GREMLIN Database
Q9HQQ2 - Uncharacterized protein
UniProt: Q9HQQ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 452 (370)
Sequences: 10473 (8014)
Seq/√Len: 416.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
330_D344_S5.1171.00
188_Q263_E4.2171.00
29_D304_S3.9881.00
385_D402_F3.6821.00
180_G203_L3.3461.00
262_E266_T3.2661.00
385_D400_E3.0981.00
58_E341_R3.0521.00
13_L16_L2.9671.00
32_R314_P2.8811.00
216_Y255_D2.8711.00
400_E403_G2.7731.00
419_R422_E2.7381.00
36_A319_V2.6751.00
263_E266_T2.6061.00
184_L263_E2.6011.00
214_P218_T2.5781.00
220_E251_R2.4781.00
181_R259_E2.3551.00
34_E316_G2.3511.00
182_E185_N2.3431.00
183_A199_V2.2931.00
387_R407_E2.2641.00
261_H271_V2.2511.00
219_K251_R2.2401.00
31_V315_T2.2321.00
319_V345_L2.2061.00
331_L346_R2.1961.00
80_R106_D2.1861.00
82_S334_V2.1521.00
383_K422_E2.1281.00
8_I332_A2.1171.00
410_G413_V2.0951.00
383_K426_G2.0881.00
23_A32_R2.0771.00
11_V257_Y2.0391.00
9_A271_V2.0391.00
34_E314_P2.0381.00
16_L273_T2.0291.00
75_L198_F1.9961.00
329_L334_V1.9841.00
8_I79_L1.9791.00
360_T426_G1.9691.00
13_L273_T1.9231.00
330_D346_R1.9141.00
54_K72_Q1.8871.00
413_V420_M1.8821.00
326_Q342_G1.8621.00
12_V274_L1.8551.00
89_F199_V1.8381.00
24_H32_R1.8301.00
85_E195_D1.8171.00
185_N189_A1.8101.00
85_E190_A1.7941.00
388_L396_G1.7871.00
346_R350_F1.7661.00
396_G424_A1.7641.00
270_Y303_I1.7501.00
184_L259_E1.7461.00
31_V313_S1.7451.00
201_L260_I1.7401.00
293_S397_Y1.7211.00
256_I259_E1.7181.00
270_Y331_L1.7151.00
183_A201_L1.7111.00
272_I328_V1.6981.00
30_G302_A1.6811.00
87_H186_Y1.6781.00
272_I303_I1.6771.00
88_G200_F1.6741.00
35_N382_D1.6701.00
46_A321_L1.6531.00
203_L256_I1.6441.00
411_D416_A1.6411.00
9_A197_E1.6401.00
13_L253_L1.6241.00
180_G260_I1.6051.00
73_P81_D1.5771.00
420_M424_A1.5521.00
180_G184_L1.5381.00
416_A419_R1.5301.00
397_Y410_G1.5221.00
188_Q266_T1.5061.00
37_W297_T1.5061.00
324_V328_V1.4951.00
31_V309_L1.4921.00
10_L272_I1.4811.00
305_S308_G1.4701.00
180_G256_I1.4631.00
78_L325_F1.4571.00
77_E103_R1.4521.00
107_E189_A1.4471.00
7_D197_E1.4231.00
325_F340_T1.4171.00
215_S255_D1.4151.00
388_L424_A1.3851.00
177_Y256_I1.3801.00
9_A264_L1.3641.00
414_P417_E1.3591.00
206_A250_V1.3551.00
87_H199_V1.3511.00
36_A301_L1.3351.00
33_Y301_L1.3311.00
4_S268_F1.3181.00
217_R248_D1.3001.00
270_Y305_S1.2941.00
186_Y190_A1.2941.00
16_L250_V1.2701.00
386_K419_R1.2671.00
38_S46_A1.2651.00
308_G350_F1.2621.00
425_A429_R1.2621.00
413_V417_E1.2601.00
10_L274_L1.2581.00
174_D252_Y1.2561.00
16_L206_A1.2511.00
54_K339_S1.2361.00
216_Y251_R1.2361.00
426_G429_R1.2331.00
38_S299_V1.2271.00
213_P216_Y1.2121.00
294_P382_D1.2091.00
177_Y252_Y1.2051.00
55_Y322_H1.2051.00
5_G82_S1.1951.00
305_S309_L1.1921.00
11_V260_I1.1921.00
78_L329_L1.1831.00
203_L253_L1.1811.00
430_R433_A1.1741.00
12_V50_L1.1721.00
218_T221_P1.1651.00
422_E426_G1.1621.00
179_D201_L1.1611.00
413_V416_A1.1531.00
44_P61_V1.1511.00
421_Q425_A1.1451.00
191_S194_S1.1401.00
175_N179_D1.1401.00
305_S331_L1.1281.00
124_W128_I1.1261.00
264_L271_V1.1231.00
176_T205_D1.1221.00
124_W127_F1.1101.00
388_L423_L1.1051.00
79_L328_V1.1001.00
87_H107_E1.0981.00
184_L188_Q1.0951.00
315_T348_A1.0941.00
10_L198_F1.0911.00
417_E421_Q1.0901.00
381_V426_G1.0891.00
213_P252_Y1.0891.00
251_R255_D1.0821.00
265_L304_S1.0801.00
294_P298_N1.0791.00
9_A269_D1.0791.00
109_H182_E1.0761.00
9_A199_V1.0741.00
97_K102_D1.0731.00
18_K298_N1.0691.00
261_H265_L1.0691.00
73_P78_L1.0691.00
386_K416_A1.0611.00
257_Y261_H1.0571.00
421_Q424_A1.0541.00
386_K398_V1.0511.00
89_F107_E1.0501.00
221_P244_T1.0501.00
7_D269_D1.0471.00
6_S268_F1.0431.00
33_Y348_A1.0381.00
214_P217_R1.0321.00
39_T320_N1.0161.00
301_L324_V1.0151.00
387_R401_Q1.0121.00
37_W294_P1.0101.00
303_I309_L1.0091.00
180_G259_E1.0051.00
383_K423_L1.0041.00
190_A195_D0.9971.00
10_L50_L0.9971.00
187_I260_I0.9941.00
310_E313_S0.9911.00
124_W130_E0.9911.00
88_G202_N0.9811.00
252_Y256_I0.9811.00
73_P77_E0.9811.00
79_L332_A0.9741.00
123_N126_Q0.9691.00
8_I328_V0.9691.00
16_L21_F0.9671.00
261_H304_S0.9551.00
8_I270_Y0.9551.00
29_D311_E0.9541.00
360_T383_K0.9521.00
381_V388_L0.9501.00
217_R245_A0.9491.00
218_T248_D0.9481.00
253_L273_T0.9441.00
43_S47_H0.9411.00
426_G430_R0.9371.00
49_S56_G0.9361.00
197_E269_D0.9351.00
315_T318_P0.9351.00
18_K24_H0.9351.00
382_D385_D0.9331.00
123_N127_F0.9331.00
259_E262_E0.9321.00
36_A321_L0.9271.00
78_L81_D0.9251.00
49_S59_I0.9231.00
29_D265_L0.9211.00
255_D259_E0.9091.00
396_G420_M0.9071.00
424_A428_D0.9011.00
68_L74_T0.9001.00
185_N188_Q0.8961.00
49_S322_H0.8851.00
26_S247_E0.8851.00
356_A359_E0.8801.00
386_K411_D0.8781.00
79_L334_V0.8751.00
190_A193_A0.8751.00
57_S364_S0.8751.00
124_W131_N0.8731.00
390_A396_G0.8701.00
292_L380_I0.8671.00
398_V420_M0.8651.00
15_A279_E0.8621.00
363_L380_I0.8601.00
419_R423_L0.8601.00
37_W382_D0.8591.00
75_L325_F0.8501.00
262_E265_L0.8481.00
219_K255_D0.8481.00
364_S367_R0.8481.00
78_L82_S0.8481.00
416_A420_M0.8461.00
275_A299_V0.8451.00
127_F130_E0.8451.00
212_A248_D0.8431.00
215_S218_T0.8431.00
15_A289_H0.8421.00
8_I331_L0.8401.00
12_V202_N0.8401.00
187_I263_E0.8371.00
361_H364_S0.8361.00
385_D419_R0.8361.00
286_T293_S0.8361.00
318_P361_H0.8341.00
216_Y252_Y0.8301.00
128_I131_N0.8281.00
325_F329_L0.8271.00
379_E390_A0.8261.00
54_K58_E0.8241.00
358_L361_H0.8221.00
6_S305_S0.8221.00
84_Y332_A0.8221.00
10_L328_V0.8221.00
51_F200_F0.8211.00
398_V419_R0.8201.00
383_K419_R0.8181.00
15_A277_H0.8181.00
240_E244_T0.8161.00
11_V271_V0.8161.00
244_T248_D0.8141.00
54_K59_I0.8111.00
363_L366_E0.8091.00
417_E420_M0.8091.00
170_L173_D0.8081.00
344_S347_A0.8011.00
39_T49_S0.7991.00
294_P387_R0.7981.00
401_Q407_E0.7961.00
20_A246_Y0.7951.00
174_D177_Y0.7921.00
85_E186_Y0.7911.00
10_L324_V0.7871.00
329_L336_P0.7861.00
79_L198_F0.7851.00
398_V423_L0.7841.00
395_S410_G0.7841.00
326_Q340_T0.7831.00
38_S321_L0.7831.00
429_R433_A0.7811.00
6_S84_Y0.7801.00
85_E106_D0.7791.00
317_K348_A0.7791.00
260_I263_E0.7781.00
21_F24_H0.7771.00
48_G59_I0.7761.00
390_A424_A0.7761.00
35_N298_N0.7741.00
181_R185_N0.7731.00
181_R184_L0.7721.00
177_Y213_P0.7701.00
284_Y295_Q0.7701.00
33_Y349_K0.7691.00
285_G405_T0.7691.00
173_D181_R0.7681.00
271_V304_S0.7671.00
187_I190_A0.7651.00
30_G304_S0.7651.00
76_A79_L0.7651.00
6_S270_Y0.7651.00
301_L319_V0.7611.00
184_L260_I0.7601.00
176_T256_I0.7591.00
31_V311_E0.7541.00
347_A352_A0.7511.00
287_W291_D0.7501.00
411_D415_D0.7491.00
220_E247_E0.7461.00
351_D354_R0.7431.00
205_D253_L0.7431.00
55_Y320_N0.7431.00
92_N95_I0.7371.00
126_Q129_K0.7361.00
212_A217_R0.7351.00
388_L420_M0.7331.00
220_E248_D0.7321.00
425_A428_D0.7281.00
381_V427_I0.7261.00
343_Q358_L0.7251.00
246_Y250_V0.7251.00
173_D178_E0.7241.00
51_F105_F0.7231.00
108_F111_R0.7211.00
253_L257_Y0.7191.00
176_T203_L0.7191.00
360_T363_L0.7161.00
258_A262_E0.7151.00
235_D238_D0.7151.00
411_D419_R0.7141.00
85_E191_S0.7141.00
270_Y328_V0.7121.00
358_L362_G0.7101.00
386_K400_E0.7101.00
177_Y215_S0.7091.00
33_Y315_T0.7091.00
89_F186_Y0.7081.00
48_G61_V0.7061.00
124_W129_K0.7051.00
78_L334_V0.7051.00
327_T345_L0.7021.00
76_A80_R0.7011.00
105_F200_F0.6991.00
320_N361_H0.6981.00
398_V411_D0.6951.00
39_T321_L0.6921.00
80_R86_T0.6921.00
215_S219_K0.6911.00
303_I349_K0.6911.00
380_I387_R0.6911.00
51_F94_Y0.6891.00
9_A260_I0.6881.00
178_E182_E0.6871.00
180_G183_A0.6861.00
23_A302_A0.6861.00
12_V200_F0.6851.00
292_L389_S0.6841.00
428_D432_D0.6841.00
126_Q130_E0.6811.00
126_Q131_N0.6801.00
216_Y219_K0.6801.00
74_T77_E0.6791.00
75_L79_L0.6771.00
81_D86_T0.6761.00
187_I199_V0.6761.00
337_E340_T0.6751.00
184_L256_I0.6721.00
180_G201_L0.6721.00
78_L337_E0.6711.00
284_Y405_T0.6700.99
176_T180_G0.6680.99
24_H302_A0.6650.99
206_A246_Y0.6620.99
379_E427_I0.6610.99
96_S102_D0.6580.99
381_V430_R0.6570.99
274_L321_L0.6500.99
125_P131_N0.6470.99
44_P64_K0.6470.99
308_G311_E0.6470.99
203_L257_Y0.6450.99
89_F183_A0.6440.99
409_V415_D0.6430.99
41_H292_L0.6400.99
205_D249_C0.6390.99
212_A245_A0.6390.99
236_D240_E0.6370.99
129_K132_K0.6360.99
345_L349_K0.6340.99
221_P241_A0.6340.99
330_D347_A0.6340.99
403_G409_V0.6330.99
177_Y181_R0.6330.99
109_H178_E0.6330.99
22_D25_F0.6310.99
197_E264_L0.6280.99
51_F76_A0.6270.99
380_I389_S0.6270.99
25_F28_M0.6260.99
88_G108_F0.6260.99
11_V201_L0.6250.99
47_H289_H0.6250.99
362_G381_V0.6210.99
314_P317_K0.6200.99
88_G92_N0.6200.99
77_E80_R0.6190.99
292_L378_Q0.6190.99
348_A356_A0.6170.99
315_T319_V0.6170.99
257_Y273_T0.6170.99
191_S195_D0.6170.99
75_L328_V0.6170.99
343_Q348_A0.6160.99
117_G211_L0.6150.99
43_S91_A0.6150.99
124_W132_K0.6140.99
89_F179_D0.6140.99
29_D261_H0.6140.99
67_T98_Y0.6130.99
331_L350_F0.6070.99
297_T363_L0.6070.99
280_A283_E0.6060.99
303_I345_L0.6060.99
297_T380_I0.6060.99
241_A244_T0.6060.99
298_N405_T0.6060.99
12_V321_L0.6030.99
52_T72_Q0.6020.99
420_M427_I0.6010.99
381_V423_L0.6010.99
177_Y259_E0.5970.99
362_G365_N0.5970.99
328_V332_A0.5970.99
123_N128_I0.5960.99
85_E193_A0.5940.99
100_D103_R0.5920.99
20_A247_E0.5910.99
33_Y303_I0.5900.99
39_T55_Y0.5880.99
36_A299_V0.5880.99
129_K182_E0.5880.99
216_Y220_E0.5880.99
28_M247_E0.5870.99
294_P401_Q0.5870.99
16_L20_A0.5870.99
415_D418_R0.5860.99
77_E81_D0.5850.99
365_N368_L0.5830.99
216_Y248_D0.5830.99
127_F131_N0.5810.99
39_T322_H0.5790.99
76_A88_G0.5790.99
125_P129_K0.5790.99
76_A105_F0.5740.98
390_A431_T0.5740.98
9_A201_L0.5730.98
274_L299_V0.5670.98
409_V413_V0.5670.98
50_L324_V0.5660.98
245_A249_C0.5650.98
398_V410_G0.5640.98
281_F288_S0.5640.98
274_L301_L0.5610.98
88_G110_S0.5610.98
12_V46_A0.5600.98
35_N316_G0.5590.98
19_D284_Y0.5570.98
420_M423_L0.5560.98
210_Y279_E0.5560.98
125_P130_E0.5550.98
360_T381_V0.5540.98
176_T252_Y0.5530.98
111_R204_M0.5530.98
215_S252_Y0.5520.98
79_L329_L0.5510.98
346_R349_K0.5500.98
212_A249_C0.5500.98
428_D431_T0.5500.98
99_F102_D0.5490.98
363_L382_D0.5490.98
69_D72_Q0.5480.98
13_L206_A0.5480.98
113_R117_G0.5460.98
30_G257_Y0.5420.98
174_D249_C0.5420.98
419_R426_G0.5410.98
362_G430_R0.5400.98
279_E282_G0.5400.98
179_D204_M0.5400.98
267_E306_E0.5390.98
360_T430_R0.5390.98
343_Q356_A0.5360.98
267_E307_D0.5360.98
43_S289_H0.5360.98
8_I198_F0.5350.98
9_A187_I0.5350.98
169_G173_D0.5350.98
360_T364_S0.5340.98
4_S267_E0.5340.98
299_V321_L0.5320.97
4_S194_S0.5320.97
183_A187_I0.5320.97
347_A351_D0.5320.97
352_A355_V0.5310.97
43_S90_S0.5310.97
32_R302_A0.5310.97
181_R256_I0.5310.97
317_K356_A0.5310.97
219_K248_D0.5300.97
44_P93_T0.5300.97
404_E409_V0.5290.97
40_T56_G0.5280.97
33_Y319_V0.5280.97
111_R114_V0.5280.97
107_E186_Y0.5270.97
382_D401_Q0.5270.97
47_H91_A0.5270.97
22_D251_R0.5240.97
55_Y341_R0.5230.97
401_Q405_T0.5220.97
123_N130_E0.5200.97
85_E107_E0.5200.97
383_K386_K0.5190.97
59_I72_Q0.5190.97
277_H299_V0.5180.97
42_Y45_A0.5150.97
184_L187_I0.5150.97
59_I62_H0.5140.97
110_S114_V0.5140.97
304_S307_D0.5120.97
21_F302_A0.5120.97
100_D105_F0.5100.97
70_C103_R0.5100.97
125_P128_I0.5100.97
294_P297_T0.5100.97
11_V203_L0.5100.97
169_G172_D0.5100.97
427_I431_T0.5090.97
16_L275_A0.5090.97
329_L340_T0.5090.97
390_A428_D0.5070.97
107_E130_E0.5070.97
272_I324_V0.5060.97
100_D104_G0.5050.97
165_L168_I0.5050.97
318_P358_L0.5050.97
24_H34_E0.5040.97
244_T247_E0.5030.96
82_S332_A0.5020.96
318_P382_D0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4upiA 2 0.9823 100 0.224 Contact Map
2vqrA 3 0.9624 100 0.229 Contact Map
4uplA 2 0.9845 100 0.229 Contact Map
4upkA 3 0.9469 100 0.237 Contact Map
4uphA 2 0.9558 100 0.238 Contact Map
2qzuA 2 0.8872 100 0.253 Contact Map
1hdhA 1 0.8916 100 0.258 Contact Map
3b5qA 1 0.8717 100 0.259 Contact Map
1p49A 3 0.9204 100 0.273 Contact Map
1aukA 3 0.8805 100 0.276 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0116 seconds.