GREMLIN Database
PURA - Adenylosuccinate synthetase
UniProt: Q9HQM6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 440 (417)
Sequences: 2985 (1488)
Seq/√Len: 72.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
348_E381_S6.1821.00
356_E376_D5.8341.00
52_S308_V5.3951.00
347_D386_S4.2301.00
82_D200_R3.6771.00
403_D407_A3.5971.00
397_G400_A3.5441.00
50_K307_T3.3621.00
358_D374_D3.3151.00
380_K411_Y3.2521.00
398_Y406_Q3.0611.00
47_E87_R3.0231.00
337_I409_V3.0141.00
299_R312_P2.9541.00
411_Y415_E2.9501.00
296_E300_E2.9051.00
388_F393_V2.6841.00
82_D86_E2.6731.00
348_E383_D2.6681.00
297_Y346_L2.6221.00
404_N407_A2.6141.00
75_E193_Q2.6081.00
318_L323_L2.5591.00
351_V411_Y2.5481.00
320_M415_E2.5191.00
350_N381_S2.4781.00
351_V382_F2.3991.00
297_Y301_E2.3811.00
111_G128_G2.3651.00
186_D189_A2.3611.00
269_E334_G2.3371.00
27_D222_D2.3311.00
73_N107_R2.2941.00
345_E387_A2.2741.00
156_R160_E2.2431.00
344_A392_V2.2181.00
101_V146_V2.1951.00
28_V217_R2.1901.00
188_D192_E2.1851.00
398_Y410_E2.1731.00
105_F162_L2.1601.00
356_E361_R2.1241.00
335_I416_L2.0821.00
300_E305_Y2.0811.00
123_E283_S2.0521.00
233_S322_M2.0511.00
216_D220_D2.0451.00
357_R375_C2.0371.00
171_E184_A1.9921.00
72_I99_A1.9891.00
150_L207_A1.9541.00
66_L70_C1.9501.00
357_R362_I1.9301.00
30_V258_S1.9291.00
334_G421_Y1.9131.00
383_D404_N1.8911.00
411_Y414_A1.8911.00
94_R208_V1.8661.00
403_D406_Q1.8501.00
351_V415_E1.8231.00
357_R374_D1.8091.00
406_Q410_E1.8041.00
382_F411_Y1.8031.00
94_R213_Y1.7821.00
78_F200_R1.7571.00
219_A417_D1.7431.00
8_A332_F1.6671.00
187_I191_H1.6661.00
82_D85_R1.6401.00
118_A121_D1.6290.99
410_E435_R1.6260.99
354_A361_R1.6210.99
318_L412_V1.6130.99
345_E386_S1.6050.99
189_A193_Q1.6000.99
199_D202_R1.5910.99
383_D407_A1.5890.99
407_A410_E1.5870.99
159_L187_I1.5760.99
301_E345_E1.5720.99
395_D400_A1.5700.99
72_I146_V1.5630.99
387_A404_N1.5610.99
413_E435_R1.5570.99
72_I77_L1.5560.99
36_D73_N1.5550.99
66_L72_I1.5450.99
155_L159_L1.5430.99
299_R305_Y1.5400.99
46_G428_G1.5300.99
146_V207_A1.5060.99
36_D102_I1.4960.99
75_E197_Y1.4940.99
160_E187_I1.4870.99
396_A400_A1.4830.99
152_E195_L1.4830.99
44_A59_V1.4800.99
156_R191_H1.4790.99
63_T94_R1.4770.99
218_I224_V1.4610.99
77_L81_V1.4590.99
155_L194_C1.4580.99
150_L202_R1.4560.99
36_D76_T1.4550.99
410_E413_E1.4490.99
295_A315_V1.4340.99
409_V420_A1.4260.99
215_A219_A1.4250.99
100_H143_G1.4190.99
352_G377_P1.4030.98
398_Y435_R1.3960.98
226_L260_L1.3880.98
327_A332_F1.3820.98
208_V213_Y1.3750.98
292_G295_A1.3610.98
99_A146_V1.3600.98
77_L93_V1.3550.98
191_H195_L1.3520.98
4_T254_A1.3450.98
357_R371_A1.3420.98
65_V210_A1.3400.98
353_H361_R1.3370.98
68_N238_H1.3280.98
410_E414_A1.3250.98
203_D206_L1.3190.98
290_L295_A1.3140.98
232_T330_N1.3110.98
388_F392_V1.3070.98
344_A388_F1.3000.97
136_E140_G1.2990.97
380_K415_E1.2960.97
274_I323_L1.2890.97
177_D184_A1.2870.97
368_T371_A1.2840.97
151_N370_E1.2820.97
75_E79_E1.2690.97
396_A430_E1.2650.97
115_A176_F1.2640.97
74_P201_I1.2610.97
112_A170_Y1.2560.97
192_E196_A1.2480.97
156_R188_D1.2440.97
327_A418_T1.2380.97
350_N379_M1.2290.96
320_M411_Y1.2250.96
28_V214_L1.2220.96
263_T333_T1.2180.96
344_A387_A1.2040.96
32_Y249_P1.1880.96
215_A264_T1.1820.96
425_V431_E1.1710.95
291_D294_Q1.1660.95
156_R187_I1.1450.95
159_L191_H1.1430.95
263_T331_G1.1400.95
321_P354_A1.1300.94
361_R376_D1.1230.94
20_D429_R1.1220.94
396_A431_E1.1210.94
61_G92_D1.1190.94
365_L372_W1.1180.94
28_V213_Y1.1170.94
217_R222_D1.1160.94
160_E164_D1.1080.94
412_V420_A1.1060.94
320_M351_V1.1060.94
393_V431_E1.1030.94
215_A328_R1.1010.93
353_H380_K1.0980.93
211_G328_R1.0940.93
78_F201_I1.0920.93
112_A176_F1.0900.93
115_A128_G1.0850.93
83_A86_E1.0820.93
144_V155_L1.0800.93
219_A264_T1.0760.93
63_T213_Y1.0690.92
154_A158_R1.0660.92
214_L224_V1.0650.92
356_E359_G1.0650.92
212_D328_R1.0630.92
296_E312_P1.0570.92
108_E111_G1.0570.92
232_T326_A1.0560.92
344_A386_S1.0550.92
97_K367_A1.0390.91
357_R360_E1.0330.91
261_G331_G1.0240.91
24_D60_R1.0240.91
395_D398_Y1.0230.91
293_D296_E1.0210.91
95_L146_V1.0190.91
217_R220_D1.0190.91
98_R367_A1.0130.90
152_E156_R1.0100.90
297_Y300_E1.0060.90
296_E299_R1.0020.90
194_C197_Y0.9940.89
326_A330_N0.9930.89
198_A202_R0.9930.89
212_D216_D0.9920.89
423_L433_V0.9900.89
382_F407_A0.9880.89
103_L194_C0.9860.89
320_M323_L0.9830.89
248_N256_T0.9800.89
192_E195_L0.9800.89
7_G13_E0.9740.88
72_I95_L0.9730.88
255_A262_P0.9650.88
218_I260_L0.9620.88
413_E420_A0.9590.88
361_R378_V0.9570.88
278_L322_M0.9560.88
320_M412_V0.9530.87
269_E421_Y0.9460.87
214_L258_S0.9420.87
108_E185_F0.9270.86
289_E314_R0.9230.86
279_S339_H0.9190.85
300_E303_G0.9190.85
230_Q234_L0.9180.85
196_A199_D0.9130.85
163_V167_R0.9110.85
298_I338_N0.9100.85
269_E333_T0.9090.85
318_L416_L0.9080.85
202_R207_A0.9040.84
233_S325_H0.9030.84
294_Q346_L0.9010.84
210_A213_Y0.9000.84
168_A173_V0.8990.84
394_A425_V0.8990.84
138_K237_D0.8990.84
156_R195_L0.8930.84
371_A374_D0.8910.84
102_I134_T0.8900.83
340_L405_A0.8880.83
362_I375_C0.8870.83
234_L280_R0.8750.82
185_F190_I0.8720.82
136_E142_R0.8700.82
409_V423_L0.8680.82
272_G332_F0.8650.82
422_V432_S0.8580.81
396_A425_V0.8560.81
252_G261_G0.8520.81
250_T253_Y0.8500.81
211_G238_H0.8440.80
83_A87_R0.8390.80
252_G256_T0.8380.80
122_S243_Y0.8340.79
428_G431_E0.8310.79
293_D297_Y0.8300.79
4_T265_V0.8290.79
85_R90_D0.8260.79
122_S157_D0.8260.79
126_T132_G0.8250.79
294_Q297_Y0.8240.78
65_V213_Y0.8230.78
104_P193_Q0.8220.78
398_Y409_V0.8220.78
146_V201_I0.8200.78
54_V231_G0.8170.78
288_T379_M0.8160.78
108_E176_F0.8160.78
393_V425_V0.8150.78
108_E170_Y0.8100.77
5_I26_T0.8090.77
388_F425_V0.8080.77
216_D363_H0.8070.77
32_Y253_Y0.8070.77
45_G430_E0.8050.77
250_T256_T0.8010.77
43_V48_E0.8000.76
41_T48_E0.7990.76
157_D161_Y0.7980.76
356_E378_V0.7970.76
226_L258_S0.7960.76
212_D364_T0.7950.76
100_H134_T0.7950.76
290_L294_Q0.7920.76
18_V422_V0.7920.76
172_D175_G0.7920.76
74_P78_F0.7910.76
426_G431_E0.7910.76
28_V63_T0.7870.75
362_I371_A0.7850.75
168_A172_D0.7820.75
96_A210_A0.7790.74
68_N257_G0.7780.74
144_V162_L0.7750.74
117_K161_Y0.7730.74
28_V65_V0.7720.74
108_E112_A0.7720.74
334_G419_P0.7720.74
48_E303_G0.7710.74
224_V260_L0.7700.74
409_V413_E0.7690.74
139_I236_I0.7670.73
305_Y312_P0.7670.73
84_L89_L0.7630.73
407_A414_A0.7630.73
323_L416_L0.7620.73
147_G367_A0.7610.73
324_R415_E0.7610.73
229_A234_L0.7600.73
152_E191_H0.7590.73
33_Q231_G0.7590.73
196_A200_R0.7580.72
372_W375_C0.7580.72
79_E83_A0.7570.72
48_E307_T0.7560.72
163_V185_F0.7560.72
193_Q196_A0.7550.72
54_V84_L0.7550.72
194_C198_A0.7520.72
332_F418_T0.7510.72
240_N280_R0.7510.72
349_V386_S0.7490.72
298_I339_H0.7490.72
73_N76_T0.7470.71
68_N248_N0.7470.71
345_E349_V0.7460.71
399_S406_Q0.7430.71
31_R229_A0.7430.71
62_K90_D0.7410.71
274_I335_I0.7410.71
85_R200_R0.7400.71
230_Q280_R0.7390.71
251_A255_A0.7380.70
277_Y342_V0.7360.70
382_F404_N0.7350.70
210_A214_L0.7330.70
52_S83_A0.7330.70
301_E346_L0.7330.70
27_D223_N0.7300.70
409_V435_R0.7290.70
53_L70_C0.7280.69
346_L349_V0.7210.69
65_V208_V0.7210.69
336_A422_V0.7210.69
370_E373_R0.7210.69
138_K145_R0.7190.68
382_F415_E0.7190.68
78_F82_D0.7190.68
325_H328_R0.7180.68
112_A128_G0.7160.68
356_E360_E0.7150.68
339_H342_V0.7150.68
300_E312_P0.7140.68
71_V135_Y0.7140.68
361_R380_K0.7110.68
46_G430_E0.7110.68
58_V64_G0.7100.67
279_S315_V0.7080.67
388_F394_A0.7050.67
302_G342_V0.7030.67
52_S76_T0.7030.67
253_Y257_G0.7030.67
354_A378_V0.7000.66
167_R171_E0.6990.66
226_L254_A0.6990.66
6_V254_A0.6980.66
28_V222_D0.6970.66
349_V408_Y0.6950.66
290_L315_V0.6950.66
229_A280_R0.6940.66
65_V214_L0.6940.66
271_V334_G0.6930.66
163_V187_I0.6920.66
105_F166_K0.6900.65
153_D157_D0.6900.65
388_F431_E0.6900.65
132_G141_R0.6860.65
324_R363_H0.6860.65
50_K64_G0.6840.65
97_K147_G0.6830.64
8_A274_I0.6830.64
61_G90_D0.6830.64
395_D406_Q0.6810.64
113_E136_E0.6810.64
76_T102_I0.6800.64
274_I337_I0.6800.64
137_D166_K0.6790.64
380_K407_A0.6780.64
380_K383_D0.6770.64
108_E128_G0.6740.63
318_L415_E0.6730.63
107_R111_G0.6730.63
195_L198_A0.6700.63
64_G307_T0.6690.63
78_F197_Y0.6640.62
58_V93_V0.6630.62
233_S365_L0.6590.62
294_Q298_I0.6590.62
143_G241_F0.6570.61
354_A363_H0.6560.61
36_D425_V0.6560.61
234_L240_N0.6550.61
66_L77_L0.6550.61
78_F81_V0.6550.61
186_D195_L0.6540.61
54_V58_V0.6520.61
97_K207_A0.6520.61
49_Y87_R0.6510.61
123_E128_G0.6500.61
302_G315_V0.6470.60
36_D299_R0.6450.60
401_L405_A0.6450.60
148_D158_R0.6420.60
335_I409_V0.6400.59
8_A272_G0.6400.59
19_V274_I0.6390.59
215_A261_G0.6390.59
107_R193_Q0.6390.59
153_D156_R0.6370.59
297_Y345_E0.6340.59
193_Q197_Y0.6320.59
167_R185_F0.6310.58
304_E313_R0.6290.58
33_Q51_L0.6290.58
195_L199_D0.6270.58
78_F95_L0.6270.58
109_L170_Y0.6260.58
33_Q249_P0.6240.58
158_R161_Y0.6230.57
321_P365_L0.6220.57
116_A168_A0.6220.57
298_I349_V0.6200.57
28_V224_V0.6200.57
387_A392_V0.6200.57
79_E82_D0.6200.57
18_V424_G0.6180.57
33_Q106_H0.6170.57
218_I264_T0.6160.57
98_R147_G0.6160.57
167_R184_A0.6150.56
293_D347_D0.6150.56
68_N237_D0.6140.56
240_N278_L0.6130.56
6_V251_A0.6130.56
126_T141_R0.6120.56
49_Y307_T0.6110.56
21_L424_G0.6110.56
189_A192_E0.6110.56
270_I332_F0.6100.56
349_V382_F0.6100.56
416_L420_A0.6090.56
422_V434_I0.6090.56
81_V206_L0.6080.56
106_H228_G0.6080.56
126_T244_V0.6070.55
424_G432_S0.6050.55
265_V270_I0.6050.55
170_Y176_F0.6030.55
237_D248_N0.6030.55
392_V425_V0.6020.55
75_E194_C0.6010.55
3_V271_V0.6010.55
32_Y424_G0.6000.55
243_Y283_S0.6000.55
67_G257_G0.5970.54
36_D166_K0.5960.54
52_S307_T0.5960.54
351_V380_K0.5960.54
100_H145_R0.5950.54
344_A425_V0.5950.54
327_A416_L0.5940.54
97_K150_L0.5930.54
30_V67_G0.5930.54
161_Y164_D0.5890.53
147_G207_A0.5880.53
147_G368_T0.5880.53
177_D186_D0.5880.53
335_I412_V0.5810.52
63_T222_D0.5800.52
165_A169_I0.5800.52
369_T373_R0.5790.52
352_G379_M0.5790.52
320_M416_L0.5780.52
124_I141_R0.5780.52
106_H134_T0.5780.52
164_D168_A0.5770.52
212_D363_H0.5770.52
392_V405_A0.5750.52
106_H137_D0.5750.52
68_N96_A0.5740.51
231_G424_G0.5740.51
351_V412_V0.5740.51
212_D215_A0.5730.51
3_V26_T0.5710.51
213_Y217_R0.5710.51
65_V94_R0.5690.51
396_A433_V0.5680.51
60_R136_E0.5670.51
142_R165_A0.5660.50
209_N325_H0.5660.50
151_N368_T0.5650.50
36_D107_R0.5630.50
51_L58_V0.5630.50
9_Q141_R0.5620.50
353_H356_E0.5620.50
52_S79_E0.5610.50
146_V202_R0.5600.50
139_I142_R0.5580.49
266_G269_E0.5570.49
42_V49_Y0.5570.49
4_T251_A0.5570.49
30_V214_L0.5550.49
277_Y302_G0.5530.49
351_V414_A0.5530.49
253_Y256_T0.5520.49
287_P375_C0.5510.49
360_E376_D0.5510.49
150_L198_A0.5510.49
425_V432_S0.5510.49
318_L351_V0.5500.48
5_I117_K0.5500.48
118_A283_S0.5500.48
8_A323_L0.5490.48
85_R88_G0.5490.48
97_K209_N0.5480.48
402_P405_A0.5470.48
288_T352_G0.5470.48
211_G215_A0.5470.48
97_K368_T0.5450.48
358_D368_T0.5450.48
33_Q56_S0.5450.48
304_E311_R0.5450.48
403_D410_E0.5450.48
107_R129_R0.5440.48
206_L337_I0.5440.48
11_G15_K0.5440.48
395_D435_R0.5430.48
316_G319_D0.5430.48
104_P190_I0.5420.47
260_L264_T0.5420.47
23_G26_T0.5410.47
18_V336_A0.5400.47
370_E374_D0.5400.47
335_I420_A0.5400.47
79_E86_E0.5390.47
44_A47_E0.5390.47
122_S161_Y0.5390.47
303_G312_P0.5380.47
129_R308_V0.5380.47
19_V42_V0.5380.47
62_K92_D0.5370.47
154_A157_D0.5370.47
65_V147_G0.5350.47
8_A231_G0.5350.47
236_I249_P0.5340.46
306_G313_R0.5330.46
24_D406_Q0.5320.46
250_T365_L0.5310.46
420_A423_L0.5310.46
408_Y412_V0.5300.46
238_H254_A0.5300.46
7_G11_G0.5300.46
407_A411_Y0.5300.46
344_A393_V0.5290.46
29_V51_L0.5290.46
42_V59_V0.5290.46
23_G60_R0.5290.46
42_V48_E0.5280.46
348_E407_A0.5280.46
144_V148_D0.5270.46
376_D380_K0.5250.45
244_V280_R0.5250.45
77_L206_L0.5250.45
42_V250_T0.5250.45
306_G309_T0.5250.45
172_D184_A0.5240.45
299_R322_M0.5230.45
112_A115_A0.5230.45
74_P101_V0.5230.45
18_V21_L0.5220.45
132_G280_R0.5220.45
54_V286_M0.5220.45
43_V428_G0.5220.45
281_V311_R0.5200.45
166_K249_P0.5200.45
329_A418_T0.5190.45
31_R106_H0.5190.45
383_D411_Y0.5190.45
216_D364_T0.5170.44
264_T331_G0.5160.44
152_E198_A0.5160.44
52_S129_R0.5150.44
36_D134_T0.5150.44
309_T313_R0.5150.44
397_G433_V0.5140.44
405_A425_V0.5130.44
73_N104_P0.5130.44
281_V309_T0.5120.44
293_D418_T0.5110.44
356_E380_K0.5100.44
52_S310_G0.5100.44
136_E165_A0.5090.43
103_L162_L0.5090.43
35_G40_H0.5090.43
250_T255_A0.5090.43
118_A122_S0.5080.43
255_A265_V0.5080.43
66_L93_V0.5080.43
147_G150_L0.5080.43
413_E419_P0.5080.43
322_M332_F0.5080.43
33_Q228_G0.5080.43
275_K304_E0.5070.43
279_S338_N0.5060.43
109_L166_K0.5050.43
160_E192_E0.5040.43
44_A229_A0.5040.43
12_D16_G0.5040.43
349_V387_A0.5030.43
210_A325_H0.5030.43
354_A380_K0.5030.43
75_E196_A0.5020.43
198_A201_I0.5010.42
230_Q240_N0.5010.42
374_D393_V0.5000.42
255_A260_L0.5000.42
127_T133_P0.5000.42
358_D362_I0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m9dA 2 0.9659 100 0.023 Contact Map
3hidA 2 0.9477 100 0.026 Contact Map
3ue9A 2 0.9409 100 0.027 Contact Map
2v40A 2 0.9273 100 0.04 Contact Map
1p9bA 2 0.95 100 0.044 Contact Map
1dj2A 2 0.9523 100 0.044 Contact Map
3r7tA 4 0.9205 100 0.046 Contact Map
2d7uA 2 0.7205 100 0.22 Contact Map
4jl5A 1 0.4045 42.9 0.98 Contact Map
1f8mA 4 0.6182 32.2 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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