GREMLIN Database
CBIX - Probable sirohydrochlorin cobaltochelatase
UniProt: Q9HQM3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 292 (233)
Sequences: 1446 (971)
Seq/√Len: 63.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_S17_S4.8121.00
130_Q256_L4.6671.00
6_I25_A4.1331.00
31_S259_D3.9971.00
59_E111_T3.5441.00
74_E156_R3.5331.00
22_Y41_F3.1321.00
4_L265_A3.0341.00
144_D201_D2.9381.00
67_I208_L2.8421.00
72_F76_V2.7101.00
38_R54_T2.6751.00
32_G266_A2.6591.00
7_V62_V2.5741.00
59_E113_H2.5251.00
47_S50_N2.5221.00
5_V51_V2.3881.00
130_Q254_E2.2311.00
32_G35_D2.2171.00
62_V81_L2.2081.00
126_E174_M2.1981.00
28_I261_V2.1801.00
260_V263_E2.1641.00
31_S258_A2.1461.00
123_S263_E2.1321.00
32_G262_L2.1201.00
27_T258_A2.0971.00
53_R106_D2.0941.00
27_T255_P2.0251.00
52_L112_I2.0111.00
5_V60_V1.9751.00
190_E193_D1.9581.00
9_H72_F1.8321.00
116_G267_D1.8111.00
43_K72_F1.7841.00
40_A51_V1.7831.00
165_Y184_F1.7120.99
72_F215_H1.7040.99
43_K76_V1.6720.99
121_H263_E1.6350.99
66_F73_T1.6180.99
149_V180_V1.6130.99
70_G215_H1.6130.99
74_E158_E1.6040.99
145_F202_D1.5800.99
123_S259_D1.5690.99
262_L266_A1.5220.99
12_H215_H1.5070.98
152_H215_H1.5030.98
15_P19_E1.4810.98
13_L16_G1.4570.98
16_G217_Q1.4440.98
152_H186_D1.4400.98
183_V194_V1.4170.98
127_V254_E1.4140.98
132_A206_V1.3870.97
126_E256_L1.3820.97
150_V183_V1.3820.97
224_M245_I1.3730.97
188_D193_D1.3630.97
5_V55_L1.3550.97
131_R254_E1.3480.97
69_E74_E1.3400.97
61_Y115_C1.3330.97
168_A182_A1.3320.97
181_Q197_F1.3060.96
71_Y152_H1.2900.96
118_V264_R1.2830.96
257_A260_V1.2740.96
207_P216_T1.2530.95
148_A183_V1.2330.95
82_R85_D1.2320.95
53_R57_S1.2320.95
81_L114_Y1.2260.95
9_H76_V1.2240.95
136_T139_E1.2050.94
145_F204_V1.1860.94
43_K215_H1.1810.94
13_L217_Q1.1790.93
6_I37_V1.1700.93
209_F216_T1.1620.93
129_V175_G1.1520.93
63_V115_C1.1450.92
70_G73_T1.1300.92
20_P250_A1.0980.91
155_E210_V1.0940.91
76_V215_H1.0870.90
69_E163_A1.0700.90
186_D215_H1.0700.90
149_V168_A1.0550.89
148_A194_V1.0490.89
16_G19_E1.0490.89
9_H43_K1.0470.89
67_I72_F1.0460.89
210_V257_A1.0460.89
120_T208_L1.0430.88
128_I206_V1.0410.88
63_V265_A1.0390.88
26_D29_R1.0370.88
66_F70_G1.0370.88
128_I149_V1.0270.88
184_F200_T1.0270.88
152_H211_S1.0260.88
184_F189_P1.0230.87
212_D217_Q1.0160.87
119_G155_E1.0120.87
216_T250_A1.0100.87
11_S42_W0.9990.86
67_I210_V0.9950.86
204_V207_P0.9810.85
171_I175_G0.9800.85
196_D230_Y0.9750.85
35_D262_L0.9720.85
183_V198_F0.9680.84
221_P247_Y0.9640.84
42_W70_G0.9620.84
48_F77_I0.9570.84
45_E79_R0.9510.83
21_A151_G0.9510.83
3_A36_E0.9430.83
6_I21_A0.9370.82
52_L84_D0.9340.82
53_R107_D0.9290.82
48_F52_L0.9260.82
147_L177_F0.9220.81
146_G200_T0.9200.81
43_K152_H0.9170.81
129_V174_M0.9140.81
193_D196_D0.9060.80
72_F78_P0.9020.80
11_S78_P0.9010.80
126_E201_D0.8920.79
169_D172_R0.8890.79
129_V171_I0.8790.78
192_D226_L0.8730.78
51_V207_P0.8730.78
33_A244_D0.8700.77
127_V257_A0.8690.77
35_D265_A0.8680.77
49_R80_E0.8640.77
66_F76_V0.8630.77
255_P262_L0.8630.77
61_Y265_A0.8610.77
5_V62_V0.8570.76
48_F80_E0.8520.76
131_R134_S0.8480.76
27_T253_T0.8450.75
126_E129_V0.8430.75
146_G203_I0.8350.74
12_H72_F0.8340.74
43_K71_Y0.8320.74
185_M209_F0.8250.74
22_Y39_E0.8250.74
28_I262_L0.8210.73
204_V248_S0.8190.73
61_Y269_G0.8140.73
25_A52_L0.8110.72
5_V40_A0.8100.72
209_F251_V0.8080.72
207_P248_S0.8080.72
154_T252_G0.8070.72
163_A170_Q0.8060.72
115_C261_V0.8030.71
132_A204_V0.8000.71
162_K166_Y0.7980.71
36_E110_K0.7960.71
9_H215_H0.7950.71
73_T117_P0.7920.70
262_L265_A0.7910.70
173_E267_D0.7900.70
124_M257_A0.7760.69
152_H209_F0.7750.69
12_H214_F0.7720.68
17_S209_F0.7720.68
8_G21_A0.7700.68
114_Y117_P0.7700.68
21_A182_A0.7660.68
134_S249_G0.7640.68
63_V75_Q0.7630.68
225_G228_D0.7600.67
225_G230_Y0.7500.66
144_D202_D0.7490.66
121_H260_V0.7440.66
66_F215_H0.7420.65
126_E130_Q0.7380.65
9_H70_G0.7340.65
194_V198_F0.7250.64
18_S253_T0.7230.63
139_E142_G0.7210.63
25_A39_E0.7200.63
169_D173_E0.7160.63
80_E117_P0.7140.62
155_E184_F0.7100.62
150_V194_V0.7090.62
127_V256_L0.7090.62
21_A25_A0.7080.62
27_T30_E0.7060.62
17_S48_F0.7050.61
186_D216_T0.7050.61
24_H211_S0.7020.61
8_G151_G0.7000.61
31_S262_L0.6980.61
32_G265_A0.6970.61
129_V133_S0.6960.60
128_I171_I0.6960.60
44_E78_P0.6940.60
269_G272_V0.6890.60
23_T226_L0.6890.60
12_H43_K0.6890.60
168_A180_V0.6880.60
202_D244_D0.6860.59
4_L29_R0.6840.59
60_V112_I0.6830.59
76_V251_V0.6810.59
60_V110_K0.6780.58
143_D178_G0.6730.58
161_A184_F0.6710.58
151_G165_Y0.6690.57
115_C264_R0.6690.57
71_Y211_S0.6690.57
8_G18_S0.6680.57
21_A39_E0.6670.57
8_G165_Y0.6660.57
155_E159_N0.6650.57
171_I254_E0.6630.57
78_P215_H0.6600.56
125_S170_Q0.6590.56
74_E116_G0.6580.56
136_T142_G0.6570.56
43_K48_F0.6550.56
74_E152_H0.6540.56
78_P214_F0.6530.56
152_H214_F0.6530.56
154_T213_G0.6480.55
80_E83_L0.6470.55
266_A270_A0.6460.55
30_E54_T0.6450.55
11_S112_I0.6450.55
152_H216_T0.6440.55
158_E166_Y0.6370.54
125_S171_I0.6370.54
26_D111_T0.6370.54
4_L71_Y0.6360.54
34_F53_R0.6340.53
148_A195_T0.6330.53
118_V148_A0.6330.53
184_F187_E0.6300.53
42_W167_H0.6290.53
161_A187_E0.6290.53
165_Y257_A0.6270.53
214_F218_E0.6240.52
35_D259_D0.6240.52
68_S211_S0.6230.52
145_F179_E0.6210.52
9_H66_F0.6170.51
137_G142_G0.6160.51
166_Y173_E0.6160.51
23_T57_S0.6150.51
255_P259_D0.6130.51
223_D226_L0.6110.51
45_E48_F0.6110.51
26_D124_M0.6100.51
66_F72_F0.6080.50
70_G159_N0.6060.50
165_Y169_D0.6040.50
37_V248_S0.6030.50
259_D262_L0.6030.50
85_D108_V0.6020.50
135_V248_S0.6010.50
21_A62_V0.5990.49
230_Y245_I0.5980.49
146_G198_F0.5950.49
49_R83_L0.5940.49
22_Y26_D0.5880.48
11_S44_E0.5870.48
132_A136_T0.5860.48
55_L62_V0.5820.47
9_H12_H0.5820.47
142_G145_F0.5810.47
252_G260_V0.5800.47
206_V248_S0.5790.47
80_E152_H0.5780.47
122_D172_R0.5760.47
108_V112_I0.5750.47
46_P72_F0.5730.46
263_E267_D0.5720.46
73_T159_N0.5720.46
62_V162_K0.5700.46
69_E147_L0.5690.46
70_G264_R0.5690.46
18_S44_E0.5680.46
146_G194_V0.5680.46
266_A269_G0.5670.46
148_A182_A0.5650.45
56_E110_K0.5620.45
118_V130_Q0.5610.45
25_A28_I0.5610.45
222_E269_G0.5590.45
66_F75_Q0.5590.45
81_L112_I0.5560.44
70_G156_R0.5550.44
150_V191_V0.5540.44
49_R52_L0.5510.44
81_L150_V0.5500.44
19_E22_Y0.5500.44
128_I265_A0.5500.44
135_V204_V0.5480.44
204_V246_W0.5470.43
65_L261_V0.5410.43
150_V220_I0.5410.43
131_R222_E0.5380.42
44_E209_F0.5360.42
115_C181_Q0.5340.42
17_S46_P0.5340.42
135_V139_E0.5330.42
11_S209_F0.5330.42
9_H78_P0.5320.42
147_L180_V0.5310.42
12_H78_P0.5310.42
132_A147_L0.5300.41
24_H257_A0.5280.41
132_A171_I0.5270.41
43_K75_Q0.5260.41
84_D159_N0.5250.41
46_P74_E0.5240.41
46_P131_R0.5230.41
124_M259_D0.5230.41
117_P121_H0.5230.41
130_Q171_I0.5220.41
171_I216_T0.5190.40
30_E33_A0.5180.40
41_F248_S0.5170.40
7_V149_V0.5150.40
156_R208_L0.5140.40
9_H207_P0.5120.39
67_I152_H0.5090.39
4_L61_Y0.5090.39
116_G188_D0.5080.39
46_P248_S0.5080.39
77_I128_I0.5080.39
41_F210_V0.5070.39
65_L147_L0.5070.39
67_I74_E0.5060.39
17_S163_A0.5050.39
38_R60_V0.5030.38
115_C158_E0.5020.38
83_L176_V0.5010.38
15_P270_A0.5010.38
41_F48_F0.5000.38
121_H124_M0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jh3A 2 0.9178 100 0.388 Contact Map
4ccsA 1 0.7603 100 0.43 Contact Map
2xvyA 3 0.8219 100 0.486 Contact Map
2xwpA 5 0.8014 100 0.521 Contact Map
1lbqA 2 0.8836 99.9 0.642 Contact Map
2h1vA 1 0.8116 99.9 0.642 Contact Map
3hcnA 2 0.9075 99.9 0.642 Contact Map
2xwsA 2 0.4178 99.9 0.675 Contact Map
1tjnA 4 0.4144 99.9 0.677 Contact Map
3lyhA 2 0.3973 99.8 0.714 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0086 seconds.