GREMLIN Database
Q9HQP1 - Uncharacterized protein
UniProt: Q9HQP1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 296 (249)
Sequences: 1298 (970)
Seq/√Len: 61.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_R64_D5.6111.00
150_L212_A4.0651.00
154_V215_L3.5291.00
156_T180_K3.4481.00
72_G76_V3.1761.00
126_A238_A3.0281.00
28_A64_D2.9741.00
95_G273_L2.9631.00
154_V212_A2.9091.00
30_A229_Q2.7071.00
230_W234_E2.6521.00
5_D164_M2.6061.00
5_D75_V2.5481.00
154_V219_A2.5411.00
23_E236_R2.5291.00
105_I254_P2.4951.00
24_R28_A2.4831.00
3_A78_A2.4821.00
242_F246_L2.4551.00
187_A209_T2.3541.00
190_T206_P2.2361.00
130_G242_F2.1831.00
87_D189_S2.1171.00
124_I128_L2.1081.00
235_Y238_A2.0511.00
88_V93_Y2.0431.00
30_A226_R2.0251.00
188_V210_L2.0101.00
99_A273_L1.9701.00
96_L276_A1.9661.00
186_S190_T1.9641.00
102_F251_L1.9611.00
236_R240_V1.9561.00
127_A248_A1.9411.00
184_M209_T1.9371.00
112_L247_M1.8911.00
214_S218_L1.8531.00
6_A83_A1.8331.00
230_W235_Y1.8081.00
165_V221_V1.7941.00
135_F252_R1.7630.99
102_F277_G1.7520.99
96_L272_P1.7260.99
87_D185_T1.7150.99
120_T123_R1.7010.99
107_A281_A1.7010.99
87_D186_S1.7000.99
27_S229_Q1.6920.99
139_A252_R1.6900.99
135_F139_A1.6790.99
100_F280_G1.6660.99
136_A139_A1.6210.99
3_A7_V1.6160.99
6_A79_V1.6120.99
18_I108_S1.5440.99
36_D62_A1.5400.99
4_A7_V1.5000.98
14_T163_A1.4990.98
83_A185_T1.4820.98
180_K183_T1.4780.98
153_M184_M1.4610.98
184_M213_F1.4580.98
229_Q233_A1.4570.98
150_L208_A1.4430.98
160_A171_G1.4380.98
1_M5_D1.4350.98
138_S252_R1.3660.97
84_S189_S1.3280.96
5_D163_A1.3210.96
162_C224_F1.3180.96
153_M209_T1.2980.96
6_A185_T1.2930.96
34_V226_R1.2900.96
77_S81_T1.2830.95
153_M213_F1.2830.95
126_A130_G1.2450.95
1_M71_L1.2370.94
288_D291_T1.2260.94
123_R237_A1.2130.94
126_A242_F1.1910.93
211_A215_L1.1880.93
109_V113_I1.1810.93
123_R238_A1.1790.93
14_T171_G1.1740.93
282_A286_V1.1700.93
275_A279_V1.1690.93
79_V188_V1.1640.92
76_V80_V1.1600.92
151_A155_V1.1530.92
1_M21_I1.1520.92
5_D160_A1.1520.92
7_V10_V1.1400.92
104_L284_V1.1250.91
146_L180_K1.1230.91
21_I71_L1.1140.91
188_V214_S1.1110.90
17_L240_V1.1080.90
4_A164_M1.1060.90
164_M171_G1.1030.90
152_V156_T1.0880.90
162_C223_T1.0860.89
4_A12_G1.0830.89
274_V278_V1.0650.89
211_A214_S1.0620.88
117_A236_R1.0600.88
208_A211_A1.0500.88
281_A285_L1.0490.88
27_S233_A1.0460.88
14_T160_A1.0450.88
153_M212_A1.0450.88
153_M183_T1.0450.88
163_A173_L1.0260.87
159_V178_L1.0170.86
146_L152_V1.0090.86
107_A240_V1.0030.85
210_L214_S0.9950.85
247_M250_A0.9880.84
105_I214_S0.9870.84
138_S247_M0.9750.84
175_L213_F0.9710.83
66_P70_V0.9630.83
84_S93_Y0.9560.82
152_V180_K0.9520.82
6_A172_S0.9520.82
78_A82_V0.9480.82
13_G172_S0.9450.82
6_A82_V0.9440.82
32_L65_V0.9430.82
123_R241_T0.9320.81
10_V105_I0.9260.80
85_V89_A0.9240.80
126_A129_G0.9240.80
34_V73_A0.9210.80
160_A164_M0.9130.79
27_S31_G0.9130.79
32_L63_L0.9050.79
125_G129_G0.9040.79
121_P125_G0.8950.78
145_T148_D0.8870.77
10_V32_L0.8850.77
6_A84_S0.8770.77
71_L80_V0.8730.76
8_P11_S0.8720.76
283_A286_V0.8700.76
28_A72_G0.8630.76
19_V284_V0.8610.75
69_A73_A0.8600.75
109_V127_A0.8570.75
36_D63_L0.8560.75
1_M16_A0.8550.75
231_A239_T0.8550.75
163_A169_V0.8470.74
80_V191_A0.8470.74
255_A258_I0.8450.74
207_V211_A0.8420.74
182_E186_S0.8310.73
268_G271_A0.8310.73
83_A116_V0.8300.73
214_S217_A0.8260.72
94_P98_F0.8210.72
70_V73_A0.8200.72
105_I266_T0.8190.72
206_P209_T0.8180.72
155_V174_I0.8180.72
4_A14_T0.8160.71
93_Y96_L0.8100.71
6_A105_I0.8080.71
24_R67_F0.8050.70
86_V161_I0.8030.70
28_A67_F0.8010.70
69_A211_A0.7940.69
254_P276_A0.7910.69
226_R229_Q0.7910.69
108_S251_L0.7910.69
127_A244_V0.7910.69
274_V289_A0.7820.68
5_D17_L0.7800.68
17_L90_Y0.7790.68
224_F228_V0.7790.68
132_A282_A0.7780.68
148_D152_V0.7770.68
285_L289_A0.7740.67
215_L219_A0.7730.67
129_G133_L0.7720.67
73_A77_S0.7720.67
187_A206_P0.7710.67
209_T254_P0.7660.66
75_V164_M0.7640.66
80_V188_V0.7640.66
184_M217_A0.7630.66
133_L272_P0.7600.66
166_L243_L0.7570.66
4_A108_S0.7560.65
140_Q185_T0.7560.65
107_A110_V0.7550.65
7_V156_T0.7530.65
163_A171_G0.7520.65
153_M180_K0.7520.65
160_A217_A0.7520.65
105_I228_V0.7510.65
87_D91_T0.7440.64
210_L218_L0.7440.64
112_L244_V0.7420.64
78_A83_A0.7420.64
5_D13_G0.7420.64
243_L247_M0.7360.63
1_M75_V0.7270.62
65_V70_V0.7260.62
174_I250_A0.7240.62
5_D171_G0.7240.62
90_Y185_T0.7240.62
32_L230_W0.7200.62
147_P180_K0.7180.61
122_G218_L0.7170.61
23_E246_L0.7170.61
282_A289_A0.7140.61
68_L72_G0.7050.60
137_V174_I0.6980.59
19_V287_L0.6940.59
62_A66_P0.6920.59
286_V290_T0.6860.58
171_G213_F0.6860.58
16_A169_V0.6820.58
86_V100_F0.6810.57
32_L277_G0.6810.57
18_I107_A0.6800.57
148_D180_K0.6770.57
245_A256_V0.6760.57
272_P275_A0.6740.57
4_A116_V0.6740.57
82_V86_V0.6720.56
25_L29_L0.6700.56
140_Q177_T0.6690.56
85_V232_L0.6690.56
228_V251_L0.6680.56
80_V84_S0.6670.56
88_V92_Q0.6660.56
83_A189_S0.6660.56
122_G211_A0.6660.56
160_A163_A0.6650.56
5_D169_V0.6650.56
188_V241_T0.6640.55
76_V271_A0.6640.55
5_D104_L0.6630.55
134_A229_Q0.6570.55
10_V15_I0.6570.55
114_G117_A0.6540.54
14_T164_M0.6530.54
95_G99_A0.6530.54
34_V37_V0.6520.54
32_L246_L0.6500.54
102_F274_V0.6490.54
213_F217_A0.6490.54
149_G152_V0.6450.53
240_V243_L0.6450.53
215_L226_R0.6450.53
81_T230_W0.6420.53
97_T100_F0.6410.53
161_I217_A0.6400.53
268_G272_P0.6400.53
211_A267_V0.6390.53
6_A86_V0.6340.52
115_E244_V0.6340.52
16_A26_V0.6340.52
8_P12_G0.6340.52
153_M222_L0.6340.52
14_T220_G0.6330.52
186_S189_S0.6330.52
1_M25_L0.6310.52
37_V124_I0.6310.52
145_T155_V0.6280.51
135_F138_S0.6240.51
136_A140_Q0.6240.51
163_A176_L0.6170.50
124_I272_P0.6170.50
1_M161_I0.6150.50
82_V189_S0.6150.50
3_A82_V0.6150.50
79_V82_V0.6140.50
247_M252_R0.6130.50
77_S105_I0.6120.50
150_L154_V0.6100.49
185_T188_V0.6070.49
130_G169_V0.6070.49
174_I178_L0.6060.49
189_S284_V0.6050.49
2_G9_G0.6040.49
4_A171_G0.6010.48
233_A282_A0.5970.48
36_D226_R0.5970.48
267_V271_A0.5920.47
89_A97_T0.5920.47
72_G186_S0.5920.47
99_A255_A0.5920.47
116_V240_V0.5850.47
207_V210_L0.5850.47
17_L254_P0.5850.47
33_S86_V0.5840.46
125_G128_L0.5830.46
31_G109_V0.5830.46
26_V172_S0.5830.46
135_F289_A0.5830.46
131_F135_F0.5820.46
215_L218_L0.5820.46
69_A272_P0.5810.46
4_A21_I0.5810.46
17_L243_L0.5800.46
21_I25_L0.5770.46
17_L112_L0.5770.46
87_D218_L0.5760.46
104_L171_G0.5750.45
231_A242_F0.5730.45
270_V274_V0.5710.45
31_G62_A0.5660.44
79_V184_M0.5640.44
64_D251_L0.5640.44
26_V77_S0.5630.44
89_A100_F0.5620.44
145_T218_L0.5620.44
5_D166_L0.5610.44
178_L260_D0.5600.44
35_A62_A0.5560.43
71_L226_R0.5530.43
270_V278_V0.5520.43
225_A230_W0.5520.43
107_A116_V0.5510.43
132_A275_A0.5510.43
166_L249_G0.5500.43
186_S191_A0.5500.43
17_L113_I0.5470.42
66_P120_T0.5440.42
92_Q208_A0.5420.42
272_P282_A0.5400.42
91_T268_G0.5400.42
1_M164_M0.5390.41
180_K273_L0.5380.41
121_P124_I0.5370.41
26_V112_L0.5350.41
3_A6_A0.5350.41
113_I244_V0.5340.41
9_G12_G0.5320.41
67_F71_L0.5320.41
104_L243_L0.5310.41
15_I183_T0.5300.40
162_C217_A0.5290.40
62_A110_V0.5290.40
77_S234_E0.5280.40
5_D12_G0.5270.40
106_A110_V0.5250.40
133_L136_A0.5250.40
5_D14_T0.5230.40
7_V28_A0.5230.40
14_T17_L0.5220.40
251_L254_P0.5200.39
87_D172_S0.5180.39
19_V30_A0.5180.39
227_V265_W0.5160.39
177_T241_T0.5160.39
224_F255_A0.5150.39
120_T127_A0.5150.39
97_T183_T0.5140.39
126_A211_A0.5110.38
231_A254_P0.5110.38
122_G238_A0.5100.38
251_L255_A0.5080.38
164_M220_G0.5080.38
83_A187_A0.5050.38
160_A220_G0.5050.38
33_S36_D0.5040.38
215_L265_W0.5030.37
162_C165_V0.5010.37
88_V275_A0.5000.37
220_G249_G0.5000.37
37_V65_V0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4httA 1 0.3378 32.2 0.96 Contact Map
4bwzA 2 0.7939 32 0.96 Contact Map
4b4aA 1 0.3378 26.1 0.961 Contact Map
4f35D 2 0.5372 13.7 0.966 Contact Map
2mofA 1 0.1419 12.7 0.967 Contact Map
2xq2A 2 0.7264 10.1 0.968 Contact Map
4pgrA 1 0.5912 7.6 0.97 Contact Map
4hzuS 1 0.5068 7.2 0.97 Contact Map
4czbA 2 0.2905 6.3 0.971 Contact Map
4cz8A 2 0.2905 6.1 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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