GREMLIN Database
GCH32 - GTP cyclohydrolase III 2
UniProt: Q9HQS9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 253 (235)
Sequences: 107 (71)
Seq/√Len: 4.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_V214_Q7.3451.00
38_F69_L3.8310.85
38_F116_A3.0690.69
38_F84_G3.0490.69
2_A58_A2.9000.64
146_Y159_I2.8520.63
81_V140_V2.6490.57
48_A51_F2.6420.57
151_S154_R2.6400.57
86_G118_S2.5850.55
36_A116_A2.2210.44
69_L116_A2.2140.43
31_L132_V2.1080.40
4_V81_V2.0880.40
69_L84_G2.0870.40
161_G168_E2.0800.39
137_F215_V1.9970.37
237_C241_G1.8480.33
46_A66_F1.8300.32
137_F227_G1.8260.32
45_Y205_V1.8200.32
151_S171_Y1.7860.31
175_D214_Q1.7840.31
220_G225_D1.7530.30
88_A97_A1.7290.30
58_A66_F1.7260.29
22_T38_F1.6920.29
22_T69_L1.6710.28
154_R171_Y1.6700.28
10_G180_F1.6650.28
141_D210_G1.6400.27
32_F152_P1.6390.27
4_V104_D1.6360.27
11_P180_F1.6360.27
2_A56_G1.6010.26
22_T84_G1.5990.26
32_F36_A1.5920.26
111_E118_S1.5780.26
37_D163_V1.5740.26
90_T219_H1.5660.26
90_T176_A1.5560.25
161_G202_T1.5500.25
56_G179_Q1.5420.25
54_M233_A1.5200.24
93_D210_G1.5050.24
66_F213_F1.5000.24
5_Q82_S1.4890.24
87_T120_R1.4810.24
61_I65_A1.4660.23
194_D197_I1.4650.23
11_P24_L1.4370.23
10_G24_L1.4360.23
30_R71_E1.4010.22
132_V176_A1.4000.22
121_S129_P1.3800.21
61_I88_A1.3770.21
56_G66_F1.3610.21
134_I178_T1.3540.21
48_A157_T1.3430.21
197_I220_G1.3410.21
45_Y227_G1.3390.21
30_R40_G1.3320.20
19_R224_H1.3190.20
24_L180_F1.3120.20
44_G222_T1.3030.20
155_A161_G1.2910.20
90_T129_P1.2880.19
100_T112_N1.2810.19
35_V73_I1.2720.19
85_I121_S1.2650.19
22_T176_A1.2610.19
3_A81_V1.2590.19
35_V99_G1.2510.19
4_V117_L1.2490.19
141_D144_G1.2490.19
127_G168_E1.2430.19
114_Q149_T1.2390.19
13_T50_R1.2310.18
81_V195_A1.2300.18
130_G196_G1.2250.18
132_V152_P1.2130.18
177_V202_T1.2000.18
43_D206_R1.2000.18
71_E146_Y1.1820.18
70_Q213_F1.1760.17
39_L187_I1.1750.17
36_A149_T1.1730.17
45_Y187_I1.1720.17
61_I200_D1.1650.17
160_Q164_T1.1620.17
86_G208_A1.1550.17
48_A198_V1.1520.17
22_T32_F1.1500.17
11_P47_F1.1470.17
169_Y173_T1.1430.17
73_I170_L1.1400.17
4_V56_G1.1380.17
165_T176_A1.1340.17
210_G225_D1.1310.17
86_G111_E1.1300.17
208_A223_P1.1260.17
14_T24_L1.1170.16
118_S121_S1.1130.16
37_D177_V1.1120.16
158_E220_G1.1040.16
43_D195_A1.1040.16
112_N121_S1.0990.16
65_A93_D1.0900.16
68_R157_T1.0770.16
58_A213_F1.0740.16
187_I205_V1.0710.16
19_R241_G1.0700.16
151_S178_T1.0550.15
35_V46_A1.0530.15
8_D72_R1.0400.15
196_G212_D1.0380.15
100_T219_H1.0320.15
211_V232_H1.0280.15
73_I90_T1.0250.15
67_E128_T1.0200.15
22_T36_A1.0200.15
159_I209_A1.0070.15
175_D194_D1.0050.15
4_V239_A1.0010.14
4_V153_V0.9970.14
121_S194_D0.9940.14
22_T224_H0.9910.14
186_A220_G0.9880.14
8_D235_E0.9770.14
38_F224_H0.9730.14
14_T180_F0.9670.14
47_F70_Q0.9630.14
92_A188_A0.9630.14
73_I85_I0.9630.14
11_P14_T0.9610.14
115_E235_E0.9610.14
22_T214_Q0.9580.14
176_A214_Q0.9560.14
51_F175_D0.9540.14
93_D101_A0.9540.14
13_T238_R0.9490.14
50_R234_L0.9490.14
50_R238_R0.9490.14
13_T234_L0.9490.14
86_G126_A0.9460.14
27_L133_T0.9360.14
70_Q180_F0.9350.13
224_H241_G0.9340.13
234_L238_R0.9320.13
16_P231_K0.9290.13
10_G14_T0.9250.13
149_T197_I0.9180.13
93_D173_T0.9080.13
29_A55_V0.9060.13
39_L155_A0.9020.13
44_G91_P0.9020.13
18_P56_G0.9000.13
100_T207_E0.9000.13
29_A59_T0.8920.13
105_A237_C0.8910.13
61_I128_T0.8860.13
55_V242_A0.8840.13
24_L75_N0.8830.13
104_D197_I0.8830.13
203_A210_G0.8820.13
69_L176_A0.8770.13
64_A229_D0.8710.13
8_D99_G0.8700.13
84_G242_A0.8700.13
64_A211_V0.8650.13
63_P203_A0.8640.12
4_V116_A0.8630.12
6_I121_S0.8610.12
214_Q224_H0.8550.12
112_N196_G0.8550.12
46_A213_F0.8520.12
236_T239_A0.8520.12
116_A176_A0.8510.12
119_H209_A0.8450.12
2_A83_V0.8430.12
19_R40_G0.8380.12
44_G61_I0.8370.12
40_G135_A0.8320.12
157_T167_A0.8230.12
229_D237_C0.8150.12
7_D53_N0.8140.12
2_A66_F0.8140.12
89_R207_E0.8110.12
61_I221_D0.8080.12
32_F69_L0.8070.12
59_T179_Q0.8060.12
49_G195_A0.8060.12
81_V221_D0.8050.12
139_V202_T0.8050.12
10_G70_Q0.8050.12
29_A134_I0.7920.12
86_G195_A0.7890.12
214_Q237_C0.7880.11
104_D200_D0.7880.11
26_A157_T0.7870.11
22_T175_D0.7870.11
112_N120_R0.7860.11
130_G149_T0.7790.11
6_I213_F0.7780.11
58_A220_G0.7770.11
8_D31_L0.7770.11
215_V231_K0.7760.11
26_A153_V0.7700.11
120_R126_A0.7630.11
193_I199_D0.7620.11
44_G143_T0.7540.11
108_A147_T0.7500.11
178_T186_A0.7500.11
128_T156_G0.7470.11
112_N130_G0.7460.11
17_A224_H0.7450.11
114_Q120_R0.7380.11
36_A69_L0.7350.11
10_G91_P0.7340.11
165_T208_A0.7280.11
157_T201_A0.7270.11
139_V201_A0.7260.11
101_A171_Y0.7240.11
64_A102_L0.7200.11
88_A100_T0.7170.11
10_G47_F0.7130.11
163_V178_T0.7060.10
154_R157_T0.7060.10
8_D66_F0.7050.10
72_R133_T0.7000.10
32_F84_G0.7000.10
83_V155_A0.6980.10
95_L237_C0.6980.10
6_I133_T0.6950.10
22_T116_A0.6930.10
55_V61_I0.6930.10
15_E57_A0.6930.10
3_A73_I0.6820.10
45_Y231_K0.6790.10
73_I211_V0.6770.10
194_D219_H0.6690.10
106_G113_R0.6680.10
178_T204_H0.6670.10
11_P27_L0.6650.10
199_D203_A0.6650.10
137_F163_V0.6640.10
101_A126_A0.6630.10
62_A111_E0.6630.10
29_A32_F0.6600.10
181_V231_K0.6580.10
8_D113_R0.6570.10
231_K235_E0.6530.10
53_N235_E0.6500.10
7_D75_N0.6490.10
15_E192_E0.6480.10
155_A167_A0.6470.10
70_Q235_E0.6410.10
39_L203_A0.6380.10
34_D148_D0.6370.10
20_R43_D0.6350.10
2_A177_V0.6350.10
133_T177_V0.6330.10
227_G237_C0.6330.10
27_L180_F0.6290.10
94_A218_G0.6280.10
117_L167_A0.6260.10
139_V215_V0.6260.10
77_Y235_E0.6250.10
112_N126_A0.6240.10
48_A167_A0.6230.10
27_L47_F0.6220.10
20_R169_Y0.6210.10
40_G232_H0.6200.10
16_P19_R0.6180.10
137_F187_I0.6170.09
99_G170_L0.6170.09
10_G82_S0.6150.09
153_V157_T0.6150.09
34_D77_Y0.6130.09
6_I151_S0.6130.09
29_A140_V0.6120.09
3_A197_I0.6110.09
93_D239_A0.6030.09
3_A57_A0.6030.09
84_G159_I0.6020.09
11_P70_Q0.6020.09
63_P89_R0.6000.09
61_I198_V0.6000.09
121_S195_A0.5990.09
120_R220_G0.5960.09
47_F180_F0.5950.09
130_G159_I0.5940.09
165_T194_D0.5910.09
103_R152_P0.5900.09
56_G59_T0.5880.09
111_E194_D0.5870.09
15_E72_R0.5840.09
56_G82_S0.5810.09
190_C224_H0.5750.09
20_R159_I0.5730.09
22_T102_L0.5690.09
69_L96_D0.5640.09
111_E208_A0.5630.09
112_N219_H0.5620.09
11_P77_Y0.5610.09
83_V213_F0.5610.09
148_D166_L0.5590.09
132_V228_A0.5560.09
29_A72_R0.5530.09
4_V169_Y0.5500.09
37_D164_T0.5480.09
74_R90_T0.5470.09
165_T209_A0.5470.09
50_R143_T0.5460.09
13_T143_T0.5460.09
51_F133_T0.5450.09
96_D194_D0.5450.09
63_P221_D0.5440.09
14_T148_D0.5380.09
88_A93_D0.5380.09
64_A74_R0.5370.09
30_R211_V0.5370.09
73_I104_D0.5360.09
89_R194_D0.5340.09
23_D75_N0.5320.09
24_L34_D0.5310.09
27_L189_V0.5300.09
149_T156_G0.5280.09
163_V168_E0.5270.09
54_M73_I0.5270.09
10_G27_L0.5240.09
16_P235_E0.5220.09
79_V215_V0.5220.09
116_A120_R0.5210.09
121_S133_T0.5200.09
36_A237_C0.5200.09
65_A221_D0.5150.08
106_G235_E0.5130.08
67_E159_I0.5100.08
220_G229_D0.5100.08
88_A126_A0.5100.08
111_E229_D0.5100.08
85_I88_A0.5090.08
39_L111_E0.5090.08
141_D169_Y0.5060.08
6_I27_L0.5040.08
40_G60_G0.5040.08
11_P108_A0.5010.08
52_D185_N0.5000.08
138_D184_D0.5000.08
138_D183_G0.5000.08
138_D182_G0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qv6A 4 0.9842 100 0.143 Contact Map
3i5cA 2 0.6917 97.1 0.93 Contact Map
3hvaA 1 0.5731 96.8 0.933 Contact Map
3tvkA 1 0.5968 96.4 0.936 Contact Map
3hvwA 1 0.5415 96.4 0.936 Contact Map
4urgA 1 0.5613 96.2 0.937 Contact Map
3x1lA 1 0.6838 96.2 0.937 Contact Map
4j40A 2 0 96.1 0.937 Contact Map
4w8yA 1 0.7708 95.9 0.938 Contact Map
3qyyA 1 0.5652 95.9 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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