GREMLIN Database
Q9HQS7 - Uncharacterized protein
UniProt: Q9HQS7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 135 (118)
Sequences: 2812 (1710)
Seq/√Len: 157.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_I40_R3.2641.00
49_G58_L3.0451.00
119_R129_S2.7011.00
117_T131_E2.6021.00
98_E102_D2.5261.00
74_R103_R2.5251.00
16_R42_T2.5181.00
14_T46_T2.3851.00
16_R44_D2.2841.00
24_Y79_L2.2741.00
12_A48_A2.2721.00
117_T129_S2.2001.00
44_D119_R2.1981.00
48_A116_L2.0881.00
75_Y99_L2.0141.00
36_V79_L1.8531.00
14_T127_W1.8041.00
43_A120_L1.7861.00
47_F64_V1.7221.00
45_V68_L1.7191.00
35_E78_T1.6671.00
44_D121_W1.6561.00
105_A132_R1.6021.00
46_T117_T1.5841.00
45_V104_I1.5641.00
70_D107_G1.5431.00
75_Y100_I1.5331.00
12_A46_T1.5161.00
19_F43_A1.4811.00
69_D73_A1.4761.00
32_P62_D1.4541.00
98_E130_H1.4521.00
101_G130_H1.4111.00
97_A118_V1.4031.00
99_L103_R1.3991.00
101_G132_R1.3971.00
95_R98_E1.3771.00
28_P31_G1.3711.00
12_A116_L1.3451.00
22_Q79_L1.3131.00
11_R98_E1.2931.00
17_R68_L1.2711.00
14_T119_R1.2501.00
81_N91_P1.2201.00
47_F59_V1.2071.00
26_T34_G1.1871.00
12_A129_S1.1541.00
14_T44_D1.1341.00
119_R127_W1.1331.00
40_R124_D1.0830.99
103_R106_D1.0680.99
56_G95_R1.0170.99
17_R65_D1.0100.99
33_E77_D1.0060.99
84_A87_G1.0050.99
60_D63_A1.0020.99
41_F93_L1.0000.99
18_E125_L1.0000.99
85_E89_A0.9840.99
21_A80_L0.9840.99
70_D73_A0.9730.99
17_R72_E0.9630.99
17_R69_D0.9540.99
68_L72_E0.9540.99
21_A41_F0.9490.99
97_A128_A0.9460.98
15_V125_L0.9180.98
62_D65_D0.9160.98
42_T124_D0.9010.98
46_T119_R0.8970.98
46_T116_L0.8850.98
18_E124_D0.8770.97
75_Y96_F0.8750.97
42_T121_W0.8730.97
74_R85_E0.8620.97
18_E40_R0.8600.97
116_L131_E0.8580.97
52_L55_H0.8540.97
102_D132_R0.8520.97
18_E42_T0.8500.97
12_A131_E0.8470.97
33_E122_E0.8400.97
71_I100_I0.8390.97
15_V126_A0.8360.97
14_T129_S0.8270.96
11_R51_E0.8250.96
121_W127_W0.8090.96
67_V70_D0.8070.96
50_G114_T0.7970.96
66_A70_D0.7960.96
12_A117_T0.7960.96
63_A66_A0.7860.95
41_F120_L0.7600.94
105_A109_G0.7540.94
29_N34_G0.7460.94
28_P57_Y0.7380.93
57_Y92_S0.7350.93
34_G92_S0.7280.93
100_I118_V0.7260.93
61_I65_D0.7250.93
59_V63_A0.7210.93
67_V107_G0.7150.92
24_Y34_G0.7110.92
75_Y85_E0.7060.92
40_R121_W0.7000.91
23_H94_E0.6860.91
101_G118_V0.6770.90
48_A114_T0.6710.90
27_V55_H0.6680.89
25_L90_N0.6680.89
102_D105_A0.6670.89
100_I120_L0.6650.89
120_L128_A0.6590.89
13_L64_V0.6560.89
15_V123_D0.6550.89
22_Q38_S0.6460.88
62_D66_A0.6430.88
61_I126_A0.6410.87
24_Y36_V0.6350.87
11_R130_H0.6330.87
53_D107_G0.6290.86
96_F100_I0.6260.86
31_G34_G0.6230.86
106_D115_R0.6220.86
25_L31_G0.6190.86
20_I124_D0.6160.85
43_A68_L0.6160.85
71_I74_R0.6150.85
26_T90_N0.6130.85
74_R78_T0.6120.85
107_G110_A0.6110.85
74_R83_H0.6050.84
97_A120_L0.6040.84
15_V68_L0.6020.84
22_Q36_V0.6010.84
78_T83_H0.6000.84
75_Y103_R0.5960.83
67_V108_L0.5940.83
90_N93_L0.5920.83
21_A81_N0.5910.83
19_F120_L0.5900.83
108_L115_R0.5880.83
27_V54_E0.5850.82
106_D109_G0.5850.82
98_E101_G0.5840.82
16_R124_D0.5820.82
93_L96_F0.5800.82
65_D69_D0.5790.82
48_A115_R0.5780.82
33_E93_L0.5780.82
100_I104_I0.5780.82
37_H122_E0.5650.80
79_L82_D0.5600.79
88_D114_T0.5590.79
11_R52_L0.5580.79
93_L124_D0.5550.79
109_G114_T0.5530.79
99_L102_D0.5500.78
40_R125_L0.5490.78
43_A75_Y0.5480.78
64_V108_L0.5430.77
101_G115_R0.5430.77
27_V34_G0.5390.77
93_L128_A0.5390.77
78_T82_D0.5390.77
16_R125_L0.5390.77
23_H122_E0.5300.76
51_E98_E0.5300.76
67_V104_I0.5270.75
41_F126_A0.5260.75
45_V118_V0.5140.73
93_L122_E0.5130.73
59_V104_I0.5130.73
43_A100_I0.5130.73
31_G57_Y0.5120.73
63_A67_V0.5040.72
32_P73_A0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3d7jA 4 0.9481 100 0.133 Contact Map
1b66A 4 0.9259 100 0.164 Contact Map
2obaA 4 0.8889 100 0.167 Contact Map
2g64A 4 0.9481 100 0.171 Contact Map
4ntkA 4 0.8889 100 0.173 Contact Map
3jygA 4 0.9111 100 0.207 Contact Map
1y13A 5 0.9185 100 0.208 Contact Map
3lx3A 4 0.9185 100 0.208 Contact Map
2dj6A 3 0.8519 100 0.233 Contact Map
2kebA 1 0.4148 14.6 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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