Q9HQT0 - HALSA - GREMLIN Contacts

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Q9HQT0 - Uncharacterized protein

UniProt:	Q9HQT0	Sequences: MTRVPRALRAQYWLLVAGFAVSGVGTAWGLSAALGHAGALRWVVAAAVPLAYVVGFLGRHLDANHRPSGVASADGGRPVRGTVGVANAVTATRGWLYAAVFGFVAVSPPVGSWWRWLPAAWYGSGVVLDTVDGALARRVGRRTVLGARLDLATDTLGFLCAPLVAVAWGRLPVWYLSLSLARYVFKLACWVRRRRGRHVGDLPPSRSRRLLAGMQMLFITVALVPVLPAAVVTPIAGIVLVPSLVVFGRDYCAVAGYFGVRDEGDAVEDTSETGGNAEGGSLR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	283 (219)
Sequences:	267 (209)
Seq/√Len:	14.1

HALSA - Q9HQT0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
84_G	87_N	4.551	1.00
180_L	184_V	4.412	1.00
185_F	202_L	3.631	0.99
207_S	249_R	3.531	0.99
202_L	250_D	3.057	0.98
202_L	208_R	2.918	0.97
185_F	254_V	2.799	0.96
207_S	245_V	2.772	0.96
221_V	235_I	2.713	0.95
205_S	210_L	2.647	0.94
155_T	243_S	2.619	0.94
208_R	250_D	2.590	0.94
243_S	246_V	2.565	0.93
152_A	182_R	2.339	0.90
116_W	225_P	2.323	0.89
155_T	158_F	2.318	0.89
120_A	177_S	2.299	0.89
185_F	250_D	2.282	0.89
98_A	102_G	2.275	0.88
128_L	131_V	2.138	0.85
130_T	213_G	2.094	0.84
122_Y	161_A	2.055	0.83
45_A	121_W	1.998	0.81
86_A	174_W	1.971	0.80
157_G	161_A	1.898	0.77
151_L	182_R	1.893	0.77
88_A	127_V	1.789	0.73
61_L	210_L	1.781	0.72
63_A	177_S	1.751	0.71
192_R	253_A	1.736	0.70
161_A	246_V	1.715	0.69
211_L	246_V	1.675	0.67
83_V	87_N	1.638	0.66
86_A	139_V	1.631	0.65
87_N	130_T	1.619	0.65
37_A	44_V	1.612	0.64
161_A	254_V	1.605	0.64
47_A	234_P	1.569	0.62
158_F	212_A	1.560	0.62
212_A	216_M	1.535	0.60
135_L	139_V	1.529	0.60
76_G	192_R	1.517	0.59
174_W	240_L	1.451	0.56
169_G	214_M	1.425	0.54
206_R	210_L	1.422	0.54
147_A	188_A	1.419	0.54
179_S	243_S	1.417	0.54
149_L	192_R	1.398	0.53
51_A	81_G	1.387	0.52
141_R	222_A	1.379	0.52
143_T	184_V	1.359	0.51
38_G	61_L	1.350	0.50
126_V	211_L	1.342	0.50
130_T	149_L	1.342	0.50
218_F	235_I	1.327	0.49
201_D	242_P	1.324	0.49
230_A	238_I	1.321	0.49
157_G	178_L	1.310	0.48
172_P	219_I	1.308	0.48
110_V	168_W	1.277	0.46
50_L	60_H	1.253	0.45
98_A	249_R	1.251	0.45
192_R	255_A	1.244	0.45
45_A	59_R	1.242	0.45
158_F	239_V	1.242	0.45
88_A	153_T	1.239	0.44
41_R	45_A	1.232	0.44
104_V	160_C	1.228	0.44
171_L	236_A	1.214	0.43
175_Y	195_R	1.214	0.43
101_F	245_V	1.210	0.43
195_R	256_G	1.207	0.43
239_V	243_S	1.200	0.42
145_L	252_C	1.190	0.42
193_R	254_V	1.180	0.41
124_S	145_L	1.177	0.41
143_T	230_A	1.176	0.41
147_A	152_A	1.158	0.40
57_L	217_L	1.148	0.40
153_T	214_M	1.143	0.39
115_R	127_V	1.137	0.39
224_V	228_P	1.135	0.39
158_F	178_L	1.128	0.39
86_A	135_L	1.122	0.38
161_A	212_A	1.116	0.38
83_V	209_R	1.112	0.38
163_L	235_I	1.112	0.38
195_R	254_V	1.112	0.38
171_L	180_L	1.112	0.38
122_Y	220_T	1.111	0.38
194_R	253_A	1.109	0.38
195_R	251_Y	1.095	0.37
115_R	218_F	1.094	0.37
84_G	212_A	1.092	0.37
188_A	195_R	1.073	0.36
209_R	213_G	1.072	0.36
56_F	101_F	1.071	0.36
178_L	251_Y	1.068	0.35
60_H	252_C	1.057	0.35
123_G	130_T	1.055	0.35
143_T	204_P	1.050	0.35
83_V	206_R	1.046	0.34
130_T	153_T	1.034	0.34
178_L	243_S	1.027	0.33
161_A	175_Y	1.026	0.33
98_A	101_F	1.023	0.33
194_R	258_F	1.021	0.33
192_R	196_G	1.017	0.33
84_G	215_Q	1.016	0.33
118_P	256_G	1.013	0.33
149_L	158_F	1.004	0.32
161_A	219_I	1.002	0.32
126_V	253_A	0.997	0.32
102_G	140_G	0.988	0.32
155_T	183_Y	0.983	0.31
120_A	184_V	0.982	0.31
236_A	244_L	0.973	0.31
181_A	211_L	0.969	0.31
100_V	200_G	0.968	0.31
155_T	246_V	0.965	0.31
180_L	217_L	0.963	0.30
188_A	254_V	0.957	0.30
57_L	111_G	0.951	0.30
149_L	209_R	0.946	0.30
238_I	241_V	0.944	0.30
186_K	239_V	0.944	0.30
57_L	234_P	0.940	0.29
191_V	200_G	0.939	0.29
46_A	78_P	0.932	0.29
161_A	172_P	0.928	0.29
50_L	131_V	0.922	0.29
125_G	243_S	0.918	0.28
222_A	236_A	0.916	0.28
179_S	246_V	0.914	0.28
246_V	254_V	0.912	0.28
194_R	255_A	0.903	0.28
148_R	183_Y	0.901	0.28
148_R	240_L	0.901	0.28
207_S	212_A	0.891	0.27
255_A	258_F	0.886	0.27
181_A	240_L	0.885	0.27
172_P	195_R	0.883	0.27
188_A	194_R	0.876	0.27
44_V	57_L	0.872	0.26
159_L	179_S	0.869	0.26
241_V	249_R	0.867	0.26
101_F	221_V	0.865	0.26
42_W	64_N	0.862	0.26
188_A	257_Y	0.858	0.26
81_G	236_A	0.857	0.26
87_N	215_Q	0.846	0.25
49_P	63_A	0.840	0.25
204_P	209_R	0.833	0.25
79_V	134_A	0.832	0.25
117_L	240_L	0.831	0.25
195_R	243_S	0.829	0.25
74_D	79_V	0.826	0.24
95_W	166_V	0.823	0.24
94_G	153_T	0.822	0.24
185_F	207_S	0.819	0.24
218_F	239_V	0.819	0.24
120_A	260_V	0.818	0.24
209_R	239_V	0.804	0.24
205_S	240_L	0.803	0.24
44_V	58_G	0.801	0.24
102_G	166_V	0.798	0.23
110_V	127_V	0.791	0.23
87_N	143_T	0.790	0.23
157_G	213_G	0.787	0.23
181_A	205_S	0.782	0.23
237_G	242_P	0.782	0.23
40_L	221_V	0.782	0.23
246_V	251_Y	0.780	0.23
166_V	225_P	0.777	0.23
209_R	216_M	0.777	0.23
122_Y	212_A	0.775	0.23
95_W	259_G	0.775	0.23
80_R	171_L	0.774	0.22
206_R	245_V	0.774	0.22
95_W	117_L	0.773	0.22
251_Y	254_V	0.766	0.22
203_P	256_G	0.764	0.22
99_A	212_A	0.763	0.22
97_Y	153_T	0.753	0.22
214_M	238_I	0.752	0.22
100_V	174_W	0.749	0.22
29_G	38_G	0.749	0.22
38_G	66_R	0.748	0.21
142_R	205_S	0.747	0.21
39_A	75_G	0.744	0.21
119_A	217_L	0.743	0.21
192_R	256_G	0.734	0.21
86_A	246_V	0.732	0.21
39_A	144_V	0.724	0.21
163_L	238_I	0.722	0.21
31_S	34_L	0.719	0.20
42_W	52_Y	0.718	0.20
205_S	250_D	0.715	0.20
167_A	236_A	0.712	0.20
175_Y	181_A	0.706	0.20
188_A	209_R	0.705	0.20
35_G	142_R	0.704	0.20
158_F	205_S	0.701	0.20
192_R	195_R	0.701	0.20
172_P	243_S	0.697	0.20
163_L	184_V	0.695	0.20
63_A	143_T	0.695	0.20
83_V	142_R	0.693	0.20
126_V	246_V	0.692	0.20
140_G	143_T	0.691	0.19
161_A	251_Y	0.691	0.19
194_R	211_L	0.689	0.19
213_G	216_M	0.688	0.19
119_A	230_A	0.685	0.19
46_A	109_P	0.677	0.19
212_A	249_R	0.674	0.19
155_T	179_S	0.674	0.19
119_A	131_V	0.674	0.19
243_S	254_V	0.670	0.19
220_T	237_G	0.669	0.19
163_L	234_P	0.669	0.19
100_V	145_L	0.664	0.19
86_A	217_L	0.664	0.19
219_I	254_V	0.663	0.19
34_L	124_S	0.663	0.19
143_T	250_D	0.661	0.18
110_V	237_G	0.656	0.18
83_V	210_L	0.652	0.18
158_F	258_F	0.652	0.18
128_L	222_A	0.650	0.18
181_A	220_T	0.649	0.18
124_S	218_F	0.644	0.18
86_A	158_F	0.643	0.18
65_H	87_N	0.642	0.18
142_R	242_P	0.638	0.18
140_G	228_P	0.637	0.18
104_V	163_L	0.636	0.18
86_A	103_F	0.632	0.18
206_R	209_R	0.632	0.18
44_V	54_V	0.629	0.17
87_N	178_L	0.629	0.17
185_F	208_R	0.627	0.17
191_V	229_A	0.627	0.17
97_Y	125_G	0.623	0.17
91_A	160_C	0.618	0.17
181_A	207_S	0.617	0.17
96_L	121_W	0.617	0.17
225_P	250_D	0.617	0.17
157_G	212_A	0.617	0.17
169_G	231_V	0.614	0.17
122_Y	157_G	0.614	0.17
97_Y	176_L	0.613	0.17
75_G	157_G	0.612	0.17
64_N	169_G	0.609	0.17
140_G	221_V	0.608	0.17
113_W	167_A	0.608	0.17
61_L	65_H	0.604	0.17
82_T	190_W	0.602	0.17
200_G	253_A	0.601	0.17
111_G	222_A	0.596	0.16
100_V	212_A	0.595	0.16
88_A	174_W	0.593	0.16
184_V	249_R	0.592	0.16
89_V	135_L	0.592	0.16
89_V	168_W	0.591	0.16
31_S	140_G	0.591	0.16
161_A	256_G	0.586	0.16
33_A	36_H	0.585	0.16
126_V	216_M	0.582	0.16
37_A	139_V	0.582	0.16
156_L	169_G	0.582	0.16
224_V	241_V	0.582	0.16
29_G	32_A	0.580	0.16
130_T	148_R	0.577	0.16
135_L	141_R	0.575	0.16
50_L	229_A	0.575	0.16
37_A	56_F	0.574	0.16
189_C	245_V	0.573	0.16
161_A	195_R	0.569	0.16
167_A	170_R	0.568	0.16
92_T	130_T	0.566	0.16
162_P	179_S	0.565	0.16
50_L	63_A	0.565	0.16
151_L	246_V	0.564	0.15
61_L	169_G	0.563	0.15
52_Y	218_F	0.563	0.15
211_L	258_F	0.561	0.15
83_V	91_A	0.560	0.15
215_Q	239_V	0.559	0.15
37_A	163_L	0.559	0.15
178_L	181_A	0.556	0.15
219_I	251_Y	0.553	0.15
33_A	227_L	0.553	0.15
172_P	253_A	0.550	0.15
53_V	59_R	0.548	0.15
130_T	212_A	0.547	0.15
94_G	184_V	0.546	0.15
50_L	108_P	0.545	0.15
92_T	241_V	0.539	0.15
117_L	192_R	0.538	0.15
195_R	219_I	0.537	0.15
219_I	246_V	0.537	0.15
85_V	139_V	0.536	0.15
38_G	85_V	0.535	0.15
107_S	143_T	0.530	0.15
186_K	192_R	0.524	0.14
44_V	124_S	0.523	0.14
175_Y	201_D	0.522	0.14
102_G	223_L	0.522	0.14
51_A	226_V	0.521	0.14
177_S	237_G	0.521	0.14
33_A	40_L	0.521	0.14
122_Y	246_V	0.518	0.14
122_Y	145_L	0.518	0.14
182_R	214_M	0.516	0.14
176_L	244_L	0.515	0.14
80_R	87_N	0.513	0.14
124_S	238_I	0.512	0.14
96_L	119_A	0.510	0.14
38_G	60_H	0.510	0.14
31_S	38_G	0.509	0.14
106_V	227_L	0.507	0.14
65_H	118_P	0.504	0.14
85_V	135_L	0.503	0.14
39_A	47_A	0.503	0.14
46_A	122_Y	0.502	0.14
175_Y	246_V	0.502	0.14
104_V	193_R	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4mndA	2	0.8233	99.2	0.844	Contact Map
4o6mA	2	0.7597	98.4	0.883	Contact Map
2kluA	1	0.1943	3.1	0.975	Contact Map
2l2tA	2	0.1519	1.8	0.978	Contact Map
4a2nB	1	0.3887	1.5	0.979	Contact Map
2kogA	1	0.1413	1.3	0.98	Contact Map
3wdoA	1	0.9435	1.3	0.98	Contact Map
3dd7B	1	0.0777	1.2	0.98	Contact Map
2mn3A	1	0.0883	1.2	0.981	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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