GREMLIN Database
Q9HQR6 - 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase
UniProt: Q9HQR6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 244 (209)
Sequences: 9876 (5897)
Seq/√Len: 407.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_N222_D3.6251.00
124_A208_L3.4571.00
166_T178_S3.3341.00
170_D175_R3.0801.00
168_A227_S2.9751.00
225_A235_E2.7961.00
110_D113_A2.7081.00
111_A193_A2.6571.00
227_S233_T2.5821.00
99_A124_A2.5391.00
111_A190_T2.5391.00
187_D190_T2.4691.00
175_R178_S2.4391.00
225_A233_T2.4231.00
106_A109_L2.3561.00
106_A117_A2.2851.00
96_A226_A2.2731.00
96_A169_L2.2621.00
115_M118_V2.2051.00
83_A237_T2.2011.00
223_R235_E2.2001.00
113_A116_A2.1561.00
168_A178_S2.1491.00
166_T229_E2.1351.00
109_L117_A2.0961.00
105_Q202_Q2.0431.00
170_D225_A1.9831.00
146_D200_T1.9731.00
179_G183_Q1.9691.00
105_Q203_P1.8641.00
54_A213_P1.8371.00
170_D227_S1.8301.00
73_P144_A1.7721.00
115_M189_P1.7711.00
100_V188_V1.7581.00
166_T180_S1.6991.00
75_T202_Q1.6611.00
151_L206_V1.6611.00
171_V176_R1.6571.00
53_A57_D1.6501.00
99_A208_L1.6341.00
85_P147_G1.6261.00
168_A175_R1.6141.00
99_A122_T1.6071.00
111_A187_D1.5891.00
164_D180_S1.5821.00
121_Y158_P1.5301.00
223_R237_T1.5161.00
99_A206_V1.5141.00
123_V228_V1.4921.00
124_A149_C1.4831.00
86_L92_V1.4741.00
94_H176_R1.4661.00
30_D33_S1.4651.00
164_D182_S1.3971.00
43_S202_Q1.3971.00
71_L140_V1.3961.00
171_V218_L1.3911.00
78_A82_D1.3711.00
96_A167_V1.3691.00
69_L195_I1.3561.00
48_V191_L1.3341.00
127_V218_L1.3291.00
149_C208_L1.3161.00
107_R146_D1.3141.00
104_T117_A1.3001.00
90_T131_T1.2971.00
54_A183_Q1.2691.00
79_G82_D1.2671.00
45_V149_C1.2511.00
125_N236_H1.2221.00
157_T160_E1.2091.00
102_I192_L1.1981.00
104_T116_A1.1921.00
76_A149_C1.1811.00
98_L228_V1.1801.00
161_V165_A1.1711.00
50_R59_R1.1691.00
50_R61_A1.1631.00
35_D82_D1.1531.00
122_T152_G1.1451.00
48_V69_L1.1341.00
122_T151_L1.1271.00
140_V144_A1.1161.00
56_A63_V1.1161.00
127_V150_P1.0921.00
186_F190_T1.0861.00
86_L220_D1.0821.00
111_A189_P1.0791.00
78_A147_G1.0741.00
46_V195_I1.0741.00
107_R200_T1.0721.00
105_Q117_A1.0441.00
84_T127_V1.0311.00
93_E130_R1.0261.00
105_Q200_T1.0251.00
102_I201_L1.0211.00
66_R135_R1.0121.00
119_E155_V1.0101.00
84_T224_V1.0081.00
52_Y209_T1.0071.00
91_R131_T1.0021.00
132_D145_F1.0001.00
170_D233_T0.9951.00
136_E141_R0.9851.00
169_L226_A0.9811.00
98_L181_I0.9771.00
100_V207_V0.9611.00
123_V226_A0.9601.00
38_P77_V0.9531.00
165_A181_I0.9501.00
141_R198_F0.9491.00
91_R134_D0.9471.00
53_A64_P0.9451.00
124_A151_L0.9441.00
54_A57_D0.9301.00
129_N148_S0.9281.00
193_A197_A0.9211.00
81_G235_E0.9171.00
55_H130_R0.9031.00
123_V231_V0.9031.00
110_D193_A0.9011.00
190_T193_A0.8941.00
103_G119_E0.8891.00
101_V155_V0.8801.00
125_N224_V0.8781.00
122_T231_V0.8731.00
80_H234_L0.8721.00
173_G225_A0.8681.00
96_A123_V0.8671.00
42_P77_V0.8651.00
46_V71_L0.8641.00
69_L194_E0.8621.00
31_R36_V0.8611.00
62_D65_D0.8601.00
46_V199_V0.8521.00
92_V238_V0.8431.00
63_V185_V0.8411.00
108_N197_A0.8391.00
162_P230_G0.8231.00
170_D173_G0.8141.00
169_L224_V0.8111.00
48_V195_I0.8041.00
130_R133_Q0.7991.00
165_A228_V0.7951.00
100_V121_Y0.7941.00
36_V80_H0.7941.00
191_L209_T0.7891.00
89_N108_N0.7881.00
194_E197_A0.7871.00
44_K146_D0.7851.00
39_P122_T0.7831.00
55_H58_E0.7811.00
86_L238_V0.7771.00
64_P186_F0.7751.00
94_H216_G0.7731.00
192_L207_V0.7701.00
92_V148_S0.7701.00
50_R68_L0.7631.00
156_A231_V0.7621.00
218_L224_V0.7611.00
81_G234_L0.7611.00
189_P193_A0.7601.00
58_E215_V0.7591.00
87_P148_S0.7581.00
101_V122_T0.7531.00
183_Q213_P0.7441.00
141_R199_V0.7391.00
84_T238_V0.7321.00
151_L208_L0.7281.00
43_S75_T0.7281.00
165_A180_S0.7241.00
59_R128_S0.7241.00
173_G223_R0.7221.00
156_A161_V0.7201.00
109_L193_A0.7201.00
67_P191_L0.7201.00
88_P108_N0.7191.00
68_L139_W0.7181.00
61_A134_D0.7171.00
106_A192_L0.7131.00
98_L188_V0.7121.00
47_C208_L0.7111.00
195_I207_V0.7091.00
224_V238_V0.7081.00
120_G155_V0.7041.00
100_V192_L0.7011.00
57_D183_Q0.6981.00
193_A196_T0.6961.00
201_L207_V0.6931.00
53_A63_V0.6911.00
90_T129_N0.6901.00
145_F148_S0.6881.00
44_K74_P0.6841.00
91_R217_E0.6821.00
191_L207_V0.6811.00
38_P80_H0.6801.00
50_R56_A0.6760.99
89_N197_A0.6760.99
101_V120_G0.6740.99
101_V206_V0.6720.99
89_N132_D0.6680.99
154_V231_V0.6670.99
84_T147_G0.6660.99
67_P194_E0.6630.99
72_K149_C0.6620.99
219_T222_D0.6610.99
55_H133_Q0.6540.99
44_K73_P0.6540.99
168_A229_E0.6520.99
53_A185_V0.6510.99
51_N191_L0.6490.99
98_L121_Y0.6470.99
218_L222_D0.6470.99
158_P161_V0.6470.99
145_F198_F0.6450.99
76_A200_T0.6440.99
127_V238_V0.6420.99
55_H215_V0.6370.99
99_A151_L0.6370.99
179_G213_P0.6360.99
45_V77_V0.6300.99
77_V151_L0.6290.99
167_V179_G0.6260.99
184_F191_L0.6240.99
102_I105_Q0.6190.99
171_V224_V0.6190.99
167_V228_V0.6170.99
118_V121_Y0.6150.99
105_Q109_L0.6140.99
41_D202_Q0.6130.99
84_T236_H0.6120.99
53_A183_Q0.6120.99
31_R34_V0.6110.99
38_P79_G0.6100.99
125_N226_A0.6090.99
102_I117_A0.6090.99
156_A159_D0.6080.99
66_R194_E0.6070.99
81_G237_T0.6070.99
116_A158_P0.6020.99
113_A117_A0.6010.99
45_V124_A0.6000.99
87_P145_F0.6000.99
114_A193_A0.6000.99
57_D63_V0.5990.99
115_M158_P0.5970.99
152_G232_G0.5970.99
100_V118_V0.5920.99
78_A84_T0.5880.99
55_H93_E0.5880.99
194_E198_F0.5870.99
134_D137_Q0.5820.98
218_L238_V0.5810.98
43_S74_P0.5800.98
114_A189_P0.5800.98
170_D178_S0.5770.98
114_A192_L0.5760.98
57_D60_D0.5740.98
56_A60_D0.5730.98
129_N132_D0.5720.98
36_V154_V0.5700.98
115_M121_Y0.5690.98
44_K202_Q0.5640.98
85_P107_R0.5610.98
84_T148_S0.5600.98
140_V145_F0.5590.98
164_D181_I0.5580.98
166_T182_S0.5570.98
184_F189_P0.5570.98
40_C101_V0.5550.98
114_A118_V0.5530.98
106_A110_D0.5530.98
153_P156_A0.5490.98
134_D217_E0.5490.98
44_K75_T0.5480.98
104_T203_P0.5480.98
86_L219_T0.5470.98
181_I188_V0.5460.98
94_H171_V0.5430.98
180_S229_E0.5430.98
84_T92_V0.5420.98
127_V147_G0.5410.98
128_S133_Q0.5400.98
155_V231_V0.5390.98
67_P186_F0.5340.97
52_Y181_I0.5330.97
44_K71_L0.5320.97
127_V236_H0.5320.97
63_V66_R0.5320.97
127_V224_V0.5310.97
91_R135_R0.5310.97
115_M188_V0.5310.97
110_D117_A0.5310.97
190_T194_E0.5260.97
167_V173_G0.5260.97
89_N129_N0.5250.97
123_V234_L0.5210.97
118_V188_V0.5180.97
109_L192_L0.5150.97
112_G193_A0.5130.97
114_A196_T0.5110.97
51_N184_F0.5110.97
158_P162_P0.5100.97
75_T146_D0.5100.97
45_V208_L0.5080.96
188_V209_T0.5070.96
89_N198_F0.5060.96
80_H235_E0.5050.96
226_A234_L0.5040.96
55_H59_R0.5020.96
78_A81_G0.5010.96
152_G231_V0.5000.96
50_R54_A0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r6oA 2 0.9098 100 0.188 Contact Map
3rr6A 1 0.9754 100 0.19 Contact Map
4dbfA 2 0.9426 100 0.198 Contact Map
1wzoA 4 0.9508 100 0.214 Contact Map
2dfuA 2 0.9549 100 0.22 Contact Map
3lzkA 2 0.9877 100 0.241 Contact Map
1gttA 1 0.959 100 0.241 Contact Map
4maqA 2 0.9221 100 0.269 Contact Map
2q18X 3 0.9139 100 0.275 Contact Map
1sawA 2 0.8197 100 0.277 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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