Q9HQS8 - HALSA - GREMLIN Contacts

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Q9HQS8 - Uncharacterized protein

UniProt:	Q9HQS8	Sequences: MDARTLYFTGPGSVAVRTGTVSDPVDDEVVVETQASGISAGSELLVYRGEFPESLPVDATIDALDGEFDYPLAYGYASVGTVTATGPDSTEWLDRRVFAFEPHATRFRTTPDAVVELPDDIATQAATLLPTVETATNLVLDAQPRIGERAVVFGAGAVGLATTQLLASFPLSEVVVVEPLASRRATAAAVGADRTIDPGSTAIADAPPFADAEPAGADVVFELSGRPETLDDAIAAAGYDSRVIVGSWYGAKRAPIDLGGSFHRDRVDIVSSQVSTLSPELRGRWDTDRRFDVAFDRLDAMDADALITHELPLDRAADAYALLDDHPDEARHIILTYQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	338 (299)
Sequences:	52675 (36510)
Seq/√Len:	2111.4

ECOLI - YGGP YCJQ YBDR RSPB FRMA ADHP YAHK YDJJ YDJL GATD YPHC TDH YJJN AHR QOR1 CURA ACUI IDND
BACSU - BDHA YJMD ADHB YOGA DHSO ADHA YHFP YFMJ YYCR TDH
HALSA - Q9HQS8 Q9HR85 Q9HP38 Q9HMB6 GLCDH
SULSO - ADH Q97YT7 Q97XR4 Q7LXK1 Q97ZV3 Q97VV5 Q97VW0 Q97WA1 Q97TZ4 GLCD2 Q97V32 GLCD3 Q97VB8 GLCD1 Q97YM2 Q97W06 Q97UW5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
34_Q	123_T	3.070	1.00
32_E	83_T	2.968	1.00
34_Q	81_T	2.931	1.00
315_R	318_D	2.742	1.00
149_R	173_E	2.594	1.00
9_T	17_R	2.577	1.00
30_V	83_T	2.532	1.00
96_R	117_L	2.372	1.00
95_R	116_E	2.336	1.00
155_A	176_V	2.331	1.00
124_Q	310_E	2.312	1.00
311_L	322_L	2.305	1.00
29_V	114_V	2.295	1.00
21_V	106_R	2.277	1.00
122_A	125_A	2.252	1.00
9_T	15_A	2.246	1.00
32_E	106_R	2.222	1.00
167_A	193_D	2.185	1.00
32_E	81_T	2.181	1.00
150_A	166_L	2.157	1.00
309_H	322_L	2.127	1.00
310_E	336_T	2.124	1.00
145_R	148_E	2.110	1.00
184_R	188_A	2.072	1.00
7_Y	17_R	2.046	1.00
25_V	28_E	2.042	1.00
26_D	87_P	2.027	1.00
206_A	209_F	2.022	1.00
26_D	88_D	2.008	1.00
30_V	108_R	1.985	1.00
91_E	111_P	1.979	1.00
173_E	194_R	1.972	1.00
140_L	169_F	1.957	1.00
83_T	106_R	1.954	1.00
163_T	192_A	1.946	1.00
78_S	99_A	1.944	1.00
48_R	324_D	1.912	1.00
78_S	102_P	1.904	1.00
321_A	325_D	1.853	1.00
27_D	88_D	1.851	1.00
184_R	195_T	1.840	1.00
168_S	302_D	1.829	1.00
120_D	299_D	1.807	1.00
242_R	268_D	1.799	1.00
79_V	123_T	1.785	1.00
96_R	123_T	1.782	1.00
312_P	315_R	1.760	1.00
322_L	327_P	1.740	1.00
185_A	189_A	1.736	1.00
140_L	293_V	1.736	1.00
151_V	177_V	1.721	1.00
218_D	238_G	1.714	1.00
242_R	270_V	1.700	1.00
151_V	217_A	1.697	1.00
296_D	300_A	1.669	1.00
185_A	188_A	1.665	1.00
186_T	189_A	1.664	1.00
117_L	123_T	1.649	1.00
318_D	321_A	1.613	1.00
311_L	319_A	1.599	1.00
318_D	322_L	1.591	1.00
175_V	217_A	1.579	1.00
308_T	322_L	1.572	1.00
30_V	106_R	1.571	1.00
6_L	316_A	1.565	1.00
23_D	84_A	1.557	1.00
81_T	96_R	1.552	1.00
173_E	193_D	1.532	1.00
4_R	18_T	1.523	1.00
201_T	206_A	1.522	1.00
85_T	93_L	1.514	1.00
92_W	95_R	1.501	1.00
117_L	126_A	1.492	1.00
181_A	197_D	1.489	1.00
84_A	93_L	1.489	1.00
237_A	243_V	1.478	1.00
178_E	184_R	1.477	1.00
153_F	233_A	1.476	1.00
181_A	185_A	1.472	1.00
220_V	237_A	1.467	1.00
237_A	267_V	1.460	1.00
103_H	320_Y	1.457	1.00
30_V	84_A	1.457	1.00
27_D	110_T	1.454	1.00
317_A	321_A	1.449	1.00
124_Q	336_T	1.435	1.00
33_T	78_S	1.426	1.00
142_A	219_V	1.415	1.00
86_G	89_S	1.413	1.00
92_W	116_E	1.411	1.00
28_E	110_T	1.409	1.00
237_A	241_S	1.406	1.00
125_A	304_D	1.402	1.00
28_E	108_R	1.393	1.00
181_A	200_S	1.383	1.00
5_T	19_G	1.367	1.00
24_P	108_R	1.358	1.00
220_V	233_A	1.344	1.00
197_D	200_S	1.332	1.00
4_R	314_D	1.326	1.00
168_S	297_R	1.325	1.00
148_E	242_R	1.316	1.00
181_A	184_R	1.299	1.00
24_P	30_V	1.299	1.00
96_R	119_D	1.294	1.00
35_A	124_Q	1.293	1.00
81_T	123_T	1.290	1.00
202_A	205_D	1.282	1.00
6_L	16_V	1.275	1.00
162_T	221_F	1.275	1.00
29_V	92_W	1.267	1.00
82_V	92_W	1.252	1.00
179_P	198_P	1.248	1.00
149_R	175_V	1.247	1.00
136_T	140_L	1.246	1.00
171_L	174_V	1.239	1.00
47_Y	320_Y	1.237	1.00
153_F	177_V	1.235	1.00
312_P	336_T	1.228	1.00
33_T	107_F	1.217	1.00
34_Q	96_R	1.217	1.00
4_R	105_T	1.194	1.00
21_V	30_V	1.192	1.00
163_T	176_V	1.180	1.00
184_R	197_D	1.163	1.00
10_G	13_S	1.161	1.00
27_D	111_P	1.155	1.00
288_D	292_D	1.151	1.00
92_W	114_V	1.142	1.00
296_D	299_D	1.135	1.00
212_A	215_A	1.134	1.00
149_R	218_D	1.131	1.00
188_A	195_T	1.128	1.00
129_L	298_L	1.122	1.00
204_A	235_A	1.116	1.00
35_A	336_T	1.114	1.00
293_V	296_D	1.093	1.00
202_A	206_A	1.087	1.00
109_T	114_V	1.069	1.00
137_N	290_R	1.068	1.00
7_Y	19_G	1.063	1.00
148_E	218_D	1.061	1.00
186_T	330_A	1.054	1.00
205_D	209_F	1.046	1.00
36_S	103_H	1.046	1.00
135_A	162_T	1.041	1.00
204_A	232_D	1.038	1.00
232_D	235_A	1.026	1.00
142_A	244_I	1.021	1.00
188_A	194_R	1.015	1.00
35_A	123_T	1.014	1.00
297_R	302_D	1.013	1.00
316_A	335_L	1.010	1.00
47_Y	324_D	1.010	1.00
16_V	314_D	0.998	1.00
38_I	319_A	0.998	1.00
235_A	260_G	0.997	1.00
89_S	111_P	0.990	1.00
321_A	324_D	0.988	1.00
31_V	97_V	0.982	1.00
9_T	13_S	0.981	1.00
83_T	93_L	0.978	1.00
140_L	290_R	0.975	1.00
136_T	293_V	0.974	1.00
224_S	229_T	0.974	1.00
31_V	80_G	0.973	1.00
6_L	313_L	0.972	1.00
138_L	246_G	0.967	1.00
175_V	194_R	0.962	1.00
179_P	199_G	0.952	1.00
322_L	333_I	0.950	1.00
176_V	187_A	0.946	1.00
144_P	148_E	0.943	1.00
293_V	297_R	0.942	1.00
200_S	206_A	0.941	1.00
24_P	28_E	0.932	1.00
204_A	208_P	0.928	1.00
144_P	172_S	0.926	1.00
90_T	111_P	0.922	1.00
155_A	178_E	0.919	1.00
155_A	187_A	0.916	1.00
180_L	183_R	0.916	1.00
35_A	334_I	0.909	1.00
72_L	100_F	0.908	1.00
138_L	221_F	0.908	1.00
292_D	296_D	0.907	1.00
183_R	330_A	0.905	1.00
103_H	316_A	0.903	1.00
135_A	165_L	0.903	1.00
155_A	163_T	0.902	1.00
121_I	126_A	0.902	1.00
231_D	235_A	0.901	1.00
98_F	295_F	0.900	1.00
311_L	315_R	0.898	1.00
148_E	219_V	0.895	1.00
160_L	186_T	0.894	1.00
4_R	16_V	0.889	1.00
176_V	192_A	0.878	1.00
44_L	323_L	0.877	1.00
189_A	305_A	0.876	1.00
240_D	266_R	0.872	1.00
39_S	77_A	0.871	1.00
11_P	70_Y	0.869	1.00
177_V	198_P	0.868	1.00
257_D	260_G	0.867	1.00
163_T	174_V	0.863	1.00
151_V	236_A	0.859	1.00
289_R	293_V	0.852	1.00
36_S	102_P	0.847	1.00
175_V	196_I	0.847	1.00
32_E	105_T	0.844	1.00
25_V	108_R	0.843	1.00
34_Q	79_V	0.843	1.00
182_S	185_A	0.843	1.00
6_L	14_V	0.842	1.00
21_V	84_A	0.841	1.00
222_E	225_G	0.839	1.00
153_F	220_V	0.835	1.00
228_E	232_D	0.835	1.00
133_E	290_R	0.834	1.00
152_V	166_L	0.829	1.00
39_S	76_Y	0.815	1.00
78_S	107_F	0.814	1.00
309_H	318_D	0.812	1.00
7_Y	73_A	0.810	1.00
85_T	89_S	0.806	1.00
189_A	306_L	0.803	1.00
5_T	73_A	0.801	1.00
260_G	265_D	0.801	1.00
169_F	293_V	0.801	1.00
21_V	83_T	0.798	1.00
9_T	12_G	0.798	1.00
29_V	111_P	0.796	1.00
102_P	107_F	0.787	1.00
19_G	100_F	0.783	1.00
115_V	292_D	0.782	1.00
164_Q	304_D	0.780	1.00
143_Q	242_R	0.778	1.00
149_R	215_A	0.777	1.00
178_E	195_T	0.772	1.00
153_F	229_T	0.767	1.00
207_P	217_A	0.767	1.00
289_R	292_D	0.764	1.00
179_P	184_R	0.761	1.00
165_L	294_A	0.760	1.00
152_V	162_T	0.758	1.00
311_L	333_I	0.757	1.00
203_I	232_D	0.755	1.00
233_A	243_V	0.754	1.00
220_V	243_V	0.751	1.00
187_A	192_A	0.751	1.00
205_D	208_P	0.750	1.00
16_V	313_L	0.750	1.00
37_G	77_A	0.746	1.00
231_D	253_R	0.744	1.00
23_D	30_V	0.742	1.00
19_G	73_A	0.742	1.00
143_Q	268_D	0.741	1.00
103_H	335_L	0.738	1.00
38_I	323_L	0.737	1.00
223_L	246_G	0.737	1.00
139_V	166_L	0.734	1.00
135_A	161_A	0.733	1.00
144_P	171_L	0.731	1.00
119_D	299_D	0.726	1.00
322_L	325_D	0.726	1.00
297_R	300_A	0.726	1.00
6_L	317_A	0.725	1.00
138_L	162_T	0.725	1.00
91_E	288_D	0.723	1.00
266_R	276_T	0.721	1.00
160_L	306_L	0.720	1.00
42_S	76_Y	0.718	1.00
165_L	297_R	0.718	1.00
307_I	310_E	0.717	1.00
24_P	84_A	0.715	1.00
149_R	217_A	0.713	1.00
186_T	306_L	0.711	1.00
147_G	172_S	0.703	1.00
44_L	324_D	0.698	1.00
166_L	174_V	0.696	1.00
132_V	161_A	0.694	1.00
245_V	269_I	0.692	1.00
204_A	236_A	0.692	1.00
202_A	232_D	0.692	1.00
98_F	117_L	0.690	1.00
194_R	206_A	0.690	1.00
39_S	43_E	0.690	1.00
261_S	269_I	0.687	1.00
27_D	112_D	0.685	1.00
175_V	207_P	0.681	1.00
97_V	114_V	0.678	1.00
311_L	335_L	0.676	1.00
22_S	108_R	0.672	1.00
136_T	297_R	0.671	1.00
137_N	266_R	0.670	1.00
24_P	86_G	0.669	1.00
144_P	219_V	0.664	1.00
33_T	36_S	0.664	1.00
27_D	87_P	0.663	1.00
323_L	333_I	0.663	1.00
79_V	127_T	0.662	1.00
143_Q	270_V	0.660	1.00
239_Y	265_D	0.658	1.00
134_T	158_V	0.647	1.00
27_D	86_G	0.647	1.00
68_F	72_L	0.644	1.00
186_T	190_V	0.639	1.00
115_V	291_F	0.638	1.00
135_A	158_V	0.637	1.00
180_L	197_D	0.637	1.00
217_A	220_V	0.637	1.00
222_E	243_V	0.636	1.00
136_T	290_R	0.636	1.00
136_T	294_A	0.635	1.00
29_V	82_V	0.634	1.00
164_Q	190_V	0.634	1.00
45_L	50_E	0.632	1.00
230_L	243_V	0.631	1.00
99_A	109_T	0.631	1.00
85_T	95_R	0.629	1.00
141_D	290_R	0.628	1.00
172_S	219_V	0.628	1.00
152_V	176_V	0.626	1.00
125_A	129_L	0.624	1.00
121_I	298_L	0.623	1.00
226_R	229_T	0.623	1.00
219_V	242_R	0.623	1.00
69_D	72_L	0.622	1.00
219_V	244_I	0.620	1.00
253_R	257_D	0.619	1.00
174_V	193_D	0.618	1.00
12_G	47_Y	0.616	1.00
149_R	172_S	0.613	1.00
31_V	99_A	0.613	1.00
137_N	141_D	0.613	1.00
163_T	190_V	0.608	1.00
166_L	172_S	0.608	1.00
39_S	131_T	0.607	1.00
208_P	216_G	0.607	1.00
135_A	139_V	0.606	1.00
42_S	46_V	0.606	1.00
309_H	333_I	0.605	1.00
13_S	317_A	0.605	1.00
140_L	165_L	0.602	1.00
231_D	255_P	0.602	1.00
35_A	79_V	0.601	1.00
79_V	117_L	0.599	1.00
231_D	260_G	0.599	1.00
166_L	171_L	0.598	1.00
254_A	257_D	0.597	1.00
34_Q	336_T	0.596	1.00
76_Y	131_T	0.593	1.00
187_A	195_T	0.592	1.00
295_F	299_D	0.592	1.00
138_L	244_I	0.590	1.00
115_V	295_F	0.588	1.00
141_D	268_D	0.588	1.00
212_A	216_G	0.587	1.00
142_A	242_R	0.586	1.00
79_V	96_R	0.586	1.00
35_A	310_E	0.585	1.00
215_A	238_G	0.584	1.00
151_V	220_V	0.581	1.00
122_A	126_A	0.580	1.00
8_F	13_S	0.580	1.00
38_I	103_H	0.576	1.00
162_T	246_G	0.576	1.00
44_L	48_R	0.575	1.00
184_R	187_A	0.572	1.00
196_I	206_A	0.570	1.00
128_L	334_I	0.570	1.00
244_I	272_S	0.569	1.00
96_R	120_D	0.569	1.00
178_E	198_P	0.569	1.00
217_A	236_A	0.568	1.00
95_R	119_D	0.568	1.00
320_Y	324_D	0.565	1.00
167_A	174_V	0.563	1.00
36_S	335_L	0.563	1.00
150_A	172_S	0.559	1.00
99_A	114_V	0.557	1.00
110_T	113_A	0.555	1.00
46_V	51_F	0.555	1.00
118_P	299_D	0.555	1.00
14_V	320_Y	0.555	1.00
297_R	301_M	0.555	1.00
203_I	207_P	0.553	1.00
115_V	288_D	0.553	1.00
261_S	267_V	0.552	1.00
272_S	275_S	0.551	1.00
308_T	331_R	0.551	1.00
290_R	293_V	0.548	1.00
98_F	130_P	0.548	1.00
258_L	261_S	0.548	1.00
149_R	194_R	0.547	1.00
22_S	28_E	0.546	1.00
160_L	190_V	0.546	1.00
42_S	45_L	0.546	1.00
20_T	23_D	0.544	1.00
39_S	132_V	0.542	1.00
309_H	330_A	0.542	1.00
220_V	236_A	0.541	1.00
75_G	103_H	0.540	1.00
31_V	114_V	0.539	1.00
150_A	219_V	0.538	1.00
179_P	187_A	0.535	1.00
228_E	231_D	0.535	1.00
129_L	294_A	0.535	1.00
252_K	257_D	0.533	1.00
165_L	169_F	0.533	1.00
161_A	165_L	0.532	1.00
309_H	315_R	0.530	1.00
22_S	106_R	0.529	1.00
91_E	116_E	0.529	1.00
141_D	270_V	0.527	1.00
189_A	304_D	0.525	1.00
146_I	169_F	0.525	1.00
229_T	233_A	0.524	1.00
161_A	164_Q	0.524	1.00
259_G	262_F	0.523	1.00
231_D	257_D	0.523	1.00
8_F	11_P	0.523	1.00
194_R	212_A	0.522	1.00
152_V	163_T	0.521	1.00
38_I	335_L	0.520	1.00
39_S	332_H	0.520	1.00
178_E	197_D	0.519	1.00
46_V	68_F	0.519	1.00
10_G	15_A	0.518	1.00
252_K	255_P	0.517	1.00
163_T	187_A	0.515	1.00
139_V	165_L	0.514	1.00
150_A	171_L	0.514	1.00
292_D	295_F	0.514	1.00
261_S	271_S	0.514	1.00
92_W	111_P	0.512	1.00
136_T	165_L	0.511	1.00
153_F	203_I	0.509	1.00
12_G	48_R	0.509	1.00
161_A	303_A	0.508	1.00
134_T	246_G	0.507	1.00
138_L	272_S	0.507	1.00
178_E	183_R	0.507	1.00
39_S	42_S	0.506	1.00
207_P	236_A	0.506	1.00
311_L	318_D	0.505	1.00
132_V	332_H	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ilkA	2	0.8964	100	0.194	Contact Map
4ej6A	1	0.9024	100	0.195	Contact Map
4oh1A	4	0.9201	100	0.196	Contact Map
1f8fA	4	0.9112	100	0.196	Contact Map
3ukoA	4	0.9142	100	0.2	Contact Map
4a27A	2	0.8876	100	0.202	Contact Map
4gkvA	4	0.8935	100	0.204	Contact Map
3uogA	4	0.9053	100	0.205	Contact Map
1cdoA	2	0.9112	100	0.207	Contact Map
1e3iA	2	0.9053	100	0.208	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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