GREMLIN Database
Q9HQQ9 - UDP-glucose dehydrogenase
UniProt: Q9HQQ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 426 (403)
Sequences: 8419 (5090)
Seq/√Len: 253.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
128_E202_R5.0951.00
33_A37_A4.8821.00
351_Y391_F4.3281.00
304_L383_V3.4891.00
2_D25_T3.4151.00
325_G389_D3.3981.00
314_R347_D3.3401.00
314_R349_V3.1801.00
38_A43_D3.0161.00
305_D344_R2.9871.00
146_A180_L2.9101.00
304_L381_G2.7111.00
199_T238_E2.7031.00
316_A379_A2.6811.00
172_R176_A2.5361.00
102_A137_S2.5251.00
317_V338_I2.5131.00
21_E57_A2.4881.00
4_S75_T2.4621.00
298_E340_G2.4541.00
40_N65_A2.4071.00
230_K303_L2.3951.00
132_E145_L2.3881.00
200_G203_E2.3731.00
284_A291_E2.3211.00
37_A41_D2.2841.00
337_V385_V2.2741.00
321_S355_A2.2571.00
235_D238_E2.2111.00
109_A114_H2.1831.00
159_D163_H2.1271.00
77_V183_V2.1011.00
315_V346_A2.0511.00
25_T64_R2.0431.00
349_V379_A2.0201.00
211_N243_I1.9971.00
69_Y103_S1.9851.00
8_S28_N1.9621.00
25_T62_R1.9491.00
102_A133_S1.9461.00
398_F404_R1.9461.00
33_A67_T1.9211.00
213_A221_L1.9011.00
177_Y198_E1.9001.00
232_L279_A1.8971.00
34_D37_A1.8961.00
199_T207_I1.8881.00
384_V412_V1.8681.00
371_S374_G1.8601.00
144_L173_R1.8551.00
44_A55_I1.8511.00
380_V402_A1.8341.00
78_T114_H1.8251.00
177_Y181_H1.8111.00
277_K287_E1.7941.00
217_S289_A1.7911.00
24_H186_P1.7841.00
87_R91_S1.7781.00
349_V369_A1.7771.00
206_M229_C1.7731.00
316_A375_A1.7521.00
113_D144_L1.7411.00
99_S102_A1.7071.00
32_D35_V1.7041.00
3_V183_V1.6711.00
2_D74_D1.6411.00
98_E102_A1.6261.00
282_E287_E1.6261.00
17_A55_I1.6151.00
214_F218_K1.6021.00
37_A40_N1.5881.00
115_M179_Q1.5771.00
21_E58_H1.5601.00
299_R303_L1.5571.00
30_D36_V1.5511.00
4_S78_T1.5371.00
340_G343_D1.5351.00
98_E129_D1.5141.00
178_D182_A1.5111.00
273_T287_E1.5001.00
19_F183_V1.4961.00
389_D392_A1.4951.00
17_A63_L1.4861.00
324_P387_D1.4761.00
287_E291_E1.4761.00
181_H198_E1.4751.00
39_I65_A1.4651.00
304_L407_V1.4641.00
231_E281_Y1.4571.00
18_C21_E1.4521.00
228_I283_P1.4361.00
230_K299_R1.4351.00
320_L350_A1.4341.00
38_A45_P1.4341.00
258_V409_G1.4341.00
227_N299_R1.4131.00
29_V69_Y1.4091.00
340_G344_R1.4071.00
214_F252_R1.3991.00
52_A56_D1.3961.00
341_L346_A1.3921.00
108_L114_H1.3811.00
17_A54_R1.3801.00
50_G53_E1.3751.00
36_V67_T1.3701.00
178_D197_V1.3681.00
227_N296_Q1.3571.00
36_V65_A1.3461.00
335_V339_D1.3391.00
68_D71_A1.3391.00
77_V115_M1.3381.00
171_A177_Y1.3371.00
301_L337_V1.3331.00
217_S221_L1.3261.00
98_E130_V1.3071.00
71_A74_D1.3001.00
18_C162_R1.3001.00
34_D38_A1.2861.00
64_R71_A1.2711.00
307_H407_V1.2611.00
238_E241_D1.2551.00
144_L176_A1.2551.00
2_D27_V1.2521.00
303_L407_V1.2501.00
285_M288_A1.2411.00
316_A382_A1.2401.00
222_I240_A1.2331.00
54_R158_V1.2221.00
227_N231_E1.2191.00
354_V390_E1.2181.00
217_S285_M1.2151.00
406_V413_V1.2151.00
21_E162_R1.2091.00
132_E136_V1.2081.00
95_S99_S1.2031.00
110_G113_D1.1911.00
229_C236_A1.1881.00
73_R109_A1.1801.00
27_V75_T1.1801.00
207_I242_A1.1711.00
156_S159_D1.1701.00
314_R378_D1.1651.00
285_M292_V1.1601.00
376_L382_A1.1601.00
318_L394_L1.1571.00
182_A185_E1.1561.00
27_V64_R1.1531.00
38_A41_D1.1481.00
58_H62_R1.1481.00
260_W290_V1.1431.00
126_T130_V1.1381.00
210_A225_L1.1381.00
129_D133_S1.1371.00
301_L340_G1.1331.00
27_V74_D1.1321.00
40_N64_R1.1321.00
69_Y107_A1.1311.00
377_A400_A1.1291.00
116_V134_A1.1271.00
200_G238_E1.1271.00
225_L236_A1.1261.00
336_P339_D1.1221.00
181_H185_E1.1201.00
316_A349_V1.1171.00
102_A106_E1.1141.00
39_I63_L1.1071.00
315_V381_G1.1041.00
174_D178_D1.0971.00
131_V135_L1.0941.00
148_N184_F1.0911.00
247_D252_R1.0901.00
70_E73_R1.0861.00
203_E234_V1.0861.00
320_L360_A1.0861.00
179_Q182_A1.0841.00
298_E302_S1.0811.00
27_V66_T1.0791.00
77_V179_Q1.0781.00
6_V100_G1.0761.00
113_D142_D1.0761.00
6_V78_T1.0741.00
54_R57_A1.0681.00
35_V45_P1.0661.00
237_Y255_R1.0611.00
101_A105_G1.0571.00
36_V40_N1.0571.00
53_E57_A1.0511.00
144_L172_R1.0511.00
128_E132_E1.0491.00
185_E195_T1.0451.00
384_V413_V1.0331.00
284_A295_R1.0311.00
173_R176_A1.0311.00
384_V406_V1.0291.00
305_D346_A1.0281.00
389_D393_A1.0271.00
160_D163_H1.0261.00
85_P93_D1.0251.00
8_S16_A1.0241.00
339_D342_Q1.0231.00
56_D59_A1.0201.00
347_D367_T1.0191.00
74_D109_A1.0191.00
176_A180_L1.0181.00
102_A134_A1.0161.00
115_M146_A1.0151.00
76_D114_H1.0091.00
310_V346_A1.0081.00
118_V127_T1.0021.00
70_E74_D0.9911.00
338_I342_Q0.9901.00
3_V19_F0.9901.00
237_Y241_D0.9821.00
304_L409_G0.9801.00
234_V239_V0.9791.00
169_F180_L0.9741.00
113_D143_P0.9701.00
228_I281_Y0.9681.00
216_A290_V0.9671.00
203_E239_V0.9661.00
80_L104_L0.9641.00
135_L138_A0.9631.00
131_V172_R0.9611.00
283_P286_L0.9611.00
108_L135_L0.9611.00
16_A28_N0.9601.00
92_I123_V0.9541.00
4_S29_V0.9541.00
305_D310_V0.9481.00
16_A63_L0.9441.00
128_E201_L0.9421.00
110_G142_D0.9421.00
313_E380_V0.9411.00
178_D181_H0.9411.00
99_S103_S0.9371.00
229_C239_V0.9371.00
241_D251_G0.9371.00
336_P340_G0.9361.00
110_G114_H0.9341.00
51_L55_I0.9301.00
258_V385_V0.9301.00
339_D343_D0.9291.00
318_L382_A0.9261.00
275_A278_D0.9231.00
18_C161_F0.9231.00
227_N295_R0.9211.00
320_L332_T0.9211.00
329_I360_A0.9211.00
314_R379_A0.9191.00
355_A368_Y0.9141.00
302_S306_G0.9121.00
21_E53_E0.9111.00
103_S106_E0.9071.00
295_R298_E0.9071.00
369_A375_A0.9051.00
8_S63_L0.9031.00
381_G405_V0.9021.00
64_R70_E0.9011.00
29_V71_A0.9011.00
127_T201_L0.9001.00
66_T71_A0.8991.00
378_D402_A0.8971.00
130_V134_A0.8971.00
181_H197_V0.8961.00
307_H405_V0.8961.00
4_S27_V0.8931.00
297_P336_P0.8931.00
315_V383_V0.8901.00
104_L116_V0.8811.00
105_G137_S0.8801.00
108_L143_P0.8781.00
308_V313_E0.8741.00
163_H189_A0.8681.00
334_A385_V0.8681.00
162_R189_A0.8681.00
77_V117_V0.8661.00
15_I161_F0.8661.00
374_G377_A0.8630.99
312_G347_D0.8620.99
342_Q365_E0.8600.99
181_H195_T0.8550.99
303_L306_G0.8540.99
98_E133_S0.8490.99
55_I63_L0.8480.99
101_A118_V0.8470.99
3_V24_H0.8430.99
80_L97_M0.8430.99
369_A374_G0.8410.99
29_V66_T0.8410.99
372_A376_L0.8400.99
387_D410_R0.8380.99
320_L329_I0.8380.99
274_A278_D0.8370.99
218_K254_L0.8330.99
129_D132_E0.8290.99
4_S72_V0.8290.99
117_V180_L0.8270.99
273_T286_L0.8250.99
300_L409_G0.8250.99
131_V201_L0.8240.99
260_W269_V0.8220.99
270_A290_V0.8190.99
31_V103_S0.8130.99
177_Y197_V0.8090.99
398_F402_A0.8080.99
304_L315_V0.8050.99
228_I272_I0.8040.99
349_V367_T0.8030.99
174_D177_Y0.8020.99
318_L391_F0.8010.99
115_M176_A0.8010.99
301_L344_R0.7990.99
178_D198_E0.7970.99
101_A134_A0.7880.99
316_A376_L0.7850.99
22_L186_P0.7820.99
399_D402_A0.7800.99
324_P389_D0.7780.99
105_G134_A0.7770.99
318_L376_L0.7770.99
329_I359_M0.7730.99
101_A131_V0.7700.99
69_Y106_E0.7660.99
294_D336_P0.7660.99
376_L400_A0.7650.99
77_V180_L0.7630.99
189_A195_T0.7630.99
300_L407_V0.7620.99
304_L341_L0.7600.99
27_V71_A0.7590.99
152_L161_F0.7580.99
78_T104_L0.7570.99
244_A253_F0.7560.99
349_V378_D0.7560.99
396_D413_V0.7560.99
320_L338_I0.7560.99
274_A277_K0.7540.99
117_V183_V0.7530.99
22_L187_L0.7530.99
110_G141_D0.7530.99
342_Q366_V0.7510.99
332_T335_V0.7500.99
387_D392_A0.7480.99
214_F254_L0.7480.99
372_A390_E0.7480.99
5_I16_A0.7460.99
382_A401_M0.7450.99
295_R302_S0.7440.99
273_T290_V0.7430.98
101_A133_S0.7410.98
92_I271_A0.7340.98
146_A171_A0.7340.98
329_I355_A0.7330.98
29_V67_T0.7330.98
171_A176_A0.7310.98
338_I350_A0.7280.98
165_D247_D0.7250.98
356_A368_Y0.7200.98
15_I166_K0.7200.98
119_K184_F0.7180.98
197_V245_E0.7170.98
73_R107_A0.7170.98
373_A400_A0.7110.98
15_I19_F0.7050.98
329_I335_V0.7040.98
357_E360_A0.7030.98
29_V103_S0.7030.98
80_L116_V0.7000.98
105_G143_P0.7000.98
54_R58_H0.6990.98
195_T245_E0.6970.98
218_K222_I0.6960.98
276_A283_P0.6940.98
236_A240_A0.6940.98
35_V38_A0.6930.98
97_M126_T0.6930.98
47_H354_V0.6890.98
171_A198_E0.6890.98
357_E370_D0.6870.97
18_C158_V0.6870.97
10_Y330_R0.6860.97
298_E336_P0.6850.97
76_D179_Q0.6840.97
401_M404_R0.6840.97
360_A368_Y0.6840.97
342_Q348_V0.6830.97
213_A286_L0.6830.97
168_V195_T0.6820.97
103_S107_A0.6790.97
70_E107_A0.6790.97
4_S71_A0.6780.97
258_V300_L0.6770.97
153_R156_S0.6760.97
8_S30_D0.6760.97
203_E238_E0.6730.97
317_V383_V0.6700.97
35_V39_I0.6700.97
72_V78_T0.6690.97
237_Y411_R0.6680.97
43_D51_L0.6680.97
102_A136_V0.6670.97
370_D374_G0.6660.97
244_A251_G0.6660.97
382_A391_F0.6650.97
225_L272_I0.6650.97
43_D52_A0.6630.97
127_T147_M0.6610.97
199_T203_E0.6610.97
101_A130_V0.6590.97
154_M322_F0.6540.97
6_V69_Y0.6540.97
104_L107_A0.6540.97
170_G177_Y0.6530.97
25_T74_D0.6510.97
31_V96_I0.6510.97
308_V315_V0.6480.96
227_N281_Y0.6480.96
168_V181_H0.6480.96
132_E135_L0.6480.96
97_M101_A0.6470.96
308_V381_G0.6450.96
105_G116_V0.6440.96
243_I251_G0.6440.96
318_L372_A0.6430.96
275_A279_A0.6430.96
356_A360_A0.6430.96
168_V207_I0.6410.96
216_A260_W0.6410.96
173_R178_D0.6410.96
228_I276_A0.6390.96
355_A359_M0.6370.96
118_V130_V0.6370.96
350_A366_V0.6360.96
240_A244_A0.6350.96
294_D297_P0.6350.96
76_D110_G0.6340.96
269_V290_V0.6340.96
146_A169_F0.6340.96
152_L157_A0.6330.96
241_D244_A0.6320.96
318_L384_V0.6300.96
224_D292_V0.6290.96
353_P391_F0.6290.96
231_E282_E0.6280.96
221_L225_L0.6270.96
30_D67_T0.6260.96
5_I15_I0.6230.96
121_T268_D0.6230.96
240_A255_R0.6230.96
396_D406_V0.6220.96
212_N268_D0.6210.95
61_T64_R0.6190.95
80_L118_V0.6190.95
167_V207_I0.6190.95
277_K282_E0.6180.95
97_M118_V0.6170.95
270_A294_D0.6160.95
29_V100_G0.6160.95
121_T264_C0.6120.95
78_T107_A0.6120.95
297_P337_V0.6110.95
308_V405_V0.6110.95
53_E56_D0.6100.95
96_I100_G0.6090.95
86_A270_A0.6090.95
133_S136_V0.6080.95
79_F183_V0.6080.95
240_A256_S0.6070.95
172_R201_L0.6050.95
104_L108_L0.6050.95
350_A368_Y0.6040.95
273_T277_K0.6020.95
181_H196_V0.6010.95
303_L307_H0.6000.95
119_K148_N0.6000.95
296_Q299_R0.5990.95
72_V114_H0.5990.95
84_T120_S0.5950.94
141_D144_L0.5950.94
246_D249_I0.5950.94
350_A356_A0.5950.94
263_S267_K0.5940.94
106_E137_S0.5930.94
20_A62_R0.5930.94
22_L162_R0.5920.94
129_D275_A0.5900.94
373_A376_L0.5890.94
222_I225_L0.5890.94
301_L310_V0.5870.94
87_R98_E0.5850.94
94_T98_E0.5850.94
301_L305_D0.5840.94
283_P287_E0.5840.94
161_F187_L0.5830.94
398_F401_M0.5810.94
144_L179_Q0.5810.94
372_A394_L0.5790.93
342_Q347_D0.5780.93
302_S344_R0.5770.93
119_K154_M0.5760.93
150_E264_C0.5760.93
119_K267_K0.5760.93
329_I334_A0.5750.93
166_K211_N0.5750.93
284_A288_A0.5740.93
269_V286_L0.5730.93
206_M225_L0.5730.93
151_F211_N0.5730.93
43_D56_D0.5720.93
6_V72_V0.5710.93
214_F222_I0.5700.93
288_A291_E0.5690.93
210_A213_A0.5680.93
39_I45_P0.5680.93
258_V337_V0.5670.93
258_V324_P0.5670.93
171_A201_L0.5670.93
140_F143_P0.5660.93
281_Y292_V0.5650.93
228_I232_L0.5640.93
44_A52_A0.5630.93
227_N230_K0.5630.93
304_L310_V0.5620.92
367_T378_D0.5620.92
351_Y372_A0.5620.92
285_M289_A0.5580.92
320_L334_A0.5580.92
273_T283_P0.5550.92
338_I366_V0.5520.92
154_M267_K0.5510.92
117_V146_A0.5510.92
297_P333_R0.5510.92
8_S39_I0.5510.92
24_H77_V0.5510.92
381_G407_V0.5480.92
376_L379_A0.5470.91
308_V403_E0.5470.91
264_C267_K0.5470.91
82_L96_I0.5460.91
268_D330_R0.5450.91
50_G54_R0.5450.91
300_L337_V0.5420.91
98_E134_A0.5420.91
168_V177_Y0.5410.91
169_F177_Y0.5410.91
50_G158_V0.5400.91
230_K296_Q0.5390.91
119_K166_K0.5390.91
22_L189_A0.5390.91
116_V143_P0.5390.91
220_S285_M0.5380.91
212_N323_K0.5380.91
184_F188_L0.5380.91
307_H381_G0.5350.91
118_V135_L0.5350.91
36_V39_I0.5350.91
225_L229_C0.5350.91
87_R90_G0.5340.90
251_G255_R0.5340.90
284_A287_E0.5320.90
24_H183_V0.5300.90
341_L348_V0.5300.90
11_V330_R0.5290.90
198_E242_A0.5270.90
374_G378_D0.5270.90
9_G12_G0.5250.90
226_G230_K0.5240.90
371_S390_E0.5240.90
106_E110_G0.5240.90
83_P267_K0.5230.90
75_T78_T0.5230.90
37_A67_T0.5230.90
85_P328_D0.5220.89
69_Y72_V0.5220.89
320_L335_V0.5210.89
203_E207_I0.5200.89
160_D164_P0.5200.89
399_D403_E0.5190.89
286_L289_A0.5180.89
338_I385_V0.5180.89
226_G296_Q0.5170.89
400_A404_R0.5170.89
342_Q363_R0.5150.89
64_R74_D0.5140.89
11_V263_S0.5140.89
85_P331_G0.5140.89
5_I19_F0.5130.89
166_K184_F0.5120.89
310_V313_E0.5100.88
124_P135_L0.5090.88
91_S278_D0.5080.88
398_F403_E0.5080.88
335_V362_Q0.5070.88
212_N264_C0.5070.88
260_W289_A0.5060.88
244_A252_R0.5050.88
17_A21_E0.5050.88
338_I348_V0.5040.88
31_V67_T0.5040.88
144_L171_A0.5030.88
10_Y327_D0.5030.88
105_G142_D0.5010.87
288_A292_V0.5000.87
177_Y180_L0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2y0cA 4 0.9906 100 0.245 Contact Map
2o3jA 4 0.9859 100 0.261 Contact Map
2q3eA 5 0.9883 100 0.265 Contact Map
3gg2A 3 0.9789 100 0.266 Contact Map
3g79A 2 0.9718 100 0.276 Contact Map
3ojoA 2 0.939 100 0.28 Contact Map
4a7pA 2 0.9789 100 0.288 Contact Map
4xr9A 2 0.9859 100 0.303 Contact Map
3vtfA 2 0.9671 100 0.307 Contact Map
1mv8A 2 0.9624 100 0.317 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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