GREMLIN Database
Y1038 - UPF0173 metal-dependent hydrolase VNG_1038C
UniProt: Q9HQR5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 240 (220)
Sequences: 5058 (3537)
Seq/√Len: 238.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_W197_M3.3211.00
101_M122_V3.3051.00
98_F127_S2.9701.00
127_S141_T2.9651.00
14_T19_D2.8571.00
102_V125_V2.8061.00
63_H84_T2.7081.00
167_A191_V2.6921.00
46_T144_H2.6571.00
186_V194_A2.6231.00
91_T98_F2.5761.00
125_V164_P2.3491.00
150_L188_W2.3421.00
180_M215_E2.3261.00
20_L42_H2.2661.00
4_T233_T2.2041.00
100_T127_S2.1921.00
71_T85_G2.1891.00
229_D232_E2.1551.00
22_V46_T2.1381.00
177_M185_A2.0941.00
93_E98_F2.0851.00
102_V123_G2.0761.00
168_A195_F2.0681.00
165_D192_D2.0671.00
155_K159_G2.0571.00
145_A170_P2.0281.00
18_T95_G1.9421.00
91_T100_T1.9251.00
142_F168_A1.9211.00
34_A37_E1.9201.00
12_R19_D1.8741.00
173_D178_G1.7951.00
11_W168_A1.7921.00
86_M101_M1.7921.00
44_L126_I1.7851.00
44_L124_Y1.7671.00
210_A214_R1.6701.00
193_V226_H1.6671.00
107_T175_F1.6651.00
155_K188_W1.6561.00
186_V191_V1.6361.00
145_A169_V1.6221.00
3_L166_A1.6171.00
42_H63_H1.6081.00
184_V187_D1.6011.00
71_T75_A1.5941.00
184_V188_W1.5881.00
211_D215_E1.5611.00
22_V144_H1.4841.00
15_V128_D1.4791.00
27_D54_A1.4561.00
56_V60_A1.4481.00
166_A195_F1.4471.00
43_V64_T1.4031.00
93_E96_D1.3911.00
144_H197_M1.3661.00
42_H94_L1.3391.00
42_H65_V1.3361.00
168_A197_M1.3351.00
158_I190_D1.3351.00
6_F32_D1.3321.00
141_T164_P1.3301.00
22_V126_I1.3221.00
68_P87_N1.2871.00
84_T92_V1.2841.00
171_V182_A1.2811.00
89_G103_R1.2751.00
215_E218_A1.2661.00
56_V59_F1.2651.00
55_H59_F1.2641.00
55_H58_A1.2601.00
154_M185_A1.2341.00
128_D138_D1.2331.00
178_G181_Q1.2301.00
18_T41_D1.2191.00
125_V161_Y1.2151.00
87_N107_T1.2141.00
226_H234_V1.2141.00
3_L11_W1.1801.00
13_V142_F1.1711.00
63_H82_D1.1651.00
6_F10_T1.1641.00
99_V124_Y1.1481.00
193_V224_D1.1411.00
145_A167_A1.1411.00
100_T161_Y1.1261.00
211_D214_R1.1231.00
4_T14_T1.1131.00
18_T97_A1.1121.00
101_M124_Y1.1111.00
10_T22_V1.1091.00
123_G145_A1.1011.00
156_D159_G1.0921.00
182_A194_A1.0721.00
26_F35_P1.0571.00
65_V92_V1.0431.00
44_L99_V1.0391.00
169_V185_A1.0371.00
13_V22_V1.0351.00
150_L184_V1.0351.00
87_N90_G1.0241.00
183_A219_T1.0181.00
64_T80_V1.0081.00
186_V216_V1.0041.00
66_G70_V1.0001.00
166_A193_V1.0001.00
65_V86_M0.9931.00
6_F26_F0.9921.00
215_E219_T0.9881.00
214_R218_A0.9861.00
25_F30_H0.9841.00
111_E115_E0.9771.00
48_G73_Y0.9771.00
187_D219_T0.9751.00
21_L40_V0.9721.00
102_V143_Y0.9711.00
26_F55_H0.9711.00
12_R40_V0.9691.00
66_G71_T0.9611.00
55_H60_A0.9591.00
19_D39_A0.9571.00
169_V189_L0.9491.00
67_T122_V0.9471.00
19_D40_V0.9471.00
86_M90_G0.9461.00
141_T162_L0.9421.00
20_L97_A0.9391.00
3_L168_A0.9361.00
208_D211_D0.9351.00
6_F12_R0.9341.00
216_V225_V0.9181.00
68_P72_G0.9121.00
126_I142_F0.9101.00
115_E118_G0.9061.00
104_A148_T0.8921.00
86_M92_V0.8850.99
84_T174_H0.8840.99
128_D139_A0.8830.99
65_V124_Y0.8810.99
207_V212_F0.8800.99
105_D151_Q0.8780.99
140_T165_D0.8710.99
212_F216_V0.8680.99
152_S156_D0.8680.99
71_T83_T0.8630.99
12_R21_L0.8610.99
36_S58_A0.8610.99
109_G117_S0.8570.99
22_V44_L0.8490.99
44_L122_V0.8490.99
5_W197_M0.8430.99
125_V157_V0.8410.99
42_H99_V0.8400.99
88_L122_V0.8370.99
213_E217_N0.8370.99
47_H147_D0.8360.99
171_V199_Y0.8350.99
167_A189_L0.8340.99
128_D142_F0.8320.99
89_G161_Y0.8310.99
145_A148_T0.8300.99
19_D41_D0.8260.99
47_H198_H0.8240.99
199_Y213_E0.8140.99
57_G60_A0.8140.99
228_L234_V0.8120.99
111_E114_Y0.8120.99
18_T42_H0.8110.99
74_V78_T0.8090.99
167_A186_V0.8070.99
70_V119_G0.8060.99
169_V186_V0.8050.99
20_L99_V0.8000.99
10_T26_F0.7980.99
65_V94_L0.7950.99
99_V126_I0.7940.99
128_D140_T0.7930.99
16_G128_D0.7930.99
228_L233_T0.7930.99
179_P207_V0.7880.99
11_W195_F0.7840.99
65_V99_V0.7830.99
72_G75_A0.7790.99
48_G119_G0.7780.99
16_G139_A0.7780.99
143_Y185_A0.7720.99
152_S155_K0.7660.98
194_A225_V0.7630.98
169_V177_M0.7550.98
15_V20_L0.7510.98
210_A213_E0.7510.98
61_D82_D0.7500.98
179_P211_D0.7460.98
193_V196_P0.7450.98
195_F226_H0.7430.98
56_V80_V0.7400.98
56_V64_T0.7390.98
209_T212_F0.7370.98
141_T165_D0.7360.98
161_Y164_P0.7340.98
4_T12_R0.7260.98
13_V20_L0.7220.98
67_T70_V0.7210.98
109_G116_Y0.7100.98
123_G143_Y0.7080.97
183_A215_E0.7060.97
49_H147_D0.7040.97
178_G182_A0.7030.97
191_V194_A0.6950.97
68_P85_G0.6940.97
10_T25_F0.6940.97
107_T116_Y0.6940.97
88_L149_S0.6940.97
143_Y189_L0.6920.97
9_S170_P0.6860.97
173_D207_V0.6830.97
10_T54_A0.6810.97
64_T74_V0.6690.96
147_D198_H0.6680.96
66_G124_Y0.6660.96
89_G156_D0.6660.96
67_T124_Y0.6640.96
74_V80_V0.6640.96
66_G83_T0.6610.96
60_A80_V0.6550.96
60_A64_T0.6520.96
100_T125_V0.6500.96
170_P182_A0.6490.96
12_R38_V0.6420.96
172_G176_T0.6420.96
18_T96_D0.6400.95
181_Q184_V0.6390.95
14_T17_T0.6370.95
3_L195_F0.6310.95
158_I164_P0.6200.95
140_T166_A0.6200.95
183_A187_D0.6190.95
183_A220_G0.6190.95
15_V97_A0.6140.94
33_T37_E0.6140.94
112_T115_E0.6120.94
158_I167_A0.6110.94
5_W199_Y0.6090.94
53_I56_V0.6090.94
89_G157_V0.6070.94
94_L97_A0.6070.94
148_T154_M0.6070.94
104_A123_G0.6070.94
142_F166_A0.6020.94
173_D204_P0.6020.94
61_D81_E0.5980.94
150_L154_M0.5980.94
100_T162_L0.5970.93
89_G102_V0.5960.93
148_T177_M0.5940.93
9_S197_M0.5930.93
70_V74_V0.5900.93
196_P199_Y0.5890.93
67_T101_M0.5880.93
144_H168_A0.5830.93
102_V157_V0.5820.93
3_L13_V0.5800.92
47_H106_H0.5790.92
171_V196_P0.5760.92
57_G78_T0.5750.92
73_Y78_T0.5740.92
15_V126_I0.5730.92
12_R33_T0.5720.92
46_T124_Y0.5710.92
53_I78_T0.5710.92
15_V140_T0.5700.92
105_D149_S0.5670.92
195_F234_V0.5660.92
179_P215_E0.5660.92
125_V143_Y0.5620.91
175_F205_I0.5610.91
21_L38_V0.5600.91
159_G190_D0.5560.91
196_P212_F0.5490.90
223_A228_L0.5480.90
45_L70_V0.5470.90
86_M122_V0.5450.90
220_G225_V0.5430.90
196_P227_V0.5420.90
214_R217_N0.5420.90
47_H51_D0.5390.89
179_P183_A0.5380.89
218_A221_S0.5360.89
187_D190_D0.5360.89
15_V138_D0.5360.89
164_P167_A0.5360.89
44_L123_G0.5330.89
202_F205_I0.5330.89
66_G74_V0.5320.89
80_V83_T0.5320.89
109_G112_T0.5320.89
8_H50_A0.5310.89
170_P178_G0.5300.89
125_V162_L0.5290.89
73_Y76_D0.5270.88
163_D192_D0.5260.88
40_V43_V0.5250.88
44_L65_V0.5250.88
48_G118_G0.5240.88
28_N54_A0.5220.88
53_I73_Y0.5210.88
154_M188_W0.5200.88
108_N119_G0.5200.88
141_T163_D0.5190.88
75_A79_G0.5190.88
10_T35_P0.5190.88
157_V164_P0.5190.88
213_E227_V0.5150.87
171_V201_T0.5140.87
185_A189_L0.5140.87
45_L74_V0.5140.87
127_S139_A0.5140.87
48_G70_V0.5130.87
126_I144_H0.5110.87
88_L120_T0.5110.87
217_N220_G0.5100.87
5_W230_G0.5040.86
183_A216_V0.5030.86
27_D31_T0.5010.86
217_N221_S0.5010.86
158_I189_L0.5010.86
216_V227_V0.5000.86
149_S181_Q0.5000.86
68_P71_T0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qn9A 2 0.95 100 0.345 Contact Map
3rpcA 2 0.9292 100 0.39 Contact Map
3bv6A 5 0.9542 100 0.467 Contact Map
2wylA 5 0.925 100 0.49 Contact Map
4jo0A 2 0.9042 100 0.508 Contact Map
3kl7A 1 0.8333 100 0.541 Contact Map
1zkpA 2 0.8625 100 0.562 Contact Map
2cbnA 2 0.9125 100 0.564 Contact Map
1vjnA 1 0.75 100 0.573 Contact Map
3zwfA 2 0.825 100 0.575 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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