SYC - HALSA - GREMLIN Contacts

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SYC - Cysteine--tRNA ligase

UniProt:	Q9HQL9	Sequences: MTQYVSNTRSGEQEAFEPDDPENVLVYTCGLTVSDDAHLGHARLWVQSDVMTRWLSHAGYGVRHVQNVTDVNEKIVARVGADGLGDTEAAVAAHYTQSVIDDMRALNLARADVYPRVSEHVPEIIDLIGDLVDAGYAYEAGGSVYFDVRRFEEYGALSGQQVDELDPQGPDAEQAEKRHPADFALWKAGGVSPDDANTHRDDELPPLDGERGQTWASPWGEGRPGWHIECSAMAMTHLDDHIDIHVGGQDLVFPHHENEIAQSEAASGERFADHWLHVRLLETDGEKMSSSLGNFFTVSNAVAERGPNVVRMLLVSTSYTQRQTYSEATVSEATQRWERLQRAHERAADAIDSVAAHAKPADDALRTAVADARGEFAAAMRADFNTRAAVSALLELASAVNRHVDGTDTYDYQGLHDAVDAFETLGGDVLGLQFDDGAGEDAVSLADDVIDLVLDVREQERTAGNYERADDLRDRLEALGVSVEDTDDGATVRR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	494 (438)
Sequences:	17804 (10273)
Seq/√Len:	490.9

ECOLI - SYC SYM SYV SYI SYL
BACSU - SYC SYM SYV SYI SYL
HALSA - SYC SYM SYV SYI SYL
SULSO - SYC SYM SYV SYL2 SYL1 SYI

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
55_L	60_Y	5.201	1.00
129_G	133_D	3.839	1.00
375_E	392_A	3.669	1.00
58_A	377_A	3.583	1.00
147_D	150_R	3.173	1.00
304_E	327_E	3.156	1.00
286_E	292_L	3.092	1.00
50_V	315_V	3.080	1.00
36_D	98_S	3.045	1.00
23_N	61_G	3.012	1.00
104_R	110_R	3.003	1.00
134_A	265_A	2.885	1.00
459_Q	463_A	2.861	1.00
78_R	81_A	2.843	1.00
130_D	133_D	2.829	1.00
56_S	109_A	2.779	1.00
82_D	94_H	2.761	1.00
416_H	420_D	2.704	1.00
136_Y	150_R	2.674	1.00
84_L	94_H	2.409	1.00
130_D	134_A	2.392	1.00
105_A	303_A	2.355	1.00
147_D	178_R	2.342	1.00
374_G	378_A	2.318	1.00
184_A	187_K	2.291	1.00
216_A	221_E	2.256	1.00
378_A	383_D	2.251	1.00
98_S	101_D	2.225	1.00
385_N	388_A	2.215	1.00
126_D	130_D	2.214	1.00
89_A	93_A	2.207	1.00
97_Q	101_D	2.146	1.00
54_W	58_A	2.142	1.00
52_T	56_S	2.128	1.00
85_G	90_A	2.050	1.00
243_D	272_A	2.031	1.00
127_L	266_A	1.987	1.00
392_A	395_E	1.972	1.00
55_L	58_A	1.964	1.00
107_N	428_D	1.962	1.00
228_I	231_S	1.918	1.00
114_Y	117_V	1.907	1.00
100_I	104_R	1.907	1.00
380_M	425_L	1.895	1.00
240_D	263_S	1.884	1.00
198_T	202_D	1.881	1.00
52_T	62_V	1.851	1.00
300_N	303_A	1.832	1.00
455_D	459_Q	1.798	1.00
123_E	236_T	1.790	1.00
93_A	97_Q	1.768	1.00
379_A	388_A	1.724	1.00
178_R	182_D	1.722	1.00
371_D	375_E	1.705	1.00
369_V	417_D	1.700	1.00
182_D	186_W	1.699	1.00
452_L	456_V	1.670	1.00
379_A	392_A	1.666	1.00
101_D	105_A	1.665	1.00
20_D	23_N	1.650	1.00
48_S	246_V	1.646	1.00
199_H	202_D	1.635	1.00
377_A	382_A	1.625	1.00
200_R	203_E	1.624	1.00
51_M	384_F	1.615	1.00
451_D	455_D	1.593	1.00
368_A	399_A	1.592	1.00
181_A	185_L	1.579	1.00
131_L	265_A	1.578	1.00
185_L	189_G	1.575	1.00
54_W	377_A	1.554	1.00
299_S	303_A	1.552	1.00
408_D	411_D	1.550	1.00
372_A	396_L	1.547	1.00
84_L	91_V	1.544	1.00
55_L	382_A	1.539	1.00
174_Q	178_R	1.521	1.00
178_R	181_A	1.505	1.00
181_A	186_W	1.501	1.00
199_H	203_E	1.496	1.00
180_P	183_F	1.488	1.00
20_D	25_L	1.480	1.00
327_E	331_S	1.466	1.00
45_W	103_M	1.453	1.00
452_L	455_D	1.443	1.00
344_H	415_L	1.431	1.00
367_T	371_D	1.431	1.00
234_A	237_H	1.414	1.00
368_A	371_D	1.413	1.00
344_H	433_Q	1.405	1.00
440_E	443_V	1.405	1.00
297_T	300_N	1.405	1.00
61_G	239_D	1.399	1.00
173_E	180_P	1.393	1.00
97_Q	100_I	1.392	1.00
422_F	430_L	1.384	1.00
182_D	185_L	1.382	1.00
76_V	80_G	1.373	1.00
149_R	179_H	1.372	1.00
113_V	117_V	1.356	1.00
207_L	210_E	1.348	1.00
301_A	310_V	1.345	1.00
309_V	334_T	1.342	1.00
183_F	187_K	1.339	1.00
46_V	314_L	1.337	1.00
143_S	177_K	1.336	1.00
183_F	186_W	1.335	1.00
283_T	326_S	1.333	1.00
375_E	378_A	1.332	1.00
181_A	184_A	1.322	1.00
228_I	232_A	1.314	1.00
77_A	81_A	1.313	1.00
185_L	188_A	1.312	1.00
446_A	449_V	1.311	1.00
362_D	403_H	1.306	1.00
186_W	189_G	1.301	1.00
26_V	52_T	1.300	1.00
57_H	420_D	1.298	1.00
206_P	210_E	1.297	1.00
443_V	446_A	1.296	1.00
459_Q	462_T	1.290	1.00
179_H	183_F	1.287	1.00
91_V	95_Y	1.287	1.00
273_D	384_F	1.281	1.00
458_E	462_T	1.281	1.00
153_E	156_A	1.279	1.00
231_S	236_T	1.274	1.00
447_D	451_D	1.272	1.00
373_R	377_A	1.272	1.00
173_E	176_E	1.270	1.00
370_A	373_R	1.266	1.00
448_D	451_D	1.266	1.00
205_P	208_D	1.261	1.00
176_E	180_P	1.257	1.00
167_P	170_P	1.253	1.00
180_P	184_A	1.253	1.00
389_A	425_L	1.250	1.00
31_L	34_S	1.245	1.00
206_P	209_G	1.242	1.00
120_H	123_E	1.241	1.00
200_R	204_L	1.236	1.00
54_W	380_M	1.235	1.00
240_D	269_E	1.234	1.00
283_T	328_A	1.232	1.00
184_A	188_A	1.221	1.00
187_K	193_P	1.221	1.00
230_C	233_M	1.218	1.00
421_A	424_T	1.216	1.00
101_D	104_R	1.215	1.00
177_K	181_A	1.214	1.00
68_V	96_T	1.210	1.00
105_A	302_V	1.208	1.00
182_D	188_A	1.208	1.00
130_D	266_A	1.205	1.00
45_W	108_L	1.204	1.00
402_R	406_G	1.198	1.00
78_R	82_D	1.198	1.00
235_M	238_L	1.196	1.00
198_T	203_E	1.195	1.00
84_L	90_A	1.185	1.00
339_R	397_A	1.184	1.00
360_P	363_D	1.180	1.00
44_L	278_V	1.180	1.00
365_L	414_G	1.175	1.00
199_H	204_L	1.173	1.00
413_Q	417_D	1.172	1.00
328_A	331_S	1.168	1.00
231_S	235_M	1.167	1.00
373_R	421_A	1.166	1.00
417_D	420_D	1.163	1.00
376_F	389_A	1.160	1.00
380_M	389_A	1.159	1.00
177_K	180_P	1.158	1.00
239_D	243_D	1.145	1.00
369_V	373_R	1.142	1.00
101_D	299_S	1.142	1.00
22_E	60_Y	1.136	1.00
233_M	236_T	1.134	1.00
198_T	201_D	1.131	1.00
177_K	183_F	1.123	1.00
308_N	341_Q	1.122	1.00
448_D	452_L	1.122	1.00
182_D	187_K	1.122	1.00
180_P	185_L	1.121	1.00
112_D	119_E	1.117	1.00
300_N	304_E	1.110	1.00
230_C	236_T	1.110	1.00
178_R	185_L	1.110	1.00
94_H	98_S	1.106	1.00
174_Q	181_A	1.105	1.00
134_A	268_G	1.101	1.00
93_A	116_R	1.093	1.00
282_E	324_T	1.091	1.00
136_Y	265_A	1.089	1.00
37_A	41_H	1.089	1.00
175_A	178_R	1.088	1.00
432_L	435_D	1.086	1.00
400_V	414_G	1.081	1.00
372_A	392_A	1.081	1.00
366_R	413_Q	1.080	1.00
129_G	132_V	1.080	1.00
53_R	427_G	1.080	1.00
75_I	88_E	1.078	1.00
166_D	169_G	1.075	1.00
455_D	458_E	1.072	1.00
285_G	324_T	1.071	1.00
115_P	118_S	1.071	1.00
417_D	421_A	1.068	1.00
189_G	193_P	1.068	1.00
256_H	274_H	1.065	1.00
376_F	380_M	1.064	1.00
52_T	109_A	1.063	1.00
232_A	236_T	1.061	1.00
105_A	299_S	1.054	1.00
176_E	182_D	1.048	1.00
304_E	331_S	1.046	1.00
166_D	170_P	1.044	1.00
363_D	367_T	1.042	1.00
176_E	183_F	1.039	1.00
178_R	183_F	1.034	1.00
231_S	237_H	1.033	1.00
351_I	412_Y	1.029	1.00
231_S	234_A	1.023	1.00
42_A	106_L	1.022	1.00
27_Y	30_G	1.018	1.00
453_V	456_V	1.014	1.00
126_D	129_G	1.013	1.00
175_A	183_F	1.013	1.00
213_Q	220_G	1.012	1.00
68_V	100_I	1.010	1.00
368_A	372_A	1.007	1.00
232_A	235_M	1.004	1.00
397_A	418_A	1.003	1.00
337_W	426_G	1.002	1.00
36_D	299_S	0.998	1.00
231_S	238_L	0.995	1.00
429_V	432_L	0.993	1.00
96_T	100_I	0.992	1.00
35_D	41_H	0.991	1.00
198_T	204_L	0.989	1.00
174_Q	177_K	0.987	1.00
177_K	186_W	0.985	1.00
175_A	181_A	0.983	1.00
419_V	433_Q	0.975	1.00
343_A	397_A	0.974	1.00
313_L	329_T	0.968	1.00
161_Q	164_E	0.968	1.00
388_A	391_S	0.967	1.00
456_V	460_E	0.966	1.00
369_V	396_L	0.966	1.00
328_A	332_E	0.962	1.00
30_G	34_S	0.959	1.00
120_H	237_H	0.954	1.00
232_A	237_H	0.950	1.00
373_R	417_D	0.949	1.00
183_F	188_A	0.948	1.00
180_P	186_W	0.948	1.00
131_L	134_A	0.947	1.00
90_A	94_H	0.946	1.00
51_M	55_L	0.944	1.00
422_F	426_G	0.943	1.00
132_V	225_G	0.935	1.00
90_A	93_A	0.935	1.00
288_M	294_N	0.929	1.00
233_M	237_H	0.925	1.00
359_K	362_D	0.922	1.00
229_E	234_A	0.921	1.00
343_A	400_V	0.921	1.00
70_D	116_R	0.918	1.00
183_F	189_G	0.917	1.00
82_D	91_V	0.916	1.00
370_A	374_G	0.915	1.00
371_D	374_G	0.915	1.00
180_P	187_K	0.914	1.00
85_G	88_E	0.911	1.00
369_V	414_G	0.905	1.00
176_E	185_L	0.904	1.00
184_A	189_G	0.904	1.00
182_D	189_G	0.904	1.00
136_Y	188_A	0.904	1.00
391_S	395_E	0.904	1.00
173_E	181_A	0.903	1.00
178_R	188_A	0.902	1.00
102_D	299_S	0.899	1.00
229_E	232_A	0.897	1.00
176_E	181_A	0.897	1.00
206_P	212_G	0.896	1.00
178_R	186_W	0.896	1.00
233_M	238_L	0.894	1.00
230_C	234_A	0.893	1.00
181_A	188_A	0.888	1.00
100_I	114_Y	0.887	1.00
173_E	185_L	0.881	1.00
176_E	179_H	0.881	1.00
423_E	430_L	0.880	1.00
376_F	392_A	0.878	1.00
72_N	76_V	0.872	1.00
141_G	177_K	0.871	1.00
334_T	338_E	0.871	1.00
376_F	393_L	0.869	1.00
340_L	419_V	0.867	1.00
214_T	221_E	0.865	1.00
363_D	440_E	0.864	1.00
176_E	186_W	0.864	1.00
445_L	448_D	0.864	1.00
375_E	379_A	0.860	1.00
179_H	182_D	0.857	1.00
283_T	295_F	0.856	1.00
175_A	182_D	0.855	1.00
180_P	188_A	0.855	1.00
395_E	399_A	0.854	1.00
302_V	307_P	0.853	1.00
175_A	180_P	0.853	1.00
19_D	273_D	0.851	1.00
375_E	388_A	0.849	1.00
57_H	423_E	0.848	1.00
252_V	276_L	0.848	1.00
29_C	34_S	0.847	1.00
230_C	235_M	0.847	1.00
54_W	382_A	0.846	1.00
134_A	267_S	0.845	1.00
35_D	78_R	0.845	1.00
173_E	178_R	0.842	1.00
229_E	233_M	0.842	1.00
431_G	435_D	0.841	1.00
164_E	167_P	0.839	1.00
174_Q	180_P	0.839	1.00
269_E	272_A	0.838	1.00
358_A	366_R	0.836	1.00
336_R	394_L	0.835	1.00
419_V	430_L	0.834	1.00
95_Y	98_S	0.830	1.00
340_L	397_A	0.830	1.00
24_V	60_Y	0.830	1.00
460_E	465_N	0.830	1.00
155_G	158_S	0.829	1.00
173_E	182_D	0.829	1.00
203_E	206_P	0.829	1.00
44_L	277_H	0.828	1.00
177_K	185_L	0.826	1.00
174_Q	182_D	0.823	1.00
449_V	453_V	0.821	1.00
306_G	309_V	0.821	1.00
201_D	204_L	0.818	1.00
428_D	431_G	0.816	1.00
28_T	246_V	0.815	1.00
447_D	450_I	0.815	1.00
379_A	389_A	0.812	1.00
390_V	425_L	0.812	1.00
36_D	102_D	0.810	1.00
288_M	295_F	0.810	1.00
379_A	383_D	0.809	1.00
123_E	126_D	0.809	1.00
430_L	433_Q	0.808	1.00
364_A	368_A	0.806	1.00
180_P	189_G	0.805	1.00
215_W	219_W	0.804	1.00
213_Q	219_W	0.804	1.00
49_D	53_R	0.803	1.00
113_V	120_H	0.800	1.00
210_E	215_W	0.800	1.00
235_M	267_S	0.799	1.00
419_V	434_F	0.797	1.00
331_S	335_Q	0.797	1.00
58_A	382_A	0.797	1.00
366_R	370_A	0.793	1.00
179_H	186_W	0.790	1.00
46_V	108_L	0.790	1.00
131_L	262_Q	0.790	1.00
117_V	124_I	0.789	1.00
434_F	438_A	0.784	1.00
431_G	434_F	0.783	1.00
270_R	273_D	0.782	1.00
441_D	444_S	0.782	1.00
228_I	234_A	0.780	1.00
174_Q	185_L	0.779	1.00
312_M	390_V	0.779	1.00
213_Q	216_A	0.778	1.00
205_P	210_E	0.778	1.00
50_V	380_M	0.777	1.00
173_E	183_F	0.776	1.00
51_M	386_T	0.775	1.00
423_E	431_G	0.775	1.00
181_A	189_G	0.774	1.00
202_D	206_P	0.774	1.00
375_E	395_E	0.771	1.00
428_D	432_L	0.769	1.00
53_R	109_A	0.767	1.00
118_S	122_P	0.766	1.00
48_S	64_H	0.766	1.00
292_L	295_F	0.764	1.00
177_K	189_G	0.762	1.00
52_T	64_H	0.762	1.00
146_F	151_F	0.761	1.00
442_A	445_L	0.759	1.00
208_D	212_G	0.759	1.00
27_Y	34_S	0.758	1.00
94_H	97_Q	0.754	1.00
247_G	256_H	0.751	1.00
177_K	188_A	0.750	1.00
426_G	429_V	0.747	1.00
122_P	126_D	0.746	1.00
25_L	63_R	0.746	1.00
445_L	449_V	0.743	1.00
36_D	95_Y	0.743	1.00
412_Y	416_H	0.743	1.00
209_G	212_G	0.741	1.00
125_I	129_G	0.740	1.00
454_L	458_E	0.739	1.00
51_M	244_I	0.737	1.00
160_Q	165_L	0.737	1.00
20_D	61_G	0.736	1.00
178_R	187_K	0.736	1.00
393_L	422_F	0.736	1.00
173_E	177_K	0.736	1.00
207_L	212_G	0.733	1.00
444_S	447_D	0.730	1.00
220_G	224_P	0.728	1.00
82_D	95_Y	0.726	1.00
423_E	434_F	0.725	1.00
178_R	184_A	0.722	1.00
460_E	463_A	0.721	1.00
456_V	459_Q	0.720	1.00
154_Y	157_L	0.720	1.00
100_I	110_R	0.713	1.00
122_P	125_I	0.712	1.00
225_G	228_I	0.712	1.00
367_T	370_A	0.711	1.00
129_G	225_G	0.711	1.00
139_E	227_H	0.710	1.00
75_I	92_A	0.709	1.00
113_V	119_E	0.709	1.00
174_Q	186_W	0.708	1.00
37_A	102_D	0.705	1.00
427_G	433_Q	0.705	1.00
376_F	421_A	0.704	1.00
175_A	179_H	0.704	1.00
202_D	205_P	0.704	1.00
284_D	324_T	0.700	1.00
346_R	405_D	0.700	1.00
331_S	334_T	0.697	1.00
364_A	367_T	0.696	1.00
379_A	385_N	0.695	1.00
103_M	108_L	0.691	1.00
176_E	189_G	0.691	1.00
234_A	242_I	0.690	1.00
372_A	375_E	0.689	1.00
31_L	44_L	0.689	1.00
119_E	123_E	0.687	1.00
372_A	376_F	0.684	1.00
249_Q	280_L	0.684	1.00
214_T	220_G	0.681	1.00
96_T	114_Y	0.679	1.00
312_M	333_A	0.678	1.00
442_A	446_A	0.678	1.00
457_R	461_R	0.678	1.00
367_T	444_S	0.677	1.00
215_W	220_G	0.677	1.00
51_M	276_L	0.675	1.00
132_V	137_A	0.675	1.00
312_M	336_R	0.674	1.00
96_T	116_R	0.673	1.00
432_L	436_D	0.670	1.00
449_V	452_L	0.668	1.00
50_V	386_T	0.668	1.00
458_E	464_G	0.667	1.00
43_R	323_Q	0.667	1.00
241_H	273_D	0.666	1.00
179_H	185_L	0.665	1.00
30_G	33_V	0.664	1.00
405_D	408_D	0.663	1.00
174_Q	188_A	0.662	1.00
329_T	332_E	0.662	1.00
419_V	424_T	0.659	1.00
85_G	89_A	0.659	1.00
413_Q	416_H	0.657	1.00
176_E	184_A	0.657	1.00
240_D	243_D	0.653	1.00
111_A	114_Y	0.651	1.00
365_L	396_L	0.650	1.00
216_A	220_G	0.650	1.00
145_Y	159_G	0.649	1.00
29_C	32_T	0.649	1.00
447_D	458_E	0.647	1.00
28_T	48_S	0.647	1.00
421_A	425_L	0.647	1.00
329_T	333_A	0.644	1.00
430_L	434_F	0.641	1.00
42_A	298_V	0.640	1.00
229_E	235_M	0.639	1.00
451_D	454_L	0.638	1.00
114_Y	118_S	0.636	1.00
245_H	259_E	0.636	1.00
458_E	461_R	0.635	1.00
244_I	273_D	0.634	1.00
146_F	265_A	0.633	1.00
160_Q	163_D	0.632	1.00
244_I	275_W	0.632	1.00
189_G	192_S	0.631	1.00
232_A	238_L	0.630	1.00
56_S	112_D	0.630	1.00
288_M	296_F	0.629	1.00
234_A	238_L	0.628	1.00
447_D	464_G	0.628	1.00
128_I	225_G	0.627	1.00
162_V	165_L	0.626	1.00
332_E	336_R	0.625	1.00
264_E	270_R	0.625	1.00
399_A	402_R	0.624	1.00
441_D	445_L	0.623	1.00
340_L	433_Q	0.623	1.00
46_V	315_V	0.622	1.00
39_L	288_M	0.622	1.00
264_E	269_E	0.621	1.00
443_V	447_D	0.618	1.00
244_I	384_F	0.618	1.00
188_A	193_P	0.618	1.00
361_A	407_T	0.618	1.00
143_S	175_A	0.615	0.99
28_T	34_S	0.613	0.99
460_E	464_G	0.613	0.99
451_D	465_N	0.612	0.99
47_Q	246_V	0.610	0.99
97_Q	104_R	0.607	0.99
121_V	125_I	0.607	0.99
378_A	382_A	0.607	0.99
462_T	466_Y	0.606	0.99
181_A	187_K	0.606	0.99
63_R	112_D	0.606	0.99
78_R	91_V	0.604	0.99
227_H	230_C	0.604	0.99
337_W	429_V	0.604	0.99
23_N	63_R	0.601	0.99
71_V	121_V	0.600	0.99
235_M	262_Q	0.599	0.99
313_L	333_A	0.599	0.99
168_Q	171_D	0.599	0.99
182_D	193_P	0.598	0.99
427_G	430_L	0.597	0.99
188_A	192_S	0.597	0.99
446_A	450_I	0.596	0.99
39_L	295_F	0.596	0.99
249_Q	322_R	0.594	0.99
278_V	281_L	0.594	0.99
107_N	307_P	0.592	0.99
25_L	243_D	0.592	0.99
177_K	184_A	0.591	0.99
33_V	45_W	0.589	0.99
312_M	426_G	0.588	0.99
363_D	443_V	0.588	0.99
25_L	242_I	0.585	0.99
174_Q	184_A	0.585	0.99
66_Q	114_Y	0.584	0.99
217_S	220_G	0.584	0.99
358_A	363_D	0.582	0.99
185_L	192_S	0.582	0.99
388_A	392_A	0.582	0.99
176_E	188_A	0.579	0.99
41_H	45_W	0.578	0.99
453_V	457_R	0.576	0.99
77_A	80_G	0.576	0.99
225_G	231_S	0.575	0.99
450_I	453_V	0.575	0.99
46_V	50_V	0.574	0.99
300_N	327_E	0.574	0.99
137_A	213_Q	0.573	0.99
461_R	466_Y	0.572	0.99
113_V	237_H	0.571	0.99
289_S	292_L	0.571	0.99
218_P	222_G	0.571	0.99
102_D	297_T	0.570	0.99
175_A	186_W	0.567	0.99
431_G	437_G	0.566	0.99
36_D	297_T	0.564	0.99
283_T	324_T	0.562	0.99
414_G	418_A	0.560	0.99
193_P	200_R	0.558	0.99
446_A	454_L	0.557	0.99
429_V	433_Q	0.556	0.99
230_C	238_L	0.555	0.99
47_Q	315_V	0.554	0.99
337_W	341_Q	0.552	0.99
458_E	465_N	0.552	0.99
79_V	88_E	0.549	0.99
447_D	455_D	0.547	0.99
118_S	121_V	0.546	0.99
169_G	172_A	0.545	0.99
24_V	244_I	0.545	0.99
451_D	463_A	0.545	0.99
173_E	179_H	0.545	0.99
27_Y	32_T	0.544	0.99
113_V	118_S	0.544	0.99
305_R	331_S	0.542	0.99
421_A	427_G	0.541	0.99
177_K	182_D	0.541	0.99
249_Q	252_V	0.540	0.99
424_T	427_G	0.540	0.99
374_G	377_A	0.539	0.99
192_S	199_H	0.538	0.99
126_D	237_H	0.538	0.99
444_S	448_D	0.536	0.99
243_D	273_D	0.536	0.99
420_D	423_E	0.534	0.99
201_D	205_P	0.533	0.99
296_F	325_Y	0.533	0.99
57_H	377_A	0.531	0.99
174_Q	183_F	0.530	0.98
113_V	116_R	0.530	0.98
230_C	237_H	0.530	0.98
212_G	219_W	0.529	0.98
315_V	390_V	0.529	0.98
346_R	404_V	0.528	0.98
175_A	189_G	0.528	0.98
56_S	62_V	0.528	0.98
173_E	189_G	0.527	0.98
451_D	464_G	0.526	0.98
270_R	274_H	0.526	0.98
63_R	113_V	0.525	0.98
449_V	456_V	0.525	0.98
441_D	446_A	0.524	0.98
103_M	110_R	0.524	0.98
371_D	447_D	0.523	0.98
345_E	349_D	0.523	0.98
24_V	29_C	0.522	0.98
389_A	392_A	0.521	0.98
120_H	236_T	0.520	0.98
263_S	267_S	0.520	0.98
428_D	434_F	0.520	0.98
372_A	399_A	0.517	0.98
210_E	213_Q	0.517	0.98
371_D	444_S	0.516	0.98
93_A	96_T	0.515	0.98
414_G	417_D	0.515	0.98
462_T	465_N	0.515	0.98
49_D	311_R	0.514	0.98
424_T	429_V	0.513	0.98
440_E	444_S	0.512	0.98
71_V	88_E	0.512	0.98
141_G	176_E	0.512	0.98
346_R	350_A	0.511	0.98
139_E	179_H	0.511	0.98
295_F	298_V	0.511	0.98
226_W	230_C	0.509	0.98
350_A	354_V	0.509	0.98
325_Y	330_V	0.508	0.98
257_E	261_A	0.508	0.98
451_D	458_E	0.505	0.98
418_A	424_T	0.504	0.98
419_V	422_F	0.504	0.98
205_P	209_G	0.504	0.98
186_W	192_S	0.503	0.98
128_I	223_R	0.503	0.98
179_H	187_K	0.502	0.98
124_I	231_S	0.501	0.98
173_E	184_A	0.501	0.98
346_R	407_T	0.501	0.98
24_V	51_M	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1gaxA	1	0.9899	100	0.239	Contact Map
1rqgA	2	0.9433	100	0.255	Contact Map
1ffyA	1	0.9919	100	0.258	Contact Map
3ziuA	1	0.9636	100	0.26	Contact Map
3tqoA	1	0.7692	100	0.274	Contact Map
3kflA	1	0.9049	100	0.275	Contact Map
1li5A	1	0.7733	100	0.28	Contact Map
1ileA	1	0.9433	100	0.284	Contact Map
4arcA	1	0.9211	100	0.293	Contact Map
1wz2A	1	0.9656	100	0.299	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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