GREMLIN Database
Q9HQN4 - Dihydroxynaphthoic acid synthase
UniProt: Q9HQN4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 304 (252)
Sequences: 28446 (18458)
Seq/√Len: 1162.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
170_K208_T3.1821.00
222_E232_T3.0831.00
167_E225_P2.9861.00
164_A220_V2.9521.00
142_A159_C2.8001.00
34_R234_L2.6651.00
232_T235_E2.6371.00
62_R137_P2.5291.00
59_D132_L2.4981.00
207_K239_E2.4111.00
168_H226_H2.2831.00
23_T38_D2.2471.00
43_R84_W2.2441.00
213_A216_D2.1851.00
261_G264_G2.1741.00
165_S168_H2.1521.00
210_D213_A2.1341.00
203_F251_L2.0951.00
201_E207_K2.0731.00
34_R73_T2.0271.00
198_T217_M1.9881.00
177_D243_K1.9791.00
143_V233_A1.9561.00
31_P68_G1.9211.00
55_Y132_L1.9071.00
36_A75_N1.9061.00
228_D231_A1.8891.00
143_V230_E1.8811.00
287_D291_D1.8691.00
24_Y33_V1.8581.00
38_D75_N1.8571.00
43_R85_A1.8571.00
149_V172_K1.8001.00
36_A73_T1.7931.00
200_R256_N1.7891.00
49_G53_E1.7791.00
163_L224_V1.7791.00
167_E212_E1.7741.00
33_V61_A1.7501.00
28_V33_V1.7301.00
201_E221_N1.7241.00
284_E293_R1.7151.00
167_E226_H1.6991.00
28_V64_Q1.6951.00
234_L238_D1.6901.00
213_A217_M1.6741.00
70_V136_M1.6471.00
33_V67_I1.6171.00
201_E222_E1.5661.00
228_D232_T1.5561.00
196_Q200_R1.5551.00
212_E216_D1.5431.00
163_L236_W1.5361.00
160_D252_K1.5191.00
164_A171_F1.5161.00
61_A70_V1.5121.00
200_R255_F1.5051.00
60_H64_Q1.5041.00
21_D53_E1.4951.00
165_S226_H1.4881.00
52_D125_H1.4851.00
62_R132_L1.4801.00
25_H29_E1.4741.00
162_T193_Q1.4651.00
21_D47_R1.4571.00
156_H162_T1.4551.00
35_I57_A1.4381.00
224_V232_T1.4351.00
131_R135_T1.4321.00
23_T75_N1.4241.00
131_R263_V1.3981.00
250_M275_L1.3951.00
200_R204_F1.3941.00
30_V238_D1.3921.00
29_E234_L1.3901.00
73_T145_P1.3681.00
145_P168_H1.3631.00
162_T197_K1.3601.00
145_P165_S1.3401.00
24_Y61_A1.3371.00
134_R189_Y1.3341.00
55_Y59_D1.3251.00
215_A223_A1.3241.00
58_L136_M1.3231.00
144_V156_H1.3141.00
133_I140_V1.3111.00
69_C237_A1.3061.00
198_T201_E1.2991.00
29_E238_D1.2971.00
207_K213_A1.2881.00
153_H173_Q1.2871.00
202_I209_Y1.2821.00
84_W145_P1.2771.00
29_E34_R1.2631.00
55_Y128_E1.2611.00
48_P94_V1.2601.00
243_K248_M1.2481.00
73_T230_E1.2401.00
253_Y257_M1.2261.00
147_W170_K1.2201.00
144_V148_A1.2161.00
62_R136_M1.2051.00
197_K221_N1.2031.00
37_F50_T1.1981.00
34_R230_E1.1981.00
47_R50_T1.1961.00
25_H36_A1.1871.00
85_A147_W1.1811.00
229_L233_A1.1791.00
165_S229_L1.1771.00
172_K208_T1.1761.00
198_T213_A1.1671.00
211_A223_A1.1601.00
176_P206_G1.1531.00
282_A286_R1.1311.00
53_E57_A1.1281.00
42_V93_S1.1091.00
37_F87_C1.1091.00
209_Y217_M1.1081.00
39_R42_V1.0951.00
230_E234_L1.0901.00
257_M268_F1.0881.00
135_T263_V1.0791.00
126_I184_G1.0721.00
48_P52_D1.0531.00
21_D49_G1.0411.00
237_A241_T1.0371.00
154_S186_G1.0361.00
25_H34_R1.0361.00
195_G198_T1.0351.00
87_C152_G1.0321.00
23_T36_A1.0301.00
70_V138_K1.0281.00
246_T281_E1.0121.00
53_E56_T1.0121.00
140_V159_C1.0031.00
194_V198_T0.9931.00
28_V66_D0.9921.00
76_G145_P0.9921.00
39_R91_D0.9821.00
225_P228_D0.9821.00
71_L233_A0.9761.00
193_Q197_K0.9731.00
56_T60_H0.9721.00
230_E233_A0.9651.00
137_P249_R0.9631.00
161_L236_W0.9571.00
57_A60_H0.9561.00
73_T143_V0.9511.00
145_P229_L0.9441.00
67_I138_K0.9361.00
215_A220_V0.9341.00
283_Q287_D0.9271.00
32_A69_C0.9271.00
212_E215_A0.9211.00
70_V140_V0.9201.00
24_Y28_V0.9181.00
253_Y272_A0.9151.00
176_P251_L0.8941.00
188_A265_Q0.8941.00
153_H171_F0.8911.00
245_P249_R0.8911.00
196_Q259_D0.8901.00
250_M272_A0.8871.00
143_V229_L0.8831.00
264_G267_T0.8821.00
144_V171_F0.8821.00
34_R71_L0.8801.00
170_K210_D0.8801.00
203_F255_F0.8691.00
250_M253_Y0.8661.00
65_A138_K0.8631.00
187_S269_A0.8631.00
28_V60_H0.8621.00
181_F276_A0.8621.00
268_F271_E0.8471.00
250_M276_A0.8381.00
144_V162_T0.8291.00
231_A235_E0.8261.00
167_E223_A0.8221.00
51_V129_V0.8221.00
254_A272_A0.8191.00
190_L194_V0.8171.00
165_S227_D0.8161.00
161_L221_N0.8141.00
234_L237_A0.8141.00
93_S290_L0.8131.00
235_E239_E0.8121.00
149_V208_T0.8111.00
59_D63_K0.8081.00
35_I70_V0.8051.00
242_A294_D0.8031.00
59_D128_E0.8031.00
240_M248_M0.7991.00
177_D208_T0.7961.00
215_A222_E0.7931.00
202_I217_M0.7921.00
194_V202_I0.7901.00
43_R88_A0.7881.00
268_F272_A0.7881.00
64_Q67_I0.7821.00
52_D56_T0.7791.00
62_R138_K0.7751.00
58_L133_I0.7731.00
154_S175_D0.7711.00
239_E243_K0.7641.00
55_Y125_H0.7561.00
119_A123_R0.7531.00
55_Y129_V0.7521.00
61_A67_I0.7491.00
233_A237_A0.7481.00
48_P125_H0.7471.00
280_D283_Q0.7471.00
144_V169_A0.7441.00
39_R47_R0.7411.00
22_I57_A0.7371.00
188_A191_A0.7361.00
85_A145_P0.7351.00
211_A220_V0.7351.00
272_A275_L0.7271.00
235_E238_D0.7211.00
137_P253_Y0.7211.00
28_V67_I0.7201.00
244_S281_E0.7181.00
117_K120_D0.7171.00
21_D50_T0.7141.00
201_E205_L0.7141.00
130_Q158_V0.7081.00
262_M266_Q0.7011.00
245_P248_M0.6981.00
286_R290_L0.6981.00
181_F254_A0.6981.00
123_R270_G0.6971.00
119_A271_E0.6971.00
157_V219_M0.6961.00
205_L236_W0.6951.00
24_Y57_A0.6881.00
42_V91_D0.6871.00
136_M140_V0.6851.00
46_F50_T0.6841.00
182_D251_L0.6841.00
28_V31_P0.6831.00
222_E236_W0.6831.00
254_A268_F0.6811.00
68_G245_P0.6801.00
145_P226_H0.6801.00
163_L232_T0.6781.00
150_G174_T0.6771.00
232_T236_W0.6771.00
32_A71_L0.6761.00
123_R128_E0.6751.00
175_D183_G0.6741.00
163_L222_E0.6741.00
96_G287_D0.6721.00
238_D242_A0.6701.00
149_V174_T0.6701.00
214_A219_M0.6691.00
64_Q138_K0.6691.00
224_V229_L0.6681.00
43_R147_W0.6671.00
99_G102_Y0.6671.00
31_P66_D0.6661.00
196_Q255_F0.6631.00
267_T271_E0.6601.00
39_R45_A0.6601.00
231_A234_L0.6601.00
47_R94_V0.6601.00
270_G274_R0.6591.00
72_L140_V0.6551.00
196_Q256_N0.6531.00
198_T215_A0.6531.00
49_G52_D0.6461.00
71_L234_L0.6461.00
61_A138_K0.6431.00
173_Q203_F0.6361.00
57_A61_A0.6331.00
71_L143_V0.6321.00
76_G84_W0.6291.00
50_T53_E0.6281.00
90_G95_R0.6281.00
175_D273_T0.6281.00
246_T279_T0.6261.00
220_V223_A0.6241.00
54_L129_V0.6201.00
171_F220_V0.6151.00
172_K206_G0.6111.00
136_M139_P0.6091.00
271_E275_L0.6091.00
59_D62_R0.6061.00
163_L233_A0.6051.00
195_G199_A0.5971.00
209_Y214_A0.5931.00
236_W239_E0.5931.00
56_T59_D0.5931.00
72_L159_C0.5931.00
24_Y60_H0.5911.00
142_A162_T0.5911.00
163_L229_L0.5901.00
251_L254_A0.5861.00
69_C241_T0.5851.00
187_S265_Q0.5841.00
128_E131_R0.5821.00
194_V217_M0.5811.00
35_I58_L0.5801.00
141_V237_A0.5781.00
212_E223_A0.5781.00
153_H219_M0.5761.00
181_F251_L0.5731.00
173_Q186_G0.5721.00
204_F248_M0.5711.00
287_D290_L0.5701.00
164_A169_A0.5691.00
68_G241_T0.5691.00
263_V267_T0.5651.00
35_I72_L0.5641.00
211_A215_A0.5631.00
76_G85_A0.5621.00
161_L240_M0.5621.00
128_E132_L0.5621.00
180_S282_A0.5611.00
188_A192_K0.5581.00
69_C141_V0.5581.00
147_W208_T0.5581.00
210_D216_D0.5571.00
153_H157_V0.5561.00
168_H211_A0.5551.00
154_S183_G0.5551.00
246_T276_A0.5541.00
191_A258_T0.5531.00
32_A237_A0.5501.00
200_R252_K0.5491.00
49_G94_V0.5471.00
205_L240_M0.5471.00
201_E213_A0.5471.00
193_Q221_N0.5461.00
205_L239_E0.5411.00
174_T178_V0.5391.00
119_A274_R0.5391.00
58_L132_L0.5391.00
96_G290_L0.5391.00
175_D182_D0.5391.00
154_S185_F0.5381.00
32_A234_L0.5371.00
145_P169_A0.5371.00
194_V199_A0.5351.00
201_E236_W0.5341.00
176_P243_K0.5331.00
191_A194_V0.5331.00
92_Q95_R0.5301.00
158_V189_Y0.5281.00
198_T216_D0.5251.00
214_A220_V0.5251.00
42_V45_A0.5241.00
284_E287_D0.5181.00
67_I70_V0.5161.00
156_H159_C0.5141.00
154_S173_Q0.5141.00
60_H63_K0.5131.00
46_F151_G0.5121.00
92_Q178_V0.5111.00
177_D239_E0.5111.00
276_A279_T0.5111.00
176_P248_M0.5101.00
58_L140_V0.5101.00
129_V132_L0.5101.00
35_I61_A0.5091.00
61_A136_M0.5091.00
207_K222_E0.5091.00
150_G173_Q0.5091.00
181_F273_T0.5071.00
21_D39_R0.5061.00
280_D284_E0.5051.00
132_L136_M0.5051.00
145_P230_E0.5041.00
252_K256_N0.5021.00
28_V34_R0.5021.00
143_V237_A0.5011.00
154_S189_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qiiA 6 0.9836 100 0.167 Contact Map
4jfcA 3 0.8421 100 0.187 Contact Map
4mi2A 3 0.852 100 0.188 Contact Map
4lk5A 3 0.8224 100 0.192 Contact Map
2fbmA 3 0.8191 100 0.192 Contact Map
3i47A 3 0.8454 100 0.193 Contact Map
3g64A 6 0.898 100 0.193 Contact Map
1nzyA 4 0.875 100 0.194 Contact Map
4hdtA 1 0.8553 100 0.194 Contact Map
2uzfA 5 0.8586 100 0.194 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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