MEND - HALSA - GREMLIN Contacts

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MEND - 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase

UniProt:	Q9HQN3	Sequences: MTAPNRNTLWARAIADELAAAGVHAVCVCPGSRSTPLTVAVDAHDDLTVYSHLDERSAAFFALGRGKRTGAPTAVLTTSGTATANLHPAVMEAAQARIPLVVLTADRPPELRGSGANQTVDQEQLYGSAVRYYEDLPEPEVTARKLRSLRTSVCRAVGHTTGPKPGPVHLNVPFRKPLEPVSVPGDVPPSFDDDHPLAAAGRGGDTPFVSVHDGTTEPAGETAAALAAAATTAARPLVVAGPADGGAGITPDAAAALADATGAPIFADPLSGLRFGPHVGDAPVVGGYDGFLAADVPHPEFVLRFGASPTSKPLRKWLAASDARQVVVDPAGGWREAEFTATDVVAADPAATARAIAARADGTRSAWTDAVLDLEARYWAAVDDFQPAATLEGEIAATVAAGAPDPATVFVSNSMPIRDFDRFAAPRGADLAVLGNRGASGIDGVVSSALGAGSATADPVVGLVGDLAYFHDSNGLLALERCGVDATIVLVNNDGGSIFHMLPIEQFDPPFTGQFKTPHGLDFAPTADTYALSFARTDTVGEFRAAYRAALGDAGTHVIEVSTDAEASHRERERLADRVTGLSV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	584 (526)
Sequences:	14219 (8962)
Seq/√Len:	390.8

ECOLI - OXC ILVB ILVG ILVI GCL POXB MEND
BACSU - ILVX MEND ILVB IOLD YDAP
HALSA - MEND
SULSO - Q7LXT8 Q97ZB3 Q97UP3 Q97U16 Q97V62 Q980V7 Q97XR3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
525_P	528_D	5.017	1.00
492_N	560_E	3.888	1.00
398_T	544_R	3.713	1.00
59_A	89_A	3.710	1.00
259_D	279_V	3.550	1.00
535_A	549_A	3.465	1.00
253_A	354_R	3.234	1.00
24_H	71_A	3.113	1.00
539_T	542_E	3.049	1.00
536_R	562_S	2.941	1.00
224_A	359_R	2.912	1.00
253_A	350_A	2.897	1.00
402_G	548_R	2.754	1.00
347_A	352_T	2.723	1.00
68_R	456_T	2.684	1.00
19_A	46_D	2.651	1.00
240_A	254_A	2.634	1.00
535_A	557_H	2.547	1.00
398_T	401_A	2.493	1.00
533_S	555_G	2.464	1.00
305_F	349_P	2.445	1.00
278_H	427_R	2.444	1.00
538_D	542_E	2.440	1.00
25_A	48_T	2.439	1.00
226_L	326_V	2.429	1.00
449_A	462_G	2.352	1.00
299_P	302_V	2.339	1.00
535_A	546_A	2.312	1.00
77_T	86_L	2.280	1.00
328_V	352_T	2.184	1.00
522_D	525_P	2.183	1.00
470_F	530_Y	2.175	1.00
536_R	560_E	2.173	1.00
401_A	544_R	2.172	1.00
72_P	161_T	2.158	1.00
84_A	88_P	2.109	1.00
101_V	157_V	2.096	1.00
533_S	549_A	2.094	1.00
229_A	343_D	2.084	1.00
12_R	40_A	2.070	1.00
304_R	307_A	2.059	1.00
90_V	102_V	2.053	1.00
526_T	529_T	2.040	1.00
52_H	58_A	2.034	1.00
104_T	169_H	1.973	1.00
229_A	301_F	1.972	1.00
229_A	324_R	1.961	1.00
238_V	258_A	1.946	1.00
152_S	170_L	1.912	1.00
524_A	534_F	1.910	1.00
537_T	546_A	1.895	1.00
72_P	101_V	1.891	1.00
230_A	303_L	1.885	1.00
453_G	485_D	1.878	1.00
16_D	20_A	1.863	1.00
260_A	357_A	1.862	1.00
63_L	67_K	1.853	1.00
258_A	265_I	1.851	1.00
480_E	532_L	1.826	1.00
404_P	407_A	1.819	1.00
469_Y	473_S	1.811	1.00
225_A	228_A	1.804	1.00
121_D	124_Q	1.802	1.00
220_G	355_A	1.776	1.00
548_R	552_G	1.765	1.00
544_R	548_R	1.749	1.00
550_A	559_I	1.741	1.00
219_A	222_T	1.740	1.00
256_A	260_A	1.736	1.00
490_L	558_V	1.730	1.00
260_A	361_D	1.719	1.00
408_T	452_A	1.718	1.00
124_Q	127_G	1.716	1.00
228_A	232_T	1.714	1.00
412_S	464_V	1.711	1.00
8_T	16_D	1.706	1.00
238_V	263_A	1.706	1.00
542_E	545_A	1.705	1.00
400_A	425_A	1.698	1.00
238_V	303_L	1.684	1.00
12_R	43_A	1.643	1.00
255_A	259_D	1.636	1.00
528_D	533_S	1.629	1.00
533_S	557_H	1.612	1.00
412_S	468_A	1.612	1.00
28_V	49_V	1.606	1.00
444_G	448_S	1.604	1.00
399_V	463_L	1.600	1.00
252_D	256_A	1.598	1.00
38_T	49_V	1.589	1.00
397_A	401_A	1.585	1.00
138_E	141_V	1.575	1.00
538_D	562_S	1.560	1.00
434_L	452_A	1.552	1.00
305_F	328_V	1.543	1.00
394_E	540_V	1.527	1.00
16_D	19_A	1.525	1.00
453_G	484_V	1.525	1.00
335_R	346_A	1.515	1.00
14_I	172_V	1.505	1.00
233_A	236_P	1.499	1.00
130_V	169_H	1.492	1.00
524_A	536_R	1.489	1.00
17_E	154_C	1.488	1.00
265_I	275_F	1.487	1.00
131_R	166_G	1.479	1.00
545_A	549_A	1.479	1.00
69_T	455_A	1.477	1.00
230_A	301_F	1.476	1.00
298_H	370_A	1.472	1.00
86_L	102_V	1.460	1.00
479_L	532_L	1.458	1.00
222_T	225_A	1.455	1.00
545_A	548_R	1.453	1.00
394_E	398_T	1.452	1.00
134_E	170_L	1.452	1.00
103_L	172_V	1.451	1.00
57_S	475_G	1.445	1.00
14_I	153_V	1.443	1.00
476_L	532_L	1.440	1.00
402_G	544_R	1.435	1.00
370_A	374_L	1.422	1.00
473_S	526_T	1.409	1.00
432_A	458_D	1.407	1.00
479_L	486_A	1.406	1.00
372_L	375_E	1.404	1.00
101_V	160_T	1.402	1.00
489_V	547_Y	1.402	1.00
365_S	369_D	1.401	1.00
398_T	402_G	1.400	1.00
262_G	281_D	1.394	1.00
52_H	61_F	1.393	1.00
48_T	482_C	1.391	1.00
489_V	559_I	1.388	1.00
404_P	459_P	1.379	1.00
324_R	342_T	1.377	1.00
139_P	179_E	1.376	1.00
257_L	261_T	1.373	1.00
407_A	459_P	1.373	1.00
218_P	352_T	1.371	1.00
395_I	561_V	1.369	1.00
90_V	100_L	1.364	1.00
227_A	359_R	1.360	1.00
369_D	373_D	1.356	1.00
405_D	427_R	1.353	1.00
72_P	157_V	1.351	1.00
408_T	456_T	1.351	1.00
21_A	157_V	1.349	1.00
442_I	471_H	1.347	1.00
454_S	484_V	1.345	1.00
227_A	356_I	1.334	1.00
403_A	461_V	1.334	1.00
256_A	357_A	1.333	1.00
83_T	104_T	1.333	1.00
485_D	555_G	1.333	1.00
223_A	359_R	1.331	1.00
301_F	326_V	1.329	1.00
450_L	479_L	1.320	1.00
109_P	175_R	1.319	1.00
19_A	45_D	1.317	1.00
461_V	551_L	1.312	1.00
233_A	301_F	1.308	1.00
305_F	353_A	1.306	1.00
25_A	454_S	1.305	1.00
453_G	459_P	1.304	1.00
489_V	561_V	1.302	1.00
136_L	149_L	1.301	1.00
59_A	86_L	1.300	1.00
487_T	550_A	1.296	1.00
21_A	154_C	1.294	1.00
237_L	299_P	1.289	1.00
257_L	353_A	1.289	1.00
390_T	561_V	1.274	1.00
532_L	558_V	1.269	1.00
257_L	357_A	1.268	1.00
526_T	530_Y	1.252	1.00
336_E	341_A	1.251	1.00
524_A	528_D	1.251	1.00
63_L	92_E	1.248	1.00
27_C	65_R	1.233	1.00
254_A	353_A	1.231	1.00
151_T	155_R	1.231	1.00
459_P	551_L	1.229	1.00
350_A	354_R	1.229	1.00
255_A	276_G	1.225	1.00
390_T	395_I	1.224	1.00
11_A	40_A	1.223	1.00
543_F	561_V	1.223	1.00
50_Y	454_S	1.215	1.00
224_A	228_A	1.212	1.00
462_G	488_I	1.212	1.00
153_V	170_L	1.207	1.00
477_L	481_R	1.207	1.00
141_V	151_T	1.206	1.00
485_D	554_A	1.206	1.00
91_M	439_A	1.201	1.00
494_D	520_G	1.197	1.00
66_G	99_P	1.197	1.00
525_P	529_T	1.194	1.00
236_P	300_E	1.193	1.00
373_D	377_R	1.188	1.00
10_W	149_L	1.186	1.00
408_T	460_V	1.185	1.00
220_G	359_R	1.185	1.00
65_R	455_A	1.184	1.00
173_P	176_K	1.174	1.00
267_A	282_A	1.170	1.00
227_A	231_T	1.169	1.00
225_A	229_A	1.167	1.00
227_A	360_A	1.156	1.00
546_A	559_I	1.150	1.00
244_D	254_A	1.149	1.00
527_A	532_L	1.148	1.00
110_E	175_R	1.145	1.00
272_G	277_P	1.144	1.00
351_A	354_R	1.144	1.00
24_H	48_T	1.142	1.00
355_A	358_A	1.142	1.00
9_L	12_R	1.141	1.00
26_V	41_V	1.138	1.00
253_A	357_A	1.131	1.00
256_A	259_D	1.129	1.00
348_D	351_A	1.128	1.00
17_E	153_V	1.125	1.00
63_L	98_I	1.125	1.00
527_A	558_V	1.118	1.00
68_R	452_A	1.111	1.00
226_L	343_D	1.111	1.00
238_V	257_L	1.109	1.00
75_V	86_L	1.108	1.00
372_L	376_A	1.105	1.00
217_E	355_A	1.104	1.00
23_V	74_A	1.104	1.00
255_A	275_F	1.099	1.00
13_A	181_V	1.096	1.00
535_A	559_I	1.095	1.00
159_H	168_V	1.092	1.00
256_A	354_R	1.087	1.00
240_A	244_D	1.087	1.00
94_A	167_P	1.085	1.00
453_G	457_A	1.084	1.00
534_F	558_V	1.084	1.00
109_P	179_E	1.083	1.00
543_F	547_Y	1.080	1.00
231_T	360_A	1.079	1.00
258_A	275_F	1.077	1.00
453_G	460_V	1.077	1.00
134_E	155_R	1.073	1.00
218_P	355_A	1.071	1.00
253_A	256_A	1.071	1.00
57_S	472_D	1.071	1.00
235_R	298_H	1.069	1.00
527_A	534_F	1.067	1.00
226_L	345_V	1.053	1.00
304_R	309_P	1.053	1.00
13_A	150_R	1.053	1.00
375_E	379_W	1.051	1.00
252_D	255_A	1.049	1.00
64_G	68_R	1.045	1.00
25_A	50_Y	1.045	1.00
84_A	125_L	1.044	1.00
9_L	180_P	1.044	1.00
533_S	553_D	1.042	1.00
34_S	37_L	1.041	1.00
77_T	102_V	1.040	1.00
238_V	254_A	1.033	1.00
87_H	125_L	1.027	1.00
231_T	361_D	1.027	1.00
487_T	557_H	1.026	1.00
258_A	281_D	1.026	1.00
376_A	380_A	1.024	1.00
59_A	75_V	1.020	1.00
133_Y	169_H	1.019	1.00
134_E	152_S	1.017	1.00
136_L	152_S	1.017	1.00
8_T	180_P	1.017	1.00
14_I	103_L	1.013	1.00
275_F	279_V	1.013	1.00
75_V	102_V	1.009	1.00
237_L	296_V	1.008	1.00
369_D	372_L	1.006	1.00
537_T	543_F	1.004	1.00
237_L	266_F	1.000	1.00
50_Y	482_C	0.997	1.00
112_R	135_D	0.997	1.00
445_V	462_G	0.991	1.00
341_A	344_V	0.990	1.00
549_A	552_G	0.988	1.00
233_A	300_E	0.985	1.00
26_V	74_A	0.984	1.00
537_T	542_E	0.984	1.00
259_D	281_D	0.982	1.00
476_L	558_V	0.980	1.00
553_D	557_H	0.980	1.00
403_A	409_V	0.979	1.00
409_V	424_A	0.976	1.00
391_L	567_A	0.976	1.00
446_V	469_Y	0.973	1.00
494_D	562_S	0.972	1.00
257_L	360_A	0.970	1.00
351_A	355_A	0.968	1.00
373_D	376_A	0.967	1.00
256_A	361_D	0.966	1.00
406_P	458_D	0.960	1.00
316_K	319_A	0.959	1.00
453_G	555_G	0.957	1.00
232_T	324_R	0.956	1.00
260_A	362_G	0.948	1.00
469_Y	490_L	0.947	1.00
459_P	487_T	0.947	1.00
106_D	171_N	0.946	1.00
410_F	462_G	0.945	1.00
14_I	37_L	0.944	1.00
473_S	530_Y	0.941	1.00
345_V	352_T	0.938	1.00
490_L	523_F	0.937	1.00
87_H	129_A	0.937	1.00
37_L	172_V	0.935	1.00
524_A	560_E	0.935	1.00
550_A	557_H	0.930	1.00
396_A	463_L	0.923	1.00
161_T	165_P	0.922	1.00
226_L	301_F	0.922	1.00
61_F	479_L	0.922	1.00
83_T	126_Y	0.919	1.00
532_L	556_T	0.919	1.00
370_A	373_D	0.917	1.00
487_T	559_I	0.917	1.00
217_E	351_A	0.916	1.00
476_L	488_I	0.913	1.00
410_F	460_V	0.912	1.00
232_T	301_F	0.912	1.00
328_V	345_V	0.911	1.00
483_G	554_A	0.909	1.00
402_G	547_Y	0.907	1.00
487_T	551_L	0.906	1.00
59_A	100_L	0.902	1.00
221_E	224_A	0.900	1.00
255_A	279_V	0.899	1.00
546_A	550_A	0.899	1.00
251_P	255_A	0.898	1.00
491_V	563_T	0.896	1.00
237_L	302_V	0.894	1.00
130_V	133_Y	0.890	1.00
479_L	556_T	0.889	1.00
420_F	463_L	0.889	1.00
84_A	91_M	0.888	1.00
155_R	159_H	0.885	1.00
67_K	98_I	0.885	1.00
477_L	530_Y	0.883	1.00
479_L	488_I	0.882	1.00
253_A	353_A	0.880	1.00
41_V	47_L	0.877	1.00
229_A	326_V	0.876	1.00
451_G	455_A	0.876	1.00
17_E	21_A	0.874	1.00
12_R	16_D	0.874	1.00
97_R	164_K	0.873	1.00
87_H	126_Y	0.873	1.00
226_L	229_A	0.873	1.00
220_G	224_A	0.869	1.00
261_T	360_A	0.865	1.00
8_T	13_A	0.864	1.00
71_A	161_T	0.863	1.00
40_A	43_A	0.862	1.00
515_F	518_P	0.862	1.00
528_D	534_F	0.859	1.00
469_Y	558_V	0.858	1.00
405_D	429_A	0.857	1.00
368_T	372_L	0.853	1.00
467_L	496_G	0.853	1.00
266_F	283_P	0.852	1.00
486_A	556_T	0.850	1.00
394_E	543_F	0.850	1.00
463_L	491_V	0.848	1.00
429_A	432_A	0.847	1.00
395_I	491_V	0.843	1.00
125_L	129_A	0.843	1.00
228_A	231_T	0.843	1.00
25_A	65_R	0.841	1.00
64_G	448_S	0.841	1.00
542_E	546_A	0.840	1.00
88_P	441_G	0.837	1.00
90_V	126_Y	0.835	1.00
123_E	133_Y	0.834	1.00
235_R	300_E	0.834	1.00
132_Y	159_H	0.832	1.00
90_V	129_A	0.832	1.00
481_R	519_H	0.832	1.00
101_V	161_T	0.829	1.00
74_A	101_V	0.829	1.00
406_P	429_A	0.827	1.00
238_V	305_F	0.826	1.00
314_L	317_W	0.825	1.00
24_H	65_R	0.825	1.00
396_A	491_V	0.825	1.00
17_E	20_A	0.823	1.00
461_V	489_V	0.822	1.00
9_L	40_A	0.820	1.00
398_T	543_F	0.818	1.00
226_L	352_T	0.817	1.00
276_G	427_R	0.816	1.00
549_A	553_D	0.815	1.00
68_R	434_L	0.815	1.00
250_T	253_A	0.815	1.00
301_F	324_R	0.814	1.00
172_V	177_P	0.814	1.00
247_A	250_T	0.813	1.00
402_G	551_L	0.812	1.00
400_A	424_A	0.810	1.00
546_A	549_A	0.808	1.00
132_Y	152_S	0.806	1.00
10_W	139_P	0.806	1.00
30_P	51_S	0.804	1.00
492_N	562_S	0.804	1.00
231_T	358_A	0.803	1.00
277_P	282_A	0.802	1.00
416_P	468_A	0.802	1.00
327_V	341_A	0.801	1.00
34_S	76_L	0.800	1.00
36_P	178_L	0.800	1.00
480_E	556_T	0.795	1.00
367_W	371_V	0.795	1.00
76_L	103_L	0.794	1.00
52_H	57_S	0.794	1.00
522_D	536_R	0.794	1.00
407_A	461_V	0.793	1.00
335_R	344_V	0.793	1.00
160_T	168_V	0.792	1.00
240_A	265_I	0.791	1.00
218_P	223_A	0.791	1.00
236_P	263_A	0.789	1.00
131_R	168_V	0.786	1.00
390_T	540_V	0.782	1.00
66_G	100_L	0.782	1.00
65_R	71_A	0.781	1.00
18_L	74_A	0.781	1.00
240_A	267_A	0.778	1.00
21_A	161_T	0.776	1.00
446_V	488_I	0.775	1.00
245_G	274_R	0.775	1.00
60_F	441_G	0.774	1.00
242_P	270_L	0.773	1.00
522_D	528_D	0.772	1.00
123_E	135_D	0.772	1.00
541_G	545_A	0.770	1.00
396_A	424_A	0.770	1.00
403_A	407_A	0.767	1.00
56_R	85_N	0.766	1.00
487_T	554_A	0.765	1.00
494_D	565_A	0.764	1.00
534_F	560_E	0.762	1.00
278_H	405_D	0.760	1.00
450_L	484_V	0.759	1.00
470_F	473_S	0.756	1.00
235_R	367_W	0.755	1.00
66_G	98_I	0.755	1.00
23_V	157_V	0.755	1.00
371_V	375_E	0.751	1.00
77_T	104_T	0.749	1.00
250_T	350_A	0.749	1.00
390_T	539_T	0.748	1.00
352_T	355_A	0.744	1.00
218_P	351_A	0.744	1.00
470_F	521_L	0.744	1.00
106_D	112_R	0.744	1.00
371_V	374_L	0.744	1.00
78_T	118_Q	0.743	1.00
29_C	86_L	0.742	1.00
68_R	455_A	0.742	1.00
26_V	76_L	0.742	1.00
411_V	433_V	0.742	1.00
382_V	397_A	0.740	1.00
332_G	346_A	0.740	1.00
19_A	24_H	0.739	1.00
231_T	359_R	0.739	1.00
225_A	343_D	0.738	1.00
223_A	355_A	0.737	1.00
238_V	265_I	0.736	1.00
276_G	279_V	0.736	1.00
480_E	531_A	0.735	1.00
375_E	378_Y	0.734	1.00
366_A	369_D	0.733	1.00
139_P	150_R	0.730	1.00
247_A	348_D	0.728	1.00
59_A	102_V	0.727	1.00
34_S	38_T	0.727	1.00
463_L	489_V	0.724	1.00
500_H	504_I	0.724	1.00
244_D	274_R	0.724	1.00
488_I	532_L	0.723	1.00
39_V	42_D	0.723	1.00
104_T	171_N	0.722	1.00
354_R	357_A	0.722	1.00
215_T	348_D	0.721	1.00
286_G	296_V	0.720	1.00
269_P	421_D	0.718	1.00
131_R	162_G	0.717	1.00
354_R	358_A	0.717	1.00
364_R	368_T	0.713	1.00
470_F	523_F	0.711	1.00
469_Y	523_F	0.710	1.00
24_H	46_D	0.709	1.00
27_C	61_F	0.708	1.00
132_Y	168_V	0.707	1.00
222_T	226_L	0.706	1.00
284_V	288_Y	0.706	1.00
449_A	486_A	0.705	1.00
230_A	261_T	0.705	1.00
412_S	445_V	0.705	1.00
355_A	359_R	0.704	1.00
400_A	427_R	0.701	1.00
98_I	444_G	0.700	1.00
446_V	464_V	0.699	1.00
411_V	420_F	0.699	1.00
275_F	282_A	0.698	1.00
236_P	301_F	0.698	1.00
303_L	328_V	0.697	1.00
374_L	377_R	0.696	1.00
37_L	177_P	0.695	1.00
251_P	430_D	0.695	1.00
93_A	100_L	0.695	1.00
288_Y	295_D	0.692	0.99
462_G	468_A	0.690	0.99
53_L	481_R	0.689	0.99
479_L	484_V	0.686	0.99
150_R	154_C	0.685	0.99
489_V	543_F	0.685	0.99
135_D	171_N	0.685	0.99
124_Q	128_S	0.685	0.99
273_L	277_P	0.684	0.99
380_A	383_D	0.684	0.99
395_I	489_V	0.683	0.99
272_G	426_P	0.682	0.99
91_M	129_A	0.678	0.99
411_V	435_G	0.677	0.99
229_A	232_T	0.677	0.99
84_A	87_H	0.674	0.99
64_G	451_G	0.674	0.99
267_A	277_P	0.673	0.99
459_P	485_D	0.671	0.99
500_H	517_T	0.668	0.99
109_P	173_P	0.668	0.99
461_V	487_T	0.667	0.99
260_A	360_A	0.665	0.99
77_T	83_T	0.665	0.99
239_V	304_R	0.665	0.99
485_D	556_T	0.663	0.99
234_A	364_R	0.663	0.99
532_L	555_G	0.662	0.99
495_G	500_H	0.661	0.99
286_G	289_D	0.661	0.99
537_T	559_I	0.661	0.99
94_A	131_R	0.660	0.99
158_G	162_G	0.659	0.99
410_F	434_L	0.657	0.99
522_D	560_E	0.656	0.99
258_A	261_T	0.655	0.99
366_A	370_A	0.655	0.99
132_Y	156_A	0.654	0.99
388_A	540_V	0.651	0.99
406_P	459_P	0.651	0.99
132_Y	155_R	0.651	0.99
85_N	88_P	0.650	0.99
546_A	557_H	0.649	0.99
15_A	45_D	0.648	0.99
358_A	361_D	0.648	0.99
159_H	164_K	0.647	0.99
136_L	173_P	0.645	0.99
126_Y	169_H	0.645	0.99
357_A	361_D	0.643	0.99
374_L	378_Y	0.642	0.99
289_D	292_L	0.642	0.99
113_G	119_T	0.641	0.99
37_L	76_L	0.641	0.99
521_L	529_T	0.641	0.99
152_S	155_R	0.641	0.99
378_Y	381_A	0.640	0.99
480_E	519_H	0.639	0.99
139_P	176_K	0.639	0.99
454_S	482_C	0.638	0.99
408_T	458_D	0.637	0.99
95_Q	439_A	0.637	0.99
243_A	329_D	0.636	0.99
239_V	268_D	0.635	0.99
223_A	356_I	0.634	0.99
36_P	177_P	0.634	0.99
139_P	181_V	0.634	0.99
60_F	92_E	0.633	0.99
446_V	475_G	0.633	0.99
155_R	158_G	0.630	0.99
304_R	325_Q	0.629	0.99
349_P	354_R	0.628	0.99
234_A	300_E	0.628	0.99
65_R	69_T	0.627	0.99
554_A	557_H	0.626	0.99
449_A	460_V	0.620	0.99
65_R	73_T	0.620	0.99
378_Y	382_V	0.619	0.99
539_T	545_A	0.618	0.99
10_W	13_A	0.617	0.99
447_S	475_G	0.616	0.99
101_V	170_L	0.615	0.99
222_T	345_V	0.615	0.99
410_F	452_A	0.615	0.99
256_A	358_A	0.615	0.99
450_L	478_A	0.615	0.99
131_R	159_H	0.614	0.99
464_V	472_D	0.613	0.99
280_G	372_L	0.611	0.99
535_A	553_D	0.611	0.99
117_N	440_S	0.609	0.99
103_L	170_L	0.607	0.99
32_S	78_T	0.607	0.99
253_A	257_L	0.606	0.99
287_G	290_G	0.606	0.99
54_D	85_N	0.606	0.99
19_A	47_L	0.606	0.99
254_A	258_A	0.605	0.99
434_L	444_G	0.604	0.99
101_V	168_V	0.601	0.99
248_G	431_L	0.598	0.99
99_P	160_T	0.597	0.99
388_A	539_T	0.596	0.99
352_T	356_I	0.596	0.99
290_G	293_A	0.595	0.98
231_T	234_A	0.593	0.98
29_C	496_G	0.592	0.98
217_E	220_G	0.591	0.98
157_V	161_T	0.591	0.98
470_F	474_N	0.591	0.98
487_T	555_G	0.591	0.98
109_P	176_K	0.589	0.98
8_T	12_R	0.589	0.98
521_L	526_T	0.588	0.98
255_A	429_A	0.588	0.98
290_G	295_D	0.587	0.98
262_G	364_R	0.586	0.98
291_F	380_A	0.586	0.98
464_V	488_I	0.586	0.98
286_G	295_D	0.585	0.98
483_G	555_G	0.585	0.98
109_P	138_E	0.584	0.98
109_P	137_P	0.583	0.98
326_V	343_D	0.582	0.98
61_F	454_S	0.580	0.98
395_I	543_F	0.580	0.98
25_A	71_A	0.580	0.98
335_R	341_A	0.580	0.98
480_E	483_G	0.579	0.98
392_E	419_D	0.579	0.98
407_A	458_D	0.578	0.98
499_F	503_P	0.578	0.98
122_Q	169_H	0.578	0.98
72_P	160_T	0.577	0.98
504_I	511_F	0.577	0.98
270_L	437_R	0.577	0.98
500_H	565_A	0.577	0.98
473_S	529_T	0.577	0.98
69_T	451_G	0.576	0.98
223_A	345_V	0.574	0.98
239_V	307_A	0.574	0.98
376_A	379_W	0.573	0.98
26_V	47_L	0.573	0.98
218_P	347_A	0.571	0.98
416_P	491_V	0.570	0.98
410_F	445_V	0.570	0.98
452_A	460_V	0.569	0.98
386_Q	541_G	0.569	0.98
262_G	280_G	0.568	0.98
103_L	153_V	0.566	0.98
446_V	479_L	0.566	0.98
156_A	170_L	0.565	0.98
394_E	544_R	0.565	0.98
31_G	78_T	0.565	0.98
32_S	502_L	0.563	0.98
17_E	150_R	0.562	0.98
537_T	545_A	0.562	0.98
487_T	553_D	0.561	0.98
175_R	179_E	0.559	0.98
53_L	477_L	0.558	0.98
511_F	514_Q	0.558	0.98
399_V	489_V	0.556	0.98
245_G	251_P	0.556	0.98
239_V	302_V	0.555	0.98
219_A	351_A	0.555	0.98
284_V	287_G	0.555	0.98
469_Y	488_I	0.551	0.98
261_T	281_D	0.550	0.97
528_D	535_A	0.549	0.97
86_L	89_A	0.549	0.97
59_A	90_V	0.549	0.97
234_A	366_A	0.548	0.97
377_R	381_A	0.548	0.97
92_E	96_A	0.547	0.97
86_L	104_T	0.547	0.97
24_H	69_T	0.546	0.97
478_A	484_V	0.545	0.97
329_D	334_W	0.545	0.97
67_K	96_A	0.545	0.97
396_A	400_A	0.544	0.97
477_L	521_L	0.543	0.97
281_D	368_T	0.542	0.97
267_A	274_R	0.541	0.97
252_D	259_D	0.541	0.97
140_E	182_S	0.540	0.97
393_G	567_A	0.539	0.97
39_V	43_A	0.539	0.97
32_S	499_F	0.538	0.97
464_V	468_A	0.538	0.97
255_A	258_A	0.538	0.97
288_Y	293_A	0.538	0.97
131_R	164_K	0.538	0.97
492_N	523_F	0.537	0.97
134_E	168_V	0.537	0.97
488_I	558_V	0.537	0.97
39_V	503_P	0.536	0.97
408_T	434_L	0.536	0.97
420_F	433_V	0.536	0.97
218_P	345_V	0.536	0.97
226_L	356_I	0.535	0.97
34_S	105_A	0.535	0.97
221_E	225_A	0.535	0.97
104_T	122_Q	0.532	0.97
231_T	362_G	0.532	0.97
324_R	343_D	0.532	0.97
50_Y	478_A	0.531	0.97
262_G	368_T	0.531	0.97
13_A	183_V	0.530	0.97
58_A	75_V	0.530	0.97
48_T	454_S	0.529	0.97
389_A	564_D	0.529	0.97
66_G	72_P	0.529	0.97
412_S	462_G	0.527	0.97
222_T	343_D	0.527	0.97
250_T	349_P	0.527	0.97
442_I	499_F	0.526	0.97
475_G	478_A	0.526	0.97
549_A	557_H	0.526	0.97
63_L	448_S	0.525	0.97
365_S	368_T	0.525	0.97
74_A	157_V	0.523	0.97
20_A	183_V	0.523	0.97
359_R	362_G	0.522	0.97
535_A	545_A	0.521	0.97
547_Y	551_L	0.520	0.96
10_W	179_E	0.520	0.96
415_M	498_I	0.519	0.96
84_A	120_V	0.518	0.96
68_R	408_T	0.518	0.96
537_T	561_V	0.518	0.96
539_T	543_F	0.517	0.96
383_D	397_A	0.517	0.96
429_A	458_D	0.517	0.96
244_D	250_T	0.516	0.96
248_G	251_P	0.516	0.96
522_D	529_T	0.515	0.96
141_V	152_S	0.515	0.96
215_T	219_A	0.515	0.96
411_V	445_V	0.515	0.96
245_G	431_L	0.514	0.96
446_V	473_S	0.514	0.96
267_A	272_G	0.513	0.96
60_F	89_A	0.513	0.96
33_R	78_T	0.512	0.96
66_G	73_T	0.511	0.96
453_G	456_T	0.511	0.96
91_M	120_V	0.510	0.96
220_G	358_A	0.510	0.96
17_E	157_V	0.509	0.96
105_A	177_P	0.509	0.96
411_V	414_S	0.508	0.96
478_A	482_C	0.508	0.96
78_T	83_T	0.506	0.96
410_F	448_S	0.505	0.96
150_R	153_V	0.504	0.96
94_A	166_G	0.504	0.96
363_T	367_W	0.504	0.96
29_C	52_H	0.504	0.96
296_V	299_P	0.504	0.96
56_R	472_D	0.503	0.96
487_T	547_Y	0.503	0.96
286_G	290_G	0.503	0.96
325_Q	339_F	0.502	0.96
288_Y	291_F	0.502	0.96
321_S	324_R	0.501	0.96
29_C	471_H	0.501	0.96
261_T	357_A	0.500	0.96
447_S	472_D	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ozhA	4	0.9212	100	0.202	Contact Map
2x7jA	4	0.9709	100	0.21	Contact Map
2panA	3	0.9401	100	0.213	Contact Map
1ybhA	4	0.9503	100	0.213	Contact Map
4rjjA	5	0.9281	100	0.214	Contact Map
1t9bA	2	0.9486	100	0.216	Contact Map
3lq1A	4	0.8699	100	0.217	Contact Map
2ihtA	4	0.9161	100	0.219	Contact Map
2uz1A	4	0.9212	100	0.22	Contact Map
3eyaA	5	0.8921	100	0.226	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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