GREMLIN Database
Q9HQQ5 - Probable transport protein
UniProt: Q9HQQ5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 475 (441)
Sequences: 17201 (14752)
Seq/√Len: 702.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
271_D274_K4.9021.00
198_T202_S3.3001.00
134_L137_V3.1671.00
96_A99_Y3.1571.00
316_Y320_L3.0411.00
41_V238_E3.0181.00
405_G409_R2.9781.00
344_R347_L2.9641.00
298_A320_L2.7631.00
133_Q264_G2.7071.00
346_K350_Y2.6881.00
344_R397_L2.6601.00
66_V131_G2.4961.00
236_V314_T2.4091.00
268_N271_D2.3741.00
309_G312_F2.3291.00
355_F386_S2.3001.00
301_G316_Y2.2951.00
221_D237_Y2.2661.00
406_E409_R2.2281.00
264_G268_N2.1861.00
328_L384_A2.1751.00
94_W110_P2.1651.00
321_V373_Y2.1501.00
301_G320_L2.1051.00
221_D363_N2.1011.00
265_I274_K2.0851.00
362_L378_A2.0451.00
318_I372_W2.0441.00
9_I136_H2.0301.00
420_I445_V2.0181.00
64_K68_E2.0141.00
209_L349_L1.9861.00
33_G36_Q1.9781.00
296_G300_V1.9731.00
300_V303_I1.9671.00
351_I389_G1.9661.00
162_G165_G1.9311.00
277_G281_V1.9241.00
321_V380_T1.9191.00
65_R203_F1.9141.00
225_L229_V1.8751.00
230_S233_L1.8381.00
73_N193_A1.8321.00
272_T276_A1.8231.00
367_T375_A1.8171.00
224_V367_T1.8101.00
371_G374_G1.7691.00
417_M421_V1.7551.00
266_S342_L1.7451.00
295_V418_A1.7191.00
42_V226_A1.7191.00
370_F377_T1.7151.00
97_R110_P1.7091.00
290_I330_G1.6951.00
296_G439_V1.6871.00
224_V363_N1.6761.00
29_T239_V1.6551.00
363_N367_T1.6481.00
229_V233_L1.6451.00
274_K277_G1.6441.00
221_D379_T1.6291.00
443_G447_F1.6241.00
317_R373_Y1.6231.00
358_T385_I1.6231.00
417_M442_G1.6181.00
279_L338_T1.6181.00
305_L319_L1.6161.00
30_R309_G1.6111.00
136_H140_L1.5951.00
229_V372_W1.5911.00
133_Q261_E1.5891.00
366_L370_F1.5881.00
213_K353_V1.5841.00
297_S323_T1.5791.00
366_L378_A1.5791.00
193_A196_E1.5751.00
128_V132_Q1.5691.00
40_Y44_L1.5611.00
302_D316_Y1.5541.00
93_L113_I1.5441.00
305_L315_G1.5391.00
374_G378_A1.5211.00
388_A392_Y1.5161.00
225_L375_A1.5131.00
294_L327_L1.5131.00
302_D320_L1.5131.00
191_M194_R1.5081.00
421_V442_G1.5071.00
392_Y396_R1.5041.00
328_L387_L1.5001.00
244_A322_L1.4951.00
317_R320_L1.4801.00
72_G76_Y1.4761.00
321_V377_T1.4751.00
418_A422_V1.4751.00
194_R198_T1.4621.00
275_I338_T1.4621.00
321_V376_A1.4621.00
262_M275_I1.4551.00
365_L368_W1.4531.00
361_L365_L1.4521.00
318_I376_A1.4521.00
152_V169_G1.4521.00
165_G169_G1.4521.00
276_A280_R1.4491.00
274_K278_L1.4401.00
291_I414_A1.4381.00
378_A382_S1.4311.00
43_V112_V1.4251.00
149_R173_G1.4131.00
225_L234_V1.4121.00
325_A380_T1.4071.00
300_V304_I1.4061.00
423_A427_L1.4041.00
359_N363_N1.3991.00
161_V165_G1.3991.00
280_R284_A1.3831.00
148_S176_V1.3821.00
233_L372_W1.3801.00
413_A417_M1.3791.00
273_S277_G1.3731.00
240_A315_G1.3681.00
206_F349_L1.3631.00
414_A418_A1.3611.00
15_L19_V1.3531.00
67_S131_G1.3481.00
296_G417_M1.3351.00
314_T317_R1.3331.00
22_F26_I1.3251.00
68_E343_D1.3211.00
16_V143_P1.3191.00
224_V364_V1.3181.00
258_L282_S1.3141.00
232_S236_V1.3061.00
94_W98_P1.3031.00
25_T242_N1.2981.00
117_G120_L1.2971.00
350_Y354_A1.2891.00
324_F380_T1.2821.00
240_A318_I1.2821.00
34_Q236_V1.2781.00
61_A203_F1.2611.00
141_L180_V1.2571.00
370_F374_G1.2521.00
219_S222_T1.2501.00
26_I30_R1.2461.00
224_V228_F1.2311.00
365_L369_R1.2221.00
305_L316_Y1.2211.00
220_M360_L1.2151.00
24_A150_S1.2141.00
351_I393_Y1.2131.00
265_I278_L1.2091.00
19_V23_F1.2081.00
95_I98_P1.2081.00
62_I78_G1.2071.00
287_G291_I1.2061.00
48_A52_M1.1971.00
179_L183_Y1.1941.00
373_Y376_A1.1901.00
17_M146_W1.1891.00
154_V158_V1.1841.00
423_A426_T1.1841.00
34_Q235_A1.1841.00
13_S139_S1.1791.00
74_Y78_G1.1681.00
351_I390_G1.1631.00
366_L369_R1.1611.00
80_I84_L1.1591.00
90_A94_W1.1571.00
335_F391_Y1.1571.00
151_I155_S1.1541.00
272_T342_L1.1521.00
41_V235_A1.1491.00
403_P406_E1.1461.00
135_V257_T1.1441.00
98_P102_D1.1441.00
359_N379_T1.1431.00
73_N77_A1.1411.00
266_S275_I1.1261.00
137_V184_F1.1231.00
141_L181_G1.1211.00
42_V234_V1.1191.00
134_L188_P1.1181.00
392_Y395_R1.1181.00
37_Y41_V1.1101.00
36_Q39_T1.1091.00
77_A197_F1.1091.00
98_P110_P1.1081.00
262_M341_A1.1061.00
125_V182_L1.1061.00
279_L335_F1.1031.00
118_V175_T1.1021.00
313_R317_R1.1011.00
236_V315_G1.1011.00
97_R101_T1.0991.00
108_A167_F1.0921.00
206_F346_K1.0901.00
65_R199_S1.0881.00
213_K356_V1.0861.00
318_I373_Y1.0841.00
213_K349_L1.0771.00
203_F345_P1.0771.00
84_L88_V1.0751.00
273_S276_A1.0731.00
25_T308_Y1.0731.00
168_A172_A1.0711.00
363_N366_L1.0701.00
294_L298_A1.0681.00
55_Q59_P1.0681.00
422_V425_R1.0671.00
298_A301_G1.0631.00
153_Q169_G1.0611.00
90_A93_L1.0601.00
199_S343_D1.0591.00
118_V178_V1.0571.00
353_V357_G1.0571.00
313_R316_Y1.0561.00
338_T394_A1.0561.00
20_S150_S1.0551.00
335_F390_G1.0521.00
297_S319_L1.0521.00
205_Q209_L1.0511.00
76_Y80_I1.0511.00
358_T362_L1.0511.00
75_V128_V1.0481.00
439_V443_G1.0471.00
63_R127_V1.0461.00
186_D189_R1.0451.00
81_L197_F1.0421.00
114_A171_V1.0421.00
362_L366_L1.0421.00
325_A376_A1.0411.00
419_G423_A1.0401.00
10_H257_T1.0401.00
61_A65_R1.0381.00
265_I271_D1.0311.00
357_G361_L1.0311.00
78_G200_L1.0311.00
152_V156_L1.0301.00
225_L237_Y1.0291.00
325_A328_L1.0291.00
259_F263_S1.0281.00
303_I425_R1.0281.00
359_N382_S1.0271.00
7_S257_T1.0261.00
422_V426_T1.0251.00
350_Y353_V1.0231.00
363_N379_T1.0141.00
216_M356_V1.0111.00
39_T231_H1.0111.00
210_G348_T1.0101.00
27_A31_I1.0061.00
65_R68_E1.0041.00
28_L166_A1.0041.00
425_R438_L1.0031.00
331_Y387_L1.0011.00
155_S159_S0.9981.00
217_F359_N0.9941.00
301_G319_L0.9931.00
95_I99_Y0.9901.00
58_L78_G0.9881.00
369_R373_Y0.9861.00
29_T308_Y0.9811.00
404_I408_S0.9771.00
300_V438_L0.9761.00
14_R18_S0.9761.00
261_E264_G0.9691.00
40_Y166_A0.9621.00
240_A322_L0.9591.00
239_V312_F0.9581.00
380_T383_S0.9561.00
110_P114_A0.9551.00
169_G173_G0.9551.00
11_F253_S0.9551.00
7_S254_I0.9531.00
410_Q414_A0.9511.00
61_A200_L0.9491.00
114_A117_G0.9441.00
320_L324_F0.9431.00
164_A167_F0.9411.00
408_S412_L0.9371.00
347_L393_Y0.9371.00
34_Q232_S0.9361.00
339_I393_Y0.9341.00
156_L161_V0.9311.00
61_A204_A0.9251.00
201_R205_Q0.9231.00
275_I342_L0.9161.00
201_R204_A0.9161.00
221_D359_N0.9131.00
180_V184_F0.9121.00
322_L376_A0.9061.00
225_L372_W0.9061.00
76_Y79_A0.9041.00
292_P295_V0.9021.00
436_I440_A0.9011.00
64_K343_D0.9001.00
244_A326_R0.8981.00
363_N375_A0.8971.00
377_T381_V0.8971.00
235_A238_E0.8931.00
33_G312_F0.8911.00
281_V284_A0.8881.00
68_E199_S0.8881.00
240_A319_L0.8871.00
168_A171_V0.8871.00
26_I29_T0.8861.00
43_V108_A0.8771.00
99_Y102_D0.8771.00
152_V172_A0.8751.00
237_Y322_L0.8721.00
10_H139_S0.8721.00
368_W375_A0.8721.00
286_S330_G0.8691.00
34_Q311_G0.8681.00
340_D348_T0.8671.00
173_G177_A0.8661.00
315_G318_I0.8651.00
393_Y396_R0.8621.00
66_V132_Q0.8591.00
298_A302_D0.8571.00
97_R100_I0.8561.00
192_P195_D0.8551.00
295_V299_L0.8551.00
226_A234_V0.8461.00
90_A117_G0.8461.00
5_R136_H0.8451.00
257_T260_P0.8441.00
295_V414_A0.8431.00
99_Y103_F0.8431.00
171_V174_A0.8371.00
377_T380_T0.8361.00
347_L350_Y0.8361.00
239_V242_N0.8341.00
306_T309_G0.8321.00
303_I438_L0.8291.00
7_S11_F0.8271.00
434_A438_L0.8271.00
385_I389_G0.8261.00
222_T234_V0.8261.00
284_A288_L0.8221.00
9_I13_S0.8211.00
339_I348_T0.8211.00
84_L87_V0.8211.00
26_I308_Y0.8191.00
32_L36_Q0.8181.00
31_I157_V0.8161.00
439_V442_G0.8131.00
228_F367_T0.8121.00
349_L353_V0.8111.00
113_I117_G0.8091.00
238_E242_N0.8091.00
40_Y163_I0.8061.00
251_G255_A0.8041.00
92_C96_A0.8031.00
129_L185_I0.8021.00
298_A324_F0.8021.00
6_T133_Q0.7981.00
170_Y174_A0.7951.00
206_F345_P0.7941.00
20_S24_A0.7931.00
411_W414_A0.7931.00
362_L365_L0.7921.00
197_F201_R0.7911.00
364_V368_W0.7891.00
81_L85_L0.7891.00
202_S205_Q0.7881.00
62_I66_V0.7881.00
424_G441_V0.7881.00
261_E265_I0.7871.00
389_G393_Y0.7851.00
88_V92_C0.7851.00
44_L48_A0.7841.00
87_V91_G0.7821.00
79_A82_Q0.7821.00
83_F87_V0.7811.00
348_T352_N0.7811.00
354_A389_G0.7801.00
28_L153_Q0.7801.00
310_D313_R0.7791.00
86_Y90_A0.7781.00
339_I394_A0.7761.00
122_L178_V0.7731.00
337_S340_D0.7721.00
219_S245_S0.7711.00
76_Y190_T0.7701.00
235_A239_V0.7701.00
239_V308_Y0.7701.00
299_L418_A0.7701.00
389_G392_Y0.7701.00
431_S434_A0.7691.00
278_L282_S0.7691.00
414_A417_M0.7681.00
391_Y395_R0.7681.00
233_L236_V0.7661.00
393_Y397_L0.7641.00
360_L364_V0.7641.00
292_P414_A0.7621.00
325_A379_T0.7611.00
202_S346_K0.7601.00
111_V171_V0.7601.00
51_T55_Q0.7571.00
115_M174_A0.7561.00
230_S234_V0.7541.00
86_Y120_L0.7541.00
384_A388_A0.7521.00
223_L227_V0.7511.00
215_R219_S0.7511.00
8_I12_L0.7501.00
145_E149_R0.7491.00
37_Y239_V0.7481.00
324_F327_L0.7471.00
45_S222_T0.7471.00
417_M420_I0.7461.00
362_L381_V0.7451.00
221_D241_W0.7451.00
212_I216_M0.7421.00
410_Q413_A0.7391.00
79_A125_V0.7391.00
150_S154_V0.7331.00
263_S266_S0.7331.00
351_I355_F0.7321.00
126_Q130_D0.7301.00
373_Y377_T0.7301.00
80_I83_F0.7291.00
149_R169_G0.7281.00
155_S158_V0.7271.00
241_W245_S0.7261.00
25_T29_T0.7231.00
292_P446_Y0.7231.00
64_K345_P0.7221.00
73_N76_Y0.7151.00
395_R399_N0.7141.00
324_F328_L0.7121.00
149_R153_Q0.7111.00
237_Y241_W0.7111.00
33_G311_G0.7101.00
97_R113_I0.7071.00
57_G204_A0.7061.00
213_K352_N0.7051.00
137_V140_L0.7041.00
35_R231_H0.7041.00
111_V167_F0.7041.00
152_V155_S0.7031.00
265_I268_N0.7011.00
298_A323_T0.7011.00
207_S345_P0.7011.00
32_L163_I0.6981.00
432_L439_V0.6981.00
6_T257_T0.6971.00
394_A397_L0.6951.00
242_N308_Y0.6941.00
282_S334_Q0.6931.00
406_E410_Q0.6901.00
301_G323_T0.6901.00
259_F337_S0.6891.00
12_L16_V0.6881.00
63_R67_S0.6881.00
242_N246_L0.6871.00
259_F341_A0.6861.00
111_V164_A0.6861.00
380_T384_A0.6851.00
242_N245_S0.6831.00
4_G8_I0.6831.00
395_R398_V0.6821.00
48_A51_T0.6811.00
219_S223_L0.6801.00
337_S341_A0.6801.00
278_L281_V0.6771.00
288_L292_P0.6771.00
68_E71_G0.6771.00
358_T361_L0.6721.00
27_A154_V0.6691.00
145_E173_G0.6691.00
118_V171_V0.6661.00
96_A100_I0.6661.00
319_L323_T0.6631.00
130_D138_S0.6601.00
121_A178_V0.6571.00
202_S206_F0.6561.00
183_Y187_V0.6551.00
37_Y235_A0.6541.00
335_F387_L0.6541.00
127_V131_G0.6531.00
11_F15_L0.6461.00
145_E177_A0.6461.00
69_A74_Y0.6421.00
354_A357_G0.6391.00
207_S340_D0.6371.00
26_I307_I0.6361.00
42_V106_I0.6361.00
89_L93_L0.6351.00
220_M224_V0.6351.00
109_A113_I0.6351.00
438_L442_G0.6341.00
63_R131_G0.6321.00
286_S334_Q0.6321.00
306_T435_G0.6301.00
435_G439_V0.6301.00
38_G235_A0.6301.00
164_A168_A0.6301.00
421_V425_R0.6291.00
110_P113_I0.6261.00
284_A406_E0.6251.00
59_P127_V0.6251.00
325_A383_S0.6251.00
192_P197_F0.6241.00
40_Y167_F0.6221.00
292_P417_M0.6211.00
436_I439_V0.6211.00
303_I434_A0.6211.00
73_N196_E0.6201.00
210_G352_N0.6191.00
424_G427_L0.6181.00
367_T374_G0.6161.00
140_L144_V0.6161.00
55_Q82_Q0.6151.00
35_R39_T0.6151.00
430_D433_P0.6151.00
200_L204_A0.6151.00
16_V20_S0.6151.00
42_V45_S0.6141.00
129_L137_V0.6141.00
412_L415_L0.6141.00
425_R434_A0.6121.00
65_R69_A0.6121.00
416_L419_G0.6111.00
47_L116_L0.6091.00
10_H14_R0.6091.00
244_A247_F0.6051.00
16_V147_S0.6051.00
222_T238_E0.6041.00
147_S151_I0.6031.00
415_L419_G0.6021.00
421_V424_G0.6011.00
177_A181_G0.6001.00
418_A421_V0.5991.00
252_S256_R0.5971.00
293_G296_G0.5961.00
296_G442_G0.5931.00
195_D198_T0.5921.00
28_L37_Y0.5921.00
94_W97_R0.5901.00
148_S151_I0.5901.00
277_G280_R0.5891.00
98_P101_T0.5891.00
196_E199_S0.5871.00
171_V175_T0.5871.00
409_R413_A0.5861.00
165_G168_A0.5861.00
363_N378_A0.5851.00
126_Q142_I0.5851.00
91_G95_I0.5841.00
177_A180_V0.5841.00
21_G25_T0.5841.00
87_V117_G0.5831.00
258_L262_M0.5831.00
47_L51_T0.5811.00
421_V438_L0.5811.00
210_G214_S0.5801.00
119_R174_A0.5791.00
182_L186_D0.5781.00
10_H135_V0.5781.00
228_F368_W0.5781.00
141_L145_E0.5761.00
82_Q86_Y0.5751.00
144_V180_V0.5731.00
302_D313_R0.5731.00
332_S387_L0.5721.00
261_E278_L0.5721.00
217_F356_V0.5711.00
49_W215_R0.5691.00
440_A443_G0.5681.00
93_L97_R0.5671.00
329_Y333_R0.5661.00
4_G7_S0.5661.00
222_T241_W0.5631.00
301_G304_I0.5631.00
101_T109_A0.5631.00
349_L352_N0.5631.00
25_T37_Y0.5631.00
34_Q312_F0.5621.00
35_R232_S0.5621.00
434_A437_V0.5611.00
229_V371_G0.5601.00
94_W113_I0.5601.00
263_S267_A0.5601.00
335_F394_A0.5571.00
403_P410_Q0.5551.00
13_S143_P0.5541.00
359_N362_L0.5531.00
35_R38_G0.5521.00
178_V182_L0.5511.00
353_V356_V0.5501.00
432_L436_I0.5481.00
417_M445_V0.5471.00
254_I258_L0.5471.00
103_F106_I0.5471.00
268_N274_K0.5461.00
347_L351_I0.5461.00
199_S203_F0.5461.00
192_P196_E0.5451.00
141_L177_A0.5451.00
114_A118_V0.5451.00
135_V139_S0.5451.00
345_P348_T0.5451.00
437_V440_A0.5411.00
379_T382_S0.5401.00
265_I275_I0.5391.00
358_T382_S0.5381.00
93_L109_A0.5351.00
419_G422_V0.5341.00
63_R260_P0.5321.00
376_A380_T0.5321.00
103_F107_D0.5311.00
217_F220_M0.5311.00
239_V315_G0.5301.00
64_K341_A0.5281.00
86_Y113_I0.5281.00
136_H139_S0.5281.00
251_G333_R0.5271.00
36_Q163_I0.5261.00
203_F207_S0.5261.00
166_A170_Y0.5261.00
28_L32_L0.5241.00
359_N378_A0.5231.00
221_D224_V0.5221.00
80_I192_P0.5221.00
332_S390_G0.5221.00
181_G185_I0.5221.00
440_A444_G0.5211.00
294_L323_T0.5201.00
253_S256_R0.5201.00
141_L184_F0.5201.00
295_V298_A0.5191.00
323_T326_R0.5191.00
144_V148_S0.5181.00
336_L348_T0.5181.00
338_T342_L0.5171.00
275_I278_L0.5171.00
352_N356_V0.5171.00
296_G443_G0.5151.00
88_V91_G0.5151.00
153_Q157_V0.5151.00
78_G82_Q0.5141.00
383_S386_S0.5141.00
77_A81_L0.5130.99
220_M359_N0.5100.99
8_I15_L0.5090.99
420_I423_A0.5090.99
336_L340_D0.5080.99
111_V168_A0.5080.99
91_G94_W0.5080.99
46_V50_T0.5070.99
125_V185_I0.5060.99
228_F364_V0.5050.99
351_I354_A0.5050.99
217_F382_S0.5040.99
74_Y200_L0.5030.99
286_S290_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3w4tA 1 0.8379 100 0.42 Contact Map
4lz6A 1 0.8463 100 0.423 Contact Map
4humA 1 0.8589 100 0.43 Contact Map
3mktA 1 0.8505 100 0.443 Contact Map
2cfqA 1 0.8084 59.5 0.94 Contact Map
3wdoA 1 0.8126 55.8 0.941 Contact Map
4n7wA 2 0.3937 39.8 0.946 Contact Map
1pw4A 1 0.4211 25.7 0.951 Contact Map
4tphA 2 0.3958 23.2 0.952 Contact Map
4w6vA 1 0.4168 18.8 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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