GREMLIN Database
Q9HQQ0 - Uncharacterized protein
UniProt: Q9HQQ0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 398 (347)
Sequences: 49657 (41796)
Seq/√Len: 2243.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
218_L291_A4.6591.00
247_E274_A3.6981.00
257_E261_K3.3601.00
172_H195_S3.1901.00
216_R249_H3.0611.00
294_F316_A3.0561.00
123_N394_F2.9381.00
249_H276_L2.7381.00
376_T380_T2.6941.00
238_Q353_A2.6771.00
234_E263_Y2.6521.00
5_G34_E2.6311.00
219_T229_H2.6061.00
240_V272_H2.4391.00
234_E349_V2.2531.00
181_R185_R2.2521.00
36_A119_I2.1811.00
228_G231_Y2.1551.00
36_A117_L2.1061.00
251_I287_E2.0931.00
263_Y267_L2.0921.00
256_L259_Q2.0571.00
216_R247_E2.0531.00
236_V248_Y2.0411.00
216_R290_E2.0341.00
238_Q350_E2.0331.00
362_D365_L2.0281.00
355_A358_R2.0241.00
249_H274_A2.0121.00
327_S332_P2.0051.00
33_H391_L1.9601.00
335_I341_G1.9181.00
7_L119_I1.8821.00
217_L293_L1.8421.00
320_E374_R1.8391.00
265_S270_S1.8341.00
358_R365_L1.8231.00
366_R370_E1.8171.00
228_G299_V1.8131.00
327_S345_P1.8071.00
340_D376_T1.8061.00
385_Q389_D1.7991.00
336_T339_E1.7961.00
214_E247_E1.7821.00
123_N148_T1.7741.00
345_P351_Q1.7671.00
342_L355_A1.7391.00
178_E181_R1.7331.00
237_S267_L1.7211.00
294_F321_T1.7111.00
358_R362_D1.7011.00
31_R388_D1.6971.00
172_H393_V1.6831.00
181_R196_V1.6721.00
279_V283_T1.6671.00
200_T383_I1.6641.00
147_V170_V1.6491.00
336_T376_T1.6431.00
232_A248_Y1.6351.00
178_E333_E1.6241.00
357_Q361_D1.5851.00
175_V194_I1.5841.00
236_V246_V1.5731.00
239_L357_Q1.5691.00
31_R391_L1.5541.00
7_L38_F1.5531.00
348_D351_Q1.5331.00
365_L368_E1.5311.00
27_E384_A1.5231.00
232_A295_V1.5161.00
27_E30_R1.5121.00
351_Q355_A1.5081.00
342_L358_R1.5051.00
336_T340_D1.5041.00
339_E372_R1.4971.00
181_R194_I1.4951.00
368_E372_R1.4881.00
391_L395_R1.4781.00
375_Q379_E1.4751.00
283_T286_N1.4711.00
27_E387_I1.4671.00
251_I276_L1.4661.00
216_R292_A1.4641.00
220_V284_L1.4581.00
253_Q257_E1.4491.00
36_A62_A1.4361.00
178_E196_V1.4311.00
22_L26_T1.4131.00
279_V287_E1.4021.00
325_S331_I1.3911.00
230_K263_Y1.3811.00
231_Y299_V1.3781.00
243_G357_Q1.3711.00
231_Y349_V1.3681.00
251_I279_V1.3611.00
280_S283_T1.3561.00
291_A321_T1.3511.00
349_V353_A1.3441.00
212_P215_D1.3421.00
217_L356_I1.3351.00
249_H287_E1.3311.00
223_L250_I1.3211.00
344_V355_A1.3141.00
238_Q349_V1.2971.00
372_R375_Q1.2941.00
8_Y28_L1.2921.00
175_V181_R1.2891.00
218_L251_I1.2891.00
263_Y266_D1.2841.00
226_K300_I1.2831.00
262_Q266_D1.2831.00
174_V390_L1.2811.00
5_G36_A1.2761.00
235_A352_L1.2731.00
8_Y125_H1.2681.00
29_K32_G1.2521.00
185_R191_T1.2501.00
36_A60_Y1.2481.00
385_Q388_D1.2461.00
217_L295_V1.2401.00
219_T232_A1.2401.00
190_V193_D1.2391.00
249_H291_A1.2371.00
229_H250_I1.2361.00
389_D392_A1.2201.00
276_L279_V1.2161.00
285_R319_S1.2111.00
351_Q354_A1.2111.00
178_E182_Q1.2081.00
243_G361_D1.2061.00
174_V393_V1.2021.00
215_D360_L1.1891.00
124_A145_C1.1851.00
215_D292_A1.1731.00
258_P261_K1.1721.00
206_F319_S1.1691.00
367_G371_T1.1601.00
182_Q185_R1.1571.00
237_S241_A1.1401.00
261_K265_S1.1401.00
20_F311_V1.1341.00
205_K285_R1.1341.00
8_Y25_I1.1331.00
296_L313_L1.1331.00
309_M314_K1.1301.00
258_P262_Q1.1281.00
150_H311_V1.1081.00
299_V347_R1.1011.00
298_C307_D1.1001.00
313_L331_I1.0991.00
249_H290_E1.0981.00
284_L288_L1.0891.00
370_E373_G1.0891.00
289_N319_S1.0751.00
176_P180_N1.0701.00
320_E371_T1.0701.00
342_L369_I1.0681.00
382_D385_Q1.0671.00
325_S343_L1.0651.00
337_D355_A1.0631.00
353_A357_Q1.0621.00
137_A141_A1.0601.00
288_L319_S1.0581.00
297_P352_L1.0551.00
231_Y347_R1.0551.00
326_T344_V1.0471.00
231_Y326_T1.0471.00
363_P366_R1.0431.00
27_E31_R1.0391.00
216_R291_A1.0391.00
230_K234_E1.0381.00
296_L312_V1.0371.00
215_D247_E1.0361.00
383_I386_S1.0351.00
354_A358_R1.0281.00
281_D284_L1.0281.00
321_T370_E1.0231.00
222_R226_K1.0191.00
365_L369_I1.0141.00
264_A275_F1.0121.00
386_S389_D1.0121.00
182_Q186_N1.0061.00
176_P199_A1.0061.00
359_L369_I1.0051.00
175_V184_L1.0011.00
231_Y234_E0.9941.00
239_L246_V0.9891.00
234_E267_L0.9891.00
344_V352_L0.9861.00
276_L287_E0.9821.00
230_K299_V0.9791.00
220_V288_L0.9771.00
238_Q241_A0.9761.00
217_L236_V0.9691.00
285_R289_N0.9671.00
264_A269_I0.9651.00
294_F312_V0.9641.00
239_L356_I0.9611.00
310_P331_I0.9581.00
218_L287_E0.9581.00
124_A147_V0.9561.00
240_V243_G0.9541.00
388_D392_A0.9541.00
363_P367_G0.9531.00
206_F285_R0.9521.00
233_L264_A0.9511.00
330_A333_E0.9501.00
317_M323_C0.9471.00
176_P308_A0.9381.00
371_T375_Q0.9381.00
25_I37_V0.9361.00
342_L359_L0.9361.00
23_N26_T0.9351.00
6_I33_H0.9351.00
23_N383_I0.9351.00
307_D310_P0.9341.00
183_Y186_N0.9291.00
220_V251_I0.9271.00
325_S335_I0.9211.00
230_K259_Q0.9191.00
125_H150_H0.9151.00
203_T382_D0.9081.00
232_A297_P0.9051.00
316_A321_T0.9041.00
175_V180_N0.9041.00
386_S390_L0.8981.00
199_A311_V0.8981.00
259_Q262_Q0.8971.00
106_R110_E0.8941.00
200_T386_S0.8931.00
236_V272_H0.8911.00
317_M373_G0.8841.00
109_L140_H0.8841.00
215_D245_D0.8831.00
227_K307_D0.8821.00
19_S23_N0.8811.00
340_D373_G0.8801.00
219_T250_I0.8791.00
313_L323_C0.8771.00
239_L360_L0.8771.00
324_V344_V0.8751.00
313_L325_S0.8741.00
293_L359_L0.8741.00
367_G370_E0.8711.00
170_V173_V0.8711.00
195_S393_V0.8661.00
145_C170_V0.8621.00
231_Y352_L0.8611.00
235_A353_A0.8591.00
370_E374_R0.8591.00
237_S240_V0.8581.00
342_L365_L0.8571.00
259_Q263_Y0.8551.00
202_K205_K0.8531.00
247_E272_H0.8511.00
246_V360_L0.8491.00
224_V255_K0.8471.00
214_E245_D0.8411.00
161_E164_R0.8401.00
329_S332_P0.8391.00
313_L334_L0.8381.00
322_A370_E0.8361.00
345_P348_D0.8351.00
219_T297_P0.8281.00
369_I372_R0.8261.00
174_V197_I0.8261.00
262_Q265_S0.8241.00
239_L353_A0.8241.00
388_D391_L0.8171.00
25_I29_K0.8141.00
197_I393_V0.8141.00
20_F150_H0.8111.00
382_D386_S0.8091.00
288_L321_T0.8071.00
324_V355_A0.8061.00
146_I174_V0.8061.00
296_L331_I0.8051.00
293_L356_I0.8041.00
295_V356_I0.7991.00
218_L288_L0.7981.00
227_K312_V0.7961.00
21_V125_H0.7961.00
287_E290_E0.7941.00
350_E354_A0.7941.00
292_A366_R0.7941.00
219_T294_F0.7911.00
5_G119_I0.7881.00
376_T381_F0.7881.00
322_A359_L0.7871.00
317_M340_D0.7851.00
221_A229_H0.7831.00
10_V21_V0.7821.00
223_L257_E0.7821.00
136_H140_H0.7801.00
151_A226_K0.7791.00
23_N202_K0.7761.00
138_S145_C0.7761.00
179_Y182_Q0.7751.00
337_D340_D0.7751.00
235_A349_V0.7741.00
20_F148_T0.7711.00
286_N290_E0.7691.00
234_E237_S0.7691.00
264_A273_V0.7671.00
237_S269_I0.7641.00
209_S289_N0.7631.00
198_P333_E0.7601.00
125_H148_T0.7591.00
328_V331_I0.7541.00
234_E238_Q0.7521.00
335_I343_L0.7501.00
198_P389_D0.7491.00
29_K35_V0.7491.00
317_M376_T0.7471.00
230_K256_L0.7451.00
383_I387_I0.7431.00
150_H176_P0.7411.00
195_S389_D0.7411.00
176_P311_V0.7381.00
185_R194_I0.7351.00
286_N289_N0.7311.00
368_E371_T0.7311.00
264_A267_L0.7281.00
384_A388_D0.7281.00
281_D285_R0.7261.00
225_E230_K0.7241.00
225_E299_V0.7181.00
140_H143_I0.7161.00
144_P171_D0.7141.00
197_I390_L0.7121.00
23_N27_E0.7111.00
327_S343_L0.7091.00
198_P381_F0.7081.00
31_R384_A0.7061.00
338_G358_R0.7031.00
358_R361_D0.7031.00
8_Y35_V0.7031.00
10_V17_S0.7001.00
8_Y123_N0.6971.00
20_F199_A0.6951.00
310_P313_L0.6941.00
146_I172_H0.6941.00
111_A117_L0.6941.00
24_E390_L0.6901.00
354_A357_Q0.6891.00
183_Y187_E0.6891.00
296_L310_P0.6851.00
121_V394_F0.6841.00
309_M381_F0.6841.00
123_N390_L0.6831.00
227_K298_C0.6801.00
217_L246_V0.6791.00
219_T248_Y0.6791.00
326_T346_P0.6741.00
392_A395_R0.6731.00
202_K206_F0.6711.00
326_T352_L0.6701.00
245_D272_H0.6691.00
165_R169_G0.6681.00
36_A40_Q0.6681.00
121_V146_I0.6681.00
324_V359_L0.6681.00
314_K381_F0.6651.00
254_G257_E0.6621.00
220_V294_F0.6611.00
25_I35_V0.6611.00
139_N169_G0.6611.00
31_R387_I0.6611.00
179_Y183_Y0.6611.00
332_P343_L0.6571.00
374_R377_V0.6561.00
390_L394_F0.6541.00
19_S281_D0.6541.00
359_L366_R0.6521.00
105_A109_L0.6511.00
340_D372_R0.6481.00
364_T368_E0.6481.00
225_E256_L0.6471.00
203_T318_A0.6431.00
141_A144_P0.6421.00
350_E353_A0.6421.00
217_L360_L0.6421.00
252_G277_D0.6401.00
261_K275_F0.6331.00
30_R384_A0.6311.00
216_R287_E0.6281.00
195_S198_P0.6281.00
29_K33_H0.6271.00
240_V244_Y0.6261.00
364_T367_G0.6261.00
369_I373_G0.6261.00
215_D246_V0.6231.00
243_G246_V0.6231.00
58_P63_Q0.6221.00
317_M370_E0.6211.00
106_R109_L0.6211.00
12_S18_E0.6201.00
295_V352_L0.6191.00
335_I340_D0.6181.00
337_D342_L0.6161.00
19_S22_L0.6161.00
185_R188_A0.6161.00
97_Q100_H0.6131.00
146_I394_F0.6131.00
221_A227_K0.6121.00
324_V356_I0.6111.00
20_F390_L0.6101.00
60_Y63_Q0.6091.00
233_L273_V0.6081.00
17_S126_F0.6081.00
124_A134_A0.6071.00
164_R168_H0.6071.00
287_E291_A0.6061.00
362_D366_R0.6031.00
236_V239_L0.6031.00
373_G376_T0.6011.00
344_V351_Q0.6001.00
279_V284_L0.6001.00
189_A193_D0.5981.00
122_I138_S0.5981.00
138_S141_A0.5971.00
288_L312_V0.5951.00
29_K58_P0.5911.00
215_D293_L0.5911.00
244_Y361_D0.5901.00
239_L244_Y0.5901.00
107_R110_E0.5891.00
23_N311_V0.5881.00
207_E289_N0.5871.00
161_E165_R0.5861.00
260_L275_F0.5851.00
312_V316_A0.5831.00
197_I389_D0.5811.00
178_E198_P0.5811.00
7_L122_I0.5801.00
232_A236_V0.5791.00
180_N183_Y0.5781.00
20_F125_H0.5781.00
387_I391_L0.5781.00
148_T390_L0.5771.00
256_L260_L0.5761.00
205_K281_D0.5761.00
126_F129_P0.5741.00
59_V62_A0.5741.00
294_F323_C0.5741.00
261_K264_A0.5731.00
102_L106_R0.5721.00
372_R376_T0.5721.00
228_G347_R0.5711.00
119_I122_I0.5691.00
7_L36_A0.5691.00
229_H256_L0.5681.00
228_G297_P0.5631.00
235_A356_I0.5621.00
293_L360_L0.5611.00
20_F24_E0.5611.00
207_E210_G0.5571.00
8_Y394_F0.5521.00
26_T30_R0.5501.00
177_S180_N0.5491.00
223_L229_H0.5491.00
179_Y332_P0.5471.00
380_T385_Q0.5461.00
180_N308_A0.5461.00
26_T57_L0.5441.00
103_L107_R0.5441.00
310_P314_K0.5441.00
288_L294_F0.5441.00
204_E207_E0.5441.00
138_S171_D0.5411.00
119_I143_I0.5401.00
239_L243_G0.5391.00
218_L294_F0.5381.00
115_L141_A0.5381.00
175_V196_V0.5361.00
248_Y273_V0.5361.00
5_G117_L0.5351.00
148_T174_V0.5351.00
293_L366_R0.5341.00
218_L249_H0.5341.00
189_A192_N0.5341.00
366_R369_I0.5341.00
34_E60_Y0.5341.00
97_Q101_S0.5331.00
13_F22_L0.5321.00
27_E383_I0.5311.00
240_V246_V0.5301.00
225_E259_Q0.5291.00
243_G360_L0.5291.00
264_A270_S0.5291.00
145_C171_D0.5281.00
230_K260_L0.5241.00
233_L260_L0.5241.00
298_C312_V0.5231.00
297_P326_T0.5231.00
32_G35_V0.5191.00
222_R227_K0.5191.00
122_I143_I0.5181.00
24_E27_E0.5161.00
96_K99_G0.5161.00
198_P309_M0.5151.00
39_A61_Y0.5131.00
105_A108_C0.5131.00
316_A323_C0.5111.00
98_I101_S0.5111.00
322_A366_R0.5101.00
150_H199_A0.5101.00
292_A363_P0.5101.00
231_Y235_A0.5101.00
320_E370_E0.5081.00
33_H395_R0.5061.00
181_R191_T0.5061.00
152_Y155_F0.5061.00
235_A239_L0.5061.00
218_L321_T0.5051.00
314_K377_V0.5051.00
380_T389_D0.5021.00
288_L316_A0.5021.00
58_P61_Y0.5011.00
317_M377_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r60A 1 0.9221 100 0.175 Contact Map
3c48A 2 0.907 100 0.184 Contact Map
4n9wA 1 0.8518 100 0.191 Contact Map
3froA 3 0.9296 100 0.204 Contact Map
2x6qA 1 0.8844 100 0.21 Contact Map
3okpA 1 0.892 100 0.212 Contact Map
1rzuA 1 0.9296 100 0.213 Contact Map
3s28A 4 0.9447 100 0.229 Contact Map
2qzsA 1 0.9271 100 0.231 Contact Map
2x0dA 2 0.8417 100 0.232 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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