Q9HQQ3 - HALSA - GREMLIN Contacts

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Q9HQQ3 - Uncharacterized protein

UniProt:	Q9HQQ3	Sequences: MAGNLRGWIKEHRAKIRASPLRGLLHAVFTAYLGFWYTLTSRWPFGTHVYDEDWDLLVILDACRVDVLDDVADEYAFIETVDSRWSIGSHSHEWLTQTFSRAHEAEIAETAYISGNGHTYETFTEREYPPDETVPVCRPNWNGVDERDFGHLDMLWETAHTDGIGVPPRAITDRTVEVARESEYDRTVAHYMQPHIPYISQAVAEDRQPTELESRGWKHLESGTADRSEIWELYEDNLRLVLDEVELLLENVDAETVVVTADHGNAFGEYTITGHPEGMLLPSVRRVPWVTTTATDTGTFDPDGDYGTASEDTTDINDHLEDLGYL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	326 (249)
Sequences:	3227 (2769)
Seq/√Len:	175.5

ECOLI - YIDJ YDEN ASLA
HALSA - Q9HQQ3 Q9HQQ2 Q9HQ44 Q9HSV3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
172_T	191_Y	4.884	1.00
180_R	251_N	4.066	1.00
60_L	63_C	3.533	1.00
173_D	247_L	3.445	1.00
293_T	296_D	3.209	1.00
63_C	259_V	2.950	1.00
175_T	187_T	2.820	1.00
202_A	206_D	2.734	1.00
58_V	245_V	2.721	1.00
70_D	80_T	2.698	1.00
204_A	243_D	2.675	1.00
249_L	257_V	2.611	1.00
59_I	260_T	2.421	1.00
176_V	251_N	2.417	1.00
174_R	177_E	2.349	1.00
60_L	259_V	2.311	1.00
189_A	248_L	2.220	1.00
175_T	189_A	2.158	1.00
244_E	247_L	2.154	1.00
114_S	117_G	2.149	1.00
172_T	248_L	2.113	1.00
54_W	185_D	2.109	1.00
78_I	290_V	2.014	1.00
113_I	117_G	2.009	1.00
293_T	297_T	1.932	1.00
110_T	114_S	1.914	1.00
56_L	185_D	1.859	1.00
57_L	258_V	1.839	1.00
85_W	285_R	1.836	1.00
56_L	257_V	1.828	1.00
207_R	239_R	1.818	1.00
79_E	301_D	1.816	1.00
79_E	297_T	1.788	1.00
118_H	125_E	1.764	1.00
71_V	80_T	1.762	1.00
60_L	241_V	1.749	1.00
117_G	120_Y	1.735	1.00
113_I	118_H	1.711	1.00
191_Y	244_E	1.710	1.00
176_V	247_L	1.688	1.00
258_V	291_T	1.676	1.00
169_R	244_E	1.675	1.00
194_P	238_L	1.645	1.00
166_V	240_L	1.633	1.00
168_P	193_Q	1.632	1.00
56_L	187_T	1.619	1.00
120_Y	125_E	1.610	1.00
85_W	282_P	1.588	1.00
58_V	248_L	1.559	1.00
84_R	289_W	1.552	1.00
117_G	125_E	1.547	1.00
86_S	94_W	1.522	1.00
113_I	120_Y	1.513	1.00
110_T	113_I	1.508	1.00
73_D	235_E	1.506	1.00
256_T	291_T	1.499	1.00
97_Q	107_I	1.499	1.00
272_I	276_P	1.463	1.00
112_Y	115_G	1.462	1.00
86_S	287_V	1.452	1.00
172_T	244_E	1.449	1.00
81_V	289_W	1.432	1.00
115_G	118_H	1.431	1.00
171_I	189_A	1.426	1.00
201_Q	204_A	1.396	1.00
114_S	118_H	1.393	1.00
272_I	275_H	1.383	1.00
63_C	194_P	1.371	1.00
138_R	141_W	1.369	1.00
56_L	252_V	1.352	1.00
111_A	115_G	1.313	1.00
172_T	176_V	1.303	1.00
121_E	125_E	1.296	1.00
118_H	124_T	1.279	1.00
59_I	98_T	1.260	1.00
118_H	121_E	1.253	1.00
62_A	265_N	1.249	1.00
83_S	286_R	1.244	1.00
293_T	299_T	1.233	1.00
133_T	137_C	1.230	1.00
56_L	248_L	1.230	1.00
57_L	260_T	1.229	1.00
273_T	276_P	1.227	1.00
167_P	171_I	1.225	1.00
113_I	116_N	1.224	1.00
115_G	120_Y	1.224	1.00
177_E	181_E	1.214	1.00
72_A	77_F	1.208	1.00
111_A	117_G	1.201	1.00
152_L	156_W	1.188	1.00
91_S	95_L	1.184	1.00
134_V	138_R	1.184	1.00
97_Q	104_E	1.175	1.00
113_I	119_T	1.172	1.00
114_S	120_Y	1.159	1.00
110_T	118_H	1.155	1.00
217_W	220_L	1.153	1.00
112_Y	116_N	1.153	1.00
245_V	249_L	1.141	1.00
63_C	238_L	1.134	1.00
291_T	297_T	1.133	1.00
133_T	141_W	1.117	1.00
240_L	244_E	1.116	1.00
270_Y	283_S	1.110	1.00
116_N	120_Y	1.109	1.00
55_D	186_R	1.085	1.00
120_Y	123_F	1.078	1.00
113_I	121_E	1.077	1.00
110_T	117_G	1.074	1.00
54_W	255_E	1.068	1.00
113_I	122_T	1.059	1.00
282_P	286_R	1.058	1.00
92_H	109_E	1.042	1.00
99_F	188_V	1.038	0.99
118_H	123_F	1.038	0.99
62_A	263_H	1.037	0.99
172_T	247_L	1.034	0.99
121_E	124_T	1.027	0.99
117_G	123_F	1.027	0.99
133_T	138_R	1.022	0.99
65_V	286_R	1.018	0.99
80_T	302_P	1.014	0.99
118_H	127_E	1.012	0.99
185_D	255_E	1.010	0.99
137_C	140_N	1.005	0.99
110_T	115_G	1.005	0.99
205_E	236_D	1.000	0.99
203_V	243_D	0.993	0.99
102_A	107_I	0.992	0.99
111_A	116_N	0.990	0.99
111_A	118_H	0.988	0.99
117_G	121_E	0.979	0.99
57_L	98_T	0.979	0.99
152_L	155_L	0.975	0.99
125_E	128_Y	0.971	0.99
68_L	71_V	0.968	0.99
111_A	114_S	0.968	0.99
110_T	120_Y	0.967	0.99
56_L	255_E	0.958	0.99
239_R	243_D	0.954	0.99
155_L	158_T	0.948	0.99
169_R	240_L	0.947	0.99
122_T	126_R	0.945	0.99
204_A	239_R	0.941	0.99
115_G	119_T	0.941	0.99
148_D	151_H	0.940	0.99
137_C	141_W	0.936	0.99
119_T	125_E	0.933	0.99
112_Y	120_Y	0.931	0.99
121_E	126_R	0.917	0.99
53_D	254_A	0.916	0.99
57_L	186_R	0.914	0.99
263_H	287_V	0.911	0.99
203_V	206_D	0.897	0.98
252_V	257_V	0.893	0.98
124_T	127_E	0.893	0.98
151_H	154_M	0.888	0.98
75_Y	235_E	0.885	0.98
67_V	235_E	0.883	0.98
202_A	205_E	0.882	0.98
59_I	190_H	0.880	0.98
59_I	188_V	0.878	0.98
55_D	256_T	0.876	0.98
117_G	127_E	0.875	0.98
62_A	95_L	0.875	0.98
253_D	256_T	0.873	0.98
119_T	122_T	0.873	0.98
96_T	107_I	0.872	0.98
111_A	125_E	0.872	0.98
232_E	236_D	0.869	0.98
134_V	137_C	0.865	0.98
115_G	121_E	0.859	0.98
143_G	147_R	0.856	0.98
113_I	125_E	0.854	0.98
249_L	292_T	0.852	0.98
166_V	169_R	0.848	0.98
134_V	139_P	0.846	0.98
203_V	207_R	0.840	0.98
241_V	259_V	0.839	0.98
117_G	122_T	0.838	0.98
273_T	277_E	0.838	0.98
297_T	300_F	0.819	0.97
257_V	292_T	0.818	0.97
145_D	148_D	0.818	0.97
84_R	287_V	0.812	0.97
148_D	156_W	0.811	0.97
118_H	126_R	0.810	0.97
206_D	236_D	0.807	0.97
265_N	268_G	0.804	0.97
87_I	97_Q	0.801	0.97
69_D	72_A	0.801	0.97
119_T	123_F	0.793	0.97
114_S	125_E	0.793	0.97
130_P	134_V	0.784	0.96
102_A	106_E	0.779	0.96
122_T	125_E	0.775	0.96
130_P	139_P	0.773	0.96
69_D	239_R	0.772	0.96
91_S	275_H	0.770	0.96
201_Q	240_L	0.769	0.96
191_Y	241_V	0.768	0.96
200_S	236_D	0.764	0.96
70_D	290_V	0.762	0.96
118_H	122_T	0.748	0.95
63_C	68_L	0.746	0.95
176_V	180_R	0.744	0.95
82_D	302_P	0.740	0.95
95_L	275_H	0.737	0.95
112_Y	117_G	0.735	0.95
132_E	137_C	0.733	0.95
298_G	301_D	0.733	0.95
115_G	125_E	0.733	0.95
208_Q	216_G	0.731	0.95
117_G	124_T	0.731	0.95
120_Y	126_R	0.730	0.95
150_G	153_D	0.727	0.95
120_Y	127_E	0.727	0.95
64_R	284_V	0.726	0.95
168_P	240_L	0.725	0.95
132_E	135_P	0.723	0.94
130_P	138_R	0.720	0.94
150_G	158_T	0.718	0.94
111_A	126_R	0.716	0.94
133_T	139_P	0.715	0.94
200_S	233_L	0.711	0.94
200_S	206_D	0.709	0.94
64_R	263_H	0.708	0.94
148_D	154_M	0.706	0.94
46_G	51_D	0.705	0.94
142_N	147_R	0.701	0.94
274_G	277_E	0.699	0.93
92_H	95_L	0.699	0.93
296_D	299_T	0.699	0.93
116_N	125_E	0.699	0.93
110_T	116_N	0.698	0.93
145_D	150_G	0.691	0.93
176_V	248_L	0.691	0.93
73_D	76_A	0.689	0.93
61_D	194_P	0.688	0.93
136_V	140_N	0.686	0.93
218_K	221_E	0.685	0.93
95_L	190_H	0.684	0.93
53_D	256_T	0.684	0.93
53_D	293_T	0.684	0.93
133_T	136_V	0.681	0.93
124_T	128_Y	0.681	0.93
153_D	156_W	0.678	0.92
51_D	254_A	0.675	0.92
136_V	139_P	0.673	0.92
136_V	141_W	0.666	0.92
96_T	109_E	0.663	0.92
56_L	179_A	0.662	0.91
191_Y	245_V	0.660	0.91
168_P	191_Y	0.657	0.91
198_Y	265_N	0.656	0.91
62_A	190_H	0.656	0.91
120_Y	124_T	0.654	0.91
76_A	239_R	0.643	0.90
111_A	122_T	0.640	0.90
115_G	124_T	0.639	0.90
228_S	232_E	0.636	0.90
135_P	140_N	0.635	0.90
136_V	146_E	0.634	0.90
73_D	77_F	0.634	0.90
54_W	184_Y	0.631	0.89
62_A	91_S	0.631	0.89
121_E	178_V	0.627	0.89
143_G	148_D	0.627	0.89
242_L	246_E	0.627	0.89
138_R	146_E	0.625	0.89
142_N	145_D	0.625	0.89
58_V	189_A	0.625	0.89
177_E	180_R	0.624	0.89
162_D	165_G	0.623	0.89
171_I	192_M	0.619	0.89
260_T	287_V	0.619	0.89
151_H	155_L	0.614	0.88
159_A	162_D	0.613	0.88
166_V	237_N	0.613	0.88
94_W	98_T	0.611	0.88
256_T	293_T	0.611	0.88
114_S	121_E	0.610	0.88
69_D	77_F	0.610	0.88
148_D	153_D	0.609	0.88
64_R	265_N	0.605	0.87
62_A	284_V	0.604	0.87
67_V	73_D	0.604	0.87
134_V	141_W	0.604	0.87
60_L	194_P	0.601	0.87
116_N	121_E	0.600	0.87
246_E	250_E	0.598	0.87
113_I	127_E	0.597	0.87
55_D	113_I	0.594	0.86
149_F	155_L	0.594	0.86
105_A	108_A	0.592	0.86
150_G	157_E	0.585	0.86
53_D	184_Y	0.585	0.86
65_V	71_V	0.584	0.86
135_P	138_R	0.582	0.85
122_T	128_Y	0.576	0.85
296_D	300_F	0.576	0.85
147_R	150_G	0.574	0.85
145_D	149_F	0.574	0.85
219_H	222_S	0.572	0.84
217_W	222_S	0.572	0.84
113_I	126_R	0.571	0.84
272_I	277_E	0.571	0.84
282_P	285_R	0.571	0.84
196_I	233_L	0.571	0.84
193_Q	241_V	0.570	0.84
248_L	251_N	0.570	0.84
116_N	119_T	0.569	0.84
241_V	245_V	0.568	0.84
185_D	252_V	0.567	0.84
121_E	127_E	0.567	0.84
170_A	174_R	0.567	0.84
112_Y	125_E	0.564	0.84
253_D	292_T	0.564	0.84
119_T	127_E	0.563	0.83
65_V	263_H	0.561	0.83
168_P	172_T	0.560	0.83
111_A	120_Y	0.556	0.83
148_D	152_L	0.556	0.83
146_E	152_L	0.554	0.82
225_A	228_S	0.554	0.82
234_Y	265_N	0.547	0.82
217_W	221_E	0.546	0.82
231_W	235_E	0.546	0.82
229_E	232_E	0.545	0.81
179_A	251_N	0.544	0.81
130_P	137_C	0.544	0.81
117_G	126_R	0.542	0.81
116_N	124_T	0.538	0.81
142_N	146_E	0.538	0.81
168_P	244_E	0.535	0.80
87_I	104_E	0.534	0.80
166_V	204_A	0.533	0.80
123_F	127_E	0.533	0.80
171_I	175_T	0.532	0.80
112_Y	118_H	0.531	0.80
56_L	189_A	0.530	0.80
78_I	293_T	0.524	0.79
297_T	301_D	0.524	0.79
87_I	103_H	0.522	0.79
111_A	123_F	0.522	0.79
200_S	204_A	0.521	0.78
179_A	248_L	0.518	0.78
129_P	133_T	0.517	0.78
71_V	290_V	0.517	0.78
139_P	143_G	0.517	0.78
62_A	193_Q	0.517	0.78
138_R	143_G	0.516	0.78
64_R	269_E	0.515	0.78
130_P	133_T	0.515	0.78
134_V	140_N	0.514	0.78
78_I	292_T	0.514	0.78
196_I	266_A	0.514	0.78
240_L	243_D	0.514	0.78
176_V	244_E	0.513	0.77
110_T	126_R	0.513	0.77
112_Y	128_Y	0.510	0.77
266_A	277_E	0.510	0.77
133_T	140_N	0.509	0.77
114_S	123_F	0.509	0.77
68_L	290_V	0.507	0.77
112_Y	119_T	0.507	0.77
144_V	147_R	0.506	0.76
261_A	287_V	0.505	0.76
57_L	61_D	0.505	0.76
173_D	176_V	0.504	0.76
53_D	297_T	0.504	0.76
149_F	157_E	0.502	0.76
143_G	146_E	0.500	0.76
133_T	146_E	0.500	0.76

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2vqrA	3	0.8252	100	0.429	Contact Map
4upiA	2	0.8252	100	0.441	Contact Map
4uplA	2	0.8344	100	0.441	Contact Map
4upkA	3	0.8252	100	0.444	Contact Map
4uphA	2	0.8252	100	0.451	Contact Map
2qzuA	2	0.8558	100	0.453	Contact Map
1p49A	3	0.7699	100	0.458	Contact Map
1hdhA	1	0.8344	100	0.46	Contact Map
3ed4A	3	0.8436	100	0.471	Contact Map
1aukA	3	0.7699	100	0.473	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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