GREMLIN Database
Q9HQS2 - CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
UniProt: Q9HQS2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 199 (181)
Sequences: 2367 (1643)
Seq/√Len: 122.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_T30_T4.6471.00
22_K74_L3.8691.00
28_P80_T3.3531.00
36_F92_L3.0631.00
26_A34_A3.0261.00
20_A24_V2.9661.00
95_Y184_H2.6751.00
39_A96_A2.6631.00
18_V77_E2.6331.00
156_T175_L2.5411.00
84_A195_W2.3491.00
21_A26_A2.2741.00
45_A60_C2.2081.00
73_A77_E2.0411.00
31_V74_L2.0271.00
105_A114_G1.9151.00
43_A103_G1.9071.00
46_F157_A1.9061.00
186_T190_R1.8731.00
40_V99_V1.8061.00
86_D130_Q1.7881.00
94_R97_D1.7591.00
68_D89_D1.7391.00
19_R77_E1.6871.00
33_V88_L1.6811.00
18_V74_L1.6501.00
188_I192_V1.6391.00
129_T132_Q1.6381.00
192_V195_W1.5651.00
142_G148_D1.5591.00
120_G184_H1.5591.00
155_V159_V1.5391.00
22_K78_V1.5271.00
46_F103_G1.5191.00
131_A135_G1.5161.00
43_A99_V1.4871.00
29_N84_A1.4791.00
117_A180_A1.4541.00
35_A67_L1.4481.00
94_R146_R1.4341.00
20_A23_T1.4241.00
21_A70_L1.4171.00
95_Y120_G1.3851.00
145_G148_D1.3851.00
38_L60_C1.3821.00
49_G54_Y1.3781.00
47_Y103_G1.3671.00
142_G186_T1.3611.00
97_D149_R1.3321.00
144_L152_L1.3231.00
103_G107_G1.3221.00
86_D134_V1.3111.00
87_L127_L1.2891.00
146_R149_R1.2751.00
11_N73_A1.2571.00
98_V123_L1.2561.00
94_R126_Y1.2541.00
105_A115_L1.2440.99
144_L182_V1.2440.99
41_V60_C1.2250.99
98_V119_T1.2150.99
170_S174_A1.2120.99
124_T186_T1.1960.99
129_T133_A1.1950.99
39_A64_N1.1930.99
90_H130_Q1.1920.99
130_Q133_A1.1890.99
179_F183_G1.1790.99
18_V73_A1.1750.99
44_A48_V1.1540.99
97_D146_R1.1510.99
37_G41_V1.1510.99
178_V182_V1.1390.99
128_G138_R1.1360.99
113_L177_V1.1290.99
27_T74_L1.1230.99
70_L73_A1.0960.99
33_V37_G1.0850.99
87_L194_A1.0720.98
32_S92_L1.0700.98
98_V122_L1.0680.98
46_F107_G1.0550.98
16_P20_A1.0440.98
19_R23_T1.0420.98
91_V127_L1.0390.98
120_G187_A1.0360.98
7_R18_V1.0360.98
47_Y106_A1.0350.98
45_A56_V1.0320.98
56_V60_C1.0310.98
31_V70_L1.0170.98
58_A154_G1.0130.98
142_G147_A1.0120.98
94_R149_R1.0120.98
28_P74_L1.0080.98
156_T172_V1.0050.98
115_L118_V1.0040.98
7_R11_N0.9930.97
181_V185_L0.9900.97
69_L147_A0.9870.97
28_P81_A0.9830.97
159_V163_T0.9800.97
90_H149_R0.9800.97
185_L189_Q0.9690.97
90_H128_G0.9680.97
17_W70_L0.9630.97
14_L73_A0.9630.97
146_R150_L0.9520.97
168_G171_P0.9430.96
46_F57_G0.9370.96
34_A38_L0.9280.96
12_R16_P0.9250.96
144_L179_F0.9240.96
16_P19_R0.9240.96
44_A47_Y0.9180.96
129_T138_R0.9150.96
65_G146_R0.9090.96
141_G193_S0.9060.96
87_L191_F0.9020.95
128_G133_A0.8950.95
64_N146_R0.8880.95
142_G190_R0.8820.95
172_V175_L0.8730.95
28_P46_F0.8640.94
21_A24_V0.8640.94
65_G69_L0.8630.94
54_Y107_G0.8630.94
185_L188_I0.8570.94
114_G176_L0.8570.94
118_V121_V0.8550.94
148_D151_A0.8550.94
180_A184_H0.8510.94
124_T187_A0.8480.94
147_A151_A0.8450.94
116_A119_T0.8420.93
55_A59_V0.8410.93
128_G132_Q0.8400.93
174_A177_V0.8140.92
20_A41_V0.8100.92
117_A183_G0.8100.92
64_N89_D0.8090.92
124_T144_L0.8070.92
138_R141_G0.8020.92
42_A60_C0.7970.91
131_A138_R0.7890.91
123_L126_Y0.7820.91
127_L191_F0.7800.91
8_P12_R0.7780.90
33_V192_V0.7770.90
15_D77_E0.7740.90
38_L67_L0.7740.90
89_D146_R0.7600.89
143_L148_D0.7560.89
38_L64_N0.7560.89
114_G117_A0.7550.89
11_N18_V0.7470.89
132_Q136_L0.7470.89
104_A172_V0.7390.88
35_A96_A0.7350.88
158_G162_I0.7350.88
9_L12_R0.7300.87
126_Y130_Q0.7300.87
104_A114_G0.7230.87
64_N68_D0.7220.87
11_N15_D0.7200.87
64_N96_A0.7200.87
132_Q138_R0.7180.87
186_T189_Q0.7170.86
84_A194_A0.7170.86
170_S178_V0.7130.86
149_R154_G0.7070.86
26_A30_T0.7060.86
55_A158_G0.7040.85
55_A162_I0.7040.85
24_V78_V0.7040.85
82_S156_T0.7040.85
37_G111_F0.7020.85
88_L92_L0.7010.85
41_V45_A0.6960.85
62_F66_W0.6910.84
41_V44_A0.6910.84
151_A155_V0.6900.84
100_V150_L0.6860.84
84_A87_L0.6800.83
123_L187_A0.6800.83
87_L90_H0.6790.83
13_L16_P0.6750.83
61_V69_L0.6740.83
74_L121_V0.6680.82
8_P11_N0.6610.82
65_G94_R0.6560.81
62_F65_G0.6510.81
152_L156_T0.6510.81
57_G104_A0.6490.80
46_F100_V0.6470.80
133_A137_D0.6420.80
133_A136_L0.6420.80
42_A61_V0.6390.79
42_A100_V0.6380.79
156_T159_V0.6370.79
128_G139_V0.6340.79
10_A147_A0.6330.79
147_A150_L0.6280.78
129_T135_G0.6280.78
125_S149_R0.6260.78
46_F49_G0.6200.77
32_S148_D0.6190.77
10_A15_D0.6100.76
68_D90_H0.6090.76
32_S61_V0.5940.74
86_D90_H0.5860.73
68_D146_R0.5840.73
30_T34_A0.5810.73
19_R158_G0.5790.72
11_N14_L0.5790.72
95_Y187_A0.5780.72
133_A138_R0.5780.72
49_G107_G0.5770.72
65_G154_G0.5770.72
45_A181_V0.5750.72
90_H94_R0.5750.72
58_A158_G0.5730.72
87_L131_A0.5710.71
126_Y129_T0.5710.71
116_A120_G0.5710.71
125_S132_Q0.5700.71
87_L134_V0.5700.71
90_H129_T0.5690.71
142_G149_R0.5620.70
150_L154_G0.5610.70
65_G150_L0.5600.70
76_R89_D0.5600.70
122_L136_L0.5580.70
14_L18_V0.5560.69
33_V178_V0.5520.69
173_V177_V0.5510.69
97_D148_D0.5510.69
176_L179_F0.5500.69
107_G114_G0.5480.68
180_A183_G0.5480.68
29_N80_T0.5460.68
57_G157_A0.5440.68
29_N192_V0.5410.67
7_R189_Q0.5400.67
142_G146_R0.5390.67
112_G116_A0.5380.67
159_V162_I0.5380.67
113_L176_L0.5380.67
138_R194_A0.5360.67
69_L148_D0.5350.67
68_D76_R0.5340.66
170_S176_L0.5310.66
54_Y57_G0.5310.66
30_T83_E0.5310.66
117_A126_Y0.5290.66
111_F122_L0.5280.66
91_V95_Y0.5250.65
64_N90_H0.5240.65
90_H97_D0.5230.65
82_S141_G0.5180.64
89_D143_L0.5180.64
32_S69_L0.5120.63
184_H187_A0.5100.63
41_V106_A0.5100.63
62_F69_L0.5090.63
152_L179_F0.5080.63
131_A194_A0.5060.62
105_A118_V0.5060.62
10_A58_A0.5050.62
37_G63_F0.5020.62
27_T80_T0.5010.62
17_W37_G0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o6mA 2 0.9397 100 0.304 Contact Map
4mndA 2 0.9347 99.9 0.429 Contact Map
3wu2A 1 0.5528 5.5 0.949 Contact Map
4leuA 1 0.3467 4.7 0.951 Contact Map
4od4A 1 0.9045 3.7 0.953 Contact Map
4tq3A 1 0.9196 3.6 0.953 Contact Map
4me2A 1 0.4472 2.5 0.957 Contact Map
4wmuA 1 0.5427 2.3 0.958 Contact Map
3ilcA 1 0.5377 2.2 0.958 Contact Map
3tx3A 2 0.9347 2.1 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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