Q9HQS6 - HALSA - GREMLIN Contacts

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Q9HQS6 - Uncharacterized protein

UniProt:	Q9HQS6	Sequences: MTQTHAQTRYLTAKQSVDERARDRRVRDRLRAALPSHPRVVEAGCGTGPTVPMLYADWEVTPAAYLGVDAAERVVAFANAVVPRVLRRRMPAETRIAATPDGCRVGDAPIRFDTGDALARLTDATADLLVAQSFLDLVPPADALDAFADALAPGGLAYAPLTFDGVTVLQPSHPADDRVRAAYHDAIDAADGRTSRAGRRLLDVLRERPAETLLAVGASDWIVRPVDGEYRADEQYFLACILSFIADAVPDATDWLATRRQQLAAGDLTYVAHGYDLLWRA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	281 (249)
Sequences:	336 (266)
Seq/√Len:	16.8

HALSA - Q9HQS6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
173_H	258_T	5.732	1.00
236_Y	240_C	4.680	1.00
240_C	243_S	4.158	1.00
236_Y	243_S	3.828	1.00
30_L	128_L	3.296	0.99
30_L	278_L	2.898	0.98
240_C	244_F	2.747	0.97
15_Q	52_P	2.711	0.97
243_S	247_D	2.695	0.97
41_V	126_A	2.477	0.95
107_D	113_D	2.466	0.95
240_C	247_D	2.406	0.94
17_V	223_V	2.251	0.92
236_Y	248_A	2.208	0.91
192_G	198_G	2.133	0.90
236_Y	244_F	2.114	0.89
26_V	30_L	2.089	0.89
191_D	196_R	2.071	0.88
236_Y	246_A	2.062	0.88
193_R	196_R	2.044	0.88
44_G	134_F	2.009	0.87
109_P	113_D	1.991	0.86
236_Y	247_D	1.953	0.85
17_V	21_A	1.912	0.84
240_C	248_A	1.907	0.84
110_I	116_D	1.897	0.83
108_A	113_D	1.886	0.83
15_Q	49_P	1.859	0.82
244_F	247_D	1.850	0.82
23_D	217_G	1.838	0.81
138_V	143_A	1.809	0.80
191_D	198_G	1.793	0.80
10_Y	14_K	1.780	0.79
197_A	200_R	1.768	0.79
220_D	223_V	1.765	0.78
67_G	78_A	1.735	0.77
19_E	53_M	1.720	0.77
110_I	113_D	1.693	0.75
26_V	217_G	1.687	0.75
244_F	248_A	1.632	0.73
44_G	278_L	1.627	0.72
168_V	271_V	1.608	0.71
40_V	128_L	1.588	0.70
164_D	219_S	1.570	0.70
192_G	197_A	1.565	0.69
191_D	197_A	1.558	0.69
237_F	240_C	1.556	0.69
191_D	194_T	1.550	0.69
237_F	244_F	1.525	0.67
41_V	68_V	1.516	0.67
234_E	240_C	1.490	0.65
26_V	278_L	1.484	0.65
113_D	116_D	1.471	0.64
107_D	114_T	1.461	0.64
239_A	243_S	1.446	0.63
109_P	114_T	1.427	0.62
19_E	49_P	1.404	0.61
106_G	109_P	1.400	0.60
240_C	246_A	1.394	0.60
22_R	53_M	1.379	0.59
40_V	182_A	1.379	0.59
26_V	134_F	1.374	0.59
190_A	194_T	1.372	0.59
34_L	278_L	1.360	0.58
161_L	274_G	1.357	0.58
148_A	252_A	1.352	0.58
180_R	184_H	1.351	0.58
157_A	279_W	1.341	0.57
196_R	199_R	1.337	0.57
117_A	123_D	1.330	0.56
241_I	244_F	1.319	0.56
50_T	53_M	1.306	0.55
194_T	200_R	1.300	0.55
25_R	218_A	1.300	0.55
192_G	196_R	1.299	0.55
44_G	131_A	1.291	0.54
163_F	183_Y	1.284	0.54
138_V	191_D	1.266	0.53
182_A	257_A	1.265	0.53
143_A	191_D	1.255	0.52
175_A	254_D	1.254	0.52
53_M	158_Y	1.243	0.51
196_R	205_L	1.242	0.51
236_Y	241_I	1.238	0.51
110_I	114_T	1.219	0.50
41_V	137_L	1.179	0.47
234_E	243_S	1.175	0.47
14_K	22_R	1.163	0.46
21_A	166_V	1.158	0.46
134_F	138_V	1.151	0.46
241_I	246_A	1.151	0.46
107_D	110_I	1.147	0.46
194_T	205_L	1.146	0.45
143_A	196_R	1.145	0.45
128_L	131_A	1.137	0.45
137_L	249_V	1.127	0.44
175_A	217_G	1.123	0.44
63_A	151_L	1.118	0.44
190_A	193_R	1.111	0.43
163_F	189_A	1.098	0.43
12_T	81_V	1.097	0.43
148_A	159_A	1.096	0.43
169_L	268_L	1.089	0.42
243_S	246_A	1.087	0.42
105_V	113_D	1.079	0.42
163_F	184_H	1.075	0.41
21_A	214_L	1.071	0.41
262_Q	268_L	1.070	0.41
144_L	205_L	1.053	0.40
66_L	126_A	1.053	0.40
69_D	165_G	1.048	0.40
105_V	109_P	1.040	0.39
149_D	209_P	1.039	0.39
14_K	274_G	1.036	0.39
68_V	255_W	1.036	0.39
194_T	197_A	1.031	0.39
22_R	187_I	1.029	0.39
197_A	205_L	1.025	0.38
234_E	237_F	1.023	0.38
234_E	244_F	1.021	0.38
14_K	65_Y	1.021	0.38
249_V	252_A	1.020	0.38
68_V	148_A	1.016	0.38
64_A	108_A	1.013	0.38
193_R	198_G	1.010	0.38
108_A	115_G	1.004	0.37
202_L	277_L	0.993	0.37
195_S	198_G	0.991	0.37
142_D	257_A	0.990	0.37
10_Y	22_R	0.988	0.36
198_G	201_L	0.982	0.36
151_L	158_Y	0.982	0.36
253_T	256_L	0.976	0.36
149_D	266_G	0.974	0.36
37_H	127_D	0.970	0.35
10_Y	272_A	0.968	0.35
50_T	63_A	0.964	0.35
33_A	156_L	0.958	0.35
10_Y	65_Y	0.956	0.35
74_V	137_L	0.945	0.34
16_S	226_V	0.940	0.34
151_L	162_T	0.939	0.34
198_G	205_L	0.934	0.33
10_Y	13_A	0.932	0.33
175_A	251_D	0.931	0.33
190_A	196_R	0.928	0.33
222_I	271_V	0.915	0.32
16_S	20_R	0.914	0.32
161_L	194_T	0.908	0.32
108_A	114_T	0.904	0.32
41_V	235_Q	0.903	0.32
23_D	26_V	0.902	0.32
141_A	204_V	0.902	0.32
36_S	218_A	0.901	0.32
41_V	255_W	0.899	0.32
195_S	200_R	0.898	0.32
42_E	74_V	0.889	0.31
30_L	54_L	0.889	0.31
24_R	253_T	0.884	0.31
135_L	162_T	0.884	0.31
192_G	199_R	0.883	0.31
111_R	114_T	0.878	0.31
139_P	193_R	0.878	0.31
10_Y	274_G	0.874	0.30
163_F	199_R	0.873	0.30
71_A	277_L	0.870	0.30
150_A	166_V	0.867	0.30
164_D	255_W	0.862	0.30
17_V	222_I	0.859	0.30
76_A	224_R	0.857	0.30
45_C	67_G	0.856	0.29
8_T	45_C	0.856	0.29
193_R	205_L	0.855	0.29
79_N	145_D	0.853	0.29
50_T	255_W	0.852	0.29
17_V	277_L	0.844	0.29
174_P	219_S	0.843	0.29
194_T	198_G	0.837	0.29
66_L	137_L	0.836	0.29
45_C	66_L	0.836	0.29
71_A	74_V	0.834	0.28
199_R	205_L	0.827	0.28
164_D	273_H	0.824	0.28
237_F	246_A	0.824	0.28
39_R	127_D	0.823	0.28
162_T	197_A	0.821	0.28
195_S	202_L	0.818	0.28
196_R	255_W	0.808	0.27
193_R	200_R	0.808	0.27
243_S	248_A	0.807	0.27
65_Y	274_G	0.807	0.27
240_C	255_W	0.805	0.27
148_A	210_A	0.801	0.27
50_T	143_A	0.801	0.27
177_D	216_V	0.798	0.27
150_A	177_D	0.795	0.27
72_E	263_L	0.792	0.26
51_V	164_D	0.788	0.26
105_V	108_A	0.786	0.26
237_F	243_S	0.783	0.26
20_R	155_G	0.779	0.26
160_P	278_L	0.776	0.26
149_D	208_R	0.772	0.26
237_F	241_I	0.770	0.25
245_I	273_H	0.764	0.25
50_T	151_L	0.762	0.25
241_I	256_L	0.762	0.25
23_D	158_Y	0.760	0.25
151_L	159_A	0.760	0.25
132_Q	186_A	0.760	0.25
134_F	160_P	0.759	0.25
135_L	144_L	0.751	0.25
179_V	252_A	0.751	0.25
171_P	262_Q	0.751	0.25
129_L	177_D	0.745	0.24
135_L	159_A	0.738	0.24
135_L	205_L	0.731	0.24
26_V	44_G	0.730	0.24
167_T	183_Y	0.730	0.24
67_G	75_V	0.728	0.24
28_D	107_D	0.725	0.23
148_A	226_V	0.725	0.23
196_R	202_L	0.724	0.23
56_A	186_A	0.722	0.23
113_D	119_A	0.720	0.23
20_R	156_L	0.719	0.23
30_L	66_L	0.715	0.23
20_R	227_D	0.715	0.23
83_P	154_G	0.715	0.23
32_A	208_R	0.711	0.23
218_A	225_P	0.710	0.23
190_A	198_G	0.709	0.23
123_D	183_Y	0.709	0.23
53_M	163_F	0.708	0.23
208_R	260_R	0.707	0.23
183_Y	220_D	0.706	0.23
170_Q	269_T	0.706	0.23
14_K	272_A	0.703	0.23
111_R	116_D	0.699	0.22
7_Q	273_H	0.698	0.22
146_A	174_P	0.698	0.22
131_A	157_A	0.692	0.22
107_D	116_D	0.689	0.22
108_A	118_L	0.689	0.22
58_W	135_L	0.688	0.22
40_V	245_I	0.681	0.22
152_A	177_D	0.678	0.21
242_L	260_R	0.670	0.21
253_T	257_A	0.668	0.21
59_E	128_L	0.668	0.21
112_F	260_R	0.666	0.21
163_F	167_T	0.663	0.21
145_D	208_R	0.662	0.21
42_E	51_V	0.662	0.21
50_T	132_Q	0.661	0.21
42_E	52_P	0.661	0.21
49_P	134_F	0.657	0.21
43_A	134_F	0.657	0.21
22_R	274_G	0.655	0.21
33_A	86_L	0.655	0.21
138_V	196_R	0.653	0.21
7_Q	141_A	0.653	0.21
137_L	199_R	0.652	0.20
133_S	221_W	0.651	0.20
43_A	74_V	0.650	0.20
12_T	271_V	0.650	0.20
137_L	198_G	0.648	0.20
161_L	186_A	0.646	0.20
50_T	158_Y	0.644	0.20
192_G	201_L	0.644	0.20
63_A	201_L	0.640	0.20
65_Y	196_R	0.640	0.20
23_D	170_Q	0.638	0.20
44_G	123_D	0.636	0.20
26_V	201_L	0.633	0.20
69_D	75_V	0.633	0.20
66_L	210_A	0.633	0.20
145_D	204_V	0.633	0.20
220_D	263_L	0.629	0.20
129_L	159_A	0.629	0.20
42_E	49_P	0.629	0.20
76_A	113_D	0.629	0.20
58_W	272_A	0.625	0.19
82_V	85_V	0.624	0.19
156_L	205_L	0.623	0.19
254_D	258_T	0.623	0.19
179_V	251_D	0.621	0.19
176_D	259_R	0.621	0.19
131_A	208_R	0.616	0.19
24_R	257_A	0.613	0.19
234_E	272_A	0.613	0.19
65_Y	186_A	0.613	0.19
62_P	152_A	0.613	0.19
19_E	122_T	0.611	0.19
53_M	183_Y	0.611	0.19
51_V	255_W	0.610	0.19
191_D	273_H	0.602	0.19
56_A	63_A	0.602	0.19
11_L	18_D	0.602	0.19
65_Y	272_A	0.601	0.19
209_P	271_V	0.598	0.18
151_L	157_A	0.598	0.18
44_G	136_D	0.595	0.18
241_I	248_A	0.594	0.18
193_R	197_A	0.594	0.18
169_L	245_I	0.593	0.18
132_Q	187_I	0.593	0.18
21_A	258_T	0.588	0.18
42_E	194_T	0.588	0.18
111_R	235_Q	0.586	0.18
37_H	79_N	0.586	0.18
79_N	128_L	0.586	0.18
20_R	177_D	0.582	0.18
11_L	136_D	0.581	0.18
26_V	200_R	0.581	0.18
26_V	277_L	0.580	0.18
39_R	66_L	0.575	0.18
188_D	200_R	0.574	0.18
86_L	180_R	0.574	0.18
45_C	84_R	0.573	0.18
40_V	49_P	0.571	0.18
191_D	255_W	0.571	0.18
34_L	38_P	0.571	0.18
78_A	132_Q	0.571	0.18
190_A	273_H	0.570	0.17
54_L	157_A	0.568	0.17
30_L	241_I	0.566	0.17
25_R	253_T	0.564	0.17
49_P	248_A	0.564	0.17
206_R	275_Y	0.563	0.17
158_Y	183_Y	0.562	0.17
66_L	216_V	0.559	0.17
194_T	274_G	0.555	0.17
164_D	169_L	0.550	0.17
45_C	109_P	0.547	0.17
179_V	241_I	0.545	0.17
81_V	260_R	0.544	0.17
107_D	112_F	0.543	0.17
142_D	181_A	0.543	0.17
139_P	143_A	0.540	0.16
245_I	256_L	0.538	0.16
241_I	245_I	0.536	0.16
116_D	173_H	0.534	0.16
73_R	265_A	0.534	0.16
30_L	144_L	0.533	0.16
146_A	222_I	0.531	0.16
178_R	261_Q	0.530	0.16
7_Q	207_E	0.528	0.16
191_D	195_S	0.527	0.16
167_T	184_H	0.524	0.16
206_R	216_V	0.523	0.16
8_T	256_L	0.519	0.16
196_R	240_C	0.519	0.16
65_Y	163_F	0.516	0.16
68_V	112_F	0.515	0.16
47_T	52_P	0.515	0.16
142_D	146_A	0.515	0.16
53_M	167_T	0.515	0.16
138_V	159_A	0.514	0.16
29_R	32_A	0.514	0.16
166_V	220_D	0.513	0.16
84_R	225_P	0.511	0.16
149_D	275_Y	0.511	0.16
59_E	63_A	0.509	0.15
27_R	134_F	0.509	0.15
141_A	208_R	0.508	0.15
145_D	152_A	0.506	0.15
51_V	241_I	0.506	0.15
21_A	224_R	0.505	0.15
158_Y	167_T	0.504	0.15
46_G	276_D	0.503	0.15
223_V	270_Y	0.501	0.15
138_V	193_R	0.500	0.15
106_G	235_Q	0.500	0.15

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3mggA	2	0.847	99.3	0.842	Contact Map
2yqzA	1	0.8541	99.1	0.855	Contact Map
3dr5A	2	0.7011	99	0.861	Contact Map
3busA	1	0.8363	99	0.861	Contact Map
4xrpC	1	0.6833	99	0.862	Contact Map
4necA	3	0.8149	98.9	0.865	Contact Map
4pcaA	4	0.6833	98.9	0.865	Contact Map
2avdA	2	0.6797	98.9	0.866	Contact Map
3c3pA	6	0.6299	98.9	0.866	Contact Map
2aotA	1	0.9075	98.9	0.866	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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