Q9HQQ0 - HALSA - GREMLIN Contacts

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Q9HQQ0 - Uncharacterized protein

UniProt:	Q9HQQ0	Sequences: MPSIGILYYVNSFPKLSESFVLNEITELKRRGHEVAVFAQNDPGEDVVHDELADIDLPVYYAQPSYTELPSILTTTAAQMVRRDPGISSPRAFSLKQIGHSLLLARRCLEAIADLDLEIDVINAHFATPTRAGAIHASNHAGIPCIVTAHAYEIFRNPDFEKIRRICHGVDHVVVPSEYNRQYLRNEAAVTNDISVIPATTKTEKFEPSGEPVEDRLLTVARLVEKKGHKYALEAVSQLVAQGYDVEYHIIGQGKLEPQLKQYASDLGISSHVAFLDHVSDETLRNELNEAALFVLPCVIAENGDRDAMPVVLKEAMASETACVSTSVSAIPELITDGEDGLLVPPRDVEQLAAAIQRLLDDPTLRGEIETRGRQTVHETFDIAQSIDDLLAVFRSEI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	398 (347)
Sequences:	49657 (41796)
Seq/√Len:	2243.7

ECOLI - WCAL RFAG WBBK GLGA RFAB WCAI WCAC
BACSU - YPJH EPSD GLGA YTCC EPSF COTSA YQGM TUAC TUAH YKVP CGEB TAGE
HALSA - Q9HQQ0 Q9HSW1 Q9HS45 Q9HSV4 Q9HRP8 Q9HSV2 Q9HQT2 Q9HRP9
SULSO - Q97UM0 Q97XT7 Q980C8 Q97V61 Q97ZD3 Q97VL4 Q97V80 Q97XU2 Q97UU3 Q97XT5 Q97XT8 Q7LXM9 Q97XT9 Q7LXI2 Q7LXF8 Q97XT1 Q97XF6 Q97XT6 Q7LXF5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
218_L	291_A	4.659	1.00
247_E	274_A	3.698	1.00
257_E	261_K	3.360	1.00
172_H	195_S	3.190	1.00
216_R	249_H	3.061	1.00
294_F	316_A	3.056	1.00
123_N	394_F	2.938	1.00
249_H	276_L	2.738	1.00
376_T	380_T	2.694	1.00
238_Q	353_A	2.677	1.00
234_E	263_Y	2.652	1.00
5_G	34_E	2.631	1.00
219_T	229_H	2.606	1.00
240_V	272_H	2.439	1.00
234_E	349_V	2.253	1.00
181_R	185_R	2.252	1.00
36_A	119_I	2.181	1.00
228_G	231_Y	2.155	1.00
36_A	117_L	2.106	1.00
251_I	287_E	2.093	1.00
263_Y	267_L	2.092	1.00
256_L	259_Q	2.057	1.00
216_R	247_E	2.053	1.00
236_V	248_Y	2.041	1.00
216_R	290_E	2.034	1.00
238_Q	350_E	2.033	1.00
362_D	365_L	2.028	1.00
355_A	358_R	2.024	1.00
249_H	274_A	2.012	1.00
327_S	332_P	2.005	1.00
33_H	391_L	1.960	1.00
335_I	341_G	1.918	1.00
7_L	119_I	1.882	1.00
217_L	293_L	1.842	1.00
320_E	374_R	1.839	1.00
265_S	270_S	1.834	1.00
358_R	365_L	1.823	1.00
366_R	370_E	1.817	1.00
228_G	299_V	1.813	1.00
327_S	345_P	1.807	1.00
340_D	376_T	1.806	1.00
385_Q	389_D	1.799	1.00
336_T	339_E	1.796	1.00
214_E	247_E	1.782	1.00
123_N	148_T	1.774	1.00
345_P	351_Q	1.767	1.00
342_L	355_A	1.739	1.00
178_E	181_R	1.733	1.00
237_S	267_L	1.721	1.00
294_F	321_T	1.711	1.00
358_R	362_D	1.701	1.00
31_R	388_D	1.697	1.00
172_H	393_V	1.683	1.00
181_R	196_V	1.672	1.00
279_V	283_T	1.667	1.00
200_T	383_I	1.664	1.00
147_V	170_V	1.649	1.00
336_T	376_T	1.643	1.00
232_A	248_Y	1.635	1.00
178_E	333_E	1.624	1.00
357_Q	361_D	1.585	1.00
175_V	194_I	1.584	1.00
236_V	246_V	1.573	1.00
239_L	357_Q	1.569	1.00
31_R	391_L	1.554	1.00
7_L	38_F	1.553	1.00
348_D	351_Q	1.533	1.00
365_L	368_E	1.531	1.00
27_E	384_A	1.523	1.00
232_A	295_V	1.516	1.00
27_E	30_R	1.512	1.00
351_Q	355_A	1.508	1.00
342_L	358_R	1.505	1.00
336_T	340_D	1.504	1.00
339_E	372_R	1.497	1.00
181_R	194_I	1.495	1.00
368_E	372_R	1.488	1.00
391_L	395_R	1.478	1.00
375_Q	379_E	1.475	1.00
283_T	286_N	1.471	1.00
27_E	387_I	1.467	1.00
251_I	276_L	1.466	1.00
216_R	292_A	1.464	1.00
220_V	284_L	1.458	1.00
253_Q	257_E	1.449	1.00
36_A	62_A	1.436	1.00
178_E	196_V	1.431	1.00
22_L	26_T	1.413	1.00
279_V	287_E	1.402	1.00
325_S	331_I	1.391	1.00
230_K	263_Y	1.381	1.00
231_Y	299_V	1.378	1.00
243_G	357_Q	1.371	1.00
231_Y	349_V	1.368	1.00
251_I	279_V	1.361	1.00
280_S	283_T	1.356	1.00
291_A	321_T	1.351	1.00
349_V	353_A	1.344	1.00
212_P	215_D	1.342	1.00
217_L	356_I	1.335	1.00
249_H	287_E	1.331	1.00
223_L	250_I	1.321	1.00
344_V	355_A	1.314	1.00
238_Q	349_V	1.297	1.00
372_R	375_Q	1.294	1.00
8_Y	28_L	1.292	1.00
175_V	181_R	1.289	1.00
218_L	251_I	1.289	1.00
263_Y	266_D	1.284	1.00
226_K	300_I	1.283	1.00
262_Q	266_D	1.283	1.00
174_V	390_L	1.281	1.00
5_G	36_A	1.276	1.00
235_A	352_L	1.273	1.00
8_Y	125_H	1.268	1.00
29_K	32_G	1.252	1.00
185_R	191_T	1.250	1.00
36_A	60_Y	1.248	1.00
385_Q	388_D	1.246	1.00
217_L	295_V	1.240	1.00
219_T	232_A	1.240	1.00
190_V	193_D	1.239	1.00
249_H	291_A	1.237	1.00
229_H	250_I	1.236	1.00
389_D	392_A	1.220	1.00
276_L	279_V	1.216	1.00
285_R	319_S	1.211	1.00
351_Q	354_A	1.211	1.00
178_E	182_Q	1.208	1.00
243_G	361_D	1.206	1.00
174_V	393_V	1.202	1.00
215_D	360_L	1.189	1.00
124_A	145_C	1.185	1.00
215_D	292_A	1.173	1.00
258_P	261_K	1.172	1.00
206_F	319_S	1.169	1.00
367_G	371_T	1.160	1.00
182_Q	185_R	1.157	1.00
237_S	241_A	1.140	1.00
261_K	265_S	1.140	1.00
20_F	311_V	1.134	1.00
205_K	285_R	1.134	1.00
8_Y	25_I	1.133	1.00
296_L	313_L	1.133	1.00
309_M	314_K	1.130	1.00
258_P	262_Q	1.128	1.00
150_H	311_V	1.108	1.00
299_V	347_R	1.101	1.00
298_C	307_D	1.100	1.00
313_L	331_I	1.099	1.00
249_H	290_E	1.098	1.00
284_L	288_L	1.089	1.00
370_E	373_G	1.089	1.00
289_N	319_S	1.075	1.00
176_P	180_N	1.070	1.00
320_E	371_T	1.070	1.00
342_L	369_I	1.068	1.00
382_D	385_Q	1.067	1.00
325_S	343_L	1.065	1.00
337_D	355_A	1.063	1.00
353_A	357_Q	1.062	1.00
137_A	141_A	1.060	1.00
288_L	319_S	1.058	1.00
297_P	352_L	1.055	1.00
231_Y	347_R	1.055	1.00
326_T	344_V	1.047	1.00
231_Y	326_T	1.047	1.00
363_P	366_R	1.043	1.00
27_E	31_R	1.039	1.00
216_R	291_A	1.039	1.00
230_K	234_E	1.038	1.00
296_L	312_V	1.037	1.00
215_D	247_E	1.036	1.00
383_I	386_S	1.035	1.00
354_A	358_R	1.028	1.00
281_D	284_L	1.028	1.00
321_T	370_E	1.023	1.00
222_R	226_K	1.019	1.00
365_L	369_I	1.014	1.00
264_A	275_F	1.012	1.00
386_S	389_D	1.012	1.00
182_Q	186_N	1.006	1.00
176_P	199_A	1.006	1.00
359_L	369_I	1.005	1.00
175_V	184_L	1.001	1.00
231_Y	234_E	0.994	1.00
239_L	246_V	0.989	1.00
234_E	267_L	0.989	1.00
344_V	352_L	0.986	1.00
276_L	287_E	0.982	1.00
230_K	299_V	0.979	1.00
220_V	288_L	0.977	1.00
238_Q	241_A	0.976	1.00
217_L	236_V	0.969	1.00
285_R	289_N	0.967	1.00
264_A	269_I	0.965	1.00
294_F	312_V	0.964	1.00
239_L	356_I	0.961	1.00
310_P	331_I	0.958	1.00
218_L	287_E	0.958	1.00
124_A	147_V	0.956	1.00
240_V	243_G	0.954	1.00
388_D	392_A	0.954	1.00
363_P	367_G	0.953	1.00
206_F	285_R	0.952	1.00
233_L	264_A	0.951	1.00
330_A	333_E	0.950	1.00
317_M	323_C	0.947	1.00
176_P	308_A	0.938	1.00
371_T	375_Q	0.938	1.00
25_I	37_V	0.936	1.00
342_L	359_L	0.936	1.00
23_N	26_T	0.935	1.00
6_I	33_H	0.935	1.00
23_N	383_I	0.935	1.00
307_D	310_P	0.934	1.00
183_Y	186_N	0.929	1.00
220_V	251_I	0.927	1.00
325_S	335_I	0.921	1.00
230_K	259_Q	0.919	1.00
125_H	150_H	0.915	1.00
203_T	382_D	0.908	1.00
232_A	297_P	0.905	1.00
316_A	321_T	0.904	1.00
175_V	180_N	0.904	1.00
386_S	390_L	0.898	1.00
199_A	311_V	0.898	1.00
259_Q	262_Q	0.897	1.00
106_R	110_E	0.894	1.00
200_T	386_S	0.893	1.00
236_V	272_H	0.891	1.00
317_M	373_G	0.884	1.00
109_L	140_H	0.884	1.00
215_D	245_D	0.883	1.00
227_K	307_D	0.882	1.00
19_S	23_N	0.881	1.00
340_D	373_G	0.880	1.00
219_T	250_I	0.879	1.00
313_L	323_C	0.877	1.00
239_L	360_L	0.877	1.00
324_V	344_V	0.875	1.00
313_L	325_S	0.874	1.00
293_L	359_L	0.874	1.00
367_G	370_E	0.871	1.00
170_V	173_V	0.871	1.00
195_S	393_V	0.866	1.00
145_C	170_V	0.862	1.00
231_Y	352_L	0.861	1.00
235_A	353_A	0.859	1.00
370_E	374_R	0.859	1.00
237_S	240_V	0.858	1.00
342_L	365_L	0.857	1.00
259_Q	263_Y	0.855	1.00
202_K	205_K	0.853	1.00
247_E	272_H	0.851	1.00
246_V	360_L	0.849	1.00
224_V	255_K	0.847	1.00
214_E	245_D	0.841	1.00
161_E	164_R	0.840	1.00
329_S	332_P	0.839	1.00
313_L	334_L	0.838	1.00
322_A	370_E	0.836	1.00
345_P	348_D	0.835	1.00
219_T	297_P	0.828	1.00
369_I	372_R	0.826	1.00
174_V	197_I	0.826	1.00
262_Q	265_S	0.824	1.00
239_L	353_A	0.824	1.00
388_D	391_L	0.817	1.00
25_I	29_K	0.814	1.00
197_I	393_V	0.814	1.00
20_F	150_H	0.811	1.00
382_D	386_S	0.809	1.00
288_L	321_T	0.807	1.00
324_V	355_A	0.806	1.00
146_I	174_V	0.806	1.00
296_L	331_I	0.805	1.00
293_L	356_I	0.804	1.00
295_V	356_I	0.799	1.00
218_L	288_L	0.798	1.00
227_K	312_V	0.796	1.00
21_V	125_H	0.796	1.00
287_E	290_E	0.794	1.00
350_E	354_A	0.794	1.00
292_A	366_R	0.794	1.00
219_T	294_F	0.791	1.00
5_G	119_I	0.788	1.00
376_T	381_F	0.788	1.00
322_A	359_L	0.787	1.00
317_M	340_D	0.785	1.00
221_A	229_H	0.783	1.00
10_V	21_V	0.782	1.00
223_L	257_E	0.782	1.00
136_H	140_H	0.780	1.00
151_A	226_K	0.779	1.00
23_N	202_K	0.776	1.00
138_S	145_C	0.776	1.00
179_Y	182_Q	0.775	1.00
337_D	340_D	0.775	1.00
235_A	349_V	0.774	1.00
20_F	148_T	0.771	1.00
286_N	290_E	0.769	1.00
234_E	237_S	0.769	1.00
264_A	273_V	0.767	1.00
237_S	269_I	0.764	1.00
209_S	289_N	0.763	1.00
198_P	333_E	0.760	1.00
125_H	148_T	0.759	1.00
328_V	331_I	0.754	1.00
234_E	238_Q	0.752	1.00
335_I	343_L	0.750	1.00
198_P	389_D	0.749	1.00
29_K	35_V	0.749	1.00
317_M	376_T	0.747	1.00
230_K	256_L	0.745	1.00
383_I	387_I	0.743	1.00
150_H	176_P	0.741	1.00
195_S	389_D	0.741	1.00
176_P	311_V	0.738	1.00
185_R	194_I	0.735	1.00
286_N	289_N	0.731	1.00
368_E	371_T	0.731	1.00
264_A	267_L	0.728	1.00
384_A	388_D	0.728	1.00
281_D	285_R	0.726	1.00
225_E	230_K	0.724	1.00
225_E	299_V	0.718	1.00
140_H	143_I	0.716	1.00
144_P	171_D	0.714	1.00
197_I	390_L	0.712	1.00
23_N	27_E	0.711	1.00
327_S	343_L	0.709	1.00
198_P	381_F	0.708	1.00
31_R	384_A	0.706	1.00
338_G	358_R	0.703	1.00
358_R	361_D	0.703	1.00
8_Y	35_V	0.703	1.00
10_V	17_S	0.700	1.00
8_Y	123_N	0.697	1.00
20_F	199_A	0.695	1.00
310_P	313_L	0.694	1.00
146_I	172_H	0.694	1.00
111_A	117_L	0.694	1.00
24_E	390_L	0.690	1.00
354_A	357_Q	0.689	1.00
183_Y	187_E	0.689	1.00
296_L	310_P	0.685	1.00
121_V	394_F	0.684	1.00
309_M	381_F	0.684	1.00
123_N	390_L	0.683	1.00
227_K	298_C	0.680	1.00
217_L	246_V	0.679	1.00
219_T	248_Y	0.679	1.00
326_T	346_P	0.674	1.00
392_A	395_R	0.673	1.00
202_K	206_F	0.671	1.00
326_T	352_L	0.670	1.00
245_D	272_H	0.669	1.00
165_R	169_G	0.668	1.00
36_A	40_Q	0.668	1.00
121_V	146_I	0.668	1.00
324_V	359_L	0.668	1.00
314_K	381_F	0.665	1.00
254_G	257_E	0.662	1.00
220_V	294_F	0.661	1.00
25_I	35_V	0.661	1.00
139_N	169_G	0.661	1.00
31_R	387_I	0.661	1.00
179_Y	183_Y	0.661	1.00
332_P	343_L	0.657	1.00
374_R	377_V	0.656	1.00
390_L	394_F	0.654	1.00
19_S	281_D	0.654	1.00
359_L	366_R	0.652	1.00
105_A	109_L	0.651	1.00
340_D	372_R	0.648	1.00
364_T	368_E	0.648	1.00
225_E	256_L	0.647	1.00
203_T	318_A	0.643	1.00
141_A	144_P	0.642	1.00
350_E	353_A	0.642	1.00
217_L	360_L	0.642	1.00
252_G	277_D	0.640	1.00
261_K	275_F	0.633	1.00
30_R	384_A	0.631	1.00
216_R	287_E	0.628	1.00
195_S	198_P	0.628	1.00
29_K	33_H	0.627	1.00
240_V	244_Y	0.626	1.00
364_T	367_G	0.626	1.00
369_I	373_G	0.626	1.00
215_D	246_V	0.623	1.00
243_G	246_V	0.623	1.00
58_P	63_Q	0.622	1.00
317_M	370_E	0.621	1.00
106_R	109_L	0.621	1.00
12_S	18_E	0.620	1.00
295_V	352_L	0.619	1.00
335_I	340_D	0.618	1.00
337_D	342_L	0.616	1.00
19_S	22_L	0.616	1.00
185_R	188_A	0.616	1.00
97_Q	100_H	0.613	1.00
146_I	394_F	0.613	1.00
221_A	227_K	0.612	1.00
324_V	356_I	0.611	1.00
20_F	390_L	0.610	1.00
60_Y	63_Q	0.609	1.00
233_L	273_V	0.608	1.00
17_S	126_F	0.608	1.00
124_A	134_A	0.607	1.00
164_R	168_H	0.607	1.00
287_E	291_A	0.606	1.00
362_D	366_R	0.603	1.00
236_V	239_L	0.603	1.00
373_G	376_T	0.601	1.00
344_V	351_Q	0.600	1.00
279_V	284_L	0.600	1.00
189_A	193_D	0.598	1.00
122_I	138_S	0.598	1.00
138_S	141_A	0.597	1.00
288_L	312_V	0.595	1.00
29_K	58_P	0.591	1.00
215_D	293_L	0.591	1.00
244_Y	361_D	0.590	1.00
239_L	244_Y	0.590	1.00
107_R	110_E	0.589	1.00
23_N	311_V	0.588	1.00
207_E	289_N	0.587	1.00
161_E	165_R	0.586	1.00
260_L	275_F	0.585	1.00
312_V	316_A	0.583	1.00
197_I	389_D	0.581	1.00
178_E	198_P	0.581	1.00
7_L	122_I	0.580	1.00
232_A	236_V	0.579	1.00
180_N	183_Y	0.578	1.00
20_F	125_H	0.578	1.00
387_I	391_L	0.578	1.00
148_T	390_L	0.577	1.00
256_L	260_L	0.576	1.00
205_K	281_D	0.576	1.00
126_F	129_P	0.574	1.00
59_V	62_A	0.574	1.00
294_F	323_C	0.574	1.00
261_K	264_A	0.573	1.00
102_L	106_R	0.572	1.00
372_R	376_T	0.572	1.00
228_G	347_R	0.571	1.00
119_I	122_I	0.569	1.00
7_L	36_A	0.569	1.00
229_H	256_L	0.568	1.00
228_G	297_P	0.563	1.00
235_A	356_I	0.562	1.00
293_L	360_L	0.561	1.00
20_F	24_E	0.561	1.00
207_E	210_G	0.557	1.00
8_Y	394_F	0.552	1.00
26_T	30_R	0.550	1.00
177_S	180_N	0.549	1.00
223_L	229_H	0.549	1.00
179_Y	332_P	0.547	1.00
380_T	385_Q	0.546	1.00
180_N	308_A	0.546	1.00
26_T	57_L	0.544	1.00
103_L	107_R	0.544	1.00
310_P	314_K	0.544	1.00
288_L	294_F	0.544	1.00
204_E	207_E	0.544	1.00
138_S	171_D	0.541	1.00
119_I	143_I	0.540	1.00
239_L	243_G	0.539	1.00
218_L	294_F	0.538	1.00
115_L	141_A	0.538	1.00
175_V	196_V	0.536	1.00
248_Y	273_V	0.536	1.00
5_G	117_L	0.535	1.00
148_T	174_V	0.535	1.00
293_L	366_R	0.534	1.00
218_L	249_H	0.534	1.00
189_A	192_N	0.534	1.00
366_R	369_I	0.534	1.00
34_E	60_Y	0.534	1.00
97_Q	101_S	0.533	1.00
13_F	22_L	0.532	1.00
27_E	383_I	0.531	1.00
240_V	246_V	0.530	1.00
225_E	259_Q	0.529	1.00
243_G	360_L	0.529	1.00
264_A	270_S	0.529	1.00
145_C	171_D	0.528	1.00
230_K	260_L	0.524	1.00
233_L	260_L	0.524	1.00
298_C	312_V	0.523	1.00
297_P	326_T	0.523	1.00
32_G	35_V	0.519	1.00
222_R	227_K	0.519	1.00
122_I	143_I	0.518	1.00
24_E	27_E	0.516	1.00
96_K	99_G	0.516	1.00
198_P	309_M	0.515	1.00
39_A	61_Y	0.513	1.00
105_A	108_C	0.513	1.00
316_A	323_C	0.511	1.00
98_I	101_S	0.511	1.00
322_A	366_R	0.510	1.00
150_H	199_A	0.510	1.00
292_A	363_P	0.510	1.00
231_Y	235_A	0.510	1.00
320_E	370_E	0.508	1.00
33_H	395_R	0.506	1.00
181_R	191_T	0.506	1.00
152_Y	155_F	0.506	1.00
235_A	239_L	0.506	1.00
218_L	321_T	0.505	1.00
314_K	377_V	0.505	1.00
380_T	389_D	0.502	1.00
288_L	316_A	0.502	1.00
58_P	61_Y	0.501	1.00
317_M	377_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2r60A	1	0.9221	100	0.175	Contact Map
3c48A	2	0.907	100	0.184	Contact Map
4n9wA	1	0.8518	100	0.191	Contact Map
3froA	3	0.9296	100	0.204	Contact Map
2x6qA	1	0.8844	100	0.21	Contact Map
3okpA	1	0.892	100	0.212	Contact Map
1rzuA	1	0.9296	100	0.213	Contact Map
3s28A	4	0.9447	100	0.229	Contact Map
2qzsA	1	0.9271	100	0.231	Contact Map
2x0dA	2	0.8417	100	0.232	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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