GREMLIN Database
Q9HQM2 - Uncharacterized protein
UniProt: Q9HQM2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 394 (334)
Sequences: 207 (180)
Seq/√Len: 9.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_S249_D4.0650.99
387_S390_A3.8940.98
292_P295_P3.7540.98
213_W223_R3.6990.98
191_R215_D3.5060.97
211_T225_V3.4670.97
188_V193_A3.4550.97
54_A241_L3.4090.96
191_R217_R3.3370.96
300_F315_A3.2950.95
327_M374_L2.8020.90
51_S248_A2.6370.86
181_S197_R2.5600.85
36_A267_I2.5370.84
327_M391_V2.4660.82
191_R222_L2.4610.82
222_L244_V2.3540.79
212_L374_L2.3500.79
15_L18_A2.3330.78
240_H386_A2.2270.75
292_P390_A2.2110.74
27_F279_A2.1860.74
58_S216_A2.1100.71
259_P263_A2.1030.71
221_P292_P2.0820.70
114_N263_A2.0460.68
53_S74_R2.0400.68
38_S286_R2.0070.67
25_C388_A2.0020.67
17_L20_V1.9800.66
55_T243_N1.9740.65
345_V352_A1.9640.65
300_F390_A1.9570.65
196_F217_R1.9520.65
116_V263_A1.9480.64
190_G200_P1.9410.64
184_G213_W1.9190.63
118_R250_L1.9090.63
100_L221_P1.9050.63
37_P345_V1.8950.62
321_G369_G1.8870.62
24_G329_K1.8700.61
13_L348_A1.8440.60
20_V278_L1.8260.59
76_S84_R1.8180.59
102_T195_G1.7940.58
213_W365_W1.7720.57
189_A222_L1.7180.54
299_S322_A1.7010.54
83_R347_V1.7000.54
42_V171_N1.6990.53
102_T290_P1.6540.51
102_T387_S1.6480.51
55_T74_R1.6060.49
22_L253_K1.5950.49
17_L34_T1.5840.48
22_L368_G1.5780.48
74_R86_S1.5610.47
196_F360_T1.5580.47
343_A354_Y1.5310.46
111_A239_S1.5030.45
292_P315_A1.4990.44
260_P347_V1.4920.44
200_P325_A1.4530.42
16_I19_L1.4340.41
51_S78_A1.4250.41
345_V363_V1.4230.41
164_A178_Y1.4160.41
281_L298_Y1.4100.40
81_S112_S1.4040.40
251_S280_A1.4040.40
220_Y275_F1.3960.40
295_P365_W1.3770.39
118_R345_V1.3760.39
55_T295_P1.3760.39
295_P390_A1.3660.39
60_I244_V1.3660.39
16_I21_V1.3640.38
116_V260_P1.3600.38
17_L22_L1.3580.38
22_L192_N1.3450.38
341_A368_G1.3410.37
11_V17_L1.3300.37
120_P317_Y1.3210.37
42_V262_D1.3140.36
13_L261_A1.3090.36
107_M265_T1.3060.36
116_V265_T1.3040.36
50_E327_M1.2970.36
34_T380_N1.2930.35
201_A219_Y1.2910.35
25_C170_D1.2860.35
107_M257_W1.2830.35
15_L20_V1.2770.35
102_T389_A1.2750.35
16_I239_S1.2720.35
185_A391_V1.2710.34
98_V297_A1.2690.34
199_T276_D1.2630.34
82_L369_G1.2630.34
325_A390_A1.2580.34
215_D315_A1.2550.34
75_I328_T1.2530.34
23_G54_A1.2450.33
226_T239_S1.2450.33
203_D347_V1.2440.33
42_V84_R1.2440.33
329_K372_Y1.2410.33
21_V175_V1.2320.33
265_T358_G1.2320.33
287_L313_V1.2300.33
217_R222_L1.2220.33
260_P263_A1.2170.32
247_N255_F1.2030.32
294_L365_W1.1970.32
84_R389_A1.1950.31
106_T256_S1.1940.31
348_A367_C1.1930.31
107_M116_V1.1910.31
342_G353_S1.1900.31
252_A379_L1.1900.31
166_A327_M1.1860.31
198_L214_L1.1840.31
302_S360_T1.1810.31
109_Y260_P1.1800.31
315_A382_S1.1720.31
195_G317_Y1.1690.30
99_T198_L1.1650.30
120_P253_K1.1580.30
264_T358_G1.1510.30
64_N270_T1.1480.30
24_G294_L1.1350.29
292_P388_A1.1330.29
287_L292_P1.1310.29
91_P244_V1.1310.29
15_L40_T1.1300.29
42_V251_S1.1300.29
65_T293_E1.1300.29
24_G365_W1.1180.28
15_L221_P1.1140.28
193_A217_R1.1120.28
374_L379_L1.1090.28
198_L286_R1.0900.27
216_A245_T1.0830.27
109_Y190_G1.0780.27
308_A331_T1.0730.27
16_I186_R1.0630.27
54_A175_V1.0560.26
92_N313_V1.0530.26
188_V388_A1.0520.26
167_D211_T1.0520.26
205_A222_L1.0480.26
73_L112_S1.0440.26
321_G379_L1.0440.26
238_R352_A1.0430.26
123_D346_T1.0420.26
100_L239_S1.0390.26
78_A82_L1.0360.26
21_V280_A1.0350.26
226_T292_P1.0310.25
171_N348_A1.0290.25
116_V180_V1.0240.25
81_S365_W1.0240.25
211_T363_V1.0230.25
85_F283_D1.0210.25
52_V244_V1.0190.25
19_L199_T1.0180.25
290_P348_A1.0140.25
202_T345_V1.0060.25
114_N345_V1.0010.24
166_A201_A0.9960.24
22_L57_V0.9920.24
86_S100_L0.9900.24
35_G352_A0.9820.24
233_T245_T0.9720.23
109_Y184_G0.9710.23
16_I366_A0.9670.23
310_H333_P0.9660.23
120_P386_A0.9640.23
253_K386_A0.9610.23
296_A374_L0.9600.23
86_S314_T0.9580.23
248_A304_R0.9550.23
107_M295_P0.9530.23
103_G346_T0.9510.23
49_I76_S0.9500.23
22_L305_T0.9500.23
48_D216_A0.9460.23
118_R321_G0.9460.23
25_C352_A0.9460.23
20_V218_Y0.9460.23
181_S343_A0.9440.22
16_I183_L0.9440.22
216_A325_A0.9400.22
106_T121_H0.9370.22
379_L383_Q0.9330.22
65_T181_S0.9330.22
36_A234_T0.9300.22
312_Q349_G0.9290.22
24_G288_S0.9290.22
317_Y372_Y0.9260.22
52_V365_W0.9240.22
38_S45_G0.9200.22
260_P317_Y0.9190.22
91_P190_G0.9170.22
244_V281_L0.9150.22
277_A280_A0.9150.22
165_D168_A0.9140.22
93_A115_R0.9060.21
233_T327_M0.8990.21
107_M285_S0.8980.21
42_V372_Y0.8970.21
196_F226_T0.8970.21
191_R251_S0.8940.21
32_D221_P0.8940.21
241_L314_T0.8930.21
253_K291_D0.8880.21
38_S94_T0.8880.21
122_N214_L0.8840.21
195_G246_F0.8840.21
16_I313_V0.8830.21
100_L116_V0.8800.21
214_L372_Y0.8760.20
232_A352_A0.8760.20
94_T238_R0.8750.20
312_Q330_F0.8740.20
51_S380_N0.8720.20
115_R347_V0.8650.20
98_V346_T0.8640.20
10_S23_G0.8630.20
22_L170_D0.8620.20
281_L289_V0.8600.20
80_D390_A0.8600.20
45_G167_D0.8560.20
218_Y246_F0.8550.20
116_V165_D0.8540.20
184_G260_P0.8540.20
51_S354_Y0.8500.20
195_G292_P0.8490.20
40_T193_A0.8490.20
190_G213_W0.8450.20
38_S183_L0.8420.19
247_N388_A0.8410.19
84_R169_T0.8370.19
196_F374_L0.8320.19
103_G389_A0.8310.19
299_S363_V0.8310.19
80_D175_V0.8300.19
330_F369_G0.8280.19
17_L24_G0.8260.19
17_L41_A0.8240.19
109_Y116_V0.8230.19
18_A120_P0.8210.19
201_A297_A0.8200.19
247_N300_F0.8190.19
238_R293_E0.8140.19
180_V377_G0.8130.19
79_G212_L0.8110.19
96_G100_L0.8110.19
119_A187_T0.8090.19
211_T310_H0.8080.18
241_L384_L0.8070.18
52_V73_L0.8070.18
14_C335_G0.8000.18
279_A300_F0.7960.18
114_N261_A0.7950.18
196_F241_L0.7940.18
264_T283_D0.7910.18
163_A311_R0.7900.18
40_T181_S0.7890.18
60_I363_V0.7890.18
93_A391_V0.7860.18
80_D238_R0.7850.18
28_V251_S0.7790.18
258_T296_A0.7780.18
80_D211_T0.7770.18
240_H278_L0.7770.18
51_S54_A0.7640.17
212_L226_T0.7630.17
237_L271_T0.7620.17
195_G258_T0.7610.17
222_L247_N0.7610.17
23_G381_R0.7550.17
17_L386_A0.7530.17
185_A211_T0.7530.17
46_L246_F0.7530.17
125_A301_D0.7530.17
200_P298_Y0.7510.17
37_P321_G0.7500.17
20_V327_M0.7490.17
50_E242_E0.7470.17
39_S197_R0.7420.17
117_T299_S0.7410.17
116_V259_P0.7400.17
75_I201_A0.7400.17
59_G238_R0.7350.17
356_V389_A0.7340.17
79_G114_N0.7300.16
171_N174_D0.7290.16
166_A191_R0.7280.16
74_R245_T0.7260.16
313_V361_R0.7230.16
238_R384_L0.7220.16
38_S219_Y0.7210.16
280_A389_A0.7180.16
170_D177_G0.7170.16
52_V273_R0.7150.16
82_L320_P0.7150.16
55_T242_E0.7130.16
372_Y384_L0.7130.16
110_D313_V0.7120.16
15_L215_D0.7120.16
212_L271_T0.7120.16
188_V213_W0.7090.16
64_N209_T0.7090.16
263_A292_P0.7080.16
236_H272_T0.7080.16
82_L329_K0.7080.16
59_G317_Y0.7040.16
14_C243_N0.7030.16
24_G50_E0.7030.16
10_S186_R0.7010.16
63_G349_G0.7000.16
112_S389_A0.7000.16
26_V285_S0.6990.16
111_A371_Q0.6970.16
44_A244_V0.6970.16
74_R259_P0.6960.16
77_L84_R0.6930.16
87_R99_T0.6930.16
118_R248_A0.6900.15
362_R379_L0.6870.15
221_P287_L0.6800.15
108_A306_S0.6770.15
109_Y257_W0.6750.15
194_H318_S0.6740.15
86_S176_P0.6730.15
328_T371_Q0.6730.15
196_F212_L0.6700.15
185_A220_Y0.6680.15
52_V196_F0.6680.15
196_F210_Q0.6660.15
193_A223_R0.6640.15
308_A330_F0.6640.15
107_M214_L0.6640.15
215_D222_L0.6630.15
39_S64_N0.6620.15
41_A106_T0.6620.15
93_A194_H0.6620.15
54_A342_G0.6620.15
100_L257_W0.6610.15
194_H210_Q0.6610.15
15_L23_G0.6610.15
83_R344_Q0.6610.15
98_V225_V0.6600.15
256_S345_V0.6590.15
76_S254_P0.6590.15
11_V16_I0.6590.15
214_L289_V0.6560.15
61_R277_A0.6550.15
186_R350_Q0.6500.15
333_P370_V0.6500.15
220_Y246_F0.6490.15
193_A365_W0.6480.14
66_S369_G0.6460.14
181_S382_S0.6410.14
261_A379_L0.6400.14
52_V84_R0.6400.14
49_I247_N0.6400.14
108_A357_T0.6390.14
15_L21_V0.6390.14
109_Y263_A0.6380.14
102_T211_T0.6340.14
118_R326_T0.6320.14
172_T328_T0.6310.14
32_D296_A0.6310.14
50_E363_V0.6310.14
38_S252_A0.6300.14
163_A263_A0.6300.14
92_N205_A0.6290.14
363_V385_L0.6280.14
315_A390_A0.6280.14
221_P369_G0.6260.14
50_E341_A0.6250.14
126_V220_Y0.6240.14
114_N343_A0.6240.14
85_F216_A0.6220.14
198_L202_T0.6210.14
73_L369_G0.6200.14
381_R387_S0.6200.14
216_A317_Y0.6190.14
105_G369_G0.6160.14
185_A285_S0.6160.14
287_L343_A0.6160.14
258_T370_V0.6160.14
301_D364_S0.6150.14
185_A348_A0.6140.14
103_G200_P0.6120.14
44_A64_N0.6110.14
207_D297_A0.6100.14
244_V265_T0.6060.14
332_A371_Q0.6050.14
320_P378_A0.6050.14
102_T119_A0.6030.13
258_T329_K0.6020.13
13_L114_N0.6010.13
163_A209_T0.5990.13
24_G309_A0.5960.13
34_T165_D0.5960.13
40_T264_T0.5950.13
85_F387_S0.5940.13
326_T379_L0.5930.13
55_T75_I0.5930.13
218_Y268_V0.5910.13
249_D374_L0.5910.13
39_S72_T0.5910.13
211_T290_P0.5900.13
195_G390_A0.5890.13
253_K387_S0.5890.13
245_T382_S0.5880.13
113_R327_M0.5880.13
64_N74_R0.5870.13
96_G111_A0.5860.13
190_G260_P0.5860.13
292_P329_K0.5860.13
18_A246_F0.5840.13
215_D218_Y0.5830.13
121_H124_A0.5820.13
104_H326_T0.5800.13
105_G232_A0.5770.13
116_V219_Y0.5740.13
83_R373_R0.5730.13
121_H296_A0.5700.13
277_A363_V0.5690.13
99_T344_Q0.5660.13
98_V113_R0.5640.13
339_L352_A0.5610.13
74_R276_D0.5600.13
214_L260_P0.5600.13
115_R297_A0.5590.13
109_Y194_H0.5580.13
15_L189_A0.5580.13
269_D364_S0.5580.13
101_V316_E0.5570.13
281_L379_L0.5570.13
330_F342_G0.5560.13
279_A285_S0.5530.12
284_A321_G0.5530.12
293_E317_Y0.5520.12
52_V361_R0.5510.12
285_S306_S0.5510.12
217_R312_Q0.5510.12
110_D119_A0.5500.12
347_V378_A0.5490.12
23_G36_A0.5490.12
233_T343_A0.5450.12
302_S361_R0.5440.12
65_T299_S0.5430.12
38_S235_Y0.5430.12
281_L329_K0.5420.12
164_A357_T0.5420.12
237_L308_A0.5380.12
329_K363_V0.5380.12
214_L360_T0.5360.12
356_V374_L0.5350.12
100_L107_M0.5350.12
306_S370_V0.5340.12
73_L365_W0.5320.12
327_M338_A0.5320.12
55_T331_T0.5320.12
312_Q317_Y0.5310.12
259_P265_T0.5300.12
50_E345_V0.5300.12
194_H264_T0.5300.12
114_N255_F0.5280.12
103_G286_R0.5270.12
193_A261_A0.5260.12
241_L352_A0.5260.12
277_A281_L0.5250.12
27_F363_V0.5230.12
38_S41_A0.5210.12
244_V298_Y0.5210.12
55_T171_N0.5210.12
116_V217_R0.5170.12
38_S186_R0.5170.12
58_S107_M0.5160.12
188_V281_L0.5160.12
186_R381_R0.5130.12
199_T311_R0.5130.12
38_S244_V0.5110.12
246_F325_A0.5100.12
117_T321_G0.5090.12
36_A192_N0.5090.12
54_A262_D0.5070.12
311_R331_T0.5070.12
255_F387_S0.5070.12
215_D231_N0.5040.12
236_H370_V0.5030.12
239_S366_A0.5020.11
114_N390_A0.5010.11
308_A354_Y0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3m4wA 2 0.7132 100 0.642 Contact Map
2yzyA 1 0.4112 100 0.718 Contact Map
4mxtA 2 0.467 99.9 0.725 Contact Map
3buuA 1 0.4873 99.9 0.74 Contact Map
4z48A 1 0.4949 99.9 0.753 Contact Map
2w7qA 1 0.4822 99.9 0.759 Contact Map
3bk5A 1 0.4949 99.9 0.765 Contact Map
1iwlA 1 0.4492 99.8 0.776 Contact Map
4qa8A 1 0.4695 98.8 0.881 Contact Map
3mh9C 1 0.4822 98.6 0.889 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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