GREMLIN Database
Q9HQP3 - Succinoglycan biosynthesis protein
UniProt: Q9HQP3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 328 (266)
Sequences: 15470 (12892)
Seq/√Len: 790.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
181_R185_L3.8161.00
45_T117_E3.0951.00
28_M107_D3.0341.00
29_D61_V2.7801.00
208_P212_R2.7781.00
20_S99_G2.6891.00
27_S59_D2.6051.00
20_S50_E2.5861.00
50_E76_V2.4971.00
118_Q226_D2.4301.00
25_T62_F2.4011.00
18_K100_D2.3981.00
54_V93_G2.3711.00
22_V93_G2.2961.00
101_I123_Y2.2751.00
80_N92_K2.2551.00
112_E230_H2.1811.00
111_A115_W2.1371.00
119_L178_S2.1311.00
129_I219_R2.1021.00
39_E69_F2.0891.00
63_E67_A2.0861.00
19_V120_L2.0731.00
122_V224_T2.0481.00
183_Q219_R2.0391.00
114_D118_Q2.0371.00
35_A39_E2.0261.00
20_S97_A2.0241.00
55_V58_N1.9761.00
95_K189_G1.9581.00
92_K96_I1.9571.00
90_R106_D1.9561.00
86_I90_R1.9351.00
40_S111_A1.9031.00
103_A178_S1.9011.00
128_A222_V1.8931.00
35_A68_D1.8491.00
36_D110_T1.8341.00
26_Y83_N1.8331.00
36_D232_K1.8271.00
123_Y178_S1.8131.00
25_T107_D1.7841.00
101_I178_S1.7711.00
130_A221_M1.7651.00
27_S58_N1.7501.00
46_H120_L1.7421.00
29_D65_V1.7311.00
61_V64_R1.7141.00
186_D216_E1.7131.00
55_V79_C1.7081.00
94_A184_F1.6821.00
35_A65_V1.6741.00
186_D219_R1.6711.00
53_L66_R1.6621.00
76_V96_I1.6361.00
94_A102_V1.6341.00
90_R104_F1.6321.00
87_S205_H1.6261.00
182_D186_D1.6051.00
84_Q88_Y1.5781.00
25_T28_M1.5681.00
46_H49_L1.5641.00
23_V51_V1.5561.00
19_V116_I1.5561.00
18_K48_D1.5381.00
115_W119_L1.5121.00
103_A115_W1.5121.00
23_V37_A1.4641.00
67_A79_C1.4621.00
39_E43_A1.4401.00
50_E98_S1.4251.00
54_V89_S1.4131.00
50_E99_G1.4121.00
102_V181_R1.3941.00
122_V126_T1.3751.00
40_S110_T1.3741.00
117_E121_G1.3681.00
123_Y131_V1.3611.00
183_Q213_L1.3551.00
118_Q121_G1.3461.00
110_T230_H1.3421.00
130_A213_L1.3391.00
177_I210_G1.3271.00
129_I180_R1.3161.00
88_Y192_P1.3141.00
20_S52_V1.3121.00
56_D83_N1.3121.00
92_K95_K1.3101.00
35_A69_F1.3081.00
78_H96_I1.3031.00
19_V178_S1.3021.00
105_I111_A1.3001.00
103_A116_I1.2991.00
122_V222_V1.2701.00
136_V230_H1.2691.00
101_I120_L1.2621.00
37_A105_I1.2531.00
191_D208_P1.2481.00
97_A181_R1.2391.00
45_T114_D1.2331.00
64_R67_A1.2321.00
61_V65_V1.2261.00
114_D117_E1.2171.00
182_D185_L1.2161.00
75_V79_C1.2081.00
63_E79_C1.1931.00
90_R205_H1.1691.00
42_L73_E1.1661.00
103_A111_A1.1631.00
25_T53_L1.1451.00
63_E77_L1.1301.00
94_A104_F1.1281.00
86_I106_D1.1231.00
81_D84_Q1.1141.00
65_V69_F1.1051.00
86_I205_H1.1031.00
91_T190_Y1.1001.00
119_L123_Y1.0981.00
91_T192_P1.0911.00
80_N84_Q1.0711.00
184_F209_V1.0611.00
65_V68_D1.0531.00
18_K99_G1.0531.00
134_D223_F1.0511.00
132_G172_T1.0481.00
100_D180_R1.0461.00
110_T232_K1.0341.00
86_I174_G1.0311.00
94_A97_A1.0171.00
21_V103_A1.0171.00
135_V175_S1.0131.00
104_F190_Y1.0131.00
24_C89_S1.0031.00
121_G125_E1.0021.00
138_D230_H0.9951.00
22_V54_V0.9951.00
118_Q224_T0.9901.00
187_V213_L0.9901.00
189_G209_V0.9891.00
68_D72_E0.9791.00
129_I183_Q0.9781.00
56_D85_G0.9761.00
234_F237_R0.9641.00
18_K124_A0.9591.00
56_D89_S0.9581.00
115_W176_N0.9471.00
23_V41_V0.9451.00
133_G176_N0.9371.00
110_T138_D0.9361.00
41_V51_V0.9331.00
38_V69_F0.9311.00
119_L133_G0.9241.00
180_R183_Q0.9201.00
129_I220_G0.9141.00
112_E228_R0.9071.00
100_D182_D0.8981.00
67_A70_G0.8981.00
68_D71_D0.8971.00
191_D260_L0.8961.00
21_V41_V0.8961.00
119_L131_V0.8951.00
101_I180_R0.8941.00
109_A231_H0.8931.00
41_V105_I0.8931.00
138_D142_Q0.8881.00
168_E220_G0.8881.00
29_D35_A0.8871.00
42_L69_F0.8841.00
213_L219_R0.8831.00
24_C107_D0.8831.00
122_V125_E0.8701.00
39_E72_E0.8681.00
29_D32_G0.8661.00
37_A41_V0.8651.00
56_D84_Q0.8631.00
28_M33_P0.8611.00
81_D92_K0.8591.00
122_V131_V0.8551.00
138_D232_K0.8531.00
38_V51_V0.8531.00
64_R68_D0.8501.00
49_L116_I0.8441.00
106_D205_H0.8411.00
38_V42_L0.8361.00
174_G190_Y0.8281.00
52_V97_A0.8271.00
52_V93_G0.8231.00
94_A189_G0.8191.00
172_T177_I0.8181.00
249_W253_S0.8171.00
123_Y180_R0.8151.00
183_Q187_V0.8121.00
115_W133_G0.8101.00
253_S256_V0.8101.00
80_N89_S0.8101.00
34_F107_D0.8091.00
179_Y209_V0.8071.00
126_T220_G0.8051.00
87_S91_T0.8041.00
55_V63_E0.8031.00
18_K98_S0.8031.00
20_S181_R0.8001.00
25_T34_F0.7911.00
46_H117_E0.7891.00
139_W143_K0.7821.00
128_A180_R0.7771.00
39_E42_L0.7751.00
120_L124_A0.7731.00
54_V92_K0.7711.00
37_A40_S0.7671.00
88_Y92_K0.7651.00
18_K49_L0.7621.00
89_S93_G0.7611.00
84_Q92_K0.7551.00
66_R77_L0.7541.00
24_C90_R0.7531.00
55_V80_N0.7501.00
27_S62_F0.7471.00
57_G81_D0.7471.00
24_C56_D0.7471.00
183_Q186_D0.7471.00
112_E136_V0.7441.00
36_D39_E0.7441.00
136_V228_R0.7411.00
184_F189_G0.7391.00
224_T227_A0.7371.00
209_V213_L0.7361.00
25_T66_R0.7251.00
21_V116_I0.7251.00
26_Y57_G0.7231.00
239_E242_W0.7211.00
43_A113_D0.7201.00
174_G206_E0.7181.00
119_L227_A0.7151.00
44_Q117_E0.7151.00
191_D212_R0.7121.00
76_V79_C0.7111.00
102_V184_F0.7081.00
33_P232_K0.7071.00
29_D107_D0.7051.00
123_Y128_A0.7041.00
78_H92_K0.7001.00
126_T222_V0.6931.00
119_L122_V0.6911.00
115_W228_R0.6911.00
173_Y206_E0.6901.00
255_R259_L0.6881.00
26_Y56_D0.6791.00
23_V53_L0.6761.00
251_G254_K0.6761.00
16_M47_D0.6751.00
41_V111_A0.6751.00
100_D124_A0.6731.00
21_V49_L0.6721.00
42_L72_E0.6721.00
70_G73_E0.6701.00
89_S106_D0.6691.00
34_F66_R0.6681.00
28_M234_F0.6681.00
18_K50_E0.6671.00
42_L75_V0.6671.00
52_V76_V0.6641.00
22_V104_F0.6631.00
37_A42_L0.6631.00
210_G221_M0.6621.00
247_S250_Q0.6611.00
129_I213_L0.6601.00
24_C86_I0.6541.00
180_R219_R0.6531.00
90_R190_Y0.6521.00
44_Q111_A0.6511.00
243_L247_S0.6501.00
109_A175_S0.6501.00
69_F73_E0.6501.00
37_A111_A0.6481.00
105_I109_A0.6461.00
245_S248_F0.6461.00
207_A211_I0.6451.00
84_Q89_S0.6441.00
174_G177_I0.6431.00
19_V103_A0.6421.00
119_L176_N0.6411.00
111_A176_N0.6411.00
81_D88_Y0.6401.00
34_F65_V0.6391.00
50_E97_A0.6351.00
257_M261_Y0.6351.00
56_D80_N0.6351.00
16_M48_D0.6341.00
101_I124_A0.6331.00
51_V75_V0.6281.00
44_Q114_D0.6271.00
285_R289_Q0.6261.00
179_Y184_F0.6261.00
120_L178_S0.6241.00
128_A220_G0.6211.00
121_G124_A0.6211.00
95_K185_L0.6191.00
155_V158_V0.6191.00
52_V96_I0.6191.00
243_L246_R0.6181.00
57_G83_N0.6171.00
90_R174_G0.6171.00
172_T210_G0.6171.00
250_Q253_S0.6151.00
136_V227_A0.6141.00
89_S92_K0.6141.00
34_F62_F0.6141.00
262_P265_E0.6131.00
288_V292_S0.6111.00
214_R221_M0.6081.00
111_A229_V0.6021.00
244_V247_S0.5991.00
35_A72_E0.5981.00
244_V248_F0.5981.00
54_V80_N0.5961.00
246_R250_Q0.5941.00
58_N62_F0.5931.00
80_N83_N0.5921.00
118_Q227_A0.5921.00
22_V94_A0.5911.00
91_T95_K0.5901.00
252_Y256_V0.5891.00
42_L51_V0.5851.00
56_D108_D0.5851.00
151_F155_V0.5851.00
71_D74_H0.5841.00
44_Q115_W0.5821.00
16_M117_E0.5821.00
156_G159_E0.5811.00
253_S261_Y0.5751.00
129_I182_D0.5751.00
91_T189_G0.5731.00
42_L74_H0.5731.00
116_I178_S0.5701.00
115_W229_V0.5691.00
176_N229_V0.5691.00
66_R70_G0.5691.00
250_Q254_K0.5691.00
22_V90_R0.5681.00
151_F154_L0.5671.00
109_A229_V0.5671.00
37_A109_A0.5671.00
273_T277_T0.5661.00
38_V53_L0.5661.00
184_F190_Y0.5661.00
253_S262_P0.5651.00
21_V44_Q0.5641.00
120_L123_Y0.5641.00
44_Q49_L0.5641.00
20_S98_S0.5581.00
175_S231_H0.5531.00
253_S260_L0.5521.00
191_D194_T0.5511.00
275_L279_F0.5501.00
147_F150_E0.5491.00
59_D62_F0.5451.00
286_N292_S0.5441.00
144_P148_P0.5431.00
256_V259_L0.5431.00
274_Q278_R0.5431.00
111_A116_I0.5421.00
17_M46_H0.5421.00
283_R286_N0.5421.00
76_V98_S0.5411.00
155_V159_E0.5391.00
260_L263_D0.5371.00
251_G257_M0.5351.00
76_V80_N0.5351.00
122_V128_A0.5291.00
90_R93_G0.5271.00
67_A71_D0.5251.00
251_G255_R0.5251.00
281_P285_R0.5231.00
45_T113_D0.5231.00
134_D228_R0.5231.00
133_G227_A0.5221.00
188_G212_R0.5221.00
183_Q218_G0.5221.00
97_A102_V0.5211.00
28_M34_F0.5211.00
122_V178_S0.5211.00
69_F72_E0.5201.00
119_L224_T0.5191.00
153_W157_C0.5161.00
45_T49_L0.5151.00
272_L275_L0.5151.00
38_V41_V0.5101.00
67_A80_N0.5101.00
22_V97_A0.5091.00
174_G210_G0.5091.00
130_A177_I0.5081.00
255_R258_D0.5051.00
277_T280_V0.5041.00
118_Q122_V0.5031.00
91_T184_F0.5021.00
29_D34_F0.5011.00
44_Q116_I0.5011.00
187_V216_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bcvA 2 0.561 100 0.375 Contact Map
2z86A 2 0.8049 100 0.379 Contact Map
1qg8A 1 0.6829 100 0.384 Contact Map
3l7iA 4 0.0518 100 0.387 Contact Map
1xhbA 1 0.9268 100 0.396 Contact Map
2d7iA 1 0.9512 100 0.4 Contact Map
4p02A 1 0.9024 100 0.406 Contact Map
5ajoA 1 0.9421 100 0.408 Contact Map
4fixA 3 0.939 100 0.43 Contact Map
3ckjA 2 0.8293 100 0.449 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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