GREMLIN Database
Q9HQP0 - Glycerol-3-phosphate dehydrogenase chain A
UniProt: Q9HQP0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 187 (163)
Sequences: 3106 (1822)
Seq/√Len: 142.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_D77_D4.0981.00
11_V41_L3.7401.00
62_E66_D3.4411.00
62_E77_D3.2761.00
69_S75_A3.1671.00
7_V64_V2.8511.00
2_H47_D2.6551.00
111_D146_R2.4841.00
61_V83_T2.4401.00
5_S46_V2.4211.00
58_D62_E2.3631.00
2_H92_S2.2751.00
13_T37_S2.2651.00
56_T61_V2.2151.00
5_S48_V2.1961.00
122_T143_V2.1941.00
56_T83_T2.1591.00
7_V46_V2.0131.00
61_V77_D1.9521.00
5_S57_P1.9341.00
142_L145_D1.8231.00
65_I77_D1.7591.00
12_E38_T1.7581.00
91_Y108_Y1.7181.00
137_E156_A1.6931.00
65_I75_A1.6831.00
27_A70_A1.6621.00
40_V84_Y1.6291.00
159_P163_H1.6161.00
142_L146_R1.6161.00
141_D153_S1.6121.00
136_A153_S1.6001.00
65_I69_S1.6001.00
9_V41_L1.5491.00
93_P97_G1.5161.00
57_P60_A1.4901.00
48_V87_V1.4701.00
107_F138_A1.4661.00
12_E81_R1.4401.00
15_E79_P1.4241.00
10_T82_T1.4211.00
50_D53_E1.4171.00
144_A149_V1.4171.00
77_D80_I1.4131.00
151_E154_R1.4101.00
28_D43_T1.4011.00
111_D122_T1.3761.00
27_A66_D1.3731.00
93_P103_I1.3641.00
137_E155_T1.3421.00
137_E153_S1.3411.00
68_C75_A1.3401.00
13_T19_V1.3391.00
124_V135_M1.2891.00
122_T142_L1.2871.00
27_A67_E1.2801.00
109_V139_T1.2391.00
32_V67_E1.2391.00
51_A54_F1.2121.00
111_D142_L1.2101.00
88_R105_R1.1771.00
10_T40_V1.1500.99
38_T81_R1.1470.99
41_L64_V1.1420.99
134_L138_A1.1380.99
26_A67_E1.1290.99
5_S85_W1.1220.99
16_T39_A1.1200.99
154_R158_E1.1120.99
90_L128_K1.1050.99
122_T139_T1.0920.99
44_T128_K1.0800.99
41_L68_C1.0760.99
134_L137_E1.0680.99
137_E141_D1.0620.99
109_V138_A1.0500.99
45_S100_A1.0280.99
46_V60_A1.0260.99
47_D103_I1.0160.99
15_E39_A1.0070.99
88_R128_K0.9960.98
7_V56_T0.9960.98
122_T146_R0.9860.98
147_L150_T0.9770.98
22_R26_A0.9550.98
112_H123_T0.9550.98
105_R128_K0.9360.98
21_N33_V0.9330.98
8_M30_D0.9320.98
14_P74_A0.9280.98
112_H119_A0.9280.98
8_M45_S0.9220.97
23_C31_I0.9210.97
11_V80_I0.9210.97
141_D155_T0.9120.97
66_D70_A0.9120.97
141_D144_A0.9080.97
90_L105_R0.9000.97
3_P107_F0.8840.97
132_H155_T0.8820.97
15_E75_A0.8670.96
102_A108_Y0.8550.96
32_V64_V0.8490.96
140_A153_S0.8490.96
165_D168_R0.8460.96
113_A146_R0.8450.96
46_V57_P0.8270.95
35_H40_V0.8260.95
7_V83_T0.8080.95
144_A150_T0.8080.95
107_F135_M0.8080.95
137_E154_R0.8060.95
4_A100_A0.8060.95
23_C26_A0.8050.95
89_P135_M0.7960.94
113_A152_P0.7940.94
12_E37_S0.7870.94
166_P169_L0.7840.94
48_V54_F0.7820.94
26_A54_F0.7810.94
143_V148_G0.7800.94
143_V147_L0.7780.93
31_I35_H0.7750.93
144_A147_L0.7730.93
33_V132_H0.7710.93
113_A119_A0.7690.93
63_R72_L0.7690.93
76_S79_P0.7680.93
17_D20_F0.7430.92
46_V59_A0.7290.91
74_A78_A0.7270.91
164_D169_L0.7220.91
44_T88_R0.7210.91
3_P51_A0.7180.90
6_G88_R0.7170.90
102_A106_G0.7170.90
44_T105_R0.7110.90
60_A106_G0.7110.90
92_S96_Y0.7070.90
91_Y125_V0.7060.90
28_D31_I0.7050.90
15_E18_T0.7040.90
89_P128_K0.7000.89
24_R71_L0.6980.89
99_D102_A0.6980.89
28_D32_V0.6930.89
132_H160_L0.6900.89
12_E79_P0.6870.88
145_D150_T0.6860.88
11_V16_T0.6760.88
140_A143_V0.6760.88
31_I84_Y0.6760.88
67_E70_A0.6730.87
62_E76_S0.6730.87
4_A47_D0.6700.87
69_S76_S0.6680.87
10_T84_Y0.6670.87
93_P104_S0.6650.87
109_V142_L0.6580.86
146_R149_V0.6580.86
6_G128_K0.6580.86
124_V139_T0.6540.86
13_T38_T0.6470.85
110_L125_V0.6470.85
17_D84_Y0.6470.85
104_S108_Y0.6440.85
46_V120_G0.6350.84
14_P68_C0.6350.84
74_A145_D0.6320.84
93_P96_Y0.6320.84
30_D63_R0.6290.84
8_M44_T0.6290.84
82_T135_M0.6260.83
141_D145_D0.6230.83
60_A84_Y0.6200.83
124_V155_T0.6190.83
13_T39_A0.6150.82
69_S79_P0.6140.82
91_Y103_I0.6130.82
132_H136_A0.6130.82
40_V131_T0.6100.82
9_V47_D0.6100.82
7_V87_V0.6060.81
9_V101_R0.5980.80
154_R157_N0.5960.80
143_V149_V0.5960.80
4_A60_A0.5960.80
112_H120_G0.5950.80
81_R106_G0.5930.80
60_A131_T0.5900.80
56_T80_I0.5850.79
48_V51_A0.5840.79
88_R127_G0.5820.79
4_A90_L0.5820.79
54_F87_V0.5790.78
67_E71_L0.5770.78
9_V61_V0.5740.78
137_E150_T0.5710.77
12_E15_E0.5710.77
167_E170_D0.5710.77
61_V65_I0.5670.77
49_D157_N0.5650.77
2_H103_I0.5650.77
22_R25_P0.5640.76
124_V136_A0.5630.76
40_V129_L0.5610.76
3_P131_T0.5570.76
146_R151_E0.5540.75
50_D87_V0.5530.75
166_P170_D0.5520.75
5_S26_A0.5490.75
45_S128_K0.5480.74
11_V75_A0.5380.73
149_V152_P0.5380.73
21_N166_P0.5380.73
13_T17_D0.5360.73
164_D170_D0.5310.72
61_V80_I0.5310.72
104_S123_T0.5310.72
112_H134_L0.5300.72
14_P39_A0.5290.72
65_I80_I0.5280.72
45_S101_R0.5270.72
30_D44_T0.5260.71
45_S64_V0.5250.71
49_D66_D0.5200.71
58_D61_V0.5200.71
32_V43_T0.5200.71
151_E160_L0.5190.70
153_S171_A0.5180.70
90_L130_T0.5180.70
43_T106_G0.5160.70
7_V60_A0.5160.70
44_T90_L0.5150.70
4_A25_P0.5140.70
19_V22_R0.5120.69
4_A45_S0.5110.69
113_A168_R0.5070.69
32_V68_C0.5060.69
59_A62_E0.5050.68
145_D149_V0.5040.68
50_D54_F0.5030.68
26_A129_L0.5010.68
106_G134_L0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rghA 2 0.9037 100 0.471 Contact Map
2qcuA 2 0.9786 100 0.473 Contact Map
3da1A 1 0.9037 100 0.51 Contact Map
3dmeA 2 0.7219 99.1 0.785 Contact Map
4x9mA 1 0.7914 99 0.801 Contact Map
1c0pA 2 0.7861 98.8 0.815 Contact Map
3wgtA 2 0.7433 98.3 0.838 Contact Map
4h1bA 1 0.8128 98.3 0.84 Contact Map
3axbA 2 0.8342 98.2 0.843 Contact Map
3pvcA 1 0.8235 98.1 0.847 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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