GREMLIN Database
Q9HQQ3 - Uncharacterized protein
UniProt: Q9HQQ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 326 (249)
Sequences: 3227 (2769)
Seq/√Len: 175.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_T191_Y4.8841.00
180_R251_N4.0661.00
60_L63_C3.5331.00
173_D247_L3.4451.00
293_T296_D3.2091.00
63_C259_V2.9501.00
175_T187_T2.8201.00
202_A206_D2.7341.00
58_V245_V2.7211.00
70_D80_T2.6981.00
204_A243_D2.6751.00
249_L257_V2.6111.00
59_I260_T2.4211.00
176_V251_N2.4171.00
174_R177_E2.3491.00
60_L259_V2.3111.00
189_A248_L2.2201.00
175_T189_A2.1581.00
244_E247_L2.1541.00
114_S117_G2.1491.00
172_T248_L2.1131.00
54_W185_D2.1091.00
78_I290_V2.0141.00
113_I117_G2.0091.00
293_T297_T1.9321.00
110_T114_S1.9141.00
56_L185_D1.8591.00
57_L258_V1.8391.00
85_W285_R1.8361.00
56_L257_V1.8281.00
207_R239_R1.8181.00
79_E301_D1.8161.00
79_E297_T1.7881.00
118_H125_E1.7641.00
71_V80_T1.7621.00
60_L241_V1.7491.00
117_G120_Y1.7351.00
113_I118_H1.7111.00
191_Y244_E1.7101.00
176_V247_L1.6881.00
258_V291_T1.6761.00
169_R244_E1.6751.00
194_P238_L1.6451.00
166_V240_L1.6331.00
168_P193_Q1.6321.00
56_L187_T1.6191.00
120_Y125_E1.6101.00
85_W282_P1.5881.00
58_V248_L1.5591.00
84_R289_W1.5521.00
117_G125_E1.5471.00
86_S94_W1.5221.00
113_I120_Y1.5131.00
110_T113_I1.5081.00
73_D235_E1.5061.00
256_T291_T1.4991.00
97_Q107_I1.4991.00
272_I276_P1.4631.00
112_Y115_G1.4621.00
86_S287_V1.4521.00
172_T244_E1.4491.00
81_V289_W1.4321.00
115_G118_H1.4311.00
171_I189_A1.4261.00
201_Q204_A1.3961.00
114_S118_H1.3931.00
272_I275_H1.3831.00
63_C194_P1.3711.00
138_R141_W1.3691.00
56_L252_V1.3521.00
111_A115_G1.3131.00
172_T176_V1.3031.00
121_E125_E1.2961.00
118_H124_T1.2791.00
59_I98_T1.2601.00
118_H121_E1.2531.00
62_A265_N1.2491.00
83_S286_R1.2441.00
293_T299_T1.2331.00
133_T137_C1.2301.00
56_L248_L1.2301.00
57_L260_T1.2291.00
273_T276_P1.2271.00
167_P171_I1.2251.00
113_I116_N1.2241.00
115_G120_Y1.2241.00
177_E181_E1.2141.00
72_A77_F1.2081.00
111_A117_G1.2011.00
152_L156_W1.1881.00
91_S95_L1.1841.00
134_V138_R1.1841.00
97_Q104_E1.1751.00
113_I119_T1.1721.00
114_S120_Y1.1591.00
110_T118_H1.1551.00
217_W220_L1.1531.00
112_Y116_N1.1531.00
245_V249_L1.1411.00
63_C238_L1.1341.00
291_T297_T1.1331.00
133_T141_W1.1171.00
240_L244_E1.1161.00
270_Y283_S1.1101.00
116_N120_Y1.1091.00
55_D186_R1.0851.00
120_Y123_F1.0781.00
113_I121_E1.0771.00
110_T117_G1.0741.00
54_W255_E1.0681.00
113_I122_T1.0591.00
282_P286_R1.0581.00
92_H109_E1.0421.00
99_F188_V1.0380.99
118_H123_F1.0380.99
62_A263_H1.0370.99
172_T247_L1.0340.99
121_E124_T1.0270.99
117_G123_F1.0270.99
133_T138_R1.0220.99
65_V286_R1.0180.99
80_T302_P1.0140.99
118_H127_E1.0120.99
185_D255_E1.0100.99
137_C140_N1.0050.99
110_T115_G1.0050.99
205_E236_D1.0000.99
203_V243_D0.9930.99
102_A107_I0.9920.99
111_A116_N0.9900.99
111_A118_H0.9880.99
117_G121_E0.9790.99
57_L98_T0.9790.99
152_L155_L0.9750.99
125_E128_Y0.9710.99
68_L71_V0.9680.99
111_A114_S0.9680.99
110_T120_Y0.9670.99
56_L255_E0.9580.99
239_R243_D0.9540.99
155_L158_T0.9480.99
169_R240_L0.9470.99
122_T126_R0.9450.99
204_A239_R0.9410.99
115_G119_T0.9410.99
148_D151_H0.9400.99
137_C141_W0.9360.99
119_T125_E0.9330.99
112_Y120_Y0.9310.99
121_E126_R0.9170.99
53_D254_A0.9160.99
57_L186_R0.9140.99
263_H287_V0.9110.99
203_V206_D0.8970.98
252_V257_V0.8930.98
124_T127_E0.8930.98
151_H154_M0.8880.98
75_Y235_E0.8850.98
67_V235_E0.8830.98
202_A205_E0.8820.98
59_I190_H0.8800.98
59_I188_V0.8780.98
55_D256_T0.8760.98
117_G127_E0.8750.98
62_A95_L0.8750.98
253_D256_T0.8730.98
119_T122_T0.8730.98
96_T107_I0.8720.98
111_A125_E0.8720.98
232_E236_D0.8690.98
134_V137_C0.8650.98
115_G121_E0.8590.98
143_G147_R0.8560.98
113_I125_E0.8540.98
249_L292_T0.8520.98
166_V169_R0.8480.98
134_V139_P0.8460.98
203_V207_R0.8400.98
241_V259_V0.8390.98
117_G122_T0.8380.98
273_T277_E0.8380.98
297_T300_F0.8190.97
257_V292_T0.8180.97
145_D148_D0.8180.97
84_R287_V0.8120.97
148_D156_W0.8110.97
118_H126_R0.8100.97
206_D236_D0.8070.97
265_N268_G0.8040.97
87_I97_Q0.8010.97
69_D72_A0.8010.97
119_T123_F0.7930.97
114_S125_E0.7930.97
130_P134_V0.7840.96
102_A106_E0.7790.96
122_T125_E0.7750.96
130_P139_P0.7730.96
69_D239_R0.7720.96
91_S275_H0.7700.96
201_Q240_L0.7690.96
191_Y241_V0.7680.96
200_S236_D0.7640.96
70_D290_V0.7620.96
118_H122_T0.7480.95
63_C68_L0.7460.95
176_V180_R0.7440.95
82_D302_P0.7400.95
95_L275_H0.7370.95
112_Y117_G0.7350.95
132_E137_C0.7330.95
298_G301_D0.7330.95
115_G125_E0.7330.95
208_Q216_G0.7310.95
117_G124_T0.7310.95
120_Y126_R0.7300.95
150_G153_D0.7270.95
120_Y127_E0.7270.95
64_R284_V0.7260.95
168_P240_L0.7250.95
132_E135_P0.7230.94
130_P138_R0.7200.94
150_G158_T0.7180.94
111_A126_R0.7160.94
133_T139_P0.7150.94
200_S233_L0.7110.94
200_S206_D0.7090.94
64_R263_H0.7080.94
148_D154_M0.7060.94
46_G51_D0.7050.94
142_N147_R0.7010.94
274_G277_E0.6990.93
92_H95_L0.6990.93
296_D299_T0.6990.93
116_N125_E0.6990.93
110_T116_N0.6980.93
145_D150_G0.6910.93
176_V248_L0.6910.93
73_D76_A0.6890.93
61_D194_P0.6880.93
136_V140_N0.6860.93
218_K221_E0.6850.93
95_L190_H0.6840.93
53_D256_T0.6840.93
53_D293_T0.6840.93
133_T136_V0.6810.93
124_T128_Y0.6810.93
153_D156_W0.6780.92
51_D254_A0.6750.92
136_V139_P0.6730.92
136_V141_W0.6660.92
96_T109_E0.6630.92
56_L179_A0.6620.91
191_Y245_V0.6600.91
168_P191_Y0.6570.91
198_Y265_N0.6560.91
62_A190_H0.6560.91
120_Y124_T0.6540.91
76_A239_R0.6430.90
111_A122_T0.6400.90
115_G124_T0.6390.90
228_S232_E0.6360.90
135_P140_N0.6350.90
136_V146_E0.6340.90
73_D77_F0.6340.90
54_W184_Y0.6310.89
62_A91_S0.6310.89
121_E178_V0.6270.89
143_G148_D0.6270.89
242_L246_E0.6270.89
138_R146_E0.6250.89
142_N145_D0.6250.89
58_V189_A0.6250.89
177_E180_R0.6240.89
162_D165_G0.6230.89
171_I192_M0.6190.89
260_T287_V0.6190.89
151_H155_L0.6140.88
159_A162_D0.6130.88
166_V237_N0.6130.88
94_W98_T0.6110.88
256_T293_T0.6110.88
114_S121_E0.6100.88
69_D77_F0.6100.88
148_D153_D0.6090.88
64_R265_N0.6050.87
62_A284_V0.6040.87
67_V73_D0.6040.87
134_V141_W0.6040.87
60_L194_P0.6010.87
116_N121_E0.6000.87
246_E250_E0.5980.87
113_I127_E0.5970.87
55_D113_I0.5940.86
149_F155_L0.5940.86
105_A108_A0.5920.86
150_G157_E0.5850.86
53_D184_Y0.5850.86
65_V71_V0.5840.86
135_P138_R0.5820.85
122_T128_Y0.5760.85
296_D300_F0.5760.85
147_R150_G0.5740.85
145_D149_F0.5740.85
219_H222_S0.5720.84
217_W222_S0.5720.84
113_I126_R0.5710.84
272_I277_E0.5710.84
282_P285_R0.5710.84
196_I233_L0.5710.84
193_Q241_V0.5700.84
248_L251_N0.5700.84
116_N119_T0.5690.84
241_V245_V0.5680.84
185_D252_V0.5670.84
121_E127_E0.5670.84
170_A174_R0.5670.84
112_Y125_E0.5640.84
253_D292_T0.5640.84
119_T127_E0.5630.83
65_V263_H0.5610.83
168_P172_T0.5600.83
111_A120_Y0.5560.83
148_D152_L0.5560.83
146_E152_L0.5540.82
225_A228_S0.5540.82
234_Y265_N0.5470.82
217_W221_E0.5460.82
231_W235_E0.5460.82
229_E232_E0.5450.81
179_A251_N0.5440.81
130_P137_C0.5440.81
117_G126_R0.5420.81
116_N124_T0.5380.81
142_N146_E0.5380.81
168_P244_E0.5350.80
87_I104_E0.5340.80
166_V204_A0.5330.80
123_F127_E0.5330.80
171_I175_T0.5320.80
112_Y118_H0.5310.80
56_L189_A0.5300.80
78_I293_T0.5240.79
297_T301_D0.5240.79
87_I103_H0.5220.79
111_A123_F0.5220.79
200_S204_A0.5210.78
179_A248_L0.5180.78
129_P133_T0.5170.78
71_V290_V0.5170.78
139_P143_G0.5170.78
62_A193_Q0.5170.78
138_R143_G0.5160.78
64_R269_E0.5150.78
130_P133_T0.5150.78
134_V140_N0.5140.78
78_I292_T0.5140.78
196_I266_A0.5140.78
240_L243_D0.5140.78
176_V244_E0.5130.77
110_T126_R0.5130.77
112_Y128_Y0.5100.77
266_A277_E0.5100.77
133_T140_N0.5090.77
114_S123_F0.5090.77
68_L290_V0.5070.77
112_Y119_T0.5070.77
144_V147_R0.5060.76
261_A287_V0.5050.76
57_L61_D0.5050.76
173_D176_V0.5040.76
53_D297_T0.5040.76
149_F157_E0.5020.76
143_G146_E0.5000.76
133_T146_E0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vqrA 3 0.8252 100 0.429 Contact Map
4upiA 2 0.8252 100 0.441 Contact Map
4uplA 2 0.8344 100 0.441 Contact Map
4upkA 3 0.8252 100 0.444 Contact Map
4uphA 2 0.8252 100 0.451 Contact Map
2qzuA 2 0.8558 100 0.453 Contact Map
1p49A 3 0.7699 100 0.458 Contact Map
1hdhA 1 0.8344 100 0.46 Contact Map
3ed4A 3 0.8436 100 0.471 Contact Map
1aukA 3 0.7699 100 0.473 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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