GREMLIN Database
Q9HQP4 - Uncharacterized protein
UniProt: Q9HQP4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 302 (242)
Sequences: 18343 (15659)
Seq/√Len: 1006.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
166_R170_E3.4251.00
20_D98_A3.3971.00
21_S51_G2.7881.00
109_T203_N2.6641.00
83_T87_N2.6381.00
12_S90_S2.4801.00
186_E190_R2.4191.00
17_V52_S2.3721.00
35_E108_E2.3191.00
103_D207_Y2.3031.00
75_Q79_A2.2401.00
26_N209_P2.2221.00
40_D67_Q2.1631.00
53_R57_R2.1521.00
25_K29_R2.1371.00
45_D70_V2.1221.00
119_V199_G2.0981.00
44_V84_G2.0841.00
113_A201_A2.0521.00
92_V114_M2.0411.00
11_V111_L1.9661.00
51_G54_R1.9551.00
94_A107_L1.9241.00
94_A163_L1.9181.00
15_I41_V1.9111.00
113_A199_G1.9111.00
19_N49_T1.9041.00
14_I84_G1.8911.00
53_R70_V1.8221.00
12_S40_D1.8191.00
102_V106_W1.8121.00
110_A163_L1.7631.00
69_L87_N1.7411.00
79_A177_A1.7221.00
168_V196_Y1.7191.00
53_R68_L1.7181.00
26_N101_T1.7171.00
15_I27_T1.7161.00
120_D165_R1.7081.00
10_H91_D1.6851.00
127_E207_Y1.6821.00
94_A106_W1.6671.00
29_R59_C1.6621.00
36_Y111_L1.6591.00
71_E83_T1.6421.00
25_K58_N1.6291.00
21_S55_R1.6181.00
43_V56_V1.6081.00
105_D109_T1.5951.00
86_Q174_P1.5911.00
92_V163_L1.5541.00
11_V107_L1.5531.00
45_D48_S1.5271.00
96_L102_V1.5181.00
25_K59_C1.5161.00
121_Y198_Q1.5161.00
83_T86_Q1.4941.00
10_H38_G1.4861.00
40_D90_S1.4771.00
120_D196_Y1.4761.00
17_V20_D1.4711.00
101_T207_Y1.4701.00
72_D75_Q1.4691.00
106_W110_A1.4621.00
17_V43_V1.4471.00
81_R97_D1.4431.00
93_L166_R1.4421.00
18_Y74_V1.4351.00
69_L83_T1.4311.00
110_A124_C1.3851.00
36_Y39_Y1.3841.00
88_A166_R1.3821.00
25_K55_R1.3701.00
67_Q87_N1.3371.00
81_R95_F1.3291.00
11_V163_L1.3261.00
29_R33_G1.3201.00
108_E112_G1.3171.00
168_V191_V1.3171.00
114_M163_L1.3131.00
19_N48_S1.2931.00
167_K171_D1.2831.00
44_V80_A1.2811.00
171_D194_A1.2771.00
12_S88_A1.2571.00
78_Y183_G1.2561.00
57_R60_A1.2481.00
57_R70_V1.2461.00
72_D83_T1.2421.00
176_D186_E1.2411.00
28_L41_V1.2371.00
162_L188_G1.2291.00
85_V95_F1.2281.00
85_V169_F1.2211.00
129_T207_Y1.2211.00
109_T112_G1.2211.00
77_S183_G1.2201.00
45_D53_R1.2191.00
15_I31_V1.2171.00
114_M122_L1.2081.00
27_T96_L1.2081.00
28_L59_C1.2011.00
92_V111_L1.1901.00
111_L115_Q1.1861.00
31_V96_L1.1851.00
40_D89_E1.1721.00
72_D79_A1.1711.00
127_E204_A1.1611.00
94_A102_V1.1591.00
91_D165_R1.1591.00
121_Y191_V1.1491.00
126_V160_C1.1471.00
20_D23_G1.1471.00
56_V68_L1.1241.00
125_N200_Y1.1231.00
39_Y107_L1.1231.00
46_N74_V1.1211.00
10_H89_E1.1201.00
211_R214_L1.1191.00
33_G104_E1.1191.00
41_V66_I1.1161.00
101_T209_P1.1151.00
17_V98_A1.1051.00
12_S42_Y1.1031.00
109_T201_A1.0981.00
10_H90_S1.0871.00
77_S81_R1.0841.00
171_D196_Y1.0731.00
71_E80_A1.0731.00
106_W124_C1.0651.00
35_E105_D1.0601.00
167_K170_E1.0481.00
28_L43_V1.0471.00
77_S215_E1.0441.00
79_A83_T1.0351.00
54_R57_R1.0331.00
101_T129_T1.0301.00
71_E75_Q1.0301.00
32_V66_I1.0261.00
105_D108_E1.0161.00
118_D197_E1.0141.00
169_F187_F1.0011.00
112_G116_E0.9991.00
85_V93_L0.9981.00
165_R168_V0.9831.00
13_C94_A0.9811.00
124_C205_T0.9731.00
30_S102_V0.9701.00
45_D71_E0.9691.00
110_A122_L0.9661.00
113_A116_E0.9651.00
16_P80_A0.9641.00
130_C134_T0.9571.00
58_N62_E0.9431.00
113_A122_L0.9391.00
67_Q89_E0.9351.00
109_T113_A0.9231.00
103_D127_E0.9171.00
46_N80_A0.9161.00
106_W205_T0.9151.00
32_V63_S0.9131.00
29_R32_V0.9121.00
46_N76_G0.9071.00
129_T209_P0.8961.00
172_V194_A0.8941.00
55_R59_C0.8921.00
17_V56_V0.8891.00
129_T133_D0.8791.00
54_R58_N0.8761.00
77_S159_T0.8751.00
51_G55_R0.8721.00
17_V24_I0.8561.00
13_C31_V0.8501.00
11_V94_A0.8441.00
28_L32_V0.8311.00
55_R58_N0.8311.00
35_E104_E0.8191.00
13_C107_L0.8161.00
81_R183_G0.8151.00
57_R68_L0.8041.00
137_G140_N0.8001.00
141_A144_G0.7991.00
159_T175_F0.7981.00
23_G209_P0.7971.00
78_Y82_K0.7961.00
227_G230_Q0.7951.00
31_V102_V0.7911.00
85_V88_A0.7891.00
32_V65_D0.7861.00
114_M119_V0.7701.00
123_G200_Y0.7701.00
27_T30_S0.7691.00
77_S80_A0.7671.00
30_S101_T0.7651.00
20_D211_R0.7601.00
29_R62_E0.7591.00
60_A66_I0.7581.00
120_D197_E0.7561.00
91_D115_Q0.7501.00
146_P149_E0.7491.00
46_N75_Q0.7451.00
60_A68_L0.7441.00
42_Y67_Q0.7331.00
58_N61_A0.7301.00
9_A115_Q0.7291.00
77_S97_D0.7271.00
49_T52_S0.7231.00
164_V188_G0.7201.00
95_F175_F0.7201.00
53_R71_E0.7181.00
159_T162_L0.7131.00
172_V191_V0.7081.00
24_I56_V0.7071.00
125_N202_E0.7071.00
123_G162_L0.7051.00
225_G228_F0.7051.00
187_F191_V0.7041.00
13_C39_Y0.7031.00
9_A91_D0.6981.00
80_A83_T0.6981.00
130_C133_D0.6941.00
109_T205_T0.6911.00
176_D190_R0.6911.00
110_A114_M0.6861.00
44_V83_T0.6851.00
10_H40_D0.6831.00
75_Q80_A0.6831.00
32_V59_C0.6831.00
14_I44_V0.6801.00
103_D106_W0.6761.00
168_V172_V0.6761.00
31_V41_V0.6741.00
128_L210_A0.6741.00
103_D205_T0.6731.00
42_Y87_N0.6701.00
82_K175_F0.6701.00
214_L217_L0.6691.00
120_D168_V0.6671.00
42_Y84_G0.6651.00
47_G72_D0.6641.00
164_V187_F0.6621.00
57_R61_A0.6601.00
17_V45_D0.6601.00
91_D167_K0.6571.00
53_R56_V0.6541.00
88_A93_L0.6521.00
160_C206_V0.6511.00
82_K174_P0.6511.00
168_V171_D0.6471.00
10_H36_Y0.6461.00
169_F174_P0.6431.00
19_N50_D0.6431.00
226_R230_Q0.6411.00
63_S66_I0.6411.00
174_P187_F0.6371.00
223_R227_G0.6361.00
75_Q83_T0.6331.00
164_V191_V0.6301.00
36_Y107_L0.6301.00
12_S166_R0.6261.00
124_C161_A0.6241.00
10_H39_Y0.6241.00
21_S25_K0.6231.00
182_G185_R0.6231.00
82_K177_A0.6211.00
24_I98_A0.6211.00
68_L71_E0.6181.00
153_D197_E0.6171.00
201_A204_A0.6161.00
85_V174_P0.6131.00
229_C233_R0.6121.00
220_K224_V0.6101.00
43_V66_I0.6101.00
52_S55_R0.6091.00
221_N224_V0.6051.00
111_L163_L0.6031.00
82_K86_Q0.6021.00
168_V195_G0.6011.00
117_Q199_G0.5971.00
34_Q107_L0.5961.00
100_E206_V0.5961.00
71_E79_A0.5961.00
27_T31_V0.5951.00
42_Y88_A0.5921.00
16_P98_A0.5901.00
113_A119_V0.5891.00
21_S50_D0.5861.00
210_A217_L0.5851.00
125_N204_A0.5821.00
131_P134_T0.5801.00
34_Q108_E0.5791.00
123_G157_A0.5771.00
120_D195_G0.5751.00
102_V107_L0.5741.00
94_A161_A0.5721.00
164_V169_F0.5691.00
75_Q177_A0.5681.00
147_V151_L0.5681.00
24_I52_S0.5661.00
247_T250_G0.5631.00
140_N143_T0.5631.00
112_G115_Q0.5621.00
59_C63_S0.5611.00
34_Q102_V0.5601.00
161_A206_V0.5581.00
15_I28_L0.5571.00
97_D183_G0.5561.00
114_M165_R0.5541.00
16_P81_R0.5541.00
231_K235_Y0.5531.00
27_T100_E0.5511.00
119_V165_R0.5481.00
117_Q120_D0.5481.00
152_E155_N0.5461.00
16_P46_N0.5451.00
92_V165_R0.5451.00
105_D203_N0.5441.00
192_H198_Q0.5431.00
122_L163_L0.5431.00
170_E174_P0.5431.00
135_L139_Y0.5421.00
96_L206_V0.5381.00
118_D165_R0.5381.00
146_P151_L0.5361.00
23_G211_R0.5361.00
15_I43_V0.5351.00
237_E240_G0.5311.00
25_K62_E0.5311.00
84_G88_A0.5281.00
27_T98_A0.5281.00
15_I96_L0.5281.00
176_D234_Y0.5271.00
9_A36_Y0.5261.00
56_V60_A0.5261.00
143_T146_P0.5251.00
24_I55_R0.5241.00
10_H115_Q0.5231.00
224_V228_F0.5231.00
157_A162_L0.5221.00
111_L114_M0.5221.00
185_R189_D0.5211.00
14_I88_A0.5211.00
21_S52_S0.5201.00
59_C62_E0.5201.00
222_F226_R0.5191.00
47_G74_V0.5171.00
93_L169_F0.5161.00
31_V34_Q0.5161.00
39_Y89_E0.5151.00
57_R71_E0.5131.00
120_D123_G0.5111.00
119_V122_L0.5091.00
193_D238_R0.5081.00
232_Q236_P0.5081.00
26_N29_R0.5081.00
11_V36_Y0.5071.00
126_V161_A0.5071.00
23_G27_T0.5051.00
141_A145_F0.5041.00
237_E241_K0.5021.00
245_P249_S0.5021.00
215_E218_A0.5011.00
113_A117_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bcvA 2 0.5828 100 0.344 Contact Map
2d7iA 1 1 100 0.352 Contact Map
1xhbA 1 0.9603 100 0.353 Contact Map
2z86A 2 0.8444 100 0.356 Contact Map
3l7iA 4 0 100 0.359 Contact Map
1qg8A 1 0.7285 100 0.361 Contact Map
5ajoA 1 0.9868 100 0.368 Contact Map
4fixA 3 0.9967 100 0.431 Contact Map
4p02A 1 0.9404 100 0.453 Contact Map
2bo4A 4 0.9172 100 0.456 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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