GREMLIN Database
Q9HQT0 - Uncharacterized protein
UniProt: Q9HQT0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 283 (219)
Sequences: 267 (209)
Seq/√Len: 14.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_G87_N4.5511.00
180_L184_V4.4121.00
185_F202_L3.6310.99
207_S249_R3.5310.99
202_L250_D3.0570.98
202_L208_R2.9180.97
185_F254_V2.7990.96
207_S245_V2.7720.96
221_V235_I2.7130.95
205_S210_L2.6470.94
155_T243_S2.6190.94
208_R250_D2.5900.94
243_S246_V2.5650.93
152_A182_R2.3390.90
116_W225_P2.3230.89
155_T158_F2.3180.89
120_A177_S2.2990.89
185_F250_D2.2820.89
98_A102_G2.2750.88
128_L131_V2.1380.85
130_T213_G2.0940.84
122_Y161_A2.0550.83
45_A121_W1.9980.81
86_A174_W1.9710.80
157_G161_A1.8980.77
151_L182_R1.8930.77
88_A127_V1.7890.73
61_L210_L1.7810.72
63_A177_S1.7510.71
192_R253_A1.7360.70
161_A246_V1.7150.69
211_L246_V1.6750.67
83_V87_N1.6380.66
86_A139_V1.6310.65
87_N130_T1.6190.65
37_A44_V1.6120.64
161_A254_V1.6050.64
47_A234_P1.5690.62
158_F212_A1.5600.62
212_A216_M1.5350.60
135_L139_V1.5290.60
76_G192_R1.5170.59
174_W240_L1.4510.56
169_G214_M1.4250.54
206_R210_L1.4220.54
147_A188_A1.4190.54
179_S243_S1.4170.54
149_L192_R1.3980.53
51_A81_G1.3870.52
141_R222_A1.3790.52
143_T184_V1.3590.51
38_G61_L1.3500.50
126_V211_L1.3420.50
130_T149_L1.3420.50
218_F235_I1.3270.49
201_D242_P1.3240.49
230_A238_I1.3210.49
157_G178_L1.3100.48
172_P219_I1.3080.48
110_V168_W1.2770.46
50_L60_H1.2530.45
98_A249_R1.2510.45
192_R255_A1.2440.45
45_A59_R1.2420.45
158_F239_V1.2420.45
88_A153_T1.2390.44
41_R45_A1.2320.44
104_V160_C1.2280.44
171_L236_A1.2140.43
175_Y195_R1.2140.43
101_F245_V1.2100.43
195_R256_G1.2070.43
239_V243_S1.2000.42
145_L252_C1.1900.42
193_R254_V1.1800.41
124_S145_L1.1770.41
143_T230_A1.1760.41
147_A152_A1.1580.40
57_L217_L1.1480.40
153_T214_M1.1430.39
115_R127_V1.1370.39
224_V228_P1.1350.39
158_F178_L1.1280.39
86_A135_L1.1220.38
161_A212_A1.1160.38
83_V209_R1.1120.38
163_L235_I1.1120.38
195_R254_V1.1120.38
171_L180_L1.1120.38
122_Y220_T1.1110.38
194_R253_A1.1090.38
195_R251_Y1.0950.37
115_R218_F1.0940.37
84_G212_A1.0920.37
188_A195_R1.0730.36
209_R213_G1.0720.36
56_F101_F1.0710.36
178_L251_Y1.0680.35
60_H252_C1.0570.35
123_G130_T1.0550.35
143_T204_P1.0500.35
83_V206_R1.0460.34
130_T153_T1.0340.34
178_L243_S1.0270.33
161_A175_Y1.0260.33
98_A101_F1.0230.33
194_R258_F1.0210.33
192_R196_G1.0170.33
84_G215_Q1.0160.33
118_P256_G1.0130.33
149_L158_F1.0040.32
161_A219_I1.0020.32
126_V253_A0.9970.32
102_G140_G0.9880.32
155_T183_Y0.9830.31
120_A184_V0.9820.31
236_A244_L0.9730.31
181_A211_L0.9690.31
100_V200_G0.9680.31
155_T246_V0.9650.31
180_L217_L0.9630.30
188_A254_V0.9570.30
57_L111_G0.9510.30
149_L209_R0.9460.30
238_I241_V0.9440.30
186_K239_V0.9440.30
57_L234_P0.9400.29
191_V200_G0.9390.29
46_A78_P0.9320.29
161_A172_P0.9280.29
50_L131_V0.9220.29
125_G243_S0.9180.28
222_A236_A0.9160.28
179_S246_V0.9140.28
246_V254_V0.9120.28
194_R255_A0.9030.28
148_R183_Y0.9010.28
148_R240_L0.9010.28
207_S212_A0.8910.27
255_A258_F0.8860.27
181_A240_L0.8850.27
172_P195_R0.8830.27
188_A194_R0.8760.27
44_V57_L0.8720.26
159_L179_S0.8690.26
241_V249_R0.8670.26
101_F221_V0.8650.26
42_W64_N0.8620.26
188_A257_Y0.8580.26
81_G236_A0.8570.26
87_N215_Q0.8460.25
49_P63_A0.8400.25
204_P209_R0.8330.25
79_V134_A0.8320.25
117_L240_L0.8310.25
195_R243_S0.8290.25
74_D79_V0.8260.24
95_W166_V0.8230.24
94_G153_T0.8220.24
185_F207_S0.8190.24
218_F239_V0.8190.24
120_A260_V0.8180.24
209_R239_V0.8040.24
205_S240_L0.8030.24
44_V58_G0.8010.24
102_G166_V0.7980.23
110_V127_V0.7910.23
87_N143_T0.7900.23
157_G213_G0.7870.23
181_A205_S0.7820.23
237_G242_P0.7820.23
40_L221_V0.7820.23
246_V251_Y0.7800.23
166_V225_P0.7770.23
209_R216_M0.7770.23
122_Y212_A0.7750.23
95_W259_G0.7750.23
80_R171_L0.7740.22
206_R245_V0.7740.22
95_W117_L0.7730.22
251_Y254_V0.7660.22
203_P256_G0.7640.22
99_A212_A0.7630.22
97_Y153_T0.7530.22
214_M238_I0.7520.22
100_V174_W0.7490.22
29_G38_G0.7490.22
38_G66_R0.7480.21
142_R205_S0.7470.21
39_A75_G0.7440.21
119_A217_L0.7430.21
192_R256_G0.7340.21
86_A246_V0.7320.21
39_A144_V0.7240.21
163_L238_I0.7220.21
31_S34_L0.7190.20
42_W52_Y0.7180.20
205_S250_D0.7150.20
167_A236_A0.7120.20
175_Y181_A0.7060.20
188_A209_R0.7050.20
35_G142_R0.7040.20
158_F205_S0.7010.20
192_R195_R0.7010.20
172_P243_S0.6970.20
163_L184_V0.6950.20
63_A143_T0.6950.20
83_V142_R0.6930.20
126_V246_V0.6920.20
140_G143_T0.6910.19
161_A251_Y0.6910.19
194_R211_L0.6890.19
213_G216_M0.6880.19
119_A230_A0.6850.19
46_A109_P0.6770.19
212_A249_R0.6740.19
155_T179_S0.6740.19
119_A131_V0.6740.19
243_S254_V0.6700.19
220_T237_G0.6690.19
163_L234_P0.6690.19
100_V145_L0.6640.19
86_A217_L0.6640.19
219_I254_V0.6630.19
34_L124_S0.6630.19
143_T250_D0.6610.18
110_V237_G0.6560.18
83_V210_L0.6520.18
158_F258_F0.6520.18
128_L222_A0.6500.18
181_A220_T0.6490.18
124_S218_F0.6440.18
86_A158_F0.6430.18
65_H87_N0.6420.18
142_R242_P0.6380.18
140_G228_P0.6370.18
104_V163_L0.6360.18
86_A103_F0.6320.18
206_R209_R0.6320.18
44_V54_V0.6290.17
87_N178_L0.6290.17
185_F208_R0.6270.17
191_V229_A0.6270.17
97_Y125_G0.6230.17
91_A160_C0.6180.17
181_A207_S0.6170.17
96_L121_W0.6170.17
225_P250_D0.6170.17
157_G212_A0.6170.17
169_G231_V0.6140.17
122_Y157_G0.6140.17
97_Y176_L0.6130.17
75_G157_G0.6120.17
64_N169_G0.6090.17
140_G221_V0.6080.17
113_W167_A0.6080.17
61_L65_H0.6040.17
82_T190_W0.6020.17
200_G253_A0.6010.17
111_G222_A0.5960.16
100_V212_A0.5950.16
88_A174_W0.5930.16
184_V249_R0.5920.16
89_V135_L0.5920.16
89_V168_W0.5910.16
31_S140_G0.5910.16
161_A256_G0.5860.16
33_A36_H0.5850.16
126_V216_M0.5820.16
37_A139_V0.5820.16
156_L169_G0.5820.16
224_V241_V0.5820.16
29_G32_A0.5800.16
130_T148_R0.5770.16
135_L141_R0.5750.16
50_L229_A0.5750.16
37_A56_F0.5740.16
189_C245_V0.5730.16
161_A195_R0.5690.16
167_A170_R0.5680.16
92_T130_T0.5660.16
162_P179_S0.5650.16
50_L63_A0.5650.16
151_L246_V0.5640.15
61_L169_G0.5630.15
52_Y218_F0.5630.15
211_L258_F0.5610.15
83_V91_A0.5600.15
215_Q239_V0.5590.15
37_A163_L0.5590.15
178_L181_A0.5560.15
219_I251_Y0.5530.15
33_A227_L0.5530.15
172_P253_A0.5500.15
53_V59_R0.5480.15
130_T212_A0.5470.15
94_G184_V0.5460.15
50_L108_P0.5450.15
92_T241_V0.5390.15
117_L192_R0.5380.15
195_R219_I0.5370.15
219_I246_V0.5370.15
85_V139_V0.5360.15
38_G85_V0.5350.15
107_S143_T0.5300.15
186_K192_R0.5240.14
44_V124_S0.5230.14
175_Y201_D0.5220.14
102_G223_L0.5220.14
51_A226_V0.5210.14
177_S237_G0.5210.14
33_A40_L0.5210.14
122_Y246_V0.5180.14
122_Y145_L0.5180.14
182_R214_M0.5160.14
176_L244_L0.5150.14
80_R87_N0.5130.14
124_S238_I0.5120.14
96_L119_A0.5100.14
38_G60_H0.5100.14
31_S38_G0.5090.14
106_V227_L0.5070.14
65_H118_P0.5040.14
85_V135_L0.5030.14
39_A47_A0.5030.14
46_A122_Y0.5020.14
175_Y246_V0.5020.14
104_V193_R0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mndA 2 0.8233 99.2 0.844 Contact Map
4o6mA 2 0.7597 98.4 0.883 Contact Map
2kluA 1 0.1943 3.1 0.975 Contact Map
2l2tA 2 0.1519 1.8 0.978 Contact Map
4a2nB 1 0.3887 1.5 0.979 Contact Map
2kogA 1 0.1413 1.3 0.98 Contact Map
3wdoA 1 0.9435 1.3 0.98 Contact Map
3dd7B 1 0.0777 1.2 0.98 Contact Map
2mn3A 1 0.0883 1.2 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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