GREMLIN Database
Q9HQS6 - Uncharacterized protein
UniProt: Q9HQS6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 281 (249)
Sequences: 336 (266)
Seq/√Len: 16.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
173_H258_T5.7321.00
236_Y240_C4.6801.00
240_C243_S4.1581.00
236_Y243_S3.8281.00
30_L128_L3.2960.99
30_L278_L2.8980.98
240_C244_F2.7470.97
15_Q52_P2.7110.97
243_S247_D2.6950.97
41_V126_A2.4770.95
107_D113_D2.4660.95
240_C247_D2.4060.94
17_V223_V2.2510.92
236_Y248_A2.2080.91
192_G198_G2.1330.90
236_Y244_F2.1140.89
26_V30_L2.0890.89
191_D196_R2.0710.88
236_Y246_A2.0620.88
193_R196_R2.0440.88
44_G134_F2.0090.87
109_P113_D1.9910.86
236_Y247_D1.9530.85
17_V21_A1.9120.84
240_C248_A1.9070.84
110_I116_D1.8970.83
108_A113_D1.8860.83
15_Q49_P1.8590.82
244_F247_D1.8500.82
23_D217_G1.8380.81
138_V143_A1.8090.80
191_D198_G1.7930.80
10_Y14_K1.7800.79
197_A200_R1.7680.79
220_D223_V1.7650.78
67_G78_A1.7350.77
19_E53_M1.7200.77
110_I113_D1.6930.75
26_V217_G1.6870.75
244_F248_A1.6320.73
44_G278_L1.6270.72
168_V271_V1.6080.71
40_V128_L1.5880.70
164_D219_S1.5700.70
192_G197_A1.5650.69
191_D197_A1.5580.69
237_F240_C1.5560.69
191_D194_T1.5500.69
237_F244_F1.5250.67
41_V68_V1.5160.67
234_E240_C1.4900.65
26_V278_L1.4840.65
113_D116_D1.4710.64
107_D114_T1.4610.64
239_A243_S1.4460.63
109_P114_T1.4270.62
19_E49_P1.4040.61
106_G109_P1.4000.60
240_C246_A1.3940.60
22_R53_M1.3790.59
40_V182_A1.3790.59
26_V134_F1.3740.59
190_A194_T1.3720.59
34_L278_L1.3600.58
161_L274_G1.3570.58
148_A252_A1.3520.58
180_R184_H1.3510.58
157_A279_W1.3410.57
196_R199_R1.3370.57
117_A123_D1.3300.56
241_I244_F1.3190.56
50_T53_M1.3060.55
194_T200_R1.3000.55
25_R218_A1.3000.55
192_G196_R1.2990.55
44_G131_A1.2910.54
163_F183_Y1.2840.54
138_V191_D1.2660.53
182_A257_A1.2650.53
143_A191_D1.2550.52
175_A254_D1.2540.52
53_M158_Y1.2430.51
196_R205_L1.2420.51
236_Y241_I1.2380.51
110_I114_T1.2190.50
41_V137_L1.1790.47
234_E243_S1.1750.47
14_K22_R1.1630.46
21_A166_V1.1580.46
134_F138_V1.1510.46
241_I246_A1.1510.46
107_D110_I1.1470.46
194_T205_L1.1460.45
143_A196_R1.1450.45
128_L131_A1.1370.45
137_L249_V1.1270.44
175_A217_G1.1230.44
63_A151_L1.1180.44
190_A193_R1.1110.43
163_F189_A1.0980.43
12_T81_V1.0970.43
148_A159_A1.0960.43
169_L268_L1.0890.42
243_S246_A1.0870.42
105_V113_D1.0790.42
163_F184_H1.0750.41
21_A214_L1.0710.41
262_Q268_L1.0700.41
144_L205_L1.0530.40
66_L126_A1.0530.40
69_D165_G1.0480.40
105_V109_P1.0400.39
149_D209_P1.0390.39
14_K274_G1.0360.39
68_V255_W1.0360.39
194_T197_A1.0310.39
22_R187_I1.0290.39
197_A205_L1.0250.38
234_E237_F1.0230.38
234_E244_F1.0210.38
14_K65_Y1.0210.38
249_V252_A1.0200.38
68_V148_A1.0160.38
64_A108_A1.0130.38
193_R198_G1.0100.38
108_A115_G1.0040.37
202_L277_L0.9930.37
195_S198_G0.9910.37
142_D257_A0.9900.37
10_Y22_R0.9880.36
198_G201_L0.9820.36
151_L158_Y0.9820.36
253_T256_L0.9760.36
149_D266_G0.9740.36
37_H127_D0.9700.35
10_Y272_A0.9680.35
50_T63_A0.9640.35
33_A156_L0.9580.35
10_Y65_Y0.9560.35
74_V137_L0.9450.34
16_S226_V0.9400.34
151_L162_T0.9390.34
198_G205_L0.9340.33
10_Y13_A0.9320.33
175_A251_D0.9310.33
190_A196_R0.9280.33
222_I271_V0.9150.32
16_S20_R0.9140.32
161_L194_T0.9080.32
108_A114_T0.9040.32
41_V235_Q0.9030.32
23_D26_V0.9020.32
141_A204_V0.9020.32
36_S218_A0.9010.32
41_V255_W0.8990.32
195_S200_R0.8980.32
42_E74_V0.8890.31
30_L54_L0.8890.31
24_R253_T0.8840.31
135_L162_T0.8840.31
192_G199_R0.8830.31
111_R114_T0.8780.31
139_P193_R0.8780.31
10_Y274_G0.8740.30
163_F199_R0.8730.30
71_A277_L0.8700.30
150_A166_V0.8670.30
164_D255_W0.8620.30
17_V222_I0.8590.30
76_A224_R0.8570.30
45_C67_G0.8560.29
8_T45_C0.8560.29
193_R205_L0.8550.29
79_N145_D0.8530.29
50_T255_W0.8520.29
17_V277_L0.8440.29
174_P219_S0.8430.29
194_T198_G0.8370.29
66_L137_L0.8360.29
45_C66_L0.8360.29
71_A74_V0.8340.28
199_R205_L0.8270.28
164_D273_H0.8240.28
237_F246_A0.8240.28
39_R127_D0.8230.28
162_T197_A0.8210.28
195_S202_L0.8180.28
196_R255_W0.8080.27
193_R200_R0.8080.27
243_S248_A0.8070.27
65_Y274_G0.8070.27
240_C255_W0.8050.27
148_A210_A0.8010.27
50_T143_A0.8010.27
177_D216_V0.7980.27
150_A177_D0.7950.27
72_E263_L0.7920.26
51_V164_D0.7880.26
105_V108_A0.7860.26
237_F243_S0.7830.26
20_R155_G0.7790.26
160_P278_L0.7760.26
149_D208_R0.7720.26
237_F241_I0.7700.25
245_I273_H0.7640.25
50_T151_L0.7620.25
241_I256_L0.7620.25
23_D158_Y0.7600.25
151_L159_A0.7600.25
132_Q186_A0.7600.25
134_F160_P0.7590.25
135_L144_L0.7510.25
179_V252_A0.7510.25
171_P262_Q0.7510.25
129_L177_D0.7450.24
135_L159_A0.7380.24
135_L205_L0.7310.24
26_V44_G0.7300.24
167_T183_Y0.7300.24
67_G75_V0.7280.24
28_D107_D0.7250.23
148_A226_V0.7250.23
196_R202_L0.7240.23
56_A186_A0.7220.23
113_D119_A0.7200.23
20_R156_L0.7190.23
30_L66_L0.7150.23
20_R227_D0.7150.23
83_P154_G0.7150.23
32_A208_R0.7110.23
218_A225_P0.7100.23
190_A198_G0.7090.23
123_D183_Y0.7090.23
53_M163_F0.7080.23
208_R260_R0.7070.23
183_Y220_D0.7060.23
170_Q269_T0.7060.23
14_K272_A0.7030.23
111_R116_D0.6990.22
7_Q273_H0.6980.22
146_A174_P0.6980.22
131_A157_A0.6920.22
107_D116_D0.6890.22
108_A118_L0.6890.22
58_W135_L0.6880.22
40_V245_I0.6810.22
152_A177_D0.6780.21
242_L260_R0.6700.21
253_T257_A0.6680.21
59_E128_L0.6680.21
112_F260_R0.6660.21
163_F167_T0.6630.21
145_D208_R0.6620.21
42_E51_V0.6620.21
50_T132_Q0.6610.21
42_E52_P0.6610.21
49_P134_F0.6570.21
43_A134_F0.6570.21
22_R274_G0.6550.21
33_A86_L0.6550.21
138_V196_R0.6530.21
7_Q141_A0.6530.21
137_L199_R0.6520.20
133_S221_W0.6510.20
43_A74_V0.6500.20
12_T271_V0.6500.20
137_L198_G0.6480.20
161_L186_A0.6460.20
50_T158_Y0.6440.20
192_G201_L0.6440.20
63_A201_L0.6400.20
65_Y196_R0.6400.20
23_D170_Q0.6380.20
44_G123_D0.6360.20
26_V201_L0.6330.20
69_D75_V0.6330.20
66_L210_A0.6330.20
145_D204_V0.6330.20
220_D263_L0.6290.20
129_L159_A0.6290.20
42_E49_P0.6290.20
76_A113_D0.6290.20
58_W272_A0.6250.19
82_V85_V0.6240.19
156_L205_L0.6230.19
254_D258_T0.6230.19
179_V251_D0.6210.19
176_D259_R0.6210.19
131_A208_R0.6160.19
24_R257_A0.6130.19
234_E272_A0.6130.19
65_Y186_A0.6130.19
62_P152_A0.6130.19
19_E122_T0.6110.19
53_M183_Y0.6110.19
51_V255_W0.6100.19
191_D273_H0.6020.19
56_A63_A0.6020.19
11_L18_D0.6020.19
65_Y272_A0.6010.19
209_P271_V0.5980.18
151_L157_A0.5980.18
44_G136_D0.5950.18
241_I248_A0.5940.18
193_R197_A0.5940.18
169_L245_I0.5930.18
132_Q187_I0.5930.18
21_A258_T0.5880.18
42_E194_T0.5880.18
111_R235_Q0.5860.18
37_H79_N0.5860.18
79_N128_L0.5860.18
20_R177_D0.5820.18
11_L136_D0.5810.18
26_V200_R0.5810.18
26_V277_L0.5800.18
39_R66_L0.5750.18
188_D200_R0.5740.18
86_L180_R0.5740.18
45_C84_R0.5730.18
40_V49_P0.5710.18
191_D255_W0.5710.18
34_L38_P0.5710.18
78_A132_Q0.5710.18
190_A273_H0.5700.17
54_L157_A0.5680.17
30_L241_I0.5660.17
25_R253_T0.5640.17
49_P248_A0.5640.17
206_R275_Y0.5630.17
158_Y183_Y0.5620.17
66_L216_V0.5590.17
194_T274_G0.5550.17
164_D169_L0.5500.17
45_C109_P0.5470.17
179_V241_I0.5450.17
81_V260_R0.5440.17
107_D112_F0.5430.17
142_D181_A0.5430.17
139_P143_A0.5400.16
245_I256_L0.5380.16
241_I245_I0.5360.16
116_D173_H0.5340.16
73_R265_A0.5340.16
30_L144_L0.5330.16
146_A222_I0.5310.16
178_R261_Q0.5300.16
7_Q207_E0.5280.16
191_D195_S0.5270.16
167_T184_H0.5240.16
206_R216_V0.5230.16
8_T256_L0.5190.16
196_R240_C0.5190.16
65_Y163_F0.5160.16
68_V112_F0.5150.16
47_T52_P0.5150.16
142_D146_A0.5150.16
53_M167_T0.5150.16
138_V159_A0.5140.16
29_R32_A0.5140.16
166_V220_D0.5130.16
84_R225_P0.5110.16
149_D275_Y0.5110.16
59_E63_A0.5090.15
27_R134_F0.5090.15
141_A208_R0.5080.15
145_D152_A0.5060.15
51_V241_I0.5060.15
21_A224_R0.5050.15
158_Y167_T0.5040.15
46_G276_D0.5030.15
223_V270_Y0.5010.15
138_V193_R0.5000.15
106_G235_Q0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mggA 2 0.847 99.3 0.842 Contact Map
2yqzA 1 0.8541 99.1 0.855 Contact Map
3dr5A 2 0.7011 99 0.861 Contact Map
3busA 1 0.8363 99 0.861 Contact Map
4xrpC 1 0.6833 99 0.862 Contact Map
4necA 3 0.8149 98.9 0.865 Contact Map
4pcaA 4 0.6833 98.9 0.865 Contact Map
2avdA 2 0.6797 98.9 0.866 Contact Map
3c3pA 6 0.6299 98.9 0.866 Contact Map
2aotA 1 0.9075 98.9 0.866 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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