GREMLIN Database
Q9HQS3 - Uncharacterized protein
UniProt: Q9HQS3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 179 (156)
Sequences: 223 (178)
Seq/√Len: 14.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_Q10_E3.1050.98
113_E135_E3.0080.97
22_A112_N2.6270.94
112_N119_R2.5330.93
85_L145_T2.3480.90
97_R122_E2.3400.90
93_I121_L2.2060.87
105_E115_A2.1480.86
38_T143_L2.0760.83
94_R128_P2.0610.83
102_L168_L2.0540.83
90_D124_G2.0490.83
113_E118_I2.0350.82
22_A91_T2.0040.81
115_A119_R1.9740.80
9_T29_D1.9040.78
10_E86_A1.8590.76
17_V26_V1.8590.76
120_K125_D1.8580.76
120_K130_D1.7840.73
70_S92_R1.7650.72
83_D145_T1.7100.69
15_K28_D1.6120.65
81_E118_I1.5930.64
130_D133_R1.5860.63
26_V136_L1.5850.63
17_V131_D1.5640.62
77_D80_D1.5520.62
100_A134_E1.5360.61
19_V173_R1.5290.60
42_S50_S1.5110.59
104_Q118_I1.5080.59
85_L165_G1.4910.58
6_M22_A1.4710.57
102_L106_E1.4700.57
104_Q108_A1.4460.56
129_S132_V1.4370.55
117_V120_K1.4080.54
6_M21_G1.3890.53
102_L142_I1.3860.53
9_T131_D1.3690.52
19_V24_I1.3460.51
6_M49_Y1.3430.50
94_R98_E1.3160.49
93_I103_S1.3150.49
34_G135_E1.3150.49
111_L129_S1.2990.48
100_A139_Y1.2970.48
85_L133_R1.2920.48
141_G166_L1.2890.47
43_S50_S1.2830.47
93_I128_P1.2820.47
11_V14_P1.2710.46
6_M33_F1.2710.46
117_V166_L1.2610.46
72_G160_G1.2470.45
104_Q112_N1.2380.45
16_T25_D1.2300.44
117_V126_S1.2180.44
20_E89_Y1.2180.44
134_E145_T1.2100.43
97_R140_L1.2050.43
122_E140_L1.2050.43
85_L134_E1.2030.43
108_A122_E1.1920.42
97_R108_A1.1920.42
133_R145_T1.1730.41
103_S123_H1.1720.41
6_M18_K1.1540.40
120_K129_S1.1510.40
89_Y136_L1.1400.39
85_L161_G1.1360.39
107_L140_L1.1270.39
121_L132_V1.1240.39
129_S133_R1.1130.38
117_V129_S1.1080.38
20_E129_S1.1040.38
161_G164_A1.1020.37
22_A171_K1.0980.37
38_T105_E1.0840.37
76_R84_E1.0790.36
120_K133_R1.0730.36
63_G121_L1.0520.35
125_D140_L1.0490.35
42_S49_Y1.0450.35
79_F82_M1.0450.35
20_E23_E1.0440.35
16_T95_S1.0440.35
107_L136_L1.0440.35
62_S65_S1.0410.34
6_M150_E1.0340.34
24_I89_Y1.0270.34
12_S99_Q1.0260.34
64_G93_I1.0240.34
131_D146_E1.0190.33
95_S106_E1.0170.33
28_D75_R1.0090.33
26_V166_L0.9960.32
104_Q115_A0.9840.32
73_R142_I0.9800.31
151_D156_D0.9710.31
120_K123_H0.9700.31
86_A92_R0.9670.31
20_E114_K0.9610.31
11_V28_D0.9310.29
15_K26_V0.9130.28
113_E132_V0.9080.28
17_V95_S0.8990.28
77_D120_K0.8860.27
6_M164_A0.8830.27
159_S165_G0.8810.27
35_T142_I0.8680.26
36_E113_E0.8580.26
108_A111_L0.8500.26
98_E123_H0.8470.26
108_A140_L0.8460.25
85_L126_S0.8450.25
85_L130_D0.8290.25
41_S99_Q0.8200.24
17_V89_Y0.8190.24
32_E131_D0.8100.24
68_T73_R0.7910.23
69_N111_L0.7900.23
105_E109_D0.7900.23
74_R132_V0.7890.23
111_L135_E0.7890.23
91_T156_D0.7880.23
94_R141_G0.7830.23
46_S49_Y0.7830.23
134_E139_Y0.7820.23
85_L157_W0.7810.23
14_P84_E0.7790.23
39_T147_S0.7770.23
83_D133_R0.7760.23
26_V157_W0.7590.22
29_D110_E0.7490.22
167_T170_D0.7450.22
41_S139_Y0.7400.21
99_Q139_Y0.7380.21
39_T143_L0.7370.21
62_S95_S0.7360.21
24_I132_V0.7340.21
151_D163_S0.7270.21
73_R141_G0.7240.21
125_D129_S0.7220.21
111_L146_E0.7210.21
168_L173_R0.7200.21
90_D172_V0.7090.20
17_V150_E0.7090.20
23_E47_T0.7080.20
159_S166_L0.7060.20
140_L166_L0.7010.20
109_D142_I0.6970.20
107_L144_L0.6850.19
92_R110_E0.6830.19
7_C27_C0.6770.19
8_G27_C0.6770.19
8_G30_C0.6770.19
7_C30_C0.6770.19
27_C30_C0.6770.19
130_D145_T0.6740.19
10_E115_A0.6690.19
31_A115_A0.6670.19
28_D88_D0.6670.19
23_E92_R0.6640.19
12_S141_G0.6640.19
92_R142_I0.6630.19
5_E137_E0.6620.19
6_M17_V0.6580.18
156_D166_L0.6570.18
49_Y142_I0.6460.18
138_D141_G0.6440.18
112_N127_L0.6430.18
24_I90_D0.6410.18
110_E148_G0.6350.18
45_T48_K0.6310.18
101_G125_D0.6300.18
16_T98_E0.6280.18
86_A151_D0.6230.17
128_P167_T0.6220.17
29_D48_K0.6200.17
132_V168_L0.6160.17
19_V95_S0.6150.17
148_G163_S0.6140.17
69_N73_R0.6100.17
83_D90_D0.6040.17
36_E93_I0.5960.17
18_K39_T0.5950.16
13_S81_E0.5940.16
11_V81_E0.5940.16
74_R113_E0.5940.16
43_S46_S0.5940.16
25_D142_I0.5900.16
10_E148_G0.5870.16
3_Q120_K0.5810.16
3_Q114_K0.5790.16
26_V31_A0.5770.16
75_R148_G0.5760.16
47_T94_R0.5740.16
156_D165_G0.5720.16
50_S121_L0.5710.16
11_V171_K0.5690.16
135_E138_D0.5680.16
81_E124_G0.5640.16
84_E130_D0.5600.15
112_N129_S0.5580.15
121_L136_L0.5540.15
161_G172_V0.5530.15
158_S161_G0.5530.15
105_E114_K0.5530.15
10_E95_S0.5480.15
63_G67_G0.5440.15
74_R80_D0.5430.15
20_E104_Q0.5370.15
14_P172_V0.5370.15
3_Q133_R0.5360.15
48_K69_N0.5350.15
9_T145_T0.5340.15
77_D130_D0.5300.15
91_T95_S0.5270.15
45_T49_Y0.5260.15
119_R128_P0.5240.14
68_T78_M0.5170.14
150_E166_L0.5170.14
127_L133_R0.5150.14
66_S69_N0.5130.14
40_Q43_S0.5110.14
74_R111_L0.5100.14
40_Q118_I0.5050.14
94_R119_R0.5050.14
26_V45_T0.5040.14
23_E28_D0.5040.14
150_E163_S0.5000.14
20_E36_E0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o9xA 2 0.6648 99.4 0.742 Contact Map
2mezA 1 0.5475 99.2 0.767 Contact Map
2wusR 1 0.4525 98.6 0.812 Contact Map
1y9qA 1 0.5531 98.6 0.815 Contact Map
1x57A 1 0.5084 98.5 0.816 Contact Map
4gqmA 2 0.5531 98.5 0.817 Contact Map
3mlfA 2 0.5307 98.5 0.817 Contact Map
3fymA 1 0.4246 98.5 0.818 Contact Map
2jvlA 1 0.5866 98.5 0.818 Contact Map
3f52A 2 0.4469 98.4 0.822 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0065 seconds.