GREMLIN Database
Q9HQS8 - Uncharacterized protein
UniProt: Q9HQS8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 338 (299)
Sequences: 52675 (36510)
Seq/√Len: 2111.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_Q123_T3.0701.00
32_E83_T2.9681.00
34_Q81_T2.9311.00
315_R318_D2.7421.00
149_R173_E2.5941.00
9_T17_R2.5771.00
30_V83_T2.5321.00
96_R117_L2.3721.00
95_R116_E2.3361.00
155_A176_V2.3311.00
124_Q310_E2.3121.00
311_L322_L2.3051.00
29_V114_V2.2951.00
21_V106_R2.2771.00
122_A125_A2.2521.00
9_T15_A2.2461.00
32_E106_R2.2221.00
167_A193_D2.1851.00
32_E81_T2.1811.00
150_A166_L2.1571.00
309_H322_L2.1271.00
310_E336_T2.1241.00
145_R148_E2.1101.00
184_R188_A2.0721.00
7_Y17_R2.0461.00
25_V28_E2.0421.00
26_D87_P2.0271.00
206_A209_F2.0221.00
26_D88_D2.0081.00
30_V108_R1.9851.00
91_E111_P1.9791.00
173_E194_R1.9721.00
140_L169_F1.9571.00
83_T106_R1.9541.00
163_T192_A1.9461.00
78_S99_A1.9441.00
48_R324_D1.9121.00
78_S102_P1.9041.00
321_A325_D1.8531.00
27_D88_D1.8511.00
184_R195_T1.8401.00
168_S302_D1.8291.00
120_D299_D1.8071.00
242_R268_D1.7991.00
79_V123_T1.7851.00
96_R123_T1.7821.00
312_P315_R1.7601.00
322_L327_P1.7401.00
185_A189_A1.7361.00
140_L293_V1.7361.00
151_V177_V1.7211.00
218_D238_G1.7141.00
242_R270_V1.7001.00
151_V217_A1.6971.00
296_D300_A1.6691.00
185_A188_A1.6651.00
186_T189_A1.6641.00
117_L123_T1.6491.00
318_D321_A1.6131.00
311_L319_A1.5991.00
318_D322_L1.5911.00
175_V217_A1.5791.00
308_T322_L1.5721.00
30_V106_R1.5711.00
6_L316_A1.5651.00
23_D84_A1.5571.00
81_T96_R1.5521.00
173_E193_D1.5321.00
4_R18_T1.5231.00
201_T206_A1.5221.00
85_T93_L1.5141.00
92_W95_R1.5011.00
117_L126_A1.4921.00
181_A197_D1.4891.00
84_A93_L1.4891.00
237_A243_V1.4781.00
178_E184_R1.4771.00
153_F233_A1.4761.00
181_A185_A1.4721.00
220_V237_A1.4671.00
237_A267_V1.4601.00
103_H320_Y1.4571.00
30_V84_A1.4571.00
27_D110_T1.4541.00
317_A321_A1.4491.00
124_Q336_T1.4351.00
33_T78_S1.4261.00
142_A219_V1.4151.00
86_G89_S1.4131.00
92_W116_E1.4111.00
28_E110_T1.4091.00
237_A241_S1.4061.00
125_A304_D1.4021.00
28_E108_R1.3931.00
181_A200_S1.3831.00
5_T19_G1.3671.00
24_P108_R1.3581.00
220_V233_A1.3441.00
197_D200_S1.3321.00
4_R314_D1.3261.00
168_S297_R1.3251.00
148_E242_R1.3161.00
181_A184_R1.2991.00
24_P30_V1.2991.00
96_R119_D1.2941.00
35_A124_Q1.2931.00
81_T123_T1.2901.00
202_A205_D1.2821.00
6_L16_V1.2751.00
162_T221_F1.2751.00
29_V92_W1.2671.00
82_V92_W1.2521.00
179_P198_P1.2481.00
149_R175_V1.2471.00
136_T140_L1.2461.00
171_L174_V1.2391.00
47_Y320_Y1.2371.00
153_F177_V1.2351.00
312_P336_T1.2281.00
33_T107_F1.2171.00
34_Q96_R1.2171.00
4_R105_T1.1941.00
21_V30_V1.1921.00
163_T176_V1.1801.00
184_R197_D1.1631.00
10_G13_S1.1611.00
27_D111_P1.1551.00
288_D292_D1.1511.00
92_W114_V1.1421.00
296_D299_D1.1351.00
212_A215_A1.1341.00
149_R218_D1.1311.00
188_A195_T1.1281.00
129_L298_L1.1221.00
204_A235_A1.1161.00
35_A336_T1.1141.00
293_V296_D1.0931.00
202_A206_A1.0871.00
109_T114_V1.0691.00
137_N290_R1.0681.00
7_Y19_G1.0631.00
148_E218_D1.0611.00
186_T330_A1.0541.00
205_D209_F1.0461.00
36_S103_H1.0461.00
135_A162_T1.0411.00
204_A232_D1.0381.00
232_D235_A1.0261.00
142_A244_I1.0211.00
188_A194_R1.0151.00
35_A123_T1.0141.00
297_R302_D1.0131.00
316_A335_L1.0101.00
47_Y324_D1.0101.00
16_V314_D0.9981.00
38_I319_A0.9981.00
235_A260_G0.9971.00
89_S111_P0.9901.00
321_A324_D0.9881.00
31_V97_V0.9821.00
9_T13_S0.9811.00
83_T93_L0.9781.00
140_L290_R0.9751.00
136_T293_V0.9741.00
224_S229_T0.9741.00
31_V80_G0.9731.00
6_L313_L0.9721.00
138_L246_G0.9671.00
175_V194_R0.9621.00
179_P199_G0.9521.00
322_L333_I0.9501.00
176_V187_A0.9461.00
144_P148_E0.9431.00
293_V297_R0.9421.00
200_S206_A0.9411.00
24_P28_E0.9321.00
204_A208_P0.9281.00
144_P172_S0.9261.00
90_T111_P0.9221.00
155_A178_E0.9191.00
155_A187_A0.9161.00
180_L183_R0.9161.00
35_A334_I0.9091.00
72_L100_F0.9081.00
138_L221_F0.9081.00
292_D296_D0.9071.00
183_R330_A0.9051.00
103_H316_A0.9031.00
135_A165_L0.9031.00
155_A163_T0.9021.00
121_I126_A0.9021.00
231_D235_A0.9011.00
98_F295_F0.9001.00
311_L315_R0.8981.00
148_E219_V0.8951.00
160_L186_T0.8941.00
4_R16_V0.8891.00
176_V192_A0.8781.00
44_L323_L0.8771.00
189_A305_A0.8761.00
240_D266_R0.8721.00
39_S77_A0.8711.00
11_P70_Y0.8691.00
177_V198_P0.8681.00
257_D260_G0.8671.00
163_T174_V0.8631.00
151_V236_A0.8591.00
289_R293_V0.8521.00
36_S102_P0.8471.00
175_V196_I0.8471.00
32_E105_T0.8441.00
25_V108_R0.8431.00
34_Q79_V0.8431.00
182_S185_A0.8431.00
6_L14_V0.8421.00
21_V84_A0.8411.00
222_E225_G0.8391.00
153_F220_V0.8351.00
228_E232_D0.8351.00
133_E290_R0.8341.00
152_V166_L0.8291.00
39_S76_Y0.8151.00
78_S107_F0.8141.00
309_H318_D0.8121.00
7_Y73_A0.8101.00
85_T89_S0.8061.00
189_A306_L0.8031.00
5_T73_A0.8011.00
260_G265_D0.8011.00
169_F293_V0.8011.00
21_V83_T0.7981.00
9_T12_G0.7981.00
29_V111_P0.7961.00
102_P107_F0.7871.00
19_G100_F0.7831.00
115_V292_D0.7821.00
164_Q304_D0.7801.00
143_Q242_R0.7781.00
149_R215_A0.7771.00
178_E195_T0.7721.00
153_F229_T0.7671.00
207_P217_A0.7671.00
289_R292_D0.7641.00
179_P184_R0.7611.00
165_L294_A0.7601.00
152_V162_T0.7581.00
311_L333_I0.7571.00
203_I232_D0.7551.00
233_A243_V0.7541.00
220_V243_V0.7511.00
187_A192_A0.7511.00
205_D208_P0.7501.00
16_V313_L0.7501.00
37_G77_A0.7461.00
231_D253_R0.7441.00
23_D30_V0.7421.00
19_G73_A0.7421.00
143_Q268_D0.7411.00
103_H335_L0.7381.00
38_I323_L0.7371.00
223_L246_G0.7371.00
139_V166_L0.7341.00
135_A161_A0.7331.00
144_P171_L0.7311.00
119_D299_D0.7261.00
322_L325_D0.7261.00
297_R300_A0.7261.00
6_L317_A0.7251.00
138_L162_T0.7251.00
91_E288_D0.7231.00
266_R276_T0.7211.00
160_L306_L0.7201.00
42_S76_Y0.7181.00
165_L297_R0.7181.00
307_I310_E0.7171.00
24_P84_A0.7151.00
149_R217_A0.7131.00
186_T306_L0.7111.00
147_G172_S0.7031.00
44_L324_D0.6981.00
166_L174_V0.6961.00
132_V161_A0.6941.00
245_V269_I0.6921.00
204_A236_A0.6921.00
202_A232_D0.6921.00
98_F117_L0.6901.00
194_R206_A0.6901.00
39_S43_E0.6901.00
261_S269_I0.6871.00
27_D112_D0.6851.00
175_V207_P0.6811.00
97_V114_V0.6781.00
311_L335_L0.6761.00
22_S108_R0.6721.00
136_T297_R0.6711.00
137_N266_R0.6701.00
24_P86_G0.6691.00
144_P219_V0.6641.00
33_T36_S0.6641.00
27_D87_P0.6631.00
323_L333_I0.6631.00
79_V127_T0.6621.00
143_Q270_V0.6601.00
239_Y265_D0.6581.00
134_T158_V0.6471.00
27_D86_G0.6471.00
68_F72_L0.6441.00
186_T190_V0.6391.00
115_V291_F0.6381.00
135_A158_V0.6371.00
180_L197_D0.6371.00
217_A220_V0.6371.00
222_E243_V0.6361.00
136_T290_R0.6361.00
136_T294_A0.6351.00
29_V82_V0.6341.00
164_Q190_V0.6341.00
45_L50_E0.6321.00
230_L243_V0.6311.00
99_A109_T0.6311.00
85_T95_R0.6291.00
141_D290_R0.6281.00
172_S219_V0.6281.00
152_V176_V0.6261.00
125_A129_L0.6241.00
121_I298_L0.6231.00
226_R229_T0.6231.00
219_V242_R0.6231.00
69_D72_L0.6221.00
219_V244_I0.6201.00
253_R257_D0.6191.00
174_V193_D0.6181.00
12_G47_Y0.6161.00
149_R172_S0.6131.00
31_V99_A0.6131.00
137_N141_D0.6131.00
163_T190_V0.6081.00
166_L172_S0.6081.00
39_S131_T0.6071.00
208_P216_G0.6071.00
135_A139_V0.6061.00
42_S46_V0.6061.00
309_H333_I0.6051.00
13_S317_A0.6051.00
140_L165_L0.6021.00
231_D255_P0.6021.00
35_A79_V0.6011.00
79_V117_L0.5991.00
231_D260_G0.5991.00
166_L171_L0.5981.00
254_A257_D0.5971.00
34_Q336_T0.5961.00
76_Y131_T0.5931.00
187_A195_T0.5921.00
295_F299_D0.5921.00
138_L244_I0.5901.00
115_V295_F0.5881.00
141_D268_D0.5881.00
212_A216_G0.5871.00
142_A242_R0.5861.00
79_V96_R0.5861.00
35_A310_E0.5851.00
215_A238_G0.5841.00
151_V220_V0.5811.00
122_A126_A0.5801.00
8_F13_S0.5801.00
38_I103_H0.5761.00
162_T246_G0.5761.00
44_L48_R0.5751.00
184_R187_A0.5721.00
196_I206_A0.5701.00
128_L334_I0.5701.00
244_I272_S0.5691.00
96_R120_D0.5691.00
178_E198_P0.5691.00
217_A236_A0.5681.00
95_R119_D0.5681.00
320_Y324_D0.5651.00
167_A174_V0.5631.00
36_S335_L0.5631.00
150_A172_S0.5591.00
99_A114_V0.5571.00
110_T113_A0.5551.00
46_V51_F0.5551.00
118_P299_D0.5551.00
14_V320_Y0.5551.00
297_R301_M0.5551.00
203_I207_P0.5531.00
115_V288_D0.5531.00
261_S267_V0.5521.00
272_S275_S0.5511.00
308_T331_R0.5511.00
290_R293_V0.5481.00
98_F130_P0.5481.00
258_L261_S0.5481.00
149_R194_R0.5471.00
22_S28_E0.5461.00
160_L190_V0.5461.00
42_S45_L0.5461.00
20_T23_D0.5441.00
39_S132_V0.5421.00
309_H330_A0.5421.00
220_V236_A0.5411.00
75_G103_H0.5401.00
31_V114_V0.5391.00
150_A219_V0.5381.00
179_P187_A0.5351.00
228_E231_D0.5351.00
129_L294_A0.5351.00
252_K257_D0.5331.00
165_L169_F0.5331.00
161_A165_L0.5321.00
309_H315_R0.5301.00
22_S106_R0.5291.00
91_E116_E0.5291.00
141_D270_V0.5271.00
189_A304_D0.5251.00
146_I169_F0.5251.00
229_T233_A0.5241.00
161_A164_Q0.5241.00
259_G262_F0.5231.00
231_D257_D0.5231.00
8_F11_P0.5231.00
194_R212_A0.5221.00
152_V163_T0.5211.00
38_I335_L0.5201.00
39_S332_H0.5201.00
178_E197_D0.5191.00
46_V68_F0.5191.00
10_G15_A0.5181.00
252_K255_P0.5171.00
163_T187_A0.5151.00
139_V165_L0.5141.00
150_A171_L0.5141.00
292_D295_F0.5141.00
261_S271_S0.5141.00
92_W111_P0.5121.00
136_T165_L0.5111.00
153_F203_I0.5091.00
12_G48_R0.5091.00
161_A303_A0.5081.00
134_T246_G0.5071.00
138_L272_S0.5071.00
178_E183_R0.5071.00
39_S42_S0.5061.00
207_P236_A0.5061.00
311_L318_D0.5051.00
132_V332_H0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ilkA 2 0.8964 100 0.194 Contact Map
4ej6A 1 0.9024 100 0.195 Contact Map
4oh1A 4 0.9201 100 0.196 Contact Map
1f8fA 4 0.9112 100 0.196 Contact Map
3ukoA 4 0.9142 100 0.2 Contact Map
4a27A 2 0.8876 100 0.202 Contact Map
4gkvA 4 0.8935 100 0.204 Contact Map
3uogA 4 0.9053 100 0.205 Contact Map
1cdoA 2 0.9112 100 0.207 Contact Map
1e3iA 2 0.9053 100 0.208 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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