PURA - HALSA - GREMLIN Contacts

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PURA - Adenylosuccinate synthetase

UniProt:	Q9HQM6	Sequences: MTVTIVGAQLGDEGKGGVVDLFGDATDVVVRYQGGDNAGHTVVAGGEEYKLSLVPSGVVRGKTGVLGNGCVINPETLFEEVDALRERGLDPDVRLAKRAHVILPFHRELDGAEEAAKADSDSEIGTTGRGIGPTYEDKIGRRGVRVGDLLNEDALRDRLEYLVDAKRAIYEDVYGFDASETDGAFDIDAIHEQCLAYADRIRDEDLAVNAGDYLADRIADGDNVMLEGAQGTSLDIDHGNFPYVTSSNPTAGYAATGSGLGPTTVGQGEIVGIIKAYLSRVGSGPMPTELDGDQAEYIREEGGEYGTVTGRPRRVGWLDMPMLRHAARANGFTGIAINHLDVLAELDEVNVGHAYERDGERIHTLPATTEAWRDCDPVMKSFDGWSAFDPAVVADAGYSALPDNAQAYVEYVEAELDTPAYVLGVGPGREESVIRQNPFE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	440 (417)
Sequences:	2985 (1488)
Seq/√Len:	72.9

ECOLI - PURA
BACSU - PURA
HALSA - PURA
SULSO - Q980P5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
348_E	381_S	6.182	1.00
356_E	376_D	5.834	1.00
52_S	308_V	5.395	1.00
347_D	386_S	4.230	1.00
82_D	200_R	3.677	1.00
403_D	407_A	3.597	1.00
397_G	400_A	3.544	1.00
50_K	307_T	3.362	1.00
358_D	374_D	3.315	1.00
380_K	411_Y	3.252	1.00
398_Y	406_Q	3.061	1.00
47_E	87_R	3.023	1.00
337_I	409_V	3.014	1.00
299_R	312_P	2.954	1.00
411_Y	415_E	2.950	1.00
296_E	300_E	2.905	1.00
388_F	393_V	2.684	1.00
82_D	86_E	2.673	1.00
348_E	383_D	2.668	1.00
297_Y	346_L	2.622	1.00
404_N	407_A	2.614	1.00
75_E	193_Q	2.608	1.00
318_L	323_L	2.559	1.00
351_V	411_Y	2.548	1.00
320_M	415_E	2.519	1.00
350_N	381_S	2.478	1.00
351_V	382_F	2.399	1.00
297_Y	301_E	2.381	1.00
111_G	128_G	2.365	1.00
186_D	189_A	2.361	1.00
269_E	334_G	2.337	1.00
27_D	222_D	2.331	1.00
73_N	107_R	2.294	1.00
345_E	387_A	2.274	1.00
156_R	160_E	2.243	1.00
344_A	392_V	2.218	1.00
101_V	146_V	2.195	1.00
28_V	217_R	2.190	1.00
188_D	192_E	2.185	1.00
398_Y	410_E	2.173	1.00
105_F	162_L	2.160	1.00
356_E	361_R	2.124	1.00
335_I	416_L	2.082	1.00
300_E	305_Y	2.081	1.00
123_E	283_S	2.052	1.00
233_S	322_M	2.051	1.00
216_D	220_D	2.045	1.00
357_R	375_C	2.037	1.00
171_E	184_A	1.992	1.00
72_I	99_A	1.989	1.00
150_L	207_A	1.954	1.00
66_L	70_C	1.950	1.00
357_R	362_I	1.930	1.00
30_V	258_S	1.929	1.00
334_G	421_Y	1.913	1.00
383_D	404_N	1.891	1.00
411_Y	414_A	1.891	1.00
94_R	208_V	1.866	1.00
403_D	406_Q	1.850	1.00
351_V	415_E	1.823	1.00
357_R	374_D	1.809	1.00
406_Q	410_E	1.804	1.00
382_F	411_Y	1.803	1.00
94_R	213_Y	1.782	1.00
78_F	200_R	1.757	1.00
219_A	417_D	1.743	1.00
8_A	332_F	1.667	1.00
187_I	191_H	1.666	1.00
82_D	85_R	1.640	1.00
118_A	121_D	1.629	0.99
410_E	435_R	1.626	0.99
354_A	361_R	1.621	0.99
318_L	412_V	1.613	0.99
345_E	386_S	1.605	0.99
189_A	193_Q	1.600	0.99
199_D	202_R	1.591	0.99
383_D	407_A	1.589	0.99
407_A	410_E	1.587	0.99
159_L	187_I	1.576	0.99
301_E	345_E	1.572	0.99
395_D	400_A	1.570	0.99
72_I	146_V	1.563	0.99
387_A	404_N	1.561	0.99
413_E	435_R	1.557	0.99
72_I	77_L	1.556	0.99
36_D	73_N	1.555	0.99
66_L	72_I	1.545	0.99
155_L	159_L	1.543	0.99
299_R	305_Y	1.540	0.99
46_G	428_G	1.530	0.99
146_V	207_A	1.506	0.99
36_D	102_I	1.496	0.99
75_E	197_Y	1.494	0.99
160_E	187_I	1.487	0.99
396_A	400_A	1.483	0.99
152_E	195_L	1.483	0.99
44_A	59_V	1.480	0.99
156_R	191_H	1.479	0.99
63_T	94_R	1.477	0.99
218_I	224_V	1.461	0.99
77_L	81_V	1.459	0.99
155_L	194_C	1.458	0.99
150_L	202_R	1.456	0.99
36_D	76_T	1.455	0.99
410_E	413_E	1.449	0.99
295_A	315_V	1.434	0.99
409_V	420_A	1.426	0.99
215_A	219_A	1.425	0.99
100_H	143_G	1.419	0.99
352_G	377_P	1.403	0.98
398_Y	435_R	1.396	0.98
226_L	260_L	1.388	0.98
327_A	332_F	1.382	0.98
208_V	213_Y	1.375	0.98
292_G	295_A	1.361	0.98
99_A	146_V	1.360	0.98
77_L	93_V	1.355	0.98
191_H	195_L	1.352	0.98
4_T	254_A	1.345	0.98
357_R	371_A	1.342	0.98
65_V	210_A	1.340	0.98
353_H	361_R	1.337	0.98
68_N	238_H	1.328	0.98
410_E	414_A	1.325	0.98
203_D	206_L	1.319	0.98
290_L	295_A	1.314	0.98
232_T	330_N	1.311	0.98
388_F	392_V	1.307	0.98
344_A	388_F	1.300	0.97
136_E	140_G	1.299	0.97
380_K	415_E	1.296	0.97
274_I	323_L	1.289	0.97
177_D	184_A	1.287	0.97
368_T	371_A	1.284	0.97
151_N	370_E	1.282	0.97
75_E	79_E	1.269	0.97
396_A	430_E	1.265	0.97
115_A	176_F	1.264	0.97
74_P	201_I	1.261	0.97
112_A	170_Y	1.256	0.97
192_E	196_A	1.248	0.97
156_R	188_D	1.244	0.97
327_A	418_T	1.238	0.97
350_N	379_M	1.229	0.96
320_M	411_Y	1.225	0.96
28_V	214_L	1.222	0.96
263_T	333_T	1.218	0.96
344_A	387_A	1.204	0.96
32_Y	249_P	1.188	0.96
215_A	264_T	1.182	0.96
425_V	431_E	1.171	0.95
291_D	294_Q	1.166	0.95
156_R	187_I	1.145	0.95
159_L	191_H	1.143	0.95
263_T	331_G	1.140	0.95
321_P	354_A	1.130	0.94
361_R	376_D	1.123	0.94
20_D	429_R	1.122	0.94
396_A	431_E	1.121	0.94
61_G	92_D	1.119	0.94
365_L	372_W	1.118	0.94
28_V	213_Y	1.117	0.94
217_R	222_D	1.116	0.94
160_E	164_D	1.108	0.94
412_V	420_A	1.106	0.94
320_M	351_V	1.106	0.94
393_V	431_E	1.103	0.94
215_A	328_R	1.101	0.93
353_H	380_K	1.098	0.93
211_G	328_R	1.094	0.93
78_F	201_I	1.092	0.93
112_A	176_F	1.090	0.93
115_A	128_G	1.085	0.93
83_A	86_E	1.082	0.93
144_V	155_L	1.080	0.93
219_A	264_T	1.076	0.93
63_T	213_Y	1.069	0.92
154_A	158_R	1.066	0.92
214_L	224_V	1.065	0.92
356_E	359_G	1.065	0.92
212_D	328_R	1.063	0.92
296_E	312_P	1.057	0.92
108_E	111_G	1.057	0.92
232_T	326_A	1.056	0.92
344_A	386_S	1.055	0.92
97_K	367_A	1.039	0.91
357_R	360_E	1.033	0.91
261_G	331_G	1.024	0.91
24_D	60_R	1.024	0.91
395_D	398_Y	1.023	0.91
293_D	296_E	1.021	0.91
95_L	146_V	1.019	0.91
217_R	220_D	1.019	0.91
98_R	367_A	1.013	0.90
152_E	156_R	1.010	0.90
297_Y	300_E	1.006	0.90
296_E	299_R	1.002	0.90
194_C	197_Y	0.994	0.89
326_A	330_N	0.993	0.89
198_A	202_R	0.993	0.89
212_D	216_D	0.992	0.89
423_L	433_V	0.990	0.89
382_F	407_A	0.988	0.89
103_L	194_C	0.986	0.89
320_M	323_L	0.983	0.89
248_N	256_T	0.980	0.89
192_E	195_L	0.980	0.89
7_G	13_E	0.974	0.88
72_I	95_L	0.973	0.88
255_A	262_P	0.965	0.88
218_I	260_L	0.962	0.88
413_E	420_A	0.959	0.88
361_R	378_V	0.957	0.88
278_L	322_M	0.956	0.88
320_M	412_V	0.953	0.87
269_E	421_Y	0.946	0.87
214_L	258_S	0.942	0.87
108_E	185_F	0.927	0.86
289_E	314_R	0.923	0.86
279_S	339_H	0.919	0.85
300_E	303_G	0.919	0.85
230_Q	234_L	0.918	0.85
196_A	199_D	0.913	0.85
163_V	167_R	0.911	0.85
298_I	338_N	0.910	0.85
269_E	333_T	0.909	0.85
318_L	416_L	0.908	0.85
202_R	207_A	0.904	0.84
233_S	325_H	0.903	0.84
294_Q	346_L	0.901	0.84
210_A	213_Y	0.900	0.84
168_A	173_V	0.899	0.84
394_A	425_V	0.899	0.84
138_K	237_D	0.899	0.84
156_R	195_L	0.893	0.84
371_A	374_D	0.891	0.84
102_I	134_T	0.890	0.83
340_L	405_A	0.888	0.83
362_I	375_C	0.887	0.83
234_L	280_R	0.875	0.82
185_F	190_I	0.872	0.82
136_E	142_R	0.870	0.82
409_V	423_L	0.868	0.82
272_G	332_F	0.865	0.82
422_V	432_S	0.858	0.81
396_A	425_V	0.856	0.81
252_G	261_G	0.852	0.81
250_T	253_Y	0.850	0.81
211_G	238_H	0.844	0.80
83_A	87_R	0.839	0.80
252_G	256_T	0.838	0.80
122_S	243_Y	0.834	0.79
428_G	431_E	0.831	0.79
293_D	297_Y	0.830	0.79
4_T	265_V	0.829	0.79
85_R	90_D	0.826	0.79
122_S	157_D	0.826	0.79
126_T	132_G	0.825	0.79
294_Q	297_Y	0.824	0.78
65_V	213_Y	0.823	0.78
104_P	193_Q	0.822	0.78
398_Y	409_V	0.822	0.78
146_V	201_I	0.820	0.78
54_V	231_G	0.817	0.78
288_T	379_M	0.816	0.78
108_E	176_F	0.816	0.78
393_V	425_V	0.815	0.78
108_E	170_Y	0.810	0.77
5_I	26_T	0.809	0.77
388_F	425_V	0.808	0.77
216_D	363_H	0.807	0.77
32_Y	253_Y	0.807	0.77
45_G	430_E	0.805	0.77
250_T	256_T	0.801	0.77
43_V	48_E	0.800	0.76
41_T	48_E	0.799	0.76
157_D	161_Y	0.798	0.76
356_E	378_V	0.797	0.76
226_L	258_S	0.796	0.76
212_D	364_T	0.795	0.76
100_H	134_T	0.795	0.76
290_L	294_Q	0.792	0.76
18_V	422_V	0.792	0.76
172_D	175_G	0.792	0.76
74_P	78_F	0.791	0.76
426_G	431_E	0.791	0.76
28_V	63_T	0.787	0.75
362_I	371_A	0.785	0.75
168_A	172_D	0.782	0.75
96_A	210_A	0.779	0.74
68_N	257_G	0.778	0.74
144_V	162_L	0.775	0.74
117_K	161_Y	0.773	0.74
28_V	65_V	0.772	0.74
108_E	112_A	0.772	0.74
334_G	419_P	0.772	0.74
48_E	303_G	0.771	0.74
224_V	260_L	0.770	0.74
409_V	413_E	0.769	0.74
139_I	236_I	0.767	0.73
305_Y	312_P	0.767	0.73
84_L	89_L	0.763	0.73
407_A	414_A	0.763	0.73
323_L	416_L	0.762	0.73
147_G	367_A	0.761	0.73
324_R	415_E	0.761	0.73
229_A	234_L	0.760	0.73
152_E	191_H	0.759	0.73
33_Q	231_G	0.759	0.73
196_A	200_R	0.758	0.72
372_W	375_C	0.758	0.72
79_E	83_A	0.757	0.72
48_E	307_T	0.756	0.72
163_V	185_F	0.756	0.72
193_Q	196_A	0.755	0.72
54_V	84_L	0.755	0.72
194_C	198_A	0.752	0.72
332_F	418_T	0.751	0.72
240_N	280_R	0.751	0.72
349_V	386_S	0.749	0.72
298_I	339_H	0.749	0.72
73_N	76_T	0.747	0.71
68_N	248_N	0.747	0.71
345_E	349_V	0.746	0.71
399_S	406_Q	0.743	0.71
31_R	229_A	0.743	0.71
62_K	90_D	0.741	0.71
274_I	335_I	0.741	0.71
85_R	200_R	0.740	0.71
230_Q	280_R	0.739	0.71
251_A	255_A	0.738	0.70
277_Y	342_V	0.736	0.70
382_F	404_N	0.735	0.70
210_A	214_L	0.733	0.70
52_S	83_A	0.733	0.70
301_E	346_L	0.733	0.70
27_D	223_N	0.730	0.70
409_V	435_R	0.729	0.70
53_L	70_C	0.728	0.69
346_L	349_V	0.721	0.69
65_V	208_V	0.721	0.69
336_A	422_V	0.721	0.69
370_E	373_R	0.721	0.69
138_K	145_R	0.719	0.68
382_F	415_E	0.719	0.68
78_F	82_D	0.719	0.68
325_H	328_R	0.718	0.68
112_A	128_G	0.716	0.68
356_E	360_E	0.715	0.68
339_H	342_V	0.715	0.68
300_E	312_P	0.714	0.68
71_V	135_Y	0.714	0.68
361_R	380_K	0.711	0.68
46_G	430_E	0.711	0.68
58_V	64_G	0.710	0.67
279_S	315_V	0.708	0.67
388_F	394_A	0.705	0.67
302_G	342_V	0.703	0.67
52_S	76_T	0.703	0.67
253_Y	257_G	0.703	0.67
354_A	378_V	0.700	0.66
167_R	171_E	0.699	0.66
226_L	254_A	0.699	0.66
6_V	254_A	0.698	0.66
28_V	222_D	0.697	0.66
349_V	408_Y	0.695	0.66
290_L	315_V	0.695	0.66
229_A	280_R	0.694	0.66
65_V	214_L	0.694	0.66
271_V	334_G	0.693	0.66
163_V	187_I	0.692	0.66
105_F	166_K	0.690	0.65
153_D	157_D	0.690	0.65
388_F	431_E	0.690	0.65
132_G	141_R	0.686	0.65
324_R	363_H	0.686	0.65
50_K	64_G	0.684	0.65
97_K	147_G	0.683	0.64
8_A	274_I	0.683	0.64
61_G	90_D	0.683	0.64
395_D	406_Q	0.681	0.64
113_E	136_E	0.681	0.64
76_T	102_I	0.680	0.64
274_I	337_I	0.680	0.64
137_D	166_K	0.679	0.64
380_K	407_A	0.678	0.64
380_K	383_D	0.677	0.64
108_E	128_G	0.674	0.63
318_L	415_E	0.673	0.63
107_R	111_G	0.673	0.63
195_L	198_A	0.670	0.63
64_G	307_T	0.669	0.63
78_F	197_Y	0.664	0.62
58_V	93_V	0.663	0.62
233_S	365_L	0.659	0.62
294_Q	298_I	0.659	0.62
143_G	241_F	0.657	0.61
354_A	363_H	0.656	0.61
36_D	425_V	0.656	0.61
234_L	240_N	0.655	0.61
66_L	77_L	0.655	0.61
78_F	81_V	0.655	0.61
186_D	195_L	0.654	0.61
54_V	58_V	0.652	0.61
97_K	207_A	0.652	0.61
49_Y	87_R	0.651	0.61
123_E	128_G	0.650	0.61
302_G	315_V	0.647	0.60
36_D	299_R	0.645	0.60
401_L	405_A	0.645	0.60
148_D	158_R	0.642	0.60
335_I	409_V	0.640	0.59
8_A	272_G	0.640	0.59
19_V	274_I	0.639	0.59
215_A	261_G	0.639	0.59
107_R	193_Q	0.639	0.59
153_D	156_R	0.637	0.59
297_Y	345_E	0.634	0.59
193_Q	197_Y	0.632	0.59
167_R	185_F	0.631	0.58
304_E	313_R	0.629	0.58
33_Q	51_L	0.629	0.58
195_L	199_D	0.627	0.58
78_F	95_L	0.627	0.58
109_L	170_Y	0.626	0.58
33_Q	249_P	0.624	0.58
158_R	161_Y	0.623	0.57
321_P	365_L	0.622	0.57
116_A	168_A	0.622	0.57
298_I	349_V	0.620	0.57
28_V	224_V	0.620	0.57
387_A	392_V	0.620	0.57
79_E	82_D	0.620	0.57
18_V	424_G	0.618	0.57
33_Q	106_H	0.617	0.57
218_I	264_T	0.616	0.57
98_R	147_G	0.616	0.57
167_R	184_A	0.615	0.56
293_D	347_D	0.615	0.56
68_N	237_D	0.614	0.56
240_N	278_L	0.613	0.56
6_V	251_A	0.613	0.56
126_T	141_R	0.612	0.56
49_Y	307_T	0.611	0.56
21_L	424_G	0.611	0.56
189_A	192_E	0.611	0.56
270_I	332_F	0.610	0.56
349_V	382_F	0.610	0.56
416_L	420_A	0.609	0.56
422_V	434_I	0.609	0.56
81_V	206_L	0.608	0.56
106_H	228_G	0.608	0.56
126_T	244_V	0.607	0.55
424_G	432_S	0.605	0.55
265_V	270_I	0.605	0.55
170_Y	176_F	0.603	0.55
237_D	248_N	0.603	0.55
392_V	425_V	0.602	0.55
75_E	194_C	0.601	0.55
3_V	271_V	0.601	0.55
32_Y	424_G	0.600	0.55
243_Y	283_S	0.600	0.55
67_G	257_G	0.597	0.54
36_D	166_K	0.596	0.54
52_S	307_T	0.596	0.54
351_V	380_K	0.596	0.54
100_H	145_R	0.595	0.54
344_A	425_V	0.595	0.54
327_A	416_L	0.594	0.54
97_K	150_L	0.593	0.54
30_V	67_G	0.593	0.54
161_Y	164_D	0.589	0.53
147_G	207_A	0.588	0.53
147_G	368_T	0.588	0.53
177_D	186_D	0.588	0.53
335_I	412_V	0.581	0.52
63_T	222_D	0.580	0.52
165_A	169_I	0.580	0.52
369_T	373_R	0.579	0.52
352_G	379_M	0.579	0.52
320_M	416_L	0.578	0.52
124_I	141_R	0.578	0.52
106_H	134_T	0.578	0.52
164_D	168_A	0.577	0.52
212_D	363_H	0.577	0.52
392_V	405_A	0.575	0.52
106_H	137_D	0.575	0.52
68_N	96_A	0.574	0.51
231_G	424_G	0.574	0.51
351_V	412_V	0.574	0.51
212_D	215_A	0.573	0.51
3_V	26_T	0.571	0.51
213_Y	217_R	0.571	0.51
65_V	94_R	0.569	0.51
396_A	433_V	0.568	0.51
60_R	136_E	0.567	0.51
142_R	165_A	0.566	0.50
209_N	325_H	0.566	0.50
151_N	368_T	0.565	0.50
36_D	107_R	0.563	0.50
51_L	58_V	0.563	0.50
9_Q	141_R	0.562	0.50
353_H	356_E	0.562	0.50
52_S	79_E	0.561	0.50
146_V	202_R	0.560	0.50
139_I	142_R	0.558	0.49
266_G	269_E	0.557	0.49
42_V	49_Y	0.557	0.49
4_T	251_A	0.557	0.49
30_V	214_L	0.555	0.49
277_Y	302_G	0.553	0.49
351_V	414_A	0.553	0.49
253_Y	256_T	0.552	0.49
287_P	375_C	0.551	0.49
360_E	376_D	0.551	0.49
150_L	198_A	0.551	0.49
425_V	432_S	0.551	0.49
318_L	351_V	0.550	0.48
5_I	117_K	0.550	0.48
118_A	283_S	0.550	0.48
8_A	323_L	0.549	0.48
85_R	88_G	0.549	0.48
97_K	209_N	0.548	0.48
402_P	405_A	0.547	0.48
288_T	352_G	0.547	0.48
211_G	215_A	0.547	0.48
97_K	368_T	0.545	0.48
358_D	368_T	0.545	0.48
33_Q	56_S	0.545	0.48
304_E	311_R	0.545	0.48
403_D	410_E	0.545	0.48
107_R	129_R	0.544	0.48
206_L	337_I	0.544	0.48
11_G	15_K	0.544	0.48
395_D	435_R	0.543	0.48
316_G	319_D	0.543	0.48
104_P	190_I	0.542	0.47
260_L	264_T	0.542	0.47
23_G	26_T	0.541	0.47
18_V	336_A	0.540	0.47
370_E	374_D	0.540	0.47
335_I	420_A	0.540	0.47
79_E	86_E	0.539	0.47
44_A	47_E	0.539	0.47
122_S	161_Y	0.539	0.47
303_G	312_P	0.538	0.47
129_R	308_V	0.538	0.47
19_V	42_V	0.538	0.47
62_K	92_D	0.537	0.47
154_A	157_D	0.537	0.47
65_V	147_G	0.535	0.47
8_A	231_G	0.535	0.47
236_I	249_P	0.534	0.46
306_G	313_R	0.533	0.46
24_D	406_Q	0.532	0.46
250_T	365_L	0.531	0.46
420_A	423_L	0.531	0.46
408_Y	412_V	0.530	0.46
238_H	254_A	0.530	0.46
7_G	11_G	0.530	0.46
407_A	411_Y	0.530	0.46
344_A	393_V	0.529	0.46
29_V	51_L	0.529	0.46
42_V	59_V	0.529	0.46
23_G	60_R	0.529	0.46
42_V	48_E	0.528	0.46
348_E	407_A	0.528	0.46
144_V	148_D	0.527	0.46
376_D	380_K	0.525	0.45
244_V	280_R	0.525	0.45
77_L	206_L	0.525	0.45
42_V	250_T	0.525	0.45
306_G	309_T	0.525	0.45
172_D	184_A	0.524	0.45
299_R	322_M	0.523	0.45
112_A	115_A	0.523	0.45
74_P	101_V	0.523	0.45
18_V	21_L	0.522	0.45
132_G	280_R	0.522	0.45
54_V	286_M	0.522	0.45
43_V	428_G	0.522	0.45
281_V	311_R	0.520	0.45
166_K	249_P	0.520	0.45
329_A	418_T	0.519	0.45
31_R	106_H	0.519	0.45
383_D	411_Y	0.519	0.45
216_D	364_T	0.517	0.44
264_T	331_G	0.516	0.44
152_E	198_A	0.516	0.44
52_S	129_R	0.515	0.44
36_D	134_T	0.515	0.44
309_T	313_R	0.515	0.44
397_G	433_V	0.514	0.44
405_A	425_V	0.513	0.44
73_N	104_P	0.513	0.44
281_V	309_T	0.512	0.44
293_D	418_T	0.511	0.44
356_E	380_K	0.510	0.44
52_S	310_G	0.510	0.44
136_E	165_A	0.509	0.43
103_L	162_L	0.509	0.43
35_G	40_H	0.509	0.43
250_T	255_A	0.509	0.43
118_A	122_S	0.508	0.43
255_A	265_V	0.508	0.43
66_L	93_V	0.508	0.43
147_G	150_L	0.508	0.43
413_E	419_P	0.508	0.43
322_M	332_F	0.508	0.43
33_Q	228_G	0.508	0.43
275_K	304_E	0.507	0.43
279_S	338_N	0.506	0.43
109_L	166_K	0.505	0.43
160_E	192_E	0.504	0.43
44_A	229_A	0.504	0.43
12_D	16_G	0.504	0.43
349_V	387_A	0.503	0.43
210_A	325_H	0.503	0.43
354_A	380_K	0.503	0.43
75_E	196_A	0.502	0.43
198_A	201_I	0.501	0.42
230_Q	240_N	0.501	0.42
374_D	393_V	0.500	0.42
255_A	260_L	0.500	0.42
127_T	133_P	0.500	0.42
358_D	362_I	0.500	0.42

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4m9dA	2	0.9659	100	0.023	Contact Map
3hidA	2	0.9477	100	0.026	Contact Map
3ue9A	2	0.9409	100	0.027	Contact Map
2v40A	2	0.9273	100	0.04	Contact Map
1p9bA	2	0.95	100	0.044	Contact Map
1dj2A	2	0.9523	100	0.044	Contact Map
3r7tA	4	0.9205	100	0.046	Contact Map
2d7uA	2	0.7205	100	0.22	Contact Map
4jl5A	1	0.4045	42.9	0.98	Contact Map
1f8mA	4	0.6182	32.2	0.981	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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