GREMLIN Database
Q9HQS5 - Uncharacterized protein
UniProt: Q9HQS5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 184 (179)
Sequences: 115 (97)
Seq/√Len: 7.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_P135_A4.6720.99
4_L166_G3.9840.96
115_D118_A3.7180.94
58_G91_S3.3330.90
73_P77_T3.0340.85
172_L177_V2.6950.77
10_G99_G2.5250.72
92_T96_L2.4590.70
57_L117_H2.3510.66
63_V80_V2.2630.63
95_V122_W2.1540.59
96_L127_V2.0800.57
137_L170_S1.9380.51
27_P31_G1.9240.50
115_D174_R1.9150.50
62_A150_V1.8890.49
129_P133_S1.8520.48
29_A151_Y1.8120.46
32_A151_Y1.8110.46
9_V143_A1.7980.46
81_G165_L1.7780.45
38_A83_G1.7680.44
44_L180_F1.7480.44
20_A125_R1.6700.41
119_G158_L1.6560.40
127_V150_V1.6320.39
44_L100_D1.5950.38
110_T170_S1.5890.38
75_A150_V1.5730.37
45_V177_V1.5700.37
98_A126_Y1.5580.37
44_L102_L1.5330.36
29_A138_A1.4470.33
160_A164_A1.4350.32
96_L163_L1.4310.32
77_T125_R1.4270.32
72_T83_G1.4260.32
34_V123_R1.4100.31
7_I100_D1.4050.31
16_P176_L1.4020.31
112_A174_R1.3960.31
13_L145_A1.3900.31
60_V128_I1.3690.30
28_A103_R1.3690.30
70_A78_V1.3660.30
31_G57_L1.3630.30
54_Y83_G1.3550.30
7_I37_G1.3410.29
141_A163_L1.3180.28
34_V60_V1.3140.28
46_G101_E1.3090.28
50_R166_G1.3000.28
96_L122_W1.2950.28
22_P69_A1.2690.27
65_A168_V1.2680.27
83_G143_A1.2610.27
31_G117_H1.2590.27
32_A147_A1.2430.26
43_L101_E1.2340.26
2_M6_H1.2240.25
2_M5_T1.2240.25
106_E174_R1.2230.25
11_F23_A1.2200.25
14_A103_R1.2100.25
109_T124_A1.2010.25
59_W63_V1.1800.24
31_G50_R1.1700.24
15_A32_A1.1590.24
33_L88_A1.1530.23
55_P116_H1.1470.23
98_A107_R1.1280.23
7_I57_L1.1270.23
46_G102_L1.1240.23
163_L179_Y1.1240.23
68_I128_I1.0990.22
9_V89_V1.0790.21
32_A88_A1.0790.21
100_D126_Y1.0710.21
33_L61_G1.0610.21
61_G148_L1.0570.21
154_V160_A1.0550.21
15_A164_A1.0510.21
41_I128_I1.0390.20
46_G107_R1.0390.20
66_A176_L1.0300.20
64_P163_L1.0290.20
91_S96_L1.0250.20
15_A33_L1.0200.20
107_R177_V1.0180.20
91_S133_S1.0160.20
26_V85_A1.0120.20
76_L152_D1.0080.20
75_A122_W0.9950.19
44_L107_R0.9940.19
89_V149_V0.9930.19
29_A147_A0.9900.19
85_A156_R0.9860.19
85_A148_L0.9850.19
100_D117_H0.9850.19
43_L133_S0.9800.19
131_D169_Y0.9800.19
30_A141_A0.9790.19
31_G82_V0.9680.19
4_L93_S0.9650.19
27_P58_G0.9640.19
20_A128_I0.9600.18
80_V106_E0.9580.18
34_V155_V0.9480.18
91_S166_G0.9450.18
78_V166_G0.9310.18
83_G124_A0.9290.18
17_V37_G0.9220.18
107_R126_Y0.9220.18
100_D107_R0.9170.17
99_G112_A0.9140.17
33_L50_R0.9050.17
14_A78_V0.8990.17
15_A31_G0.8910.17
50_R56_V0.8780.17
126_Y140_A0.8750.17
44_L117_H0.8730.17
32_A36_G0.8700.16
143_A170_S0.8630.16
50_R57_L0.8620.16
120_R161_A0.8570.16
54_Y147_A0.8520.16
70_A152_D0.8480.16
99_G109_T0.8430.16
73_P165_L0.8360.16
102_L109_T0.8350.16
152_D164_A0.8350.16
91_S135_A0.8340.16
41_I68_I0.8340.16
66_A142_A0.8330.16
103_R106_E0.8270.16
125_R149_V0.8250.15
126_Y166_G0.8240.15
22_P131_D0.8220.15
3_V115_D0.8210.15
14_A137_L0.8150.15
57_L91_S0.8140.15
25_G156_R0.8090.15
18_A144_A0.8030.15
8_A32_A0.7970.15
93_S96_L0.7960.15
3_V86_A0.7930.15
24_L150_V0.7920.15
50_R150_V0.7890.15
145_A167_A0.7880.15
177_V180_F0.7870.15
86_A140_A0.7850.15
138_A156_R0.7770.15
99_G152_D0.7730.14
142_A155_V0.7670.14
1_M122_W0.7580.14
28_A58_G0.7550.14
58_G123_R0.7540.14
31_G88_A0.7540.14
97_G101_E0.7510.14
125_R144_A0.7480.14
69_A146_P0.7470.14
41_I165_L0.7460.14
162_L176_L0.7430.14
140_A143_A0.7420.14
37_G149_V0.7390.14
127_V148_L0.7260.14
7_I78_V0.7250.14
36_G93_S0.7210.13
63_V177_V0.7190.13
92_T122_W0.7180.13
4_L135_A0.7160.13
41_I60_V0.7130.13
32_A103_R0.7080.13
38_A79_F0.7080.13
137_L140_A0.7050.13
54_Y168_V0.7050.13
91_S147_A0.7040.13
38_A58_G0.6960.13
29_A54_Y0.6880.13
96_L154_V0.6870.13
72_T159_L0.6830.13
117_H175_R0.6800.13
67_V76_L0.6790.13
7_I111_A0.6770.13
45_V75_A0.6740.13
3_V147_A0.6740.13
128_I155_V0.6740.13
91_S123_R0.6680.13
34_V108_T0.6670.13
23_A168_V0.6650.12
140_A166_G0.6650.12
133_S141_A0.6630.12
118_A142_A0.6620.12
44_L98_A0.6620.12
57_L61_G0.6560.12
96_L106_E0.6550.12
7_I17_V0.6550.12
50_R59_W0.6520.12
68_I81_G0.6500.12
35_G136_D0.6470.12
8_A100_D0.6450.12
108_T171_L0.6440.12
43_L80_V0.6430.12
158_L167_A0.6430.12
86_A96_L0.6400.12
32_A99_G0.6400.12
30_A68_I0.6340.12
77_T155_V0.6260.12
106_E166_G0.6250.12
11_F32_A0.6240.12
111_A159_L0.6210.12
45_V128_I0.6190.12
57_L84_A0.6180.12
25_G128_I0.6170.12
98_A110_T0.6140.12
120_R138_A0.6120.12
8_A144_A0.6120.12
18_A119_G0.6100.12
89_V138_A0.6060.12
127_V140_A0.6060.12
4_L91_S0.6060.12
14_A52_L0.6020.11
24_L160_A0.6020.11
30_A61_G0.5980.11
59_W149_V0.5940.11
31_G162_L0.5920.11
167_A170_S0.5890.11
68_I157_W0.5870.11
98_A124_A0.5790.11
8_A176_L0.5750.11
9_V86_A0.5750.11
68_I80_V0.5740.11
18_A71_V0.5720.11
26_V165_L0.5720.11
18_A171_L0.5680.11
7_I61_G0.5680.11
25_G85_A0.5640.11
17_V144_A0.5590.11
5_T10_G0.5550.11
6_H10_G0.5550.11
27_P79_F0.5550.11
60_V161_A0.5550.11
147_A151_Y0.5540.11
95_V140_A0.5440.11
109_T159_L0.5400.11
4_L162_L0.5390.11
59_W85_A0.5390.11
15_A68_I0.5360.10
103_R137_L0.5360.10
16_P103_R0.5260.10
91_S179_Y0.5250.10
166_G171_L0.5230.10
12_L43_L0.5190.10
76_L167_A0.5170.10
80_V110_T0.5160.10
96_L172_L0.5160.10
9_V161_A0.5140.10
73_P80_V0.5110.10
64_P112_A0.5100.10
14_A117_H0.5100.10
103_R175_R0.5090.10
139_V158_L0.5090.10
172_L176_L0.5070.10
17_V70_A0.5040.10
7_I30_A0.5040.10
36_G56_V0.5020.10
3_V174_R0.5010.10
72_T165_L0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yvpA 2 0.3696 5.5 0.971 Contact Map
1wazA 1 0.2337 2.6 0.975 Contact Map
4u7uA 1 0.375 2.5 0.975 Contact Map
2ysbA 1 0.1902 2.4 0.975 Contact Map
3ewtE 1 0.0652 2.3 0.976 Contact Map
2m7xA 1 0.163 1.9 0.977 Contact Map
2mdwA 2 0.1196 1.9 0.977 Contact Map
1pq1B 1 0.1576 1.8 0.977 Contact Map
1wr3A 1 0.1576 1.5 0.978 Contact Map
3ckjA 2 0.3043 1.2 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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