GREMLIN Database
KAD6 - Putative adenylate kinase
UniProt: Q9HQS1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 169 (151)
Sequences: 6021 (3529)
Seq/√Len: 287.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_P116_A3.7331.00
40_D43_D3.3751.00
41_G44_A3.1671.00
33_V56_V2.8311.00
139_R147_A2.7871.00
86_R134_I2.6491.00
19_R145_A2.5811.00
35_T39_Y2.5611.00
113_E117_I2.4591.00
41_G45_D2.3991.00
127_G134_I2.2671.00
57_R71_H2.2481.00
84_V134_I2.2091.00
106_A109_N2.1181.00
36_E62_G2.1071.00
91_T94_T2.1001.00
139_R143_A2.0481.00
42_V45_D2.0361.00
85_L137_T1.9551.00
88_A138_D1.8721.00
81_A133_E1.8181.00
114_A118_I1.8051.00
40_D44_A1.7971.00
145_A149_Q1.7931.00
109_N112_S1.7191.00
133_E151_V1.6991.00
140_S143_A1.6931.00
11_T87_C1.6211.00
120_S124_R1.5871.00
91_T138_D1.5861.00
19_R142_D1.5751.00
100_G104_E1.5531.00
124_R128_A1.5491.00
116_A120_S1.5401.00
5_V17_T1.5131.00
44_A52_D1.5021.00
40_D45_D1.4721.00
52_D55_A1.4281.00
6_T123_V1.4071.00
36_E59_H1.3701.00
87_C137_T1.3531.00
97_Q110_A1.3531.00
85_L148_I1.3281.00
16_A148_I1.3231.00
36_E39_Y1.2941.00
19_R22_T1.2931.00
82_V132_Y1.2931.00
146_A150_A1.2761.00
98_D101_D1.2741.00
84_V123_V1.2701.00
143_A147_A1.2361.00
105_K108_E1.2301.00
4_A79_L1.2211.00
10_G96_L1.1741.00
124_R127_G1.1731.00
100_G103_P1.1411.00
139_R144_V1.1381.00
8_T115_L1.1321.00
98_D102_S1.1231.00
58_D61_A1.1161.00
18_G22_T1.1021.00
53_V74_H1.0901.00
89_P113_E1.0881.00
146_A149_Q1.0851.00
101_D104_E1.0671.00
5_V20_L1.0621.00
28_H31_D1.0551.00
147_A150_A1.0491.00
42_V46_R1.0441.00
136_T139_R1.0431.00
43_D47_G1.0261.00
90_E94_T1.0221.00
16_A145_A1.0111.00
143_A146_A0.9631.00
115_L119_L0.9611.00
66_V79_L0.9581.00
55_A58_D0.9581.00
2_R66_V0.9561.00
5_V67_L0.9551.00
79_L131_V0.9151.00
2_R80_D0.9101.00
14_T69_E0.9061.00
93_A97_Q0.9051.00
8_T92_L0.8951.00
21_D26_V0.8931.00
6_T82_V0.8891.00
78_D125_G0.8891.00
97_Q109_N0.8831.00
101_D105_K0.8831.00
30_N34_G0.8811.00
83_V148_I0.8731.00
18_G26_V0.8721.00
86_R123_V0.8681.00
32_L36_E0.8661.00
7_G10_G0.8651.00
135_D151_V0.8621.00
57_R60_F0.8551.00
93_A110_A0.8441.00
56_V60_F0.8421.00
97_Q100_G0.8411.00
20_L148_I0.8411.00
24_L66_V0.8401.00
24_L65_D0.8341.00
32_L59_H0.8331.00
135_D144_V0.8331.00
3_V81_A0.8291.00
125_G129_D0.8131.00
136_T144_V0.8100.99
25_D65_D0.8100.99
18_G21_D0.8100.99
119_L123_V0.8090.99
37_G45_D0.8080.99
5_V85_L0.8070.99
2_R79_L0.8040.99
138_D144_V0.7910.99
136_T147_A0.7900.99
104_E109_N0.7860.99
20_L67_L0.7810.99
17_T26_V0.7800.99
30_N73_A0.7770.99
12_G15_T0.7710.99
97_Q104_E0.7700.99
141_P145_A0.7690.99
114_A117_I0.7660.99
46_R106_A0.7650.99
78_D126_H0.7620.99
33_V60_F0.7550.99
31_D35_T0.7490.99
53_V76_L0.7460.99
53_V77_D0.7450.99
103_P106_A0.7440.99
45_D58_D0.7440.99
137_T144_V0.7400.99
33_V37_G0.7390.99
84_V132_Y0.7330.99
7_G11_T0.7260.99
21_D25_D0.7250.99
74_H77_D0.7220.99
40_D58_D0.7130.99
12_G95_R0.7110.99
9_P112_S0.7040.99
23_A64_E0.7040.99
72_L77_D0.7000.99
54_D58_D0.6970.98
75_R125_G0.6920.98
97_Q103_P0.6910.98
113_E116_A0.6900.98
8_T11_T0.6890.98
142_D146_A0.6890.98
89_P93_A0.6890.98
94_T98_D0.6850.98
16_A19_R0.6790.98
81_A151_V0.6730.98
27_A32_L0.6730.98
36_E58_D0.6730.98
2_R6_T0.6690.98
29_L60_F0.6570.98
138_D147_A0.6530.98
108_E112_S0.6490.98
75_R122_A0.6480.98
81_A152_L0.6460.98
87_C92_L0.6440.97
21_D67_L0.6400.97
16_A144_V0.6340.97
104_E108_E0.6260.97
16_A135_D0.6240.97
129_D132_Y0.6210.97
88_A91_T0.6210.97
82_V131_V0.6210.97
5_V83_V0.6200.97
122_A126_H0.6180.97
137_T141_P0.6140.97
35_T38_L0.6090.96
2_R24_L0.6060.96
51_V56_V0.6050.96
104_E110_A0.6020.96
16_A141_P0.6010.96
49_K52_D0.6010.96
148_I151_V0.5980.96
6_T84_V0.5980.96
57_R61_A0.5950.96
90_E93_A0.5860.96
115_L126_H0.5840.96
33_V36_E0.5840.96
9_P92_L0.5780.95
119_L122_A0.5760.95
43_D46_R0.5750.95
103_P107_A0.5710.95
25_D63_R0.5700.95
123_V132_Y0.5690.95
88_A92_L0.5680.95
99_R108_E0.5670.95
4_A82_V0.5670.95
40_D54_D0.5630.95
34_G73_A0.5630.95
51_V70_S0.5600.94
99_R107_A0.5510.94
122_A132_Y0.5500.94
14_T99_R0.5480.94
142_D145_A0.5450.94
15_T69_E0.5400.93
87_C95_R0.5390.93
25_D32_L0.5370.93
71_H76_L0.5320.93
86_R136_T0.5270.92
29_L32_L0.5270.92
18_G103_P0.5210.92
83_V133_E0.5190.92
25_D66_V0.5170.92
50_I56_V0.5160.92
94_T97_Q0.5160.92
140_S144_V0.5150.92
48_S51_V0.5140.92
102_S108_E0.5140.92
65_D80_D0.5110.91
17_T85_L0.5080.91
84_V115_L0.5080.91
40_D55_A0.5060.91
6_T132_Y0.5060.91
115_L122_A0.5060.91
19_R141_P0.5050.91
30_N99_R0.5030.91
3_V152_L0.5020.91
39_Y44_A0.5010.90
75_R96_L0.5010.90
147_A151_V0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qbgB 1 0.929 99.9 0.454 Contact Map
2xb4A 4 0.9053 99.9 0.467 Contact Map
4jzkA 1 0.9053 99.9 0.482 Contact Map
3tlxA 1 0.9112 99.9 0.484 Contact Map
4jl5A 1 0.9053 99.9 0.484 Contact Map
3gmtA 1 0.8047 99.9 0.485 Contact Map
1ukzA 1 0.9231 99.9 0.486 Contact Map
1akyA 1 0.9172 99.9 0.488 Contact Map
3be4A 1 0.8994 99.9 0.488 Contact Map
1zakA 2 0.9704 99.9 0.488 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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