GREMLIN Database
Q9HQP5 - Uncharacterized protein
UniProt: Q9HQP5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 253 (203)
Sequences: 1395 (1298)
Seq/√Len: 91.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
188_V195_V4.3041.00
105_A121_V4.2531.00
127_G166_V4.0421.00
102_P162_V3.7791.00
130_E171_Q3.1371.00
79_A97_A3.0611.00
132_E163_D3.0151.00
168_P171_Q2.9551.00
98_I172_I2.9541.00
128_A194_D2.8141.00
127_G191_G2.8141.00
105_A123_E2.8011.00
96_I122_C2.7751.00
125_A166_V2.4501.00
76_D185_K2.3991.00
170_D198_G2.3901.00
79_A108_A2.3811.00
128_A197_R2.1881.00
124_Y167_V2.1271.00
170_D199_F2.0901.00
132_E165_D2.0711.00
169_G199_F2.0351.00
134_T163_D2.0201.00
101_F104_N2.0161.00
100_P123_E1.9991.00
98_I126_V1.9911.00
170_D203_L1.9581.00
134_T161_S1.9421.00
94_Q120_T1.9311.00
71_D93_G1.8941.00
125_A164_V1.8811.00
209_V227_L1.8521.00
112_C119_A1.8291.00
84_H88_I1.8081.00
85_S119_A1.7821.00
133_A166_V1.7191.00
77_I126_V1.7091.00
74_L88_I1.7081.00
186_I195_V1.6841.00
130_E167_V1.6621.00
72_D182_D1.6591.00
77_I186_I1.6571.00
98_I122_C1.6441.00
105_A108_A1.6221.00
105_A109_R1.6151.00
69_R72_D1.6051.00
207_R232_F1.5891.00
167_V171_Q1.5871.00
86_C111_N1.5581.00
122_C172_I1.5451.00
77_I195_V1.4140.99
130_E168_P1.4090.99
112_C121_V1.3970.99
183_V210_L1.3090.99
61_I83_T1.3050.99
79_A99_E1.2910.99
74_L95_T1.2850.99
184_I209_V1.2760.99
199_F203_L1.2700.99
193_A197_R1.2400.98
57_E60_V1.2090.98
126_V167_V1.2070.98
80_N212_E1.2060.98
60_V210_L1.2050.98
68_I74_L1.1930.98
100_P125_A1.1880.98
75_W181_P1.1880.98
200_D204_Q1.1860.98
108_A111_N1.1840.98
124_Y165_D1.1760.98
89_G117_V1.1750.98
109_R123_E1.1690.98
188_V192_E1.1550.97
197_R222_E1.1510.97
170_D201_R1.1450.97
184_I199_F1.1380.97
101_F137_V1.1380.97
126_V195_V1.1350.97
89_G95_T1.1300.97
127_G194_D1.1270.97
101_F135_L1.1080.97
74_L93_G1.1010.97
187_D212_E1.0910.96
127_G131_G1.0750.96
83_T87_Y1.0720.96
193_A226_L1.0630.96
170_D202_G1.0570.96
125_A133_A1.0530.96
170_D200_D1.0500.95
184_I206_A1.0380.95
110_E113_S1.0260.95
97_A108_A1.0180.95
102_P123_E1.0160.95
72_D93_G1.0020.94
206_A232_F1.0010.94
96_I172_I0.9960.94
188_V198_G0.9760.93
61_I87_Y0.9740.93
75_W169_G0.9700.93
120_T176_R0.9640.93
74_L85_S0.9460.92
80_N83_T0.9450.92
68_I88_I0.9430.92
225_R229_S0.9400.92
84_H214_H0.9340.92
172_I176_R0.9230.91
199_F202_G0.9220.91
64_L74_L0.9190.91
86_C115_N0.9080.91
195_V198_G0.9010.90
213_V223_I0.8940.90
54_Y60_V0.8860.89
186_I196_L0.8790.89
96_I120_T0.8770.89
191_G194_D0.8760.89
77_I98_I0.8740.89
133_A150_F0.8730.89
198_G203_L0.8640.88
197_R226_L0.8590.88
108_A121_V0.8570.88
174_Q201_R0.8550.88
226_L230_H0.8550.88
169_G202_G0.8490.87
150_F166_V0.8490.87
126_V169_G0.8430.87
189_E214_H0.8320.86
188_V191_G0.8310.86
104_N148_G0.8290.86
127_G133_A0.8170.85
189_E192_E0.8160.85
104_N108_A0.8140.85
112_C117_V0.8110.85
95_T119_A0.8100.85
98_I168_P0.8090.85
85_S97_A0.8080.85
228_E234_V0.8080.85
111_N114_L0.8080.85
181_P206_A0.8060.85
207_R233_S0.8040.84
60_V63_A0.8000.84
147_V189_E0.7930.84
84_H183_V0.7870.83
126_V168_P0.7810.83
104_N111_N0.7780.82
126_V199_F0.7720.82
200_D230_H0.7710.82
84_H87_Y0.7680.82
130_E165_D0.7660.81
211_V223_I0.7640.81
109_R121_V0.7550.80
137_V162_V0.7550.80
109_R113_S0.7540.80
75_W96_I0.7440.79
168_P173_I0.7440.79
33_I36_V0.7420.79
80_N185_K0.7410.79
84_H210_L0.7390.79
135_L148_G0.7330.78
144_V147_V0.7300.78
98_I124_Y0.7300.78
168_P198_G0.7290.78
75_W184_I0.7240.78
78_G190_G0.7180.77
200_D203_L0.7170.77
125_A131_G0.7140.77
69_R182_D0.7120.76
99_E105_A0.7110.76
75_W98_I0.7110.76
196_L211_V0.7050.76
209_V232_F0.7050.76
77_I188_V0.7030.76
89_G119_A0.7030.76
76_D86_C0.7010.75
80_N104_N0.6990.75
226_L232_F0.6980.75
173_I178_V0.6970.75
170_D204_Q0.6960.75
73_V182_D0.6910.74
112_C115_N0.6890.74
100_P166_V0.6890.74
44_T47_E0.6830.73
100_P105_A0.6770.73
85_S95_T0.6760.73
70_S92_A0.6760.73
167_V172_I0.6760.73
71_D92_A0.6670.72
128_A205_N0.6620.71
204_Q230_H0.6620.71
101_F148_G0.6610.71
105_A122_C0.6600.71
60_V76_D0.6590.71
212_E215_P0.6510.70
215_P218_V0.6490.70
89_G115_N0.6460.69
215_P224_T0.6440.69
68_I72_D0.6420.69
167_V175_N0.6410.69
203_L206_A0.6400.69
35_S43_D0.6320.68
80_N181_P0.6270.67
54_Y68_I0.6260.67
63_A237_L0.6200.66
77_I198_G0.6180.66
131_G165_D0.6170.66
211_V224_T0.6170.66
224_T228_E0.6160.66
133_A164_V0.6140.65
73_V180_L0.6130.65
193_A196_L0.6120.65
222_E225_R0.6100.65
125_A162_V0.6090.65
40_F44_T0.6090.65
79_A85_S0.6080.65
189_E212_E0.6070.64
92_A95_T0.6050.64
73_V96_I0.6050.64
184_I231_G0.6030.64
68_I71_D0.5990.63
83_T86_C0.5960.63
49_L53_D0.5930.63
85_S112_C0.5930.63
182_D207_R0.5930.63
193_A222_E0.5920.63
191_G214_H0.5900.62
194_D197_R0.5890.62
221_D233_S0.5850.62
77_I184_I0.5850.62
135_L162_V0.5820.61
47_E56_N0.5800.61
49_L52_V0.5790.61
35_S39_S0.5780.61
33_I42_V0.5760.60
208_A232_F0.5730.60
133_A137_V0.5710.60
113_S118_D0.5680.59
135_L161_S0.5680.59
202_G206_A0.5670.59
41_H196_L0.5660.59
89_G93_G0.5650.59
183_V208_A0.5620.59
55_Q83_T0.5590.58
225_R228_E0.5570.58
81_I111_N0.5560.58
106_Q116_D0.5550.58
215_P219_D0.5550.58
44_T115_N0.5530.57
186_I192_E0.5530.57
192_E211_V0.5530.57
63_A67_T0.5520.57
169_G195_V0.5510.57
197_R200_D0.5510.57
76_D97_A0.5470.57
46_R81_I0.5470.57
92_A182_D0.5440.56
227_L234_V0.5430.56
217_Y220_R0.5430.56
98_I123_E0.5410.56
135_L147_V0.5400.56
76_D80_N0.5380.55
100_P185_K0.5380.55
55_Q60_V0.5380.55
47_E107_R0.5380.55
56_N88_I0.5370.55
221_D224_T0.5370.55
60_V237_L0.5350.55
40_F47_E0.5350.55
214_H217_Y0.5340.55
123_E162_V0.5330.55
78_G82_G0.5290.54
134_T160_Q0.5290.54
85_S88_I0.5290.54
136_A149_T0.5270.54
86_C89_G0.5260.54
57_E213_V0.5240.53
105_A111_N0.5230.53
174_Q233_S0.5230.53
188_V212_E0.5220.53
59_F153_Q0.5220.53
79_A107_R0.5220.53
131_G166_V0.5220.53
133_A194_D0.5200.53
76_D79_A0.5200.53
137_V148_G0.5200.53
83_T214_H0.5160.52
35_S40_F0.5160.52
93_G182_D0.5160.52
200_D226_L0.5160.52
68_I81_I0.5160.52
162_V165_D0.5140.52
188_V213_V0.5130.52
46_R53_D0.5120.52
120_T225_R0.5110.52
107_R111_N0.5100.51
197_R203_L0.5100.51
74_L182_D0.5090.51
60_V186_I0.5080.51
186_I199_F0.5080.51
72_D232_F0.5080.51
90_Q117_V0.5070.51
149_T152_L0.5040.51
186_I237_L0.5040.51
85_S115_N0.5040.51
221_D229_S0.5020.50
136_A221_D0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2py6A 4 0.8735 100 0.433 Contact Map
3k6rA 1 0.7905 98.1 0.833 Contact Map
3v97A 1 0.8063 98.1 0.835 Contact Map
2b3tA 1 0.8696 98 0.835 Contact Map
2b78A 1 0.834 98 0.839 Contact Map
2nxcA 1 0.7589 98 0.839 Contact Map
3a27A 1 0.751 97.9 0.84 Contact Map
2jjqA 1 0.7787 97.9 0.841 Contact Map
3evzA 1 0.7391 97.9 0.842 Contact Map
3d2lA 1 0.7826 97.9 0.842 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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