GREMLIN Database
SYC - Cysteine--tRNA ligase
UniProt: Q9HQL9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 494 (438)
Sequences: 17804 (10273)
Seq/√Len: 490.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_L60_Y5.2011.00
129_G133_D3.8391.00
375_E392_A3.6691.00
58_A377_A3.5831.00
147_D150_R3.1731.00
304_E327_E3.1561.00
286_E292_L3.0921.00
50_V315_V3.0801.00
36_D98_S3.0451.00
23_N61_G3.0121.00
104_R110_R3.0031.00
134_A265_A2.8851.00
459_Q463_A2.8611.00
78_R81_A2.8431.00
130_D133_D2.8291.00
56_S109_A2.7791.00
82_D94_H2.7611.00
416_H420_D2.7041.00
136_Y150_R2.6741.00
84_L94_H2.4091.00
130_D134_A2.3921.00
105_A303_A2.3551.00
147_D178_R2.3421.00
374_G378_A2.3181.00
184_A187_K2.2911.00
216_A221_E2.2561.00
378_A383_D2.2511.00
98_S101_D2.2251.00
385_N388_A2.2151.00
126_D130_D2.2141.00
89_A93_A2.2071.00
97_Q101_D2.1461.00
54_W58_A2.1421.00
52_T56_S2.1281.00
85_G90_A2.0501.00
243_D272_A2.0311.00
127_L266_A1.9871.00
392_A395_E1.9721.00
55_L58_A1.9641.00
107_N428_D1.9621.00
228_I231_S1.9181.00
114_Y117_V1.9071.00
100_I104_R1.9071.00
380_M425_L1.8951.00
240_D263_S1.8841.00
198_T202_D1.8811.00
52_T62_V1.8511.00
300_N303_A1.8321.00
455_D459_Q1.7981.00
123_E236_T1.7901.00
93_A97_Q1.7681.00
379_A388_A1.7241.00
178_R182_D1.7221.00
371_D375_E1.7051.00
369_V417_D1.7001.00
182_D186_W1.6991.00
452_L456_V1.6701.00
379_A392_A1.6661.00
101_D105_A1.6651.00
20_D23_N1.6501.00
48_S246_V1.6461.00
199_H202_D1.6351.00
377_A382_A1.6251.00
200_R203_E1.6241.00
51_M384_F1.6151.00
451_D455_D1.5931.00
368_A399_A1.5921.00
181_A185_L1.5791.00
131_L265_A1.5781.00
185_L189_G1.5751.00
54_W377_A1.5541.00
299_S303_A1.5521.00
408_D411_D1.5501.00
372_A396_L1.5471.00
84_L91_V1.5441.00
55_L382_A1.5391.00
174_Q178_R1.5211.00
178_R181_A1.5051.00
181_A186_W1.5011.00
199_H203_E1.4961.00
180_P183_F1.4881.00
20_D25_L1.4801.00
327_E331_S1.4661.00
45_W103_M1.4531.00
452_L455_D1.4431.00
344_H415_L1.4311.00
367_T371_D1.4311.00
234_A237_H1.4141.00
368_A371_D1.4131.00
344_H433_Q1.4051.00
440_E443_V1.4051.00
297_T300_N1.4051.00
61_G239_D1.3991.00
173_E180_P1.3931.00
97_Q100_I1.3921.00
422_F430_L1.3841.00
182_D185_L1.3821.00
76_V80_G1.3731.00
149_R179_H1.3721.00
113_V117_V1.3561.00
207_L210_E1.3481.00
301_A310_V1.3451.00
309_V334_T1.3421.00
183_F187_K1.3391.00
46_V314_L1.3371.00
143_S177_K1.3361.00
183_F186_W1.3351.00
283_T326_S1.3331.00
375_E378_A1.3321.00
181_A184_A1.3221.00
228_I232_A1.3141.00
77_A81_A1.3131.00
185_L188_A1.3121.00
446_A449_V1.3111.00
362_D403_H1.3061.00
186_W189_G1.3011.00
26_V52_T1.3001.00
57_H420_D1.2981.00
206_P210_E1.2971.00
443_V446_A1.2961.00
459_Q462_T1.2901.00
179_H183_F1.2871.00
91_V95_Y1.2871.00
273_D384_F1.2811.00
458_E462_T1.2811.00
153_E156_A1.2791.00
231_S236_T1.2741.00
447_D451_D1.2721.00
373_R377_A1.2721.00
173_E176_E1.2701.00
370_A373_R1.2661.00
448_D451_D1.2661.00
205_P208_D1.2611.00
176_E180_P1.2571.00
167_P170_P1.2531.00
180_P184_A1.2531.00
389_A425_L1.2501.00
31_L34_S1.2451.00
206_P209_G1.2421.00
120_H123_E1.2411.00
200_R204_L1.2361.00
54_W380_M1.2351.00
240_D269_E1.2341.00
283_T328_A1.2321.00
184_A188_A1.2211.00
187_K193_P1.2211.00
230_C233_M1.2181.00
421_A424_T1.2161.00
101_D104_R1.2151.00
177_K181_A1.2141.00
68_V96_T1.2101.00
105_A302_V1.2081.00
182_D188_A1.2081.00
130_D266_A1.2051.00
45_W108_L1.2041.00
402_R406_G1.1981.00
78_R82_D1.1981.00
235_M238_L1.1961.00
198_T203_E1.1951.00
84_L90_A1.1851.00
339_R397_A1.1841.00
360_P363_D1.1801.00
44_L278_V1.1801.00
365_L414_G1.1751.00
199_H204_L1.1731.00
413_Q417_D1.1721.00
328_A331_S1.1681.00
231_S235_M1.1671.00
373_R421_A1.1661.00
417_D420_D1.1631.00
376_F389_A1.1601.00
380_M389_A1.1591.00
177_K180_P1.1581.00
239_D243_D1.1451.00
369_V373_R1.1421.00
101_D299_S1.1421.00
22_E60_Y1.1361.00
233_M236_T1.1341.00
198_T201_D1.1311.00
177_K183_F1.1231.00
308_N341_Q1.1221.00
448_D452_L1.1221.00
182_D187_K1.1221.00
180_P185_L1.1211.00
112_D119_E1.1171.00
300_N304_E1.1101.00
230_C236_T1.1101.00
178_R185_L1.1101.00
94_H98_S1.1061.00
174_Q181_A1.1051.00
134_A268_G1.1011.00
93_A116_R1.0931.00
282_E324_T1.0911.00
136_Y265_A1.0891.00
37_A41_H1.0891.00
175_A178_R1.0881.00
432_L435_D1.0861.00
400_V414_G1.0811.00
372_A392_A1.0811.00
366_R413_Q1.0801.00
129_G132_V1.0801.00
53_R427_G1.0801.00
75_I88_E1.0781.00
166_D169_G1.0751.00
455_D458_E1.0721.00
285_G324_T1.0711.00
115_P118_S1.0711.00
417_D421_A1.0681.00
189_G193_P1.0681.00
256_H274_H1.0651.00
376_F380_M1.0641.00
52_T109_A1.0631.00
232_A236_T1.0611.00
105_A299_S1.0541.00
176_E182_D1.0481.00
304_E331_S1.0461.00
166_D170_P1.0441.00
363_D367_T1.0421.00
176_E183_F1.0391.00
178_R183_F1.0341.00
231_S237_H1.0331.00
351_I412_Y1.0291.00
231_S234_A1.0231.00
42_A106_L1.0221.00
27_Y30_G1.0181.00
453_V456_V1.0141.00
126_D129_G1.0131.00
175_A183_F1.0131.00
213_Q220_G1.0121.00
68_V100_I1.0101.00
368_A372_A1.0071.00
232_A235_M1.0041.00
397_A418_A1.0031.00
337_W426_G1.0021.00
36_D299_S0.9981.00
231_S238_L0.9951.00
429_V432_L0.9931.00
96_T100_I0.9921.00
35_D41_H0.9911.00
198_T204_L0.9891.00
174_Q177_K0.9871.00
177_K186_W0.9851.00
175_A181_A0.9831.00
419_V433_Q0.9751.00
343_A397_A0.9741.00
313_L329_T0.9681.00
161_Q164_E0.9681.00
388_A391_S0.9671.00
456_V460_E0.9661.00
369_V396_L0.9661.00
328_A332_E0.9621.00
30_G34_S0.9591.00
120_H237_H0.9541.00
232_A237_H0.9501.00
373_R417_D0.9491.00
183_F188_A0.9481.00
180_P186_W0.9481.00
131_L134_A0.9471.00
90_A94_H0.9461.00
51_M55_L0.9441.00
422_F426_G0.9431.00
132_V225_G0.9351.00
90_A93_A0.9351.00
288_M294_N0.9291.00
233_M237_H0.9251.00
359_K362_D0.9221.00
229_E234_A0.9211.00
343_A400_V0.9211.00
70_D116_R0.9181.00
183_F189_G0.9171.00
82_D91_V0.9161.00
370_A374_G0.9151.00
371_D374_G0.9151.00
180_P187_K0.9141.00
85_G88_E0.9111.00
369_V414_G0.9051.00
176_E185_L0.9041.00
184_A189_G0.9041.00
182_D189_G0.9041.00
136_Y188_A0.9041.00
391_S395_E0.9041.00
173_E181_A0.9031.00
178_R188_A0.9021.00
102_D299_S0.8991.00
229_E232_A0.8971.00
176_E181_A0.8971.00
206_P212_G0.8961.00
178_R186_W0.8961.00
233_M238_L0.8941.00
230_C234_A0.8931.00
181_A188_A0.8881.00
100_I114_Y0.8871.00
173_E185_L0.8811.00
176_E179_H0.8811.00
423_E430_L0.8801.00
376_F392_A0.8781.00
72_N76_V0.8721.00
141_G177_K0.8711.00
334_T338_E0.8711.00
376_F393_L0.8691.00
340_L419_V0.8671.00
214_T221_E0.8651.00
363_D440_E0.8641.00
176_E186_W0.8641.00
445_L448_D0.8641.00
375_E379_A0.8601.00
179_H182_D0.8571.00
283_T295_F0.8561.00
175_A182_D0.8551.00
180_P188_A0.8551.00
395_E399_A0.8541.00
302_V307_P0.8531.00
175_A180_P0.8531.00
19_D273_D0.8511.00
375_E388_A0.8491.00
57_H423_E0.8481.00
252_V276_L0.8481.00
29_C34_S0.8471.00
230_C235_M0.8471.00
54_W382_A0.8461.00
134_A267_S0.8451.00
35_D78_R0.8451.00
173_E178_R0.8421.00
229_E233_M0.8421.00
431_G435_D0.8411.00
164_E167_P0.8391.00
174_Q180_P0.8391.00
269_E272_A0.8381.00
358_A366_R0.8361.00
336_R394_L0.8351.00
419_V430_L0.8341.00
95_Y98_S0.8301.00
340_L397_A0.8301.00
24_V60_Y0.8301.00
460_E465_N0.8301.00
155_G158_S0.8291.00
173_E182_D0.8291.00
203_E206_P0.8291.00
44_L277_H0.8281.00
177_K185_L0.8261.00
174_Q182_D0.8231.00
449_V453_V0.8211.00
306_G309_V0.8211.00
201_D204_L0.8181.00
428_D431_G0.8161.00
28_T246_V0.8151.00
447_D450_I0.8151.00
379_A389_A0.8121.00
390_V425_L0.8121.00
36_D102_D0.8101.00
288_M295_F0.8101.00
379_A383_D0.8091.00
123_E126_D0.8091.00
430_L433_Q0.8081.00
364_A368_A0.8061.00
180_P189_G0.8051.00
215_W219_W0.8041.00
213_Q219_W0.8041.00
49_D53_R0.8031.00
113_V120_H0.8001.00
210_E215_W0.8001.00
235_M267_S0.7991.00
419_V434_F0.7971.00
331_S335_Q0.7971.00
58_A382_A0.7971.00
366_R370_A0.7931.00
179_H186_W0.7901.00
46_V108_L0.7901.00
131_L262_Q0.7901.00
117_V124_I0.7891.00
434_F438_A0.7841.00
431_G434_F0.7831.00
270_R273_D0.7821.00
441_D444_S0.7821.00
228_I234_A0.7801.00
174_Q185_L0.7791.00
312_M390_V0.7791.00
213_Q216_A0.7781.00
205_P210_E0.7781.00
50_V380_M0.7771.00
173_E183_F0.7761.00
51_M386_T0.7751.00
423_E431_G0.7751.00
181_A189_G0.7741.00
202_D206_P0.7741.00
375_E395_E0.7711.00
428_D432_L0.7691.00
53_R109_A0.7671.00
118_S122_P0.7661.00
48_S64_H0.7661.00
292_L295_F0.7641.00
177_K189_G0.7621.00
52_T64_H0.7621.00
146_F151_F0.7611.00
442_A445_L0.7591.00
208_D212_G0.7591.00
27_Y34_S0.7581.00
94_H97_Q0.7541.00
247_G256_H0.7511.00
177_K188_A0.7501.00
426_G429_V0.7471.00
122_P126_D0.7461.00
25_L63_R0.7461.00
445_L449_V0.7431.00
36_D95_Y0.7431.00
412_Y416_H0.7431.00
209_G212_G0.7411.00
125_I129_G0.7401.00
454_L458_E0.7391.00
51_M244_I0.7371.00
160_Q165_L0.7371.00
20_D61_G0.7361.00
178_R187_K0.7361.00
393_L422_F0.7361.00
173_E177_K0.7361.00
207_L212_G0.7331.00
444_S447_D0.7301.00
220_G224_P0.7281.00
82_D95_Y0.7261.00
423_E434_F0.7251.00
178_R184_A0.7221.00
460_E463_A0.7211.00
456_V459_Q0.7201.00
154_Y157_L0.7201.00
100_I110_R0.7131.00
122_P125_I0.7121.00
225_G228_I0.7121.00
367_T370_A0.7111.00
129_G225_G0.7111.00
139_E227_H0.7101.00
75_I92_A0.7091.00
113_V119_E0.7091.00
174_Q186_W0.7081.00
37_A102_D0.7051.00
427_G433_Q0.7051.00
376_F421_A0.7041.00
175_A179_H0.7041.00
202_D205_P0.7041.00
284_D324_T0.7001.00
346_R405_D0.7001.00
331_S334_T0.6971.00
364_A367_T0.6961.00
379_A385_N0.6951.00
103_M108_L0.6911.00
176_E189_G0.6911.00
234_A242_I0.6901.00
372_A375_E0.6891.00
31_L44_L0.6891.00
119_E123_E0.6871.00
372_A376_F0.6841.00
249_Q280_L0.6841.00
214_T220_G0.6811.00
96_T114_Y0.6791.00
312_M333_A0.6781.00
442_A446_A0.6781.00
457_R461_R0.6781.00
367_T444_S0.6771.00
215_W220_G0.6771.00
51_M276_L0.6751.00
132_V137_A0.6751.00
312_M336_R0.6741.00
96_T116_R0.6731.00
432_L436_D0.6701.00
449_V452_L0.6681.00
50_V386_T0.6681.00
458_E464_G0.6671.00
43_R323_Q0.6671.00
241_H273_D0.6661.00
179_H185_L0.6651.00
30_G33_V0.6641.00
405_D408_D0.6631.00
174_Q188_A0.6621.00
329_T332_E0.6621.00
419_V424_T0.6591.00
85_G89_A0.6591.00
413_Q416_H0.6571.00
176_E184_A0.6571.00
240_D243_D0.6531.00
111_A114_Y0.6511.00
365_L396_L0.6501.00
216_A220_G0.6501.00
145_Y159_G0.6491.00
29_C32_T0.6491.00
447_D458_E0.6471.00
28_T48_S0.6471.00
421_A425_L0.6471.00
329_T333_A0.6441.00
430_L434_F0.6411.00
42_A298_V0.6401.00
229_E235_M0.6391.00
451_D454_L0.6381.00
114_Y118_S0.6361.00
245_H259_E0.6361.00
458_E461_R0.6351.00
244_I273_D0.6341.00
146_F265_A0.6331.00
160_Q163_D0.6321.00
244_I275_W0.6321.00
189_G192_S0.6311.00
232_A238_L0.6301.00
56_S112_D0.6301.00
288_M296_F0.6291.00
234_A238_L0.6281.00
447_D464_G0.6281.00
128_I225_G0.6271.00
162_V165_L0.6261.00
332_E336_R0.6251.00
264_E270_R0.6251.00
399_A402_R0.6241.00
441_D445_L0.6231.00
340_L433_Q0.6231.00
46_V315_V0.6221.00
39_L288_M0.6221.00
264_E269_E0.6211.00
443_V447_D0.6181.00
244_I384_F0.6181.00
188_A193_P0.6181.00
361_A407_T0.6181.00
143_S175_A0.6150.99
28_T34_S0.6130.99
460_E464_G0.6130.99
451_D465_N0.6120.99
47_Q246_V0.6100.99
97_Q104_R0.6070.99
121_V125_I0.6070.99
378_A382_A0.6070.99
462_T466_Y0.6060.99
181_A187_K0.6060.99
63_R112_D0.6060.99
78_R91_V0.6040.99
227_H230_C0.6040.99
337_W429_V0.6040.99
23_N63_R0.6010.99
71_V121_V0.6000.99
235_M262_Q0.5990.99
313_L333_A0.5990.99
168_Q171_D0.5990.99
182_D193_P0.5980.99
427_G430_L0.5970.99
188_A192_S0.5970.99
446_A450_I0.5960.99
39_L295_F0.5960.99
249_Q322_R0.5940.99
278_V281_L0.5940.99
107_N307_P0.5920.99
25_L243_D0.5920.99
177_K184_A0.5910.99
33_V45_W0.5890.99
312_M426_G0.5880.99
363_D443_V0.5880.99
25_L242_I0.5850.99
174_Q184_A0.5850.99
66_Q114_Y0.5840.99
217_S220_G0.5840.99
358_A363_D0.5820.99
185_L192_S0.5820.99
388_A392_A0.5820.99
176_E188_A0.5790.99
41_H45_W0.5780.99
453_V457_R0.5760.99
77_A80_G0.5760.99
225_G231_S0.5750.99
450_I453_V0.5750.99
46_V50_V0.5740.99
300_N327_E0.5740.99
137_A213_Q0.5730.99
461_R466_Y0.5720.99
113_V237_H0.5710.99
289_S292_L0.5710.99
218_P222_G0.5710.99
102_D297_T0.5700.99
175_A186_W0.5670.99
431_G437_G0.5660.99
36_D297_T0.5640.99
283_T324_T0.5620.99
414_G418_A0.5600.99
193_P200_R0.5580.99
446_A454_L0.5570.99
429_V433_Q0.5560.99
230_C238_L0.5550.99
47_Q315_V0.5540.99
337_W341_Q0.5520.99
458_E465_N0.5520.99
79_V88_E0.5490.99
447_D455_D0.5470.99
118_S121_V0.5460.99
169_G172_A0.5450.99
24_V244_I0.5450.99
451_D463_A0.5450.99
173_E179_H0.5450.99
27_Y32_T0.5440.99
113_V118_S0.5440.99
305_R331_S0.5420.99
421_A427_G0.5410.99
177_K182_D0.5410.99
249_Q252_V0.5400.99
424_T427_G0.5400.99
374_G377_A0.5390.99
192_S199_H0.5380.99
126_D237_H0.5380.99
444_S448_D0.5360.99
243_D273_D0.5360.99
420_D423_E0.5340.99
201_D205_P0.5330.99
296_F325_Y0.5330.99
57_H377_A0.5310.99
174_Q183_F0.5300.98
113_V116_R0.5300.98
230_C237_H0.5300.98
212_G219_W0.5290.98
315_V390_V0.5290.98
346_R404_V0.5280.98
175_A189_G0.5280.98
56_S62_V0.5280.98
173_E189_G0.5270.98
451_D464_G0.5260.98
270_R274_H0.5260.98
63_R113_V0.5250.98
449_V456_V0.5250.98
441_D446_A0.5240.98
103_M110_R0.5240.98
371_D447_D0.5230.98
345_E349_D0.5230.98
24_V29_C0.5220.98
389_A392_A0.5210.98
120_H236_T0.5200.98
263_S267_S0.5200.98
428_D434_F0.5200.98
372_A399_A0.5170.98
210_E213_Q0.5170.98
371_D444_S0.5160.98
93_A96_T0.5150.98
414_G417_D0.5150.98
462_T465_N0.5150.98
49_D311_R0.5140.98
424_T429_V0.5130.98
440_E444_S0.5120.98
71_V88_E0.5120.98
141_G176_E0.5120.98
346_R350_A0.5110.98
139_E179_H0.5110.98
295_F298_V0.5110.98
226_W230_C0.5090.98
350_A354_V0.5090.98
325_Y330_V0.5080.98
257_E261_A0.5080.98
451_D458_E0.5050.98
418_A424_T0.5040.98
419_V422_F0.5040.98
205_P209_G0.5040.98
186_W192_S0.5030.98
128_I223_R0.5030.98
179_H187_K0.5020.98
124_I231_S0.5010.98
173_E184_A0.5010.98
346_R407_T0.5010.98
24_V51_M0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gaxA 1 0.9899 100 0.239 Contact Map
1rqgA 2 0.9433 100 0.255 Contact Map
1ffyA 1 0.9919 100 0.258 Contact Map
3ziuA 1 0.9636 100 0.26 Contact Map
3tqoA 1 0.7692 100 0.274 Contact Map
3kflA 1 0.9049 100 0.275 Contact Map
1li5A 1 0.7733 100 0.28 Contact Map
1ileA 1 0.9433 100 0.284 Contact Map
4arcA 1 0.9211 100 0.293 Contact Map
1wz2A 1 0.9656 100 0.299 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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