GREMLIN Database
Q9HQP7 - Uncharacterized protein
UniProt: Q9HQP7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 338 (267)
Sequences: 167 (150)
Seq/√Len: 9.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
177_T194_Y7.0991.00
180_A192_V4.2980.99
173_P251_R3.6710.97
92_V103_N3.6610.97
228_W276_E3.6050.97
94_T287_S3.5990.97
58_K89_T3.4400.96
73_H276_E3.2980.94
65_V271_I3.1090.92
203_G247_S2.9900.91
201_F276_E2.8910.89
96_T124_F2.8450.89
231_V241_L2.7530.87
277_A290_H2.6090.84
173_P203_G2.5910.83
228_W285_A2.5690.83
96_T195_F2.5020.81
260_V268_Y2.4210.79
117_T188_A2.3790.77
86_V299_A2.3130.75
59_D267_R2.2970.75
62_C263_T2.2410.73
148_T272_G2.2250.72
242_G276_E2.2100.72
96_T160_W2.1660.70
168_L172_P2.1600.70
96_T272_G2.0850.67
62_C268_Y2.0570.66
77_L250_R2.0440.65
254_A260_V2.0300.65
88_P295_K1.9860.63
123_A330_R1.9680.62
170_V228_W1.9590.62
73_H242_G1.9580.62
120_T127_D1.9400.61
248_N276_E1.8810.59
206_R247_S1.8780.58
164_W170_V1.8660.58
164_W330_R1.8110.56
71_H86_V1.7970.55
327_T330_R1.6900.50
56_R153_F1.6880.50
116_A153_F1.6850.50
170_V199_A1.6810.50
121_S176_T1.6770.50
120_T164_W1.6650.49
237_S240_E1.6520.49
96_T104_W1.6500.48
120_T123_A1.6370.48
54_E103_N1.6080.47
276_E287_S1.6060.47
186_D306_D1.6000.46
180_A190_M1.5400.44
96_T148_T1.5320.43
123_A228_W1.5060.42
160_W164_W1.5040.42
82_F86_V1.4870.41
96_T149_P1.4440.40
100_L160_W1.4250.39
177_T259_L1.4210.39
62_C99_Y1.4170.38
107_T111_P1.4030.38
78_F82_F1.3950.38
160_W234_G1.3910.37
73_H201_F1.3850.37
93_A98_E1.3800.37
157_V179_R1.3410.35
96_T122_E1.3400.35
123_A164_W1.3370.35
262_Q305_K1.3180.34
100_L124_F1.3120.34
331_L336_Y1.3080.34
331_L335_G1.3080.34
205_R267_R1.2860.33
190_M327_T1.2740.33
228_W242_G1.2690.33
71_H88_P1.2550.32
82_F270_L1.2470.32
108_Y111_P1.2420.31
150_I269_V1.2420.31
100_L164_W1.2400.31
121_S171_C1.2310.31
48_Q92_V1.2240.31
120_T153_F1.2090.30
65_V152_H1.2020.30
202_I251_R1.1990.30
203_G251_R1.1800.29
53_A93_A1.1800.29
122_E245_Y1.1790.29
74_L86_V1.1770.29
164_W228_W1.1680.29
331_L334_L1.1660.29
56_R194_Y1.1610.28
94_T284_F1.1510.28
164_W171_C1.1490.28
181_I262_Q1.1410.28
194_Y252_V1.1330.27
92_V102_Y1.1300.27
60_S91_T1.1260.27
245_Y276_E1.1200.27
68_A326_T1.1170.27
68_A276_E1.1170.27
84_G299_A1.1150.27
163_S175_P1.1080.27
119_V180_A1.0970.26
55_L167_E1.0950.26
65_V99_Y1.0820.26
49_A294_N1.0810.26
173_P209_L1.0680.25
260_V305_K1.0650.25
62_C267_R1.0610.25
188_A306_D1.0580.25
277_A288_M1.0560.25
76_T328_R1.0550.25
314_Y317_P1.0520.25
64_I263_T1.0520.25
276_E285_A1.0490.25
174_E309_P1.0460.25
83_E301_V1.0450.25
68_A281_Y1.0390.24
96_T294_N1.0380.24
54_E58_K1.0360.24
154_T157_V1.0330.24
159_V163_S1.0260.24
185_D188_A1.0210.24
154_T188_A1.0190.24
65_V264_Q1.0170.24
156_L299_A1.0120.23
288_M293_V1.0100.23
159_V176_T1.0100.23
199_A276_E1.0080.23
62_C194_Y1.0050.23
72_D245_Y0.9960.23
120_T176_T0.9940.23
262_Q311_M0.9840.23
241_L284_F0.9820.23
111_P188_A0.9740.22
261_S270_L0.9740.22
85_R166_S0.9730.22
75_E269_V0.9720.22
242_G278_L0.9650.22
100_L149_P0.9640.22
159_V169_R0.9640.22
174_E255_A0.9610.22
123_A165_D0.9590.22
231_V242_G0.9540.22
201_F228_W0.9380.21
183_R186_D0.9300.21
277_A293_V0.9290.21
329_S333_E0.9210.21
185_D267_R0.9200.21
186_D269_V0.9070.20
174_E258_K0.9030.20
117_T258_K0.8990.20
117_T186_D0.8950.20
100_L125_E0.8940.20
58_K269_V0.8890.20
229_D284_F0.8840.20
204_E327_T0.8800.20
253_L259_L0.8760.19
162_D179_R0.8670.19
78_F99_Y0.8670.19
227_V278_L0.8650.19
96_T157_V0.8610.19
182_A190_M0.8520.19
65_V272_G0.8490.19
173_P202_I0.8480.19
117_T154_T0.8440.19
171_C201_F0.8390.18
76_T246_S0.8380.18
291_P317_P0.8350.18
58_K216_I0.8340.18
270_L299_A0.8310.18
324_T333_E0.8300.18
194_Y259_L0.8260.18
61_F91_T0.8200.18
75_E202_I0.8180.18
72_D280_E0.8140.18
188_A266_D0.8140.18
318_T321_E0.8060.18
170_V287_S0.8060.18
195_F276_E0.7960.17
271_I324_T0.7930.17
268_Y303_T0.7930.17
83_E304_T0.7910.17
233_S239_S0.7900.17
99_Y299_A0.7880.17
153_F234_G0.7820.17
203_G206_R0.7820.17
111_P178_R0.7800.17
231_V284_F0.7790.17
124_F294_N0.7750.17
167_E332_K0.7740.17
153_F228_W0.7740.17
123_A153_F0.7730.17
98_E271_I0.7730.17
254_A270_L0.7720.17
117_T281_Y0.7710.17
48_Q102_Y0.7710.17
55_L269_V0.7650.17
70_R245_Y0.7640.17
188_A309_P0.7610.16
45_L50_D0.7590.16
58_K300_E0.7570.16
120_T125_E0.7540.16
66_L70_R0.7460.16
88_P305_K0.7450.16
120_T160_W0.7440.16
309_P312_W0.7400.16
222_K226_D0.7370.16
62_C188_A0.7370.16
229_D243_Q0.7370.16
202_I233_S0.7340.16
107_T272_G0.7330.16
173_P201_F0.7320.16
216_I332_K0.7310.16
60_S122_E0.7290.16
56_R116_A0.7270.16
180_A284_F0.7260.16
120_T234_G0.7250.16
258_K309_P0.7230.16
59_D238_T0.7200.15
313_E316_A0.7180.15
96_T110_Y0.7170.15
93_A215_T0.7160.15
170_V276_E0.7150.15
188_A281_Y0.7150.15
183_R188_A0.7100.15
73_H278_L0.7100.15
61_F193_H0.7050.15
172_P291_P0.7020.15
256_V261_S0.7000.15
264_Q301_V0.6990.15
55_L241_L0.6970.15
79_P255_A0.6920.15
167_E202_I0.6900.15
166_S320_N0.6880.15
95_N195_F0.6870.15
252_V303_T0.6870.15
156_L164_W0.6850.15
84_G275_G0.6850.15
89_T100_L0.6840.15
118_P173_P0.6820.15
251_R280_E0.6800.15
119_V195_F0.6770.15
117_T307_G0.6770.15
264_Q275_G0.6770.15
177_T252_V0.6760.15
103_N269_V0.6750.14
108_Y152_H0.6740.14
204_E247_S0.6710.14
173_P276_E0.6700.14
233_S293_V0.6670.14
84_G189_R0.6660.14
106_E246_S0.6650.14
74_L78_F0.6640.14
56_R109_A0.6630.14
55_L93_A0.6600.14
58_K250_R0.6590.14
230_A236_I0.6580.14
170_V330_R0.6580.14
267_R306_D0.6570.14
174_E304_T0.6560.14
201_F222_K0.6550.14
231_V276_E0.6520.14
176_T333_E0.6510.14
190_M222_K0.6490.14
78_F299_A0.6470.14
151_N241_L0.6400.14
45_L191_V0.6390.14
182_A272_G0.6390.14
266_D302_E0.6380.14
86_V307_G0.6360.14
228_W248_N0.6330.14
54_E270_L0.6330.14
301_V304_T0.6320.14
199_A228_W0.6320.14
232_K242_G0.6300.14
119_V330_R0.6280.13
225_E272_G0.6280.13
96_T181_I0.6270.13
53_A92_V0.6260.13
160_W165_D0.6170.13
234_G280_E0.6150.13
257_S260_V0.6150.13
125_E149_P0.6140.13
64_I195_F0.6120.13
173_P237_S0.6090.13
83_E191_V0.6070.13
194_Y262_Q0.6070.13
120_T156_L0.6040.13
44_A323_G0.6040.13
236_I256_V0.6040.13
74_L299_A0.6020.13
56_R257_S0.6020.13
110_Y314_Y0.6010.13
75_E167_E0.5990.13
165_D192_V0.5980.13
77_L178_R0.5930.13
54_E57_R0.5910.13
64_I310_S0.5910.13
76_T236_I0.5900.13
223_I234_G0.5880.13
59_D295_K0.5880.13
158_E161_R0.5880.13
117_T277_A0.5860.13
102_Y294_N0.5850.13
99_Y187_A0.5830.13
153_F287_S0.5820.13
182_A330_R0.5790.13
66_L298_W0.5780.12
102_Y333_E0.5770.12
57_R323_G0.5770.12
306_D312_W0.5720.12
110_Y155_D0.5710.12
54_E92_V0.5710.12
249_L253_L0.5710.12
117_T187_A0.5660.12
192_V253_L0.5650.12
323_G326_T0.5650.12
170_V241_L0.5640.12
85_R320_N0.5640.12
293_V300_E0.5630.12
55_L96_T0.5630.12
317_P324_T0.5620.12
257_S275_G0.5610.12
208_D247_S0.5610.12
269_V293_V0.5600.12
46_P51_L0.5600.12
162_D184_A0.5590.12
160_W228_W0.5580.12
161_R312_W0.5570.12
50_D111_P0.5570.12
158_E205_R0.5540.12
55_L293_V0.5540.12
248_N330_R0.5520.12
319_E329_S0.5520.12
177_T262_Q0.5500.12
57_R321_E0.5480.12
99_Y302_E0.5470.12
174_E287_S0.5460.12
100_L192_V0.5450.12
148_T152_H0.5440.12
183_R262_Q0.5420.12
160_W330_R0.5420.12
95_N272_G0.5420.12
173_P191_V0.5410.12
56_R177_T0.5390.12
193_H334_L0.5380.12
186_D263_T0.5360.12
303_T329_S0.5280.12
73_H246_S0.5260.12
74_L103_N0.5260.12
96_T159_V0.5250.12
238_T276_E0.5240.11
257_S308_C0.5210.11
96_T155_D0.5210.11
208_D242_G0.5190.11
103_N308_C0.5180.11
258_K302_E0.5170.11
108_Y250_R0.5170.11
65_V322_T0.5160.11
100_L191_V0.5150.11
68_A193_H0.5150.11
201_F248_N0.5140.11
229_D295_K0.5130.11
64_I239_S0.5120.11
159_V249_L0.5120.11
89_T333_E0.5110.11
90_K216_I0.5090.11
252_V270_L0.5070.11
62_C110_Y0.5060.11
123_A201_F0.5050.11
207_P269_V0.5050.11
123_A234_G0.5040.11
237_S292_L0.5030.11
67_D286_H0.5000.11
67_D274_H0.5000.11
67_D273_D0.5000.11
67_D297_P0.5000.11
67_D200_P0.5000.11
67_D198_H0.5000.11
273_D297_P0.5000.11
286_H297_P0.5000.11
67_D197_P0.5000.11
274_H297_P0.5000.11
274_H286_H0.5000.11
198_H297_P0.5000.11
198_H286_H0.5000.11
198_H274_H0.5000.11
198_H273_D0.5000.11
197_P297_P0.5000.11
197_P286_H0.5000.11
197_P274_H0.5000.11
197_P273_D0.5000.11
197_P200_P0.5000.11
200_P273_D0.5000.11
200_P274_H0.5000.11
200_P286_H0.5000.11
273_D286_H0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tn0A 1 0.7308 98.6 0.913 Contact Map
4kavA 1 0.8047 98.2 0.922 Contact Map
2vqrA 3 0.7988 98.2 0.923 Contact Map
4uphA 2 0.7929 98.1 0.925 Contact Map
4upkA 3 0.8018 98.1 0.926 Contact Map
2qzuA 2 0.8107 98 0.926 Contact Map
3b5qA 1 0.7515 98 0.927 Contact Map
4uplA 2 0.8077 97.9 0.928 Contact Map
4upiA 2 0.7988 97.9 0.929 Contact Map
2w8dA 1 0.7722 97.8 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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