A	0.532	1.00
11_L	22_V	0.532	1.00
77_P	80_G	0.531	1.00
217_V	221_L	0.529	1.00
140_N	144_S	0.527	1.00
21_C	36_L	0.526	1.00
145_R	149_P	0.526	1.00
96_R	100_A	0.525	1.00
57_V	61_A	0.525	1.00
225_G	228_L	0.524	1.00
164_W	311_D	0.524	1.00
181_H	353_F	0.521	1.00
298_G	344_P	0.521	1.00
322_E	327_A	0.519	1.00
117_S	156_T	0.518	1.00
184_V	296_A	0.518	1.00
14_R	262_D	0.518	1.00
272_L	294_Y	0.516	1.00
23_H	183_P	0.515	1.00
328_V	331_I	0.515	1.00
219_D	254_R	0.514	1.00
123_F	126_F	0.512	1.00
332_A	335_I	0.511	1.00
216_D	250_A	0.511	1.00
334_A	337_D	0.508	1.00
230_C	257_V	0.508	1.00
268_I	271_L	0.507	1.00
300_L	340_Q	0.507	1.00
70_A	73_S	0.505	1.00
277_Y	335_I	0.504	1.00
170_E	176_R	0.504	1.00
157_R	176_R	0.504	1.00
169_F	173_Y	0.504	1.00
121_V	124_P	0.502	1.00
234_G	261_T	0.500	1.00
202_L	290_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2r60A	1	0.9782	100	0.247	Contact Map
4n9wA	1	0.8801	100	0.257	Contact Map
3froA	3	0.9837	100	0.261	Contact Map
3okpA	1	0.9046	100	0.262	Contact Map
3c48A	2	0.9428	100	0.264	Contact Map
1rzuA	1	0.9782	100	0.278	Contact Map
3oy2A	2	0.8992	100	0.294	Contact Map
2qzsA	1	0.97	100	0.296	Contact Map
2x6qA	1	0.9128	100	0.298	Contact Map
3s28A	4	0.9891	100	0.304	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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