GREMLIN Database
Q9HQM0 - Uncharacterized protein
UniProt: Q9HQM0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 102 (90)
Sequences: 301 (227)
Seq/√Len: 23.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_E62_S3.6501.00
14_A66_A3.1661.00
39_I48_L2.8410.99
19_M27_T2.8030.99
20_S61_H2.7070.99
7_A38_R2.6410.99
31_S38_R2.6070.99
6_H38_R2.2270.97
70_Q74_E2.1490.96
31_S35_V1.9000.92
4_D42_L1.8730.92
39_I43_T1.8370.91
38_R61_H1.7970.90
33_A38_R1.6940.87
53_N63_V1.6230.85
48_L63_V1.5630.83
52_I55_R1.5520.82
35_V38_R1.4860.79
28_C40_D1.4340.77
12_A79_E1.4130.76
6_H30_A1.4110.75
23_Q67_T1.3780.74
17_D68_L1.3030.69
34_T69_T1.3020.69
11_L20_S1.2970.69
76_D79_E1.2760.68
26_E64_Y1.2580.67
3_D59_N1.2370.65
30_A93_D1.2360.65
25_S32_T1.2300.65
32_T35_V1.1840.62
31_S45_L1.1810.62
62_S80_F1.1440.59
2_L73_L1.1370.59
32_T65_R1.1120.57
20_S90_D1.0930.55
23_Q30_A1.0880.55
14_A18_P1.0800.55
16_R78_G1.0690.54
33_A64_Y1.0470.52
12_A80_F1.0230.51
7_A31_S1.0090.50
39_I45_L1.0070.49
30_A54_V0.9750.47
32_T75_L0.9640.46
2_L8_R0.9620.46
21_A52_I0.9580.46
48_L60_H0.9580.46
51_S63_V0.9560.46
54_V92_A0.9450.45
31_S61_H0.9410.45
30_A35_V0.9260.44
16_R49_E0.9220.43
28_C51_S0.9170.43
43_T48_L0.9070.42
10_I28_C0.9010.42
76_D81_T0.8840.41
23_Q84_V0.8770.40
33_A61_H0.8760.40
38_R92_A0.8570.39
74_E83_E0.8560.39
35_V89_E0.8500.38
29_D62_S0.8490.38
46_G82_T0.8330.37
23_Q69_T0.8250.37
2_L5_E0.8200.37
72_T88_T0.8170.36
46_G78_G0.8120.36
32_T59_N0.8060.36
22_T32_T0.8000.35
4_D60_H0.7960.35
41_D45_L0.7880.34
6_H31_S0.7680.33
17_D86_C0.7680.33
19_M23_Q0.7640.33
9_A26_E0.7560.32
13_A52_I0.7460.32
48_L65_R0.7430.32
11_L83_E0.7400.31
11_L59_N0.7230.30
71_F91_V0.7190.30
41_D70_Q0.6980.29
81_T84_V0.6960.29
64_Y76_D0.6940.29
24_L28_C0.6930.29
43_T50_E0.6900.28
3_D22_T0.6850.28
3_D62_S0.6830.28
34_T65_R0.6800.28
53_N88_T0.6760.28
16_R91_V0.6760.28
14_A63_V0.6740.28
75_L80_F0.6660.27
14_A68_L0.6620.27
26_E88_T0.6580.27
4_D75_L0.6500.26
26_E73_L0.6400.26
25_S30_A0.6390.26
55_R59_N0.6370.25
49_E73_L0.6300.25
5_E67_T0.6280.25
13_A19_M0.6230.25
66_A84_V0.6180.24
41_D66_A0.6180.24
23_Q49_E0.6140.24
21_A35_V0.6110.24
25_S73_L0.6060.24
22_T82_T0.5980.23
21_A29_D0.5980.23
35_V55_R0.5940.23
27_T44_E0.5920.23
58_G72_T0.5890.23
8_R21_A0.5860.23
73_L82_T0.5780.22
18_P36_Y0.5770.22
22_T27_T0.5760.22
17_D76_D0.5710.22
4_D7_A0.5710.22
3_D24_L0.5620.22
29_D44_E0.5590.22
13_A27_T0.5570.21
12_A18_P0.5540.21
33_A85_E0.5510.21
73_L83_E0.5500.21
14_A53_N0.5480.21
67_T83_E0.5470.21
20_S92_A0.5430.21
80_F84_V0.5420.21
49_E60_H0.5420.21
57_D80_F0.5360.20
5_E44_E0.5360.20
4_D93_D0.5130.19
59_N66_A0.5080.19
24_L37_R0.5050.19
9_A71_F0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g6qA 4 0.9216 98.6 0.725 Contact Map
2qlzA 2 0.9706 98.5 0.735 Contact Map
1q1hA 1 0.6765 98.3 0.754 Contact Map
2p4wA 2 0.9804 98.2 0.756 Contact Map
3f6vA 2 0.8529 98.2 0.756 Contact Map
2oqgA 4 0.8627 98.2 0.761 Contact Map
3f6oA 2 0.8137 98.2 0.761 Contact Map
3u1dA 2 0.902 98 0.772 Contact Map
1u2wA 2 0.7941 98 0.772 Contact Map
3pqkA 2 0.7843 98 0.772 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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