CBIX - HALSA - GREMLIN Contacts

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CBIX - Probable sirohydrochlorin cobaltochelatase

UniProt:	Q9HQM3	Sequences: MQALVIVGHGSHLNPGSSEPAYTHADTIRESGAFDEVREAFWKEEPSFRNVLRTLESDEVYVVPLFISEGYFTEQVIPRELRLDDFDPDDWDSDGTDADHVTLEADDVEKTIHYCGPVGTHDSMSEVIVQRASSVTGREEFGDDFGLAVVGHGTERNENSAKAIYYHADQIREMGVFGEVQAVFMDEDPEVDDVTDFFDTDDIVVVPLFVSDGFHTQEDIPEDMGLTDDYRTGYDIPTAVDGHDIWYSGAVGTEPLAADVVLERAADAGAPVGDAVDAVREQTRGANAAAGD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	292 (233)
Sequences:	1446 (971)
Seq/√Len:	63.6

BACSU - SIRB
HALSA - CBIX Q9HPL9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
11_S	17_S	4.812	1.00
130_Q	256_L	4.667	1.00
6_I	25_A	4.133	1.00
31_S	259_D	3.997	1.00
59_E	111_T	3.544	1.00
74_E	156_R	3.533	1.00
22_Y	41_F	3.132	1.00
4_L	265_A	3.034	1.00
144_D	201_D	2.938	1.00
67_I	208_L	2.842	1.00
72_F	76_V	2.710	1.00
38_R	54_T	2.675	1.00
32_G	266_A	2.659	1.00
7_V	62_V	2.574	1.00
59_E	113_H	2.525	1.00
47_S	50_N	2.522	1.00
5_V	51_V	2.388	1.00
130_Q	254_E	2.231	1.00
32_G	35_D	2.217	1.00
62_V	81_L	2.208	1.00
126_E	174_M	2.198	1.00
28_I	261_V	2.180	1.00
260_V	263_E	2.164	1.00
31_S	258_A	2.146	1.00
123_S	263_E	2.132	1.00
32_G	262_L	2.120	1.00
27_T	258_A	2.097	1.00
53_R	106_D	2.094	1.00
27_T	255_P	2.025	1.00
52_L	112_I	2.011	1.00
5_V	60_V	1.975	1.00
190_E	193_D	1.958	1.00
9_H	72_F	1.832	1.00
116_G	267_D	1.811	1.00
43_K	72_F	1.784	1.00
40_A	51_V	1.783	1.00
165_Y	184_F	1.712	0.99
72_F	215_H	1.704	0.99
43_K	76_V	1.672	0.99
121_H	263_E	1.635	0.99
66_F	73_T	1.618	0.99
149_V	180_V	1.613	0.99
70_G	215_H	1.613	0.99
74_E	158_E	1.604	0.99
145_F	202_D	1.580	0.99
123_S	259_D	1.569	0.99
262_L	266_A	1.522	0.99
12_H	215_H	1.507	0.98
152_H	215_H	1.503	0.98
15_P	19_E	1.481	0.98
13_L	16_G	1.457	0.98
16_G	217_Q	1.444	0.98
152_H	186_D	1.440	0.98
183_V	194_V	1.417	0.98
127_V	254_E	1.414	0.98
132_A	206_V	1.387	0.97
126_E	256_L	1.382	0.97
150_V	183_V	1.382	0.97
224_M	245_I	1.373	0.97
188_D	193_D	1.363	0.97
5_V	55_L	1.355	0.97
131_R	254_E	1.348	0.97
69_E	74_E	1.340	0.97
61_Y	115_C	1.333	0.97
168_A	182_A	1.332	0.97
181_Q	197_F	1.306	0.96
71_Y	152_H	1.290	0.96
118_V	264_R	1.283	0.96
257_A	260_V	1.274	0.96
207_P	216_T	1.253	0.95
148_A	183_V	1.233	0.95
82_R	85_D	1.232	0.95
53_R	57_S	1.232	0.95
81_L	114_Y	1.226	0.95
9_H	76_V	1.224	0.95
136_T	139_E	1.205	0.94
145_F	204_V	1.186	0.94
43_K	215_H	1.181	0.94
13_L	217_Q	1.179	0.93
6_I	37_V	1.170	0.93
209_F	216_T	1.162	0.93
129_V	175_G	1.152	0.93
63_V	115_C	1.145	0.92
70_G	73_T	1.130	0.92
20_P	250_A	1.098	0.91
155_E	210_V	1.094	0.91
76_V	215_H	1.087	0.90
69_E	163_A	1.070	0.90
186_D	215_H	1.070	0.90
149_V	168_A	1.055	0.89
148_A	194_V	1.049	0.89
16_G	19_E	1.049	0.89
9_H	43_K	1.047	0.89
67_I	72_F	1.046	0.89
210_V	257_A	1.046	0.89
120_T	208_L	1.043	0.88
128_I	206_V	1.041	0.88
63_V	265_A	1.039	0.88
26_D	29_R	1.037	0.88
66_F	70_G	1.037	0.88
128_I	149_V	1.027	0.88
184_F	200_T	1.027	0.88
152_H	211_S	1.026	0.88
184_F	189_P	1.023	0.87
212_D	217_Q	1.016	0.87
119_G	155_E	1.012	0.87
216_T	250_A	1.010	0.87
11_S	42_W	0.999	0.86
67_I	210_V	0.995	0.86
204_V	207_P	0.981	0.85
171_I	175_G	0.980	0.85
196_D	230_Y	0.975	0.85
35_D	262_L	0.972	0.85
183_V	198_F	0.968	0.84
221_P	247_Y	0.964	0.84
42_W	70_G	0.962	0.84
48_F	77_I	0.957	0.84
45_E	79_R	0.951	0.83
21_A	151_G	0.951	0.83
3_A	36_E	0.943	0.83
6_I	21_A	0.937	0.82
52_L	84_D	0.934	0.82
53_R	107_D	0.929	0.82
48_F	52_L	0.926	0.82
147_L	177_F	0.922	0.81
146_G	200_T	0.920	0.81
43_K	152_H	0.917	0.81
129_V	174_M	0.914	0.81
193_D	196_D	0.906	0.80
72_F	78_P	0.902	0.80
11_S	78_P	0.901	0.80
126_E	201_D	0.892	0.79
169_D	172_R	0.889	0.79
129_V	171_I	0.879	0.78
192_D	226_L	0.873	0.78
51_V	207_P	0.873	0.78
33_A	244_D	0.870	0.77
127_V	257_A	0.869	0.77
35_D	265_A	0.868	0.77
49_R	80_E	0.864	0.77
66_F	76_V	0.863	0.77
255_P	262_L	0.863	0.77
61_Y	265_A	0.861	0.77
5_V	62_V	0.857	0.76
48_F	80_E	0.852	0.76
131_R	134_S	0.848	0.76
27_T	253_T	0.845	0.75
126_E	129_V	0.843	0.75
146_G	203_I	0.835	0.74
12_H	72_F	0.834	0.74
43_K	71_Y	0.832	0.74
185_M	209_F	0.825	0.74
22_Y	39_E	0.825	0.74
28_I	262_L	0.821	0.73
204_V	248_S	0.819	0.73
61_Y	269_G	0.814	0.73
25_A	52_L	0.811	0.72
5_V	40_A	0.810	0.72
209_F	251_V	0.808	0.72
207_P	248_S	0.808	0.72
154_T	252_G	0.807	0.72
163_A	170_Q	0.806	0.72
115_C	261_V	0.803	0.71
132_A	204_V	0.800	0.71
162_K	166_Y	0.798	0.71
36_E	110_K	0.796	0.71
9_H	215_H	0.795	0.71
73_T	117_P	0.792	0.70
262_L	265_A	0.791	0.70
173_E	267_D	0.790	0.70
124_M	257_A	0.776	0.69
152_H	209_F	0.775	0.69
12_H	214_F	0.772	0.68
17_S	209_F	0.772	0.68
8_G	21_A	0.770	0.68
114_Y	117_P	0.770	0.68
21_A	182_A	0.766	0.68
134_S	249_G	0.764	0.68
63_V	75_Q	0.763	0.68
225_G	228_D	0.760	0.67
225_G	230_Y	0.750	0.66
144_D	202_D	0.749	0.66
121_H	260_V	0.744	0.66
66_F	215_H	0.742	0.65
126_E	130_Q	0.738	0.65
9_H	70_G	0.734	0.65
194_V	198_F	0.725	0.64
18_S	253_T	0.723	0.63
139_E	142_G	0.721	0.63
25_A	39_E	0.720	0.63
169_D	173_E	0.716	0.63
80_E	117_P	0.714	0.62
155_E	184_F	0.710	0.62
150_V	194_V	0.709	0.62
127_V	256_L	0.709	0.62
21_A	25_A	0.708	0.62
27_T	30_E	0.706	0.62
17_S	48_F	0.705	0.61
186_D	216_T	0.705	0.61
24_H	211_S	0.702	0.61
8_G	151_G	0.700	0.61
31_S	262_L	0.698	0.61
32_G	265_A	0.697	0.61
129_V	133_S	0.696	0.60
128_I	171_I	0.696	0.60
44_E	78_P	0.694	0.60
269_G	272_V	0.689	0.60
23_T	226_L	0.689	0.60
12_H	43_K	0.689	0.60
168_A	180_V	0.688	0.60
202_D	244_D	0.686	0.59
4_L	29_R	0.684	0.59
60_V	112_I	0.683	0.59
76_V	251_V	0.681	0.59
60_V	110_K	0.678	0.58
143_D	178_G	0.673	0.58
161_A	184_F	0.671	0.58
151_G	165_Y	0.669	0.57
115_C	264_R	0.669	0.57
71_Y	211_S	0.669	0.57
8_G	18_S	0.668	0.57
21_A	39_E	0.667	0.57
8_G	165_Y	0.666	0.57
155_E	159_N	0.665	0.57
171_I	254_E	0.663	0.57
78_P	215_H	0.660	0.56
125_S	170_Q	0.659	0.56
74_E	116_G	0.658	0.56
136_T	142_G	0.657	0.56
43_K	48_F	0.655	0.56
74_E	152_H	0.654	0.56
78_P	214_F	0.653	0.56
152_H	214_F	0.653	0.56
154_T	213_G	0.648	0.55
80_E	83_L	0.647	0.55
266_A	270_A	0.646	0.55
30_E	54_T	0.645	0.55
11_S	112_I	0.645	0.55
152_H	216_T	0.644	0.55
158_E	166_Y	0.637	0.54
125_S	171_I	0.637	0.54
26_D	111_T	0.637	0.54
4_L	71_Y	0.636	0.54
34_F	53_R	0.634	0.53
148_A	195_T	0.633	0.53
118_V	148_A	0.633	0.53
184_F	187_E	0.630	0.53
42_W	167_H	0.629	0.53
161_A	187_E	0.629	0.53
165_Y	257_A	0.627	0.53
214_F	218_E	0.624	0.52
35_D	259_D	0.624	0.52
68_S	211_S	0.623	0.52
145_F	179_E	0.621	0.52
9_H	66_F	0.617	0.51
137_G	142_G	0.616	0.51
166_Y	173_E	0.616	0.51
23_T	57_S	0.615	0.51
255_P	259_D	0.613	0.51
223_D	226_L	0.611	0.51
45_E	48_F	0.611	0.51
26_D	124_M	0.610	0.51
66_F	72_F	0.608	0.50
70_G	159_N	0.606	0.50
165_Y	169_D	0.604	0.50
37_V	248_S	0.603	0.50
259_D	262_L	0.603	0.50
85_D	108_V	0.602	0.50
135_V	248_S	0.601	0.50
21_A	62_V	0.599	0.49
230_Y	245_I	0.598	0.49
146_G	198_F	0.595	0.49
49_R	83_L	0.594	0.49
22_Y	26_D	0.588	0.48
11_S	44_E	0.587	0.48
132_A	136_T	0.586	0.48
55_L	62_V	0.582	0.47
9_H	12_H	0.582	0.47
142_G	145_F	0.581	0.47
252_G	260_V	0.580	0.47
206_V	248_S	0.579	0.47
80_E	152_H	0.578	0.47
122_D	172_R	0.576	0.47
108_V	112_I	0.575	0.47
46_P	72_F	0.573	0.46
263_E	267_D	0.572	0.46
73_T	159_N	0.572	0.46
62_V	162_K	0.570	0.46
69_E	147_L	0.569	0.46
70_G	264_R	0.569	0.46
18_S	44_E	0.568	0.46
146_G	194_V	0.568	0.46
266_A	269_G	0.567	0.46
148_A	182_A	0.565	0.45
56_E	110_K	0.562	0.45
118_V	130_Q	0.561	0.45
25_A	28_I	0.561	0.45
222_E	269_G	0.559	0.45
66_F	75_Q	0.559	0.45
81_L	112_I	0.556	0.44
70_G	156_R	0.555	0.44
150_V	191_V	0.554	0.44
49_R	52_L	0.551	0.44
81_L	150_V	0.550	0.44
19_E	22_Y	0.550	0.44
128_I	265_A	0.550	0.44
135_V	204_V	0.548	0.44
204_V	246_W	0.547	0.43
65_L	261_V	0.541	0.43
150_V	220_I	0.541	0.43
131_R	222_E	0.538	0.42
44_E	209_F	0.536	0.42
115_C	181_Q	0.534	0.42
17_S	46_P	0.534	0.42
135_V	139_E	0.533	0.42
11_S	209_F	0.533	0.42
9_H	78_P	0.532	0.42
147_L	180_V	0.531	0.42
12_H	78_P	0.531	0.42
132_A	147_L	0.530	0.41
24_H	257_A	0.528	0.41
132_A	171_I	0.527	0.41
43_K	75_Q	0.526	0.41
84_D	159_N	0.525	0.41
46_P	74_E	0.524	0.41
46_P	131_R	0.523	0.41
124_M	259_D	0.523	0.41
117_P	121_H	0.523	0.41
130_Q	171_I	0.522	0.41
171_I	216_T	0.519	0.40
30_E	33_A	0.518	0.40
41_F	248_S	0.517	0.40
7_V	149_V	0.515	0.40
156_R	208_L	0.514	0.40
9_H	207_P	0.512	0.39
67_I	152_H	0.509	0.39
4_L	61_Y	0.509	0.39
116_G	188_D	0.508	0.39
46_P	248_S	0.508	0.39
77_I	128_I	0.508	0.39
41_F	210_V	0.507	0.39
65_L	147_L	0.507	0.39
67_I	74_E	0.506	0.39
17_S	163_A	0.505	0.39
38_R	60_V	0.503	0.38
115_C	158_E	0.502	0.38
83_L	176_V	0.501	0.38
15_P	270_A	0.501	0.38
41_F	48_F	0.500	0.38
121_H	124_M	0.500	0.38

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2jh3A	2	0.9178	100	0.388	Contact Map
4ccsA	1	0.7603	100	0.43	Contact Map
2xvyA	3	0.8219	100	0.486	Contact Map
2xwpA	5	0.8014	100	0.521	Contact Map
1lbqA	2	0.8836	99.9	0.642	Contact Map
2h1vA	1	0.8116	99.9	0.642	Contact Map
3hcnA	2	0.9075	99.9	0.642	Contact Map
2xwsA	2	0.4178	99.9	0.675	Contact Map
1tjnA	4	0.4144	99.9	0.677	Contact Map
3lyhA	2	0.3973	99.8	0.714	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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