GREMLIN Database
Q9HQN7 - Chloromuconate cycloisomerase
UniProt: Q9HQN7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 281 (256)
Sequences: 8858 (5403)
Seq/√Len: 337.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_S264_R4.2171.00
126_D129_A2.8311.00
134_A145_I2.7371.00
31_S197_D2.6721.00
78_A110_T2.6621.00
153_R156_A2.5741.00
105_R140_L2.3631.00
74_S110_T2.3611.00
135_D138_G2.3431.00
180_L211_V2.3091.00
134_A161_G2.2951.00
193_L202_A2.2491.00
60_P86_D2.2311.00
39_S46_L2.2271.00
69_T72_A2.2021.00
101_L136_A2.1871.00
261_A266_Q2.1701.00
78_A82_A2.1651.00
116_S143_E2.1611.00
138_G162_G2.1371.00
255_P276_E2.1251.00
70_A74_S2.0701.00
44_R48_S2.0051.00
177_D181_A1.9961.00
136_A139_S1.9701.00
106_A109_D1.9471.00
133_A137_C1.9451.00
58_S266_Q1.9381.00
81_A115_L1.9071.00
181_A209_A1.8621.00
198_R201_D1.7911.00
105_R109_D1.7801.00
31_S35_M1.7631.00
40_C276_E1.7471.00
102_D105_R1.7411.00
199_A231_L1.6701.00
233_A267_V1.6671.00
88_V115_L1.6641.00
46_L273_H1.6611.00
38_D42_A1.6531.00
118_R143_E1.6261.00
79_D83_D1.6211.00
72_A75_A1.6121.00
105_R139_S1.6041.00
176_L202_A1.5901.00
200_R204_R1.5881.00
91_K122_N1.5791.00
131_R160_I1.5751.00
157_T160_I1.5651.00
101_L140_L1.5341.00
39_S49_A1.5311.00
138_G163_V1.5231.00
54_A57_D1.5091.00
96_S99_A1.5001.00
119_A142_I1.4971.00
149_L160_I1.4951.00
35_M197_D1.4711.00
255_P278_T1.4591.00
78_A81_A1.4561.00
45_P48_S1.4471.00
60_P264_R1.4461.00
166_A185_Y1.4451.00
68_G72_A1.4431.00
179_A183_A1.4351.00
74_S109_D1.4331.00
178_A181_A1.4291.00
149_L156_A1.4261.00
127_L159_S1.4201.00
180_L205_T1.4071.00
108_S112_P1.3951.00
99_A102_D1.3791.00
204_R207_R1.3761.00
101_L105_R1.3681.00
256_D270_D1.3641.00
201_D207_R1.3631.00
93_G100_D1.3271.00
77_V111_A1.3111.00
74_S111_A1.3081.00
166_A187_V1.3071.00
111_A117_L1.3051.00
176_L186_V1.2921.00
138_G161_G1.2911.00
75_A79_D1.2911.00
90_V107_A1.2841.00
75_A78_A1.2791.00
177_D205_T1.2761.00
36_D40_C1.2671.00
81_A88_V1.2601.00
132_Q136_A1.2331.00
77_V88_V1.2271.00
42_A49_A1.2261.00
167_L179_A1.2131.00
188_L199_A1.2071.00
104_L119_A1.2021.00
180_L209_A1.2021.00
74_S78_A1.1991.00
108_S117_L1.1951.00
32_L227_A1.1931.00
98_R102_D1.1921.00
205_T209_A1.1831.00
44_R49_A1.1791.00
70_A106_A1.1781.00
190_P199_A1.1751.00
80_A83_D1.1741.00
106_A110_T1.1741.00
135_D162_G1.1731.00
127_L160_I1.1721.00
193_L199_A1.1511.00
125_W133_A1.1451.00
203_A235_I1.1371.00
79_D82_A1.1361.00
212_E239_P1.1261.00
97_V133_A1.1251.00
147_Q187_V1.1211.00
111_A115_L1.1171.00
175_P178_A1.1171.00
87_T118_R1.1131.00
189_K216_S1.1061.00
172_H175_P1.1051.00
201_D204_R1.1051.00
71_A75_A1.1051.00
200_R234_S1.1011.00
205_T208_Q1.0891.00
121_A145_I1.0871.00
70_A102_D1.0791.00
46_L196_I1.0661.00
102_D106_A1.0661.00
104_L137_C1.0651.00
227_A273_H1.0651.00
37_A41_A1.0651.00
108_S113_A1.0641.00
104_L140_L1.0641.00
156_A160_I1.0641.00
156_A159_S1.0541.00
155_D160_I1.0411.00
142_I163_V1.0401.00
46_L50_L1.0351.00
121_A125_W1.0341.00
63_A80_A1.0301.00
127_L156_A1.0301.00
54_A269_A1.0281.00
113_A141_P1.0231.00
270_D276_E1.0091.00
125_W145_I1.0081.00
177_D209_A0.9981.00
107_A111_A0.9961.00
180_L186_V0.9941.00
108_S141_P0.9911.00
63_A85_F0.9901.00
131_R135_D0.9851.00
48_S269_A0.9841.00
207_R237_D0.9841.00
76_A79_D0.9721.00
101_L139_S0.9711.00
92_V121_A0.9641.00
167_L183_A0.9591.00
158_R182_V0.9591.00
157_T167_L0.9561.00
171_L175_P0.9551.00
58_S262_G0.9551.00
74_S106_A0.9531.00
171_L176_L0.9531.00
183_A186_V0.9521.00
186_V206_A0.9511.00
131_R159_S0.9501.00
207_R236_P0.9411.00
38_D41_A0.9401.00
127_L149_L0.9361.00
43_G271_P0.9351.00
132_Q135_D0.9321.00
229_V267_V0.9201.00
87_T116_S0.9181.00
98_R136_A0.9171.00
34_R38_D0.9131.00
260_V265_I0.9081.00
47_A230_H0.9041.00
39_S44_R0.9021.00
190_P228_A0.8871.00
38_D49_A0.8761.00
171_L179_A0.8731.00
129_A132_Q0.8721.00
248_R252_A0.8711.00
266_Q269_A0.8691.00
118_R144_Y0.8681.00
229_V265_I0.8601.00
77_V107_A0.8381.00
247_D252_A0.8361.00
232_A241_C0.8351.00
90_V104_L0.8261.00
135_D139_S0.8261.00
97_V101_L0.8251.00
261_A264_R0.8241.00
155_D178_A0.8221.00
161_G184_D0.8181.00
149_L157_T0.8161.00
99_A103_R0.8101.00
168_D189_K0.8101.00
108_S114_G0.8101.00
92_V125_W0.8101.00
46_L230_H0.8091.00
100_D125_W0.8071.00
155_D181_A0.8051.00
35_M46_L0.8031.00
127_L131_R0.8011.00
47_A267_V0.8001.00
233_A268_P0.7971.00
188_L213_P0.7961.00
259_P266_Q0.7891.00
50_L196_I0.7851.00
252_A255_P0.7841.00
86_D262_G0.7811.00
46_L49_A0.7761.00
154_L160_I0.7751.00
88_V111_A0.7741.00
155_D159_S0.7731.00
58_S261_A0.7711.00
143_E164_P0.7701.00
206_A211_V0.7651.00
187_V216_S0.7641.00
154_L179_A0.7641.00
75_A110_T0.7611.00
62_N118_R0.7611.00
200_R235_I0.7551.00
199_A215_V0.7501.00
147_Q168_D0.7491.00
154_L157_T0.7481.00
148_P165_I0.7450.99
153_R160_I0.7390.99
123_G151_P0.7390.99
61_V265_I0.7370.99
81_A112_P0.7340.99
36_D39_S0.7330.99
39_S271_P0.7320.99
128_D132_Q0.7280.99
73_T103_R0.7270.99
37_A40_C0.7250.99
23_A27_R0.7250.99
67_D73_T0.7240.99
40_C270_D0.7240.99
32_L196_I0.7220.99
196_I200_R0.7220.99
154_L182_V0.7200.99
71_A74_S0.7200.99
78_A111_A0.7200.99
256_D276_E0.7180.99
131_R161_G0.7170.99
196_I231_L0.7130.99
47_A54_A0.7120.99
34_R37_A0.7110.99
154_L178_A0.7050.99
161_G165_I0.6910.99
60_P116_S0.6840.99
68_G73_T0.6810.99
119_A137_C0.6800.99
123_G170_A0.6790.99
203_A213_P0.6760.99
134_A163_V0.6740.99
222_V254_A0.6710.99
130_A134_A0.6710.99
65_V80_A0.6690.99
196_I227_A0.6690.99
74_S77_V0.6630.99
48_S54_A0.6590.99
81_A111_A0.6550.99
92_V119_A0.6540.99
45_P49_A0.6540.99
160_I165_I0.6540.99
191_M224_A0.6520.99
226_T275_V0.6520.99
204_R208_Q0.6500.99
206_A213_P0.6480.99
48_S52_D0.6480.99
42_A45_P0.6470.99
76_A80_A0.6470.99
174_H177_D0.6450.99
186_V211_V0.6430.99
35_M39_S0.6400.98
147_Q170_A0.6400.98
136_A140_L0.6390.98
81_A110_T0.6380.98
77_V110_T0.6370.98
247_D250_A0.6360.98
127_L153_R0.6360.98
251_D255_P0.6350.98
130_A149_L0.6340.98
101_L133_A0.6310.98
77_V106_A0.6300.98
64_T91_K0.6290.98
132_Q141_P0.6270.98
25_A192_V0.6260.98
104_L142_I0.6260.98
39_S42_A0.6200.98
47_A269_A0.6180.98
32_L191_M0.6150.98
105_R136_A0.6120.98
130_A145_I0.6090.98
32_L46_L0.6070.98
144_Y214_V0.6060.98
101_L104_L0.6020.98
234_S237_D0.6010.98
50_L200_R0.5990.98
30_V34_R0.5980.98
112_P115_L0.5980.98
174_H178_A0.5950.98
72_A76_A0.5950.98
203_A237_D0.5940.98
90_V103_R0.5920.97
59_V232_A0.5910.97
45_P51_S0.5910.97
57_D269_A0.5890.97
133_A136_A0.5890.97
68_G76_A0.5890.97
214_V240_A0.5890.97
97_V136_A0.5880.97
32_L223_V0.5870.97
249_L252_A0.5840.97
256_D259_P0.5830.97
28_H191_M0.5750.97
136_A141_P0.5720.97
158_R184_D0.5710.97
86_D264_R0.5690.97
197_D200_R0.5680.97
258_A265_I0.5680.97
128_D131_R0.5670.97
176_L188_L0.5670.97
185_Y212_E0.5660.97
108_S140_L0.5660.97
222_V252_A0.5640.97
94_S99_A0.5640.97
67_D76_A0.5620.97
35_M196_I0.5620.97
180_L206_A0.5610.97
198_R202_A0.5600.96
24_P27_R0.5590.96
62_N187_V0.5590.96
197_D201_D0.5590.96
35_M49_A0.5590.96
32_L273_H0.5540.96
176_L211_V0.5530.96
47_A50_L0.5510.96
71_A106_A0.5500.96
74_S107_A0.5490.96
223_V275_V0.5480.96
142_I145_I0.5470.96
235_I238_V0.5470.96
47_A52_D0.5460.96
157_T182_V0.5450.96
203_A207_R0.5450.96
231_L234_S0.5410.96
147_Q169_E0.5390.96
101_L137_C0.5390.96
226_T230_H0.5380.96
45_P230_H0.5360.95
190_P231_L0.5360.95
220_D224_A0.5350.95
223_V277_V0.5330.95
98_R113_A0.5320.95
248_R251_D0.5320.95
232_A238_V0.5270.95
153_R210_G0.5270.95
92_V100_D0.5260.95
129_A133_A0.5250.95
40_C273_H0.5240.95
65_V73_T0.5240.95
213_P235_I0.5220.95
164_P185_Y0.5220.95
89_K242_G0.5220.95
109_D140_L0.5210.95
91_K120_D0.5160.94
187_V214_V0.5150.94
67_D72_A0.5150.94
144_Y185_Y0.5140.94
86_D115_L0.5140.94
70_A99_A0.5140.94
191_M218_T0.5130.94
45_P52_D0.5110.94
47_A51_S0.5110.94
123_G147_Q0.5100.94
216_S242_G0.5100.94
149_L167_L0.5080.94
98_R132_Q0.5050.94
87_T143_E0.5040.94
134_A165_I0.5000.94
200_R231_L0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s5sA 2 0.9609 100 0.184 Contact Map
3u9iA 2 0.9609 100 0.185 Contact Map
3rcyA 5 0.9893 100 0.187 Contact Map
3dgbA 5 0.9786 100 0.189 Contact Map
3i4kA 4 0.9786 100 0.191 Contact Map
3t6cA 5 0.9964 100 0.192 Contact Map
3fcpA 5 0.9644 100 0.192 Contact Map
2qddA 5 0.9644 100 0.198 Contact Map
3i6eA 4 0.9751 100 0.198 Contact Map
3tjiA 5 0.9964 100 0.198 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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