GREMLIN Database
Q9HQQ6 - Glycosyl transferase-like
UniProt: Q9HQQ6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 305 (261)
Sequences: 22235 (18095)
Seq/√Len: 1120.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_A46_D3.8671.00
159_A163_D3.8311.00
40_D60_Q3.5961.00
9_C79_A3.2441.00
17_E87_G2.8331.00
14_T47_T2.7571.00
177_E181_E2.7441.00
81_Y103_L2.7361.00
46_D49_A2.6651.00
39_V73_G2.6421.00
48_A60_Q2.5771.00
9_C35_H2.5751.00
35_H57_E2.4821.00
108_A190_R2.4161.00
48_A52_A2.3891.00
7_E80_A2.3501.00
161_S187_I2.2711.00
98_R194_T2.2231.00
40_D43_S2.1791.00
22_A26_D2.1441.00
72_E76_L2.1401.00
22_A50_V2.1001.00
102_P190_R2.0291.00
102_P192_V2.0191.00
83_L156_A2.0181.00
51_A58_V2.0141.00
26_D54_H2.0081.00
48_A58_V1.9911.00
102_P105_A1.9781.00
11_L73_G1.9131.00
22_A53_E1.9091.00
66_K70_V1.9081.00
109_E158_T1.9081.00
35_H79_A1.9061.00
103_L156_A1.8991.00
52_A60_Q1.8851.00
7_E33_V1.8661.00
109_E187_I1.8351.00
38_V51_A1.8151.00
99_L156_A1.8151.00
16_N44_A1.7931.00
8_V100_L1.7851.00
25_I54_H1.7741.00
81_Y156_A1.7691.00
9_C77_I1.7311.00
74_V162_F1.7241.00
98_R101_D1.7101.00
59_V76_L1.7081.00
70_V84_L1.6811.00
164_R187_I1.6711.00
9_C37_L1.6611.00
12_V24_V1.6321.00
18_A50_V1.6201.00
83_L96_A1.6151.00
22_A54_H1.5861.00
16_N43_S1.5431.00
46_D50_V1.5271.00
101_D105_A1.5251.00
91_N95_Q1.5191.00
94_A98_R1.5151.00
7_E78_E1.5091.00
50_V53_E1.5021.00
164_R185_H1.5021.00
70_V86_D1.4961.00
23_D90_T1.4881.00
8_V96_A1.4621.00
15_R63_G1.4591.00
72_E75_S1.4581.00
110_H189_T1.4551.00
12_V36_V1.4491.00
49_A53_E1.4351.00
102_P106_G1.4351.00
7_E79_A1.4081.00
160_E164_R1.3911.00
26_D30_E1.3801.00
27_G91_N1.3711.00
83_L95_Q1.3621.00
103_L158_T1.3521.00
64_D68_Q1.3521.00
35_H78_E1.3481.00
39_V69_A1.3361.00
50_V54_H1.3331.00
161_S182_C1.3301.00
82_V159_A1.3301.00
14_T87_G1.3271.00
57_E76_L1.3101.00
23_D26_D1.3031.00
128_N131_G1.2971.00
41_G63_G1.2881.00
17_E20_T1.2781.00
40_D48_A1.2721.00
85_L91_N1.2651.00
107_E188_T1.2561.00
81_Y100_L1.2561.00
14_T38_V1.2481.00
25_I38_V1.2351.00
74_V82_V1.2231.00
169_A172_F1.2161.00
14_T17_E1.2131.00
59_V72_E1.2101.00
77_I159_A1.2051.00
97_S101_D1.2041.00
27_G90_T1.1901.00
29_F55_G1.1731.00
110_H182_C1.1681.00
115_R153_G1.1611.00
67_G174_I1.1601.00
158_T161_S1.1451.00
23_D200_P1.1441.00
13_P69_A1.1291.00
61_Q64_D1.1291.00
177_E180_V1.1151.00
66_K86_D1.1141.00
30_E93_P1.1051.00
25_I29_F1.0881.00
37_L57_E1.0841.00
49_A52_A1.0831.00
75_S166_F1.0641.00
103_L111_V1.0471.00
10_A28_L1.0461.00
116_T195_T1.0431.00
113_G154_Y1.0411.00
175_E179_A1.0301.00
174_I177_E1.0271.00
196_Y199_R1.0221.00
27_G94_A1.0111.00
160_E163_D1.0051.00
80_A158_T1.0041.00
100_L104_V1.0041.00
203_S206_N0.9911.00
12_V87_G0.9891.00
66_K174_I0.9831.00
10_A96_A0.9811.00
74_V84_L0.9771.00
11_L39_V0.9731.00
31_V97_S0.9731.00
66_K152_S0.9661.00
212_D216_I0.9661.00
219_T222_S0.9571.00
10_A83_L0.9541.00
34_G55_G0.9461.00
126_T129_Q0.9431.00
192_V195_T0.9401.00
23_D27_G0.9321.00
176_T180_V0.9301.00
95_Q99_L0.9161.00
124_M127_L0.9131.00
102_P111_V0.9071.00
209_P212_D0.9071.00
71_R75_S0.9071.00
101_D104_V0.8991.00
132_N135_I0.8811.00
99_L113_G0.8761.00
114_D193_P0.8731.00
95_Q154_Y0.8711.00
137_R141_R0.8641.00
25_I36_V0.8601.00
82_V162_F0.8551.00
20_T200_P0.8551.00
99_L103_L0.8501.00
80_A160_E0.8491.00
29_F54_H0.8471.00
139_F143_H0.8441.00
106_G190_R0.8401.00
74_V77_I0.8401.00
94_A97_S0.8391.00
24_V27_G0.8391.00
57_E78_E0.8321.00
24_V28_L0.8321.00
41_G65_G0.8311.00
70_V174_I0.8301.00
254_D258_H0.8291.00
237_G241_G0.8231.00
205_T208_H0.8201.00
81_Y158_T0.8201.00
157_F162_F0.8131.00
27_G31_V0.8111.00
114_D191_V0.8071.00
26_D29_F0.8061.00
28_L36_V0.8051.00
98_R102_P0.8041.00
89_G199_R0.8031.00
132_N136_N0.7961.00
61_Q72_E0.7881.00
90_T118_D0.7861.00
124_M131_G0.7851.00
212_D215_R0.7851.00
36_V56_A0.7841.00
260_V263_E0.7781.00
215_R219_T0.7751.00
9_C159_A0.7741.00
173_G176_T0.7741.00
12_V28_L0.7741.00
150_I155_R0.7731.00
140_H143_H0.7691.00
241_G244_G0.7591.00
216_I220_L0.7591.00
7_E35_H0.7591.00
182_C187_I0.7561.00
67_G71_R0.7561.00
21_I87_G0.7551.00
37_L77_I0.7521.00
79_A159_A0.7511.00
135_I139_F0.7501.00
21_I50_V0.7481.00
14_T21_I0.7481.00
34_G96_A0.7421.00
18_A45_D0.7401.00
28_L85_L0.7391.00
209_P213_G0.7391.00
161_S165_M0.7361.00
9_C78_E0.7361.00
165_M182_C0.7351.00
68_Q169_A0.7331.00
8_V156_A0.7331.00
215_R218_L0.7281.00
168_S177_E0.7271.00
99_L111_V0.7231.00
155_R179_A0.7211.00
38_V56_A0.7201.00
157_F182_C0.7201.00
176_T179_A0.7201.00
13_P41_G0.7191.00
95_Q98_R0.7161.00
27_G30_E0.7161.00
253_Y257_L0.7161.00
124_M128_N0.7131.00
28_L91_N0.7121.00
218_L222_S0.7101.00
77_I82_V0.7081.00
92_P198_A0.7041.00
29_F56_A0.7041.00
24_V85_L0.6981.00
125_S128_N0.6971.00
73_G77_I0.6961.00
168_S171_G0.6951.00
98_R192_V0.6951.00
102_P108_A0.6931.00
95_Q113_G0.6921.00
242_T246_A0.6911.00
43_S47_T0.6901.00
15_R41_G0.6881.00
48_A51_A0.6861.00
83_L99_L0.6851.00
25_I56_A0.6841.00
152_S155_R0.6831.00
27_G197_R0.6831.00
106_G188_T0.6831.00
141_R145_E0.6801.00
13_P70_V0.6791.00
179_A183_S0.6791.00
100_L156_A0.6791.00
61_Q68_Q0.6751.00
37_L76_L0.6751.00
172_F175_E0.6731.00
263_E266_A0.6721.00
179_A182_C0.6721.00
217_I220_L0.6721.00
91_N196_Y0.6701.00
20_T24_V0.6691.00
52_A58_V0.6661.00
62_S65_G0.6661.00
112_V150_I0.6641.00
21_I47_T0.6631.00
37_L73_G0.6631.00
17_E21_I0.6621.00
178_M182_C0.6601.00
21_I51_A0.6591.00
251_V254_D0.6581.00
212_D219_T0.6561.00
99_L154_Y0.6551.00
267_L270_G0.6551.00
18_A22_A0.6531.00
157_F178_M0.6481.00
238_A241_G0.6471.00
92_P95_Q0.6471.00
13_P87_G0.6451.00
103_L108_A0.6441.00
13_P66_K0.6431.00
109_E182_C0.6421.00
214_A218_L0.6421.00
69_A72_E0.6411.00
66_K69_A0.6371.00
12_V38_V0.6371.00
66_K84_L0.6351.00
250_Y254_D0.6331.00
134_L137_R0.6331.00
109_E188_T0.6291.00
127_L131_G0.6281.00
14_T51_A0.6251.00
158_T187_I0.6231.00
44_A47_T0.6221.00
31_V96_A0.6171.00
83_L91_N0.6151.00
41_G69_A0.6131.00
12_V85_L0.6121.00
68_Q72_E0.6111.00
181_E184_R0.6111.00
213_G216_I0.6111.00
173_G177_E0.6101.00
131_G134_L0.6081.00
179_A189_T0.6071.00
39_V72_E0.6071.00
198_A201_D0.6061.00
261_S264_V0.6041.00
216_I219_T0.6021.00
228_N231_F0.6011.00
237_G244_G0.6011.00
99_L195_T0.6001.00
161_S164_R0.5991.00
146_D188_T0.5991.00
249_G253_Y0.5981.00
109_E161_S0.5961.00
199_R203_S0.5961.00
126_T131_G0.5961.00
175_E178_M0.5931.00
210_I213_G0.5911.00
11_L77_I0.5901.00
41_G64_D0.5871.00
126_T130_I0.5851.00
260_V265_I0.5841.00
32_G104_V0.5821.00
17_E66_K0.5821.00
18_A49_A0.5791.00
33_V55_G0.5781.00
175_E180_V0.5781.00
139_F142_I0.5781.00
35_H77_I0.5761.00
7_E34_G0.5761.00
15_R44_A0.5701.00
51_A56_A0.5671.00
7_E104_V0.5671.00
36_V55_G0.5671.00
133_R136_N0.5661.00
245_V248_A0.5641.00
81_Y104_V0.5631.00
31_V94_A0.5621.00
92_P196_Y0.5621.00
80_A159_A0.5601.00
137_R140_H0.5601.00
138_A142_I0.5591.00
24_V89_G0.5581.00
64_D72_E0.5571.00
222_S226_T0.5561.00
268_V271_V0.5561.00
266_A270_G0.5551.00
162_F178_M0.5541.00
16_N47_T0.5521.00
213_G217_I0.5521.00
11_L82_V0.5481.00
219_T223_L0.5471.00
232_Y236_I0.5461.00
112_V115_R0.5451.00
124_M129_Q0.5441.00
150_I179_A0.5421.00
21_I26_D0.5411.00
267_L271_V0.5381.00
233_F237_G0.5381.00
111_V192_V0.5351.00
137_R142_I0.5321.00
17_E86_D0.5301.00
32_G97_S0.5301.00
42_N61_Q0.5281.00
234_G237_G0.5261.00
136_N139_F0.5261.00
70_V152_S0.5251.00
260_V264_V0.5251.00
136_N140_H0.5211.00
244_G248_A0.5211.00
177_E227_S0.5191.00
241_G245_V0.5181.00
109_E160_E0.5181.00
210_I214_A0.5171.00
220_L224_A0.5171.00
261_S265_I0.5151.00
84_L167_L0.5151.00
237_G240_F0.5151.00
196_Y200_P0.5131.00
91_N154_Y0.5121.00
15_R42_N0.5111.00
42_N63_G0.5091.00
190_R193_P0.5081.00
213_G220_L0.5071.00
134_L138_A0.5051.00
154_Y197_R0.5051.00
209_P216_I0.5041.00
246_A250_Y0.5041.00
96_A156_A0.5031.00
127_L130_I0.5021.00
173_G219_T0.5011.00
235_S239_G0.5011.00
255_W265_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p02A 1 0.9967 100 0.361 Contact Map
3bcvA 2 0.5607 100 0.408 Contact Map
2z86A 2 0.7967 100 0.429 Contact Map
4fixA 3 0.9738 100 0.432 Contact Map
1qg8A 1 0.6951 100 0.437 Contact Map
2d7iA 1 0.9639 100 0.444 Contact Map
3l7iA 4 0.0492 100 0.444 Contact Map
5ajoA 1 0.9574 100 0.446 Contact Map
1xhbA 1 0.9541 100 0.453 Contact Map
3ckjA 2 0.8295 100 0.472 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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