Q9HQP3 - HALSA - GREMLIN Contacts

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Q9HQP3 - Succinoglycan biosynthesis protein

UniProt:	Q9HQP3	Sequences: MPQSTILIQAPVTFPMMKVSVVVCTYSMDRYGPFADAVESVLAQTHDDLEVVLVVDGNDDVFERVRADFGDEEHVVLHCNDENQGISYSRTKGAKIASGDIVAFIDDDATAEDDWIEQLLGVYAETDAIAVGGDVVPDWQTQKPDFFPAEFYWLVGCVEPGFADDGEEVRNTYGSNISYRRDQFLDVGGYDPNTGRKGDKHLQAHEAPVGIRLREEYGRGMVFTRDARVHHKLFDYRGEFGWLVSRSFWQGYSKRVMDLLYPDAEDNKSSYLTQLLTRFVPTRARNLVQSPSVQRLQQLVAIFVFTAAVGLGYVYAIATPNLVAHANS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	328 (266)
Sequences:	15470 (12892)
Seq/√Len:	790.5

ECOLI - PGAC YIBD YAIP ARNC WCAA WCAE GTRB WBBL
BACSU - GGAA CGED YDAM GGAB EPSH SPSA EPSJ EPSE CSBB TUAG YKOT YKCC YFNE YWDF
HALSA - Q9HQP3 Q9HQP4 Q9HSC8 Q9HSB1 Q9HQP8 Q9HQQ6 Q9HNK3 Q9HR08
SULSO - Q97TY0 Q97TZ0 Q7LXF7 Q97W52 Q7LXY2 Q97UK7 Q97YM4 Q97WK7 Q97X05 Q97YG5 Q7LXG6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
181_R	185_L	3.816	1.00
45_T	117_E	3.095	1.00
28_M	107_D	3.034	1.00
29_D	61_V	2.780	1.00
208_P	212_R	2.778	1.00
20_S	99_G	2.689	1.00
27_S	59_D	2.605	1.00
20_S	50_E	2.586	1.00
50_E	76_V	2.497	1.00
118_Q	226_D	2.430	1.00
25_T	62_F	2.401	1.00
18_K	100_D	2.398	1.00
54_V	93_G	2.371	1.00
22_V	93_G	2.296	1.00
101_I	123_Y	2.275	1.00
80_N	92_K	2.255	1.00
112_E	230_H	2.181	1.00
111_A	115_W	2.137	1.00
119_L	178_S	2.131	1.00
129_I	219_R	2.102	1.00
39_E	69_F	2.089	1.00
63_E	67_A	2.086	1.00
19_V	120_L	2.073	1.00
122_V	224_T	2.048	1.00
183_Q	219_R	2.039	1.00
114_D	118_Q	2.037	1.00
35_A	39_E	2.026	1.00
20_S	97_A	2.024	1.00
55_V	58_N	1.976	1.00
95_K	189_G	1.958	1.00
92_K	96_I	1.957	1.00
90_R	106_D	1.956	1.00
86_I	90_R	1.935	1.00
40_S	111_A	1.903	1.00
103_A	178_S	1.901	1.00
128_A	222_V	1.893	1.00
35_A	68_D	1.849	1.00
36_D	110_T	1.834	1.00
26_Y	83_N	1.833	1.00
36_D	232_K	1.827	1.00
123_Y	178_S	1.813	1.00
25_T	107_D	1.784	1.00
101_I	178_S	1.771	1.00
130_A	221_M	1.765	1.00
27_S	58_N	1.750	1.00
46_H	120_L	1.742	1.00
29_D	65_V	1.731	1.00
61_V	64_R	1.714	1.00
186_D	216_E	1.713	1.00
55_V	79_C	1.708	1.00
94_A	184_F	1.682	1.00
35_A	65_V	1.674	1.00
186_D	219_R	1.671	1.00
53_L	66_R	1.662	1.00
76_V	96_I	1.636	1.00
94_A	102_V	1.634	1.00
90_R	104_F	1.632	1.00
87_S	205_H	1.626	1.00
182_D	186_D	1.605	1.00
84_Q	88_Y	1.578	1.00
25_T	28_M	1.568	1.00
46_H	49_L	1.564	1.00
23_V	51_V	1.556	1.00
19_V	116_I	1.556	1.00
18_K	48_D	1.538	1.00
115_W	119_L	1.512	1.00
103_A	115_W	1.512	1.00
23_V	37_A	1.464	1.00
67_A	79_C	1.462	1.00
39_E	43_A	1.440	1.00
50_E	98_S	1.425	1.00
54_V	89_S	1.413	1.00
50_E	99_G	1.412	1.00
102_V	181_R	1.394	1.00
122_V	126_T	1.375	1.00
40_S	110_T	1.374	1.00
117_E	121_G	1.368	1.00
123_Y	131_V	1.361	1.00
183_Q	213_L	1.355	1.00
118_Q	121_G	1.346	1.00
110_T	230_H	1.342	1.00
130_A	213_L	1.339	1.00
177_I	210_G	1.327	1.00
129_I	180_R	1.316	1.00
88_Y	192_P	1.314	1.00
20_S	52_V	1.312	1.00
56_D	83_N	1.312	1.00
92_K	95_K	1.310	1.00
35_A	69_F	1.308	1.00
78_H	96_I	1.303	1.00
19_V	178_S	1.302	1.00
105_I	111_A	1.300	1.00
103_A	116_I	1.299	1.00
122_V	222_V	1.270	1.00
136_V	230_H	1.269	1.00
101_I	120_L	1.262	1.00
37_A	105_I	1.253	1.00
191_D	208_P	1.248	1.00
97_A	181_R	1.239	1.00
45_T	114_D	1.233	1.00
64_R	67_A	1.232	1.00
61_V	65_V	1.226	1.00
114_D	117_E	1.217	1.00
182_D	185_L	1.216	1.00
75_V	79_C	1.208	1.00
63_E	79_C	1.193	1.00
90_R	205_H	1.169	1.00
42_L	73_E	1.166	1.00
103_A	111_A	1.163	1.00
25_T	53_L	1.145	1.00
63_E	77_L	1.130	1.00
94_A	104_F	1.128	1.00
86_I	106_D	1.123	1.00
81_D	84_Q	1.114	1.00
65_V	69_F	1.105	1.00
86_I	205_H	1.103	1.00
91_T	190_Y	1.100	1.00
119_L	123_Y	1.098	1.00
91_T	192_P	1.091	1.00
80_N	84_Q	1.071	1.00
184_F	209_V	1.061	1.00
65_V	68_D	1.053	1.00
18_K	99_G	1.053	1.00
134_D	223_F	1.051	1.00
132_G	172_T	1.048	1.00
100_D	180_R	1.046	1.00
110_T	232_K	1.034	1.00
86_I	174_G	1.031	1.00
94_A	97_A	1.017	1.00
21_V	103_A	1.017	1.00
135_V	175_S	1.013	1.00
104_F	190_Y	1.013	1.00
24_C	89_S	1.003	1.00
121_G	125_E	1.002	1.00
138_D	230_H	0.995	1.00
22_V	54_V	0.995	1.00
118_Q	224_T	0.990	1.00
187_V	213_L	0.990	1.00
189_G	209_V	0.989	1.00
68_D	72_E	0.979	1.00
129_I	183_Q	0.978	1.00
56_D	85_G	0.976	1.00
234_F	237_R	0.964	1.00
18_K	124_A	0.959	1.00
56_D	89_S	0.958	1.00
115_W	176_N	0.947	1.00
23_V	41_V	0.945	1.00
133_G	176_N	0.937	1.00
110_T	138_D	0.936	1.00
41_V	51_V	0.933	1.00
38_V	69_F	0.931	1.00
119_L	133_G	0.924	1.00
180_R	183_Q	0.920	1.00
129_I	220_G	0.914	1.00
112_E	228_R	0.907	1.00
100_D	182_D	0.898	1.00
67_A	70_G	0.898	1.00
68_D	71_D	0.897	1.00
191_D	260_L	0.896	1.00
21_V	41_V	0.896	1.00
119_L	131_V	0.895	1.00
101_I	180_R	0.894	1.00
109_A	231_H	0.893	1.00
41_V	105_I	0.893	1.00
138_D	142_Q	0.888	1.00
168_E	220_G	0.888	1.00
29_D	35_A	0.887	1.00
42_L	69_F	0.884	1.00
213_L	219_R	0.883	1.00
24_C	107_D	0.883	1.00
122_V	125_E	0.870	1.00
39_E	72_E	0.868	1.00
29_D	32_G	0.866	1.00
37_A	41_V	0.865	1.00
56_D	84_Q	0.863	1.00
28_M	33_P	0.861	1.00
81_D	92_K	0.859	1.00
122_V	131_V	0.855	1.00
138_D	232_K	0.853	1.00
38_V	51_V	0.853	1.00
64_R	68_D	0.850	1.00
49_L	116_I	0.844	1.00
106_D	205_H	0.841	1.00
38_V	42_L	0.836	1.00
174_G	190_Y	0.828	1.00
52_V	97_A	0.827	1.00
52_V	93_G	0.823	1.00
94_A	189_G	0.819	1.00
172_T	177_I	0.818	1.00
249_W	253_S	0.817	1.00
123_Y	180_R	0.815	1.00
183_Q	187_V	0.812	1.00
115_W	133_G	0.810	1.00
253_S	256_V	0.810	1.00
80_N	89_S	0.810	1.00
34_F	107_D	0.809	1.00
179_Y	209_V	0.807	1.00
126_T	220_G	0.805	1.00
87_S	91_T	0.804	1.00
55_V	63_E	0.803	1.00
18_K	98_S	0.803	1.00
20_S	181_R	0.800	1.00
25_T	34_F	0.791	1.00
46_H	117_E	0.789	1.00
139_W	143_K	0.782	1.00
128_A	180_R	0.777	1.00
39_E	42_L	0.775	1.00
120_L	124_A	0.773	1.00
54_V	92_K	0.771	1.00
37_A	40_S	0.767	1.00
88_Y	92_K	0.765	1.00
18_K	49_L	0.762	1.00
89_S	93_G	0.761	1.00
84_Q	92_K	0.755	1.00
66_R	77_L	0.754	1.00
24_C	90_R	0.753	1.00
55_V	80_N	0.750	1.00
27_S	62_F	0.747	1.00
57_G	81_D	0.747	1.00
24_C	56_D	0.747	1.00
183_Q	186_D	0.747	1.00
112_E	136_V	0.744	1.00
36_D	39_E	0.744	1.00
136_V	228_R	0.741	1.00
184_F	189_G	0.739	1.00
224_T	227_A	0.737	1.00
209_V	213_L	0.736	1.00
25_T	66_R	0.725	1.00
21_V	116_I	0.725	1.00
26_Y	57_G	0.723	1.00
239_E	242_W	0.721	1.00
43_A	113_D	0.720	1.00
174_G	206_E	0.718	1.00
119_L	227_A	0.715	1.00
44_Q	117_E	0.715	1.00
191_D	212_R	0.712	1.00
76_V	79_C	0.711	1.00
102_V	184_F	0.708	1.00
33_P	232_K	0.707	1.00
29_D	107_D	0.705	1.00
123_Y	128_A	0.704	1.00
78_H	92_K	0.700	1.00
126_T	222_V	0.693	1.00
119_L	122_V	0.691	1.00
115_W	228_R	0.691	1.00
173_Y	206_E	0.690	1.00
255_R	259_L	0.688	1.00
26_Y	56_D	0.679	1.00
23_V	53_L	0.676	1.00
251_G	254_K	0.676	1.00
16_M	47_D	0.675	1.00
41_V	111_A	0.675	1.00
100_D	124_A	0.673	1.00
21_V	49_L	0.672	1.00
42_L	72_E	0.672	1.00
70_G	73_E	0.670	1.00
89_S	106_D	0.669	1.00
34_F	66_R	0.668	1.00
28_M	234_F	0.668	1.00
18_K	50_E	0.667	1.00
42_L	75_V	0.667	1.00
52_V	76_V	0.664	1.00
22_V	104_F	0.663	1.00
37_A	42_L	0.663	1.00
210_G	221_M	0.662	1.00
247_S	250_Q	0.661	1.00
129_I	213_L	0.660	1.00
24_C	86_I	0.654	1.00
180_R	219_R	0.653	1.00
90_R	190_Y	0.652	1.00
44_Q	111_A	0.651	1.00
243_L	247_S	0.650	1.00
109_A	175_S	0.650	1.00
69_F	73_E	0.650	1.00
37_A	111_A	0.648	1.00
105_I	109_A	0.646	1.00
245_S	248_F	0.646	1.00
207_A	211_I	0.645	1.00
84_Q	89_S	0.644	1.00
174_G	177_I	0.643	1.00
19_V	103_A	0.642	1.00
119_L	176_N	0.641	1.00
111_A	176_N	0.641	1.00
81_D	88_Y	0.640	1.00
34_F	65_V	0.639	1.00
50_E	97_A	0.635	1.00
257_M	261_Y	0.635	1.00
56_D	80_N	0.635	1.00
16_M	48_D	0.634	1.00
101_I	124_A	0.633	1.00
51_V	75_V	0.628	1.00
44_Q	114_D	0.627	1.00
285_R	289_Q	0.626	1.00
179_Y	184_F	0.626	1.00
120_L	178_S	0.624	1.00
128_A	220_G	0.621	1.00
121_G	124_A	0.621	1.00
95_K	185_L	0.619	1.00
155_V	158_V	0.619	1.00
52_V	96_I	0.619	1.00
243_L	246_R	0.618	1.00
57_G	83_N	0.617	1.00
90_R	174_G	0.617	1.00
172_T	210_G	0.617	1.00
250_Q	253_S	0.615	1.00
136_V	227_A	0.614	1.00
89_S	92_K	0.614	1.00
34_F	62_F	0.614	1.00
262_P	265_E	0.613	1.00
288_V	292_S	0.611	1.00
214_R	221_M	0.608	1.00
111_A	229_V	0.602	1.00
244_V	247_S	0.599	1.00
35_A	72_E	0.598	1.00
244_V	248_F	0.598	1.00
54_V	80_N	0.596	1.00
246_R	250_Q	0.594	1.00
58_N	62_F	0.593	1.00
80_N	83_N	0.592	1.00
118_Q	227_A	0.592	1.00
22_V	94_A	0.591	1.00
91_T	95_K	0.590	1.00
252_Y	256_V	0.589	1.00
42_L	51_V	0.585	1.00
56_D	108_D	0.585	1.00
151_F	155_V	0.585	1.00
71_D	74_H	0.584	1.00
44_Q	115_W	0.582	1.00
16_M	117_E	0.582	1.00
156_G	159_E	0.581	1.00
253_S	261_Y	0.575	1.00
129_I	182_D	0.575	1.00
91_T	189_G	0.573	1.00
42_L	74_H	0.573	1.00
116_I	178_S	0.570	1.00
115_W	229_V	0.569	1.00
176_N	229_V	0.569	1.00
66_R	70_G	0.569	1.00
250_Q	254_K	0.569	1.00
22_V	90_R	0.568	1.00
151_F	154_L	0.567	1.00
109_A	229_V	0.567	1.00
37_A	109_A	0.567	1.00
273_T	277_T	0.566	1.00
38_V	53_L	0.566	1.00
184_F	190_Y	0.566	1.00
253_S	262_P	0.565	1.00
21_V	44_Q	0.564	1.00
120_L	123_Y	0.564	1.00
44_Q	49_L	0.564	1.00
20_S	98_S	0.558	1.00
175_S	231_H	0.553	1.00
253_S	260_L	0.552	1.00
191_D	194_T	0.551	1.00
275_L	279_F	0.550	1.00
147_F	150_E	0.549	1.00
59_D	62_F	0.545	1.00
286_N	292_S	0.544	1.00
144_P	148_P	0.543	1.00
256_V	259_L	0.543	1.00
274_Q	278_R	0.543	1.00
111_A	116_I	0.542	1.00
17_M	46_H	0.542	1.00
283_R	286_N	0.542	1.00
76_V	98_S	0.541	1.00
155_V	159_E	0.539	1.00
260_L	263_D	0.537	1.00
251_G	257_M	0.535	1.00
76_V	80_N	0.535	1.00
122_V	128_A	0.529	1.00
90_R	93_G	0.527	1.00
67_A	71_D	0.525	1.00
251_G	255_R	0.525	1.00
281_P	285_R	0.523	1.00
45_T	113_D	0.523	1.00
134_D	228_R	0.523	1.00
133_G	227_A	0.522	1.00
188_G	212_R	0.522	1.00
183_Q	218_G	0.522	1.00
97_A	102_V	0.521	1.00
28_M	34_F	0.521	1.00
122_V	178_S	0.521	1.00
69_F	72_E	0.520	1.00
119_L	224_T	0.519	1.00
153_W	157_C	0.516	1.00
45_T	49_L	0.515	1.00
272_L	275_L	0.515	1.00
38_V	41_V	0.510	1.00
67_A	80_N	0.510	1.00
22_V	97_A	0.509	1.00
174_G	210_G	0.509	1.00
130_A	177_I	0.508	1.00
255_R	258_D	0.505	1.00
277_T	280_V	0.504	1.00
118_Q	122_V	0.503	1.00
91_T	184_F	0.502	1.00
29_D	34_F	0.501	1.00
44_Q	116_I	0.501	1.00
187_V	216_E	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3bcvA	2	0.561	100	0.375	Contact Map
2z86A	2	0.8049	100	0.379	Contact Map
1qg8A	1	0.6829	100	0.384	Contact Map
3l7iA	4	0.0518	100	0.387	Contact Map
1xhbA	1	0.9268	100	0.396	Contact Map
2d7iA	1	0.9512	100	0.4	Contact Map
4p02A	1	0.9024	100	0.406	Contact Map
5ajoA	1	0.9421	100	0.408	Contact Map
4fixA	3	0.939	100	0.43	Contact Map
3ckjA	2	0.8293	100	0.449	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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