Q9HQP5 - HALSA - GREMLIN Contacts

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Q9HQP5 - Uncharacterized protein

UniProt:	Q9HQP5	Sequences: MAESLLASVSNHFEWRYLQFRYRISSERISRTIGSVESSFHVDTYREFLRVVDYQNEEFVIEALLDTIRSDDVLWDIGANIGTHSCYIGQKAGQTIAIEPFPDNAQRARENCSLNDVDATVCEYAVGAHEGEATLAVPDTDDNVVGVGTFSLQTDARNAQSVDVDVVPGDQIIQNRGVALPDVIKIDVEGGEADVLRGFDRGLQNARAVLVEVHPRYVDRDEITRLLESHGFSVSILRQRNDEVHVLATVDDR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	253 (203)
Sequences:	1395 (1298)
Seq/√Len:	91.1

HALSA - Q9HQP5 Q9HSW3
SULSO - Q7LXE9 Q97X54 Q97XG4 Q97XU3 Q7LXG2 Q7LXF6 Q7LXE1 Q97XT4 Q7LXF9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
188_V	195_V	4.304	1.00
105_A	121_V	4.253	1.00
127_G	166_V	4.042	1.00
102_P	162_V	3.779	1.00
130_E	171_Q	3.137	1.00
79_A	97_A	3.061	1.00
132_E	163_D	3.015	1.00
168_P	171_Q	2.955	1.00
98_I	172_I	2.954	1.00
128_A	194_D	2.814	1.00
127_G	191_G	2.814	1.00
105_A	123_E	2.801	1.00
96_I	122_C	2.775	1.00
125_A	166_V	2.450	1.00
76_D	185_K	2.399	1.00
170_D	198_G	2.390	1.00
79_A	108_A	2.381	1.00
128_A	197_R	2.188	1.00
124_Y	167_V	2.127	1.00
170_D	199_F	2.090	1.00
132_E	165_D	2.071	1.00
169_G	199_F	2.035	1.00
134_T	163_D	2.020	1.00
101_F	104_N	2.016	1.00
100_P	123_E	1.999	1.00
98_I	126_V	1.991	1.00
170_D	203_L	1.958	1.00
134_T	161_S	1.942	1.00
94_Q	120_T	1.931	1.00
71_D	93_G	1.894	1.00
125_A	164_V	1.881	1.00
209_V	227_L	1.852	1.00
112_C	119_A	1.829	1.00
84_H	88_I	1.808	1.00
85_S	119_A	1.782	1.00
133_A	166_V	1.719	1.00
77_I	126_V	1.709	1.00
74_L	88_I	1.708	1.00
186_I	195_V	1.684	1.00
130_E	167_V	1.662	1.00
72_D	182_D	1.659	1.00
77_I	186_I	1.657	1.00
98_I	122_C	1.644	1.00
105_A	108_A	1.622	1.00
105_A	109_R	1.615	1.00
69_R	72_D	1.605	1.00
207_R	232_F	1.589	1.00
167_V	171_Q	1.587	1.00
86_C	111_N	1.558	1.00
122_C	172_I	1.545	1.00
77_I	195_V	1.414	0.99
130_E	168_P	1.409	0.99
112_C	121_V	1.397	0.99
183_V	210_L	1.309	0.99
61_I	83_T	1.305	0.99
79_A	99_E	1.291	0.99
74_L	95_T	1.285	0.99
184_I	209_V	1.276	0.99
199_F	203_L	1.270	0.99
193_A	197_R	1.240	0.98
57_E	60_V	1.209	0.98
126_V	167_V	1.207	0.98
80_N	212_E	1.206	0.98
60_V	210_L	1.205	0.98
68_I	74_L	1.193	0.98
100_P	125_A	1.188	0.98
75_W	181_P	1.188	0.98
200_D	204_Q	1.186	0.98
108_A	111_N	1.184	0.98
124_Y	165_D	1.176	0.98
89_G	117_V	1.175	0.98
109_R	123_E	1.169	0.98
188_V	192_E	1.155	0.97
197_R	222_E	1.151	0.97
170_D	201_R	1.145	0.97
184_I	199_F	1.138	0.97
101_F	137_V	1.138	0.97
126_V	195_V	1.135	0.97
89_G	95_T	1.130	0.97
127_G	194_D	1.127	0.97
101_F	135_L	1.108	0.97
74_L	93_G	1.101	0.97
187_D	212_E	1.091	0.96
127_G	131_G	1.075	0.96
83_T	87_Y	1.072	0.96
193_A	226_L	1.063	0.96
170_D	202_G	1.057	0.96
125_A	133_A	1.053	0.96
170_D	200_D	1.050	0.95
184_I	206_A	1.038	0.95
110_E	113_S	1.026	0.95
97_A	108_A	1.018	0.95
102_P	123_E	1.016	0.95
72_D	93_G	1.002	0.94
206_A	232_F	1.001	0.94
96_I	172_I	0.996	0.94
188_V	198_G	0.976	0.93
61_I	87_Y	0.974	0.93
75_W	169_G	0.970	0.93
120_T	176_R	0.964	0.93
74_L	85_S	0.946	0.92
80_N	83_T	0.945	0.92
68_I	88_I	0.943	0.92
225_R	229_S	0.940	0.92
84_H	214_H	0.934	0.92
172_I	176_R	0.923	0.91
199_F	202_G	0.922	0.91
64_L	74_L	0.919	0.91
86_C	115_N	0.908	0.91
195_V	198_G	0.901	0.90
213_V	223_I	0.894	0.90
54_Y	60_V	0.886	0.89
186_I	196_L	0.879	0.89
96_I	120_T	0.877	0.89
191_G	194_D	0.876	0.89
77_I	98_I	0.874	0.89
133_A	150_F	0.873	0.89
198_G	203_L	0.864	0.88
197_R	226_L	0.859	0.88
108_A	121_V	0.857	0.88
174_Q	201_R	0.855	0.88
226_L	230_H	0.855	0.88
169_G	202_G	0.849	0.87
150_F	166_V	0.849	0.87
126_V	169_G	0.843	0.87
189_E	214_H	0.832	0.86
188_V	191_G	0.831	0.86
104_N	148_G	0.829	0.86
127_G	133_A	0.817	0.85
189_E	192_E	0.816	0.85
104_N	108_A	0.814	0.85
112_C	117_V	0.811	0.85
95_T	119_A	0.810	0.85
98_I	168_P	0.809	0.85
85_S	97_A	0.808	0.85
228_E	234_V	0.808	0.85
111_N	114_L	0.808	0.85
181_P	206_A	0.806	0.85
207_R	233_S	0.804	0.84
60_V	63_A	0.800	0.84
147_V	189_E	0.793	0.84
84_H	183_V	0.787	0.83
126_V	168_P	0.781	0.83
104_N	111_N	0.778	0.82
126_V	199_F	0.772	0.82
200_D	230_H	0.771	0.82
84_H	87_Y	0.768	0.82
130_E	165_D	0.766	0.81
211_V	223_I	0.764	0.81
109_R	121_V	0.755	0.80
137_V	162_V	0.755	0.80
109_R	113_S	0.754	0.80
75_W	96_I	0.744	0.79
168_P	173_I	0.744	0.79
33_I	36_V	0.742	0.79
80_N	185_K	0.741	0.79
84_H	210_L	0.739	0.79
135_L	148_G	0.733	0.78
144_V	147_V	0.730	0.78
98_I	124_Y	0.730	0.78
168_P	198_G	0.729	0.78
75_W	184_I	0.724	0.78
78_G	190_G	0.718	0.77
200_D	203_L	0.717	0.77
125_A	131_G	0.714	0.77
69_R	182_D	0.712	0.76
99_E	105_A	0.711	0.76
75_W	98_I	0.711	0.76
196_L	211_V	0.705	0.76
209_V	232_F	0.705	0.76
77_I	188_V	0.703	0.76
89_G	119_A	0.703	0.76
76_D	86_C	0.701	0.75
80_N	104_N	0.699	0.75
226_L	232_F	0.698	0.75
173_I	178_V	0.697	0.75
170_D	204_Q	0.696	0.75
73_V	182_D	0.691	0.74
112_C	115_N	0.689	0.74
100_P	166_V	0.689	0.74
44_T	47_E	0.683	0.73
100_P	105_A	0.677	0.73
85_S	95_T	0.676	0.73
70_S	92_A	0.676	0.73
167_V	172_I	0.676	0.73
71_D	92_A	0.667	0.72
128_A	205_N	0.662	0.71
204_Q	230_H	0.662	0.71
101_F	148_G	0.661	0.71
105_A	122_C	0.660	0.71
60_V	76_D	0.659	0.71
212_E	215_P	0.651	0.70
215_P	218_V	0.649	0.70
89_G	115_N	0.646	0.69
215_P	224_T	0.644	0.69
68_I	72_D	0.642	0.69
167_V	175_N	0.641	0.69
203_L	206_A	0.640	0.69
35_S	43_D	0.632	0.68
80_N	181_P	0.627	0.67
54_Y	68_I	0.626	0.67
63_A	237_L	0.620	0.66
77_I	198_G	0.618	0.66
131_G	165_D	0.617	0.66
211_V	224_T	0.617	0.66
224_T	228_E	0.616	0.66
133_A	164_V	0.614	0.65
73_V	180_L	0.613	0.65
193_A	196_L	0.612	0.65
222_E	225_R	0.610	0.65
125_A	162_V	0.609	0.65
40_F	44_T	0.609	0.65
79_A	85_S	0.608	0.65
189_E	212_E	0.607	0.64
92_A	95_T	0.605	0.64
73_V	96_I	0.605	0.64
184_I	231_G	0.603	0.64
68_I	71_D	0.599	0.63
83_T	86_C	0.596	0.63
49_L	53_D	0.593	0.63
85_S	112_C	0.593	0.63
182_D	207_R	0.593	0.63
193_A	222_E	0.592	0.63
191_G	214_H	0.590	0.62
194_D	197_R	0.589	0.62
221_D	233_S	0.585	0.62
77_I	184_I	0.585	0.62
135_L	162_V	0.582	0.61
47_E	56_N	0.580	0.61
49_L	52_V	0.579	0.61
35_S	39_S	0.578	0.61
33_I	42_V	0.576	0.60
208_A	232_F	0.573	0.60
133_A	137_V	0.571	0.60
113_S	118_D	0.568	0.59
135_L	161_S	0.568	0.59
202_G	206_A	0.567	0.59
41_H	196_L	0.566	0.59
89_G	93_G	0.565	0.59
183_V	208_A	0.562	0.59
55_Q	83_T	0.559	0.58
225_R	228_E	0.557	0.58
81_I	111_N	0.556	0.58
106_Q	116_D	0.555	0.58
215_P	219_D	0.555	0.58
44_T	115_N	0.553	0.57
186_I	192_E	0.553	0.57
192_E	211_V	0.553	0.57
63_A	67_T	0.552	0.57
169_G	195_V	0.551	0.57
197_R	200_D	0.551	0.57
76_D	97_A	0.547	0.57
46_R	81_I	0.547	0.57
92_A	182_D	0.544	0.56
227_L	234_V	0.543	0.56
217_Y	220_R	0.543	0.56
98_I	123_E	0.541	0.56
135_L	147_V	0.540	0.56
76_D	80_N	0.538	0.55
100_P	185_K	0.538	0.55
55_Q	60_V	0.538	0.55
47_E	107_R	0.538	0.55
56_N	88_I	0.537	0.55
221_D	224_T	0.537	0.55
60_V	237_L	0.535	0.55
40_F	47_E	0.535	0.55
214_H	217_Y	0.534	0.55
123_E	162_V	0.533	0.55
78_G	82_G	0.529	0.54
134_T	160_Q	0.529	0.54
85_S	88_I	0.529	0.54
136_A	149_T	0.527	0.54
86_C	89_G	0.526	0.54
57_E	213_V	0.524	0.53
105_A	111_N	0.523	0.53
174_Q	233_S	0.523	0.53
188_V	212_E	0.522	0.53
59_F	153_Q	0.522	0.53
79_A	107_R	0.522	0.53
131_G	166_V	0.522	0.53
133_A	194_D	0.520	0.53
76_D	79_A	0.520	0.53
137_V	148_G	0.520	0.53
83_T	214_H	0.516	0.52
35_S	40_F	0.516	0.52
93_G	182_D	0.516	0.52
200_D	226_L	0.516	0.52
68_I	81_I	0.516	0.52
162_V	165_D	0.514	0.52
188_V	213_V	0.513	0.52
46_R	53_D	0.512	0.52
120_T	225_R	0.511	0.52
107_R	111_N	0.510	0.51
197_R	203_L	0.510	0.51
74_L	182_D	0.509	0.51
60_V	186_I	0.508	0.51
186_I	199_F	0.508	0.51
72_D	232_F	0.508	0.51
90_Q	117_V	0.507	0.51
149_T	152_L	0.504	0.51
186_I	237_L	0.504	0.51
85_S	115_N	0.504	0.51
221_D	229_S	0.502	0.50
136_A	221_D	0.500	0.50

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2py6A	4	0.8735	100	0.433	Contact Map
3k6rA	1	0.7905	98.1	0.833	Contact Map
3v97A	1	0.8063	98.1	0.835	Contact Map
2b3tA	1	0.8696	98	0.835	Contact Map
2b78A	1	0.834	98	0.839	Contact Map
2nxcA	1	0.7589	98	0.839	Contact Map
3a27A	1	0.751	97.9	0.84	Contact Map
2jjqA	1	0.7787	97.9	0.841	Contact Map
3evzA	1	0.7391	97.9	0.842	Contact Map
3d2lA	1	0.7826	97.9	0.842	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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