Q9HQM0 - HALSA - GREMLIN Contacts

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Q9HQM0 - Uncharacterized protein

UniProt:	Q9HQM0	Sequences: MLDDEHARAILAAASRDPMSATQLSETCDASTATVYRRIDDLTELGLLEESINVRSDGNHHSVYRATLTQFTLELDDGEFTTEVECETEDVADRFTRMWEGL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	102 (90)
Sequences:	301 (227)
Seq/√Len:	23.9

HALSA - Q9HQM0 Q9HMS0 Q9HPS6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
50_E	62_S	3.650	1.00
14_A	66_A	3.166	1.00
39_I	48_L	2.841	0.99
19_M	27_T	2.803	0.99
20_S	61_H	2.707	0.99
7_A	38_R	2.641	0.99
31_S	38_R	2.607	0.99
6_H	38_R	2.227	0.97
70_Q	74_E	2.149	0.96
31_S	35_V	1.900	0.92
4_D	42_L	1.873	0.92
39_I	43_T	1.837	0.91
38_R	61_H	1.797	0.90
33_A	38_R	1.694	0.87
53_N	63_V	1.623	0.85
48_L	63_V	1.563	0.83
52_I	55_R	1.552	0.82
35_V	38_R	1.486	0.79
28_C	40_D	1.434	0.77
12_A	79_E	1.413	0.76
6_H	30_A	1.411	0.75
23_Q	67_T	1.378	0.74
17_D	68_L	1.303	0.69
34_T	69_T	1.302	0.69
11_L	20_S	1.297	0.69
76_D	79_E	1.276	0.68
26_E	64_Y	1.258	0.67
3_D	59_N	1.237	0.65
30_A	93_D	1.236	0.65
25_S	32_T	1.230	0.65
32_T	35_V	1.184	0.62
31_S	45_L	1.181	0.62
62_S	80_F	1.144	0.59
2_L	73_L	1.137	0.59
32_T	65_R	1.112	0.57
20_S	90_D	1.093	0.55
23_Q	30_A	1.088	0.55
14_A	18_P	1.080	0.55
16_R	78_G	1.069	0.54
33_A	64_Y	1.047	0.52
12_A	80_F	1.023	0.51
7_A	31_S	1.009	0.50
39_I	45_L	1.007	0.49
30_A	54_V	0.975	0.47
32_T	75_L	0.964	0.46
2_L	8_R	0.962	0.46
21_A	52_I	0.958	0.46
48_L	60_H	0.958	0.46
51_S	63_V	0.956	0.46
54_V	92_A	0.945	0.45
31_S	61_H	0.941	0.45
30_A	35_V	0.926	0.44
16_R	49_E	0.922	0.43
28_C	51_S	0.917	0.43
43_T	48_L	0.907	0.42
10_I	28_C	0.901	0.42
76_D	81_T	0.884	0.41
23_Q	84_V	0.877	0.40
33_A	61_H	0.876	0.40
38_R	92_A	0.857	0.39
74_E	83_E	0.856	0.39
35_V	89_E	0.850	0.38
29_D	62_S	0.849	0.38
46_G	82_T	0.833	0.37
23_Q	69_T	0.825	0.37
2_L	5_E	0.820	0.37
72_T	88_T	0.817	0.36
46_G	78_G	0.812	0.36
32_T	59_N	0.806	0.36
22_T	32_T	0.800	0.35
4_D	60_H	0.796	0.35
41_D	45_L	0.788	0.34
6_H	31_S	0.768	0.33
17_D	86_C	0.768	0.33
19_M	23_Q	0.764	0.33
9_A	26_E	0.756	0.32
13_A	52_I	0.746	0.32
48_L	65_R	0.743	0.32
11_L	83_E	0.740	0.31
11_L	59_N	0.723	0.30
71_F	91_V	0.719	0.30
41_D	70_Q	0.698	0.29
81_T	84_V	0.696	0.29
64_Y	76_D	0.694	0.29
24_L	28_C	0.693	0.29
43_T	50_E	0.690	0.28
3_D	22_T	0.685	0.28
3_D	62_S	0.683	0.28
34_T	65_R	0.680	0.28
53_N	88_T	0.676	0.28
16_R	91_V	0.676	0.28
14_A	63_V	0.674	0.28
75_L	80_F	0.666	0.27
14_A	68_L	0.662	0.27
26_E	88_T	0.658	0.27
4_D	75_L	0.650	0.26
26_E	73_L	0.640	0.26
25_S	30_A	0.639	0.26
55_R	59_N	0.637	0.25
49_E	73_L	0.630	0.25
5_E	67_T	0.628	0.25
13_A	19_M	0.623	0.25
66_A	84_V	0.618	0.24
41_D	66_A	0.618	0.24
23_Q	49_E	0.614	0.24
21_A	35_V	0.611	0.24
25_S	73_L	0.606	0.24
22_T	82_T	0.598	0.23
21_A	29_D	0.598	0.23
35_V	55_R	0.594	0.23
27_T	44_E	0.592	0.23
58_G	72_T	0.589	0.23
8_R	21_A	0.586	0.23
73_L	82_T	0.578	0.22
18_P	36_Y	0.577	0.22
22_T	27_T	0.576	0.22
17_D	76_D	0.571	0.22
4_D	7_A	0.571	0.22
3_D	24_L	0.562	0.22
29_D	44_E	0.559	0.22
13_A	27_T	0.557	0.21
12_A	18_P	0.554	0.21
33_A	85_E	0.551	0.21
73_L	83_E	0.550	0.21
14_A	53_N	0.548	0.21
67_T	83_E	0.547	0.21
20_S	92_A	0.543	0.21
80_F	84_V	0.542	0.21
49_E	60_H	0.542	0.21
57_D	80_F	0.536	0.20
5_E	44_E	0.536	0.20
4_D	93_D	0.513	0.19
59_N	66_A	0.508	0.19
24_L	37_R	0.505	0.19
9_A	71_F	0.500	0.19

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4g6qA	4	0.9216	98.6	0.725	Contact Map
2qlzA	2	0.9706	98.5	0.735	Contact Map
1q1hA	1	0.6765	98.3	0.754	Contact Map
2p4wA	2	0.9804	98.2	0.756	Contact Map
3f6vA	2	0.8529	98.2	0.756	Contact Map
2oqgA	4	0.8627	98.2	0.761	Contact Map
3f6oA	2	0.8137	98.2	0.761	Contact Map
3u1dA	2	0.902	98	0.772	Contact Map
1u2wA	2	0.7941	98	0.772	Contact Map
3pqkA	2	0.7843	98	0.772	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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