GREMLIN Database
Q9HQQ4 - Glucose-1-phosphate thymidylyltransferase
UniProt: Q9HQQ4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 240 (229)
Sequences: 22790 (14501)
Seq/√Len: 958.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_E183_K3.5131.00
31_K39_E3.2501.00
145_D153_Q2.7541.00
145_D154_E2.7111.00
35_T63_H2.6711.00
124_A210_D2.6011.00
48_K72_P2.5451.00
82_N86_H2.5371.00
132_E165_N2.5331.00
147_N151_E2.4301.00
181_A205_S2.4051.00
132_E213_P2.3791.00
130_V211_A2.2461.00
119_Q127_A2.2331.00
98_D175_S2.2271.00
48_K74_T2.2101.00
181_A201_L2.1201.00
147_N153_Q2.0871.00
124_A208_T2.0591.00
151_E210_D2.0401.00
200_D204_K2.0031.00
3_A46_A1.9801.00
38_F49_I1.9721.00
3_A41_L1.9501.00
76_A90_K1.9271.00
58_Q62_S1.9031.00
89_L92_E1.8981.00
201_L205_S1.8511.00
7_A51_A1.7771.00
41_L102_M1.7751.00
145_D164_S1.7571.00
118_R212_I1.7441.00
4_V91_A1.7401.00
88_L101_L1.7381.00
35_T39_E1.7381.00
122_E210_D1.7261.00
15_R19_E1.7231.00
98_D120_Q1.7071.00
53_V57_K1.6621.00
219_I229_E1.6611.00
113_E117_N1.6581.00
201_L204_K1.6531.00
21_K27_E1.6481.00
59_N62_S1.6461.00
125_D175_S1.5821.00
50_V94_H1.5721.00
154_E200_D1.5631.00
166_L213_P1.5591.00
158_K162_P1.5471.00
61_I77_H1.5431.00
137_E140_R1.5401.00
21_K59_N1.5351.00
32_P35_T1.5291.00
42_V71_V1.5281.00
146_T166_L1.5011.00
152_I209_I1.4951.00
130_V144_C1.4841.00
197_D200_D1.4741.00
114_D117_N1.4651.00
49_I71_V1.4561.00
25_M59_N1.4521.00
57_K77_H1.4361.00
152_I211_A1.4141.00
50_V76_A1.4041.00
144_C152_I1.4031.00
227_R231_E1.4011.00
134_D138_A1.3921.00
151_E208_T1.3881.00
117_N121_E1.3711.00
118_R122_E1.3681.00
115_V129_L1.3611.00
86_H90_K1.3441.00
217_W233_R1.3351.00
95_V99_F1.3331.00
74_T94_H1.3331.00
177_A180_Q1.3011.00
109_R217_W1.2921.00
126_A174_F1.2891.00
99_F176_P1.2661.00
125_D208_T1.2521.00
228_D232_E1.2511.00
53_V77_H1.2351.00
65_G75_Y1.2281.00
103_L170_G1.2161.00
223_Y226_D1.2151.00
181_A198_A1.2151.00
53_V61_I1.2041.00
107_I110_A1.1951.00
89_L183_K1.1941.00
98_D176_P1.1931.00
97_E176_P1.1861.00
50_V91_A1.1841.00
181_A184_L1.1831.00
57_K61_I1.1831.00
184_L201_L1.1771.00
10_E81_Q1.1681.00
156_V163_P1.1551.00
221_V230_A1.1481.00
146_T211_A1.1441.00
180_Q184_L1.1351.00
86_H89_L1.1271.00
114_D118_R1.1231.00
145_D156_V1.1201.00
226_D229_E1.1151.00
100_M173_T1.1121.00
184_L205_S1.1111.00
196_S200_D1.1071.00
115_V173_T1.0971.00
14_L26_V1.0911.00
25_M63_H1.0741.00
111_N114_D1.0721.00
101_L174_F1.0631.00
31_K36_H1.0501.00
8_A52_I1.0501.00
174_F199_I1.0471.00
56_R59_N1.0421.00
180_Q183_K1.0401.00
34_L64_Y1.0381.00
125_D207_R1.0271.00
46_A100_M1.0271.00
118_R210_D1.0161.00
147_N150_G1.0081.00
219_I233_R0.9991.00
61_I75_Y0.9911.00
50_V74_T0.9901.00
33_I221_V0.9891.00
53_V60_I0.9891.00
118_R121_E0.9881.00
54_G57_K0.9871.00
130_V166_L0.9831.00
202_L207_R0.9591.00
34_L60_I0.9581.00
34_L51_A0.9491.00
89_L182_C0.9451.00
4_V99_F0.9451.00
168_M172_Y0.9401.00
53_V75_Y0.9341.00
98_D173_T0.9251.00
199_I209_I0.9251.00
139_S158_K0.9231.00
225_E229_E0.9221.00
76_A94_H0.9191.00
228_D231_E0.9131.00
29_A36_H0.9121.00
150_G213_P0.9061.00
117_N120_Q0.9051.00
140_R226_D0.9021.00
83_G195_L0.8991.00
142_G157_E0.8941.00
27_E32_P0.8921.00
132_E166_L0.8831.00
43_A110_A0.8811.00
213_P216_G0.8791.00
229_E232_E0.8771.00
31_K35_T0.8761.00
5_V104_G0.8691.00
14_L18_T0.8641.00
39_E42_V0.8621.00
119_Q173_T0.8611.00
33_I37_C0.8531.00
32_P63_H0.8511.00
58_Q61_I0.8481.00
96_N176_P0.8461.00
219_I230_A0.8431.00
18_T26_V0.8391.00
35_T67_E0.8371.00
143_V167_V0.8371.00
44_L113_E0.8371.00
177_A207_R0.8351.00
84_L103_L0.8311.00
100_M116_V0.8201.00
38_F73_I0.8181.00
47_E72_P0.8171.00
24_G104_G0.7991.00
29_A231_E0.7981.00
42_V70_G0.7981.00
123_R175_S0.7971.00
209_I214_M0.7941.00
71_V74_T0.7861.00
125_D177_A0.7791.00
119_Q175_S0.7741.00
124_A151_E0.7681.00
42_V49_I0.7641.00
177_A181_A0.7631.00
106_N218_R0.7621.00
30_G36_H0.7601.00
162_P165_N0.7551.00
156_V159_P0.7541.00
46_A116_V0.7521.00
102_M112_L0.7491.00
229_E233_R0.7461.00
38_F64_Y0.7441.00
154_E161_D0.7411.00
188_S194_E0.7371.00
92_E179_F0.7351.00
115_V212_I0.7351.00
186_Q189_D0.7331.00
51_A73_I0.7331.00
160_D163_P0.7321.00
178_I202_L0.7291.00
6_L103_L0.7281.00
116_V120_Q0.7241.00
38_F71_V0.7181.00
26_V227_R0.7171.00
42_V47_E0.7171.00
133_V138_A0.7161.00
76_A91_A0.7121.00
32_P36_H0.7111.00
155_V168_M0.7101.00
140_R158_K0.7091.00
61_I65_G0.7091.00
127_A210_D0.7041.00
22_P59_N0.7031.00
53_V58_Q0.6991.00
210_D213_P0.6981.00
126_A209_I0.6941.00
192_E195_L0.6901.00
181_A202_L0.6891.00
36_H234_I0.6871.00
92_E99_F0.6861.00
198_A201_L0.6851.00
126_A202_L0.6831.00
88_L178_I0.6821.00
3_A49_I0.6801.00
27_E30_G0.6761.00
145_D163_P0.6751.00
52_I87_A0.6731.00
40_Q44_L0.6721.00
186_Q201_L0.6711.00
17_L21_K0.6691.00
76_A79_R0.6671.00
114_D212_I0.6631.00
153_Q156_V0.6621.00
40_Q110_A0.6611.00
4_V52_I0.6601.00
176_P179_F0.6571.00
127_A131_E0.6541.00
63_H66_D0.6461.00
181_A207_R0.6441.00
115_V127_A0.6431.00
185_V201_L0.6391.00
102_M171_F0.6361.00
11_G23_K0.6341.00
43_A113_E0.6341.00
177_A205_S0.6331.00
36_H39_E0.6331.00
81_Q86_H0.6321.00
51_A64_Y0.6291.00
224_P228_D0.6291.00
116_V173_T0.6271.00
70_G73_I0.6261.00
4_V50_V0.6241.00
17_L20_D0.6231.00
154_E204_K0.6231.00
103_L106_N0.6211.00
35_T64_Y0.6211.00
126_A130_V0.6211.00
17_L224_P0.6201.00
6_L84_L0.6201.00
182_C185_V0.6191.00
92_E95_V0.6161.00
39_E67_E0.6161.00
65_G69_D0.6151.00
108_F111_N0.6151.00
38_F51_A0.6111.00
5_V102_M0.6101.00
166_L211_A0.6081.00
71_V75_Y0.6061.00
180_Q205_S0.6041.00
220_D226_D0.6031.00
62_S65_G0.6011.00
197_D201_L0.6011.00
13_R23_K0.6001.00
125_D129_L0.6001.00
127_A130_V0.5991.00
42_V72_P0.5981.00
113_E116_V0.5941.00
17_L26_V0.5871.00
5_V37_C0.5831.00
95_V179_F0.5831.00
131_E169_T0.5811.00
64_Y73_I0.5771.00
189_D194_E0.5761.00
185_V193_Y0.5751.00
122_E127_A0.5741.00
126_A199_I0.5721.00
128_F144_C0.5711.00
112_L115_V0.5701.00
80_E191_A0.5701.00
29_A234_I0.5691.00
116_V119_Q0.5681.00
130_V213_P0.5671.00
40_Q171_F0.5621.00
118_R127_A0.5621.00
212_I216_G0.5591.00
37_C40_Q0.5581.00
93_E96_N0.5571.00
54_G81_Q0.5561.00
140_R223_Y0.5531.00
52_I91_A0.5511.00
28_I231_E0.5481.00
41_L100_M0.5461.00
110_A113_E0.5451.00
119_Q212_I0.5411.00
191_A194_E0.5401.00
138_A141_Y0.5391.00
133_V137_E0.5381.00
177_A208_T0.5381.00
86_H193_Y0.5351.00
36_H40_Q0.5321.00
148_D151_E0.5321.00
160_D164_S0.5311.00
52_I76_A0.5301.00
67_E75_Y0.5301.00
107_I230_A0.5291.00
152_I155_V0.5291.00
134_D137_E0.5271.00
131_E167_V0.5261.00
10_E15_R0.5241.00
112_L119_Q0.5231.00
25_M57_K0.5221.00
187_P193_Y0.5211.00
150_G153_Q0.5191.00
8_A81_Q0.5191.00
209_I216_G0.5181.00
37_C102_M0.5181.00
196_S199_I0.5171.00
191_A195_L0.5151.00
137_E141_Y0.5121.00
4_V88_L0.5101.00
82_N193_Y0.5101.00
64_Y75_Y0.5091.00
181_A185_V0.5081.00
39_E43_A0.5081.00
84_L168_M0.5061.00
89_L193_Y0.5041.00
80_E86_H0.5031.00
179_F182_C0.5021.00
115_V119_Q0.5021.00
185_V198_A0.5021.00
74_T77_H0.5011.00
190_R194_E0.5011.00
6_L101_L0.5001.00
225_E228_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3jukA 3 0.9875 100 0.245 Contact Map
2e3dA 3 0.9833 100 0.261 Contact Map
2ux8A 4 0.9917 100 0.264 Contact Map
2pa4A 3 0.9958 100 0.279 Contact Map
1lvwA 3 0.9917 100 0.291 Contact Map
1iimA 3 0.9875 100 0.292 Contact Map
4ho4A 3 0.9875 100 0.295 Contact Map
3brkX 2 0.95 100 0.298 Contact Map
1mc3A 3 0.9875 100 0.3 Contact Map
1yp2A 4 0.9792 100 0.3 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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