GREMLIN Database
Q9HQL8 - Uncharacterized protein
UniProt: Q9HQL8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 278 (224)
Sequences: 385 (272)
Seq/√Len: 18.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
116_H239_R4.7921.00
65_T82_A4.2391.00
183_F189_F3.8821.00
87_L156_L3.8231.00
158_P181_I3.1580.99
226_G232_E2.8590.98
172_S210_I2.7190.98
124_S128_V2.5580.97
196_T199_G2.5250.97
83_L151_F2.2810.94
48_F157_F2.2610.94
159_T184_Q2.2480.93
35_F102_F2.2060.93
93_R97_V2.1780.92
166_A216_Q2.1150.91
52_F223_G2.0590.90
84_L152_G2.0410.90
33_E37_E2.0130.89
68_P104_K1.9900.88
232_E235_Q1.9660.88
123_L134_W1.9430.87
53_G192_I1.9160.86
52_F175_C1.8900.85
226_G235_Q1.8530.84
138_V148_E1.8530.84
32_W36_S1.8400.84
67_V79_F1.8270.83
111_S114_D1.8040.83
162_A165_Y1.8010.83
69_S206_I1.7970.82
124_S127_H1.7900.82
184_Q189_F1.7600.81
127_H253_F1.7360.80
189_F199_G1.7160.79
67_V82_A1.7090.79
71_T105_P1.6950.78
123_L207_Q1.6920.78
188_L210_I1.6830.78
55_E190_E1.6580.77
127_H251_A1.6230.75
132_E152_G1.6220.75
184_Q192_I1.6200.75
116_H244_Q1.6170.75
199_G233_W1.6060.74
142_T219_H1.5580.72
222_L249_C1.5550.72
53_G189_F1.5280.71
56_S62_P1.4560.67
74_D129_H1.4530.67
52_F165_Y1.4280.65
32_W57_V1.4170.65
136_A252_T1.3990.64
126_L246_P1.3990.64
67_V103_W1.3600.61
67_V101_T1.3570.61
51_H222_L1.3560.61
53_G184_Q1.3540.61
56_S98_S1.3520.61
188_L230_D1.3430.60
183_F190_E1.3380.60
140_T228_D1.3350.60
171_Y214_D1.3340.60
86_Y196_T1.3260.59
129_H151_F1.3160.59
111_S132_E1.3040.58
76_L122_I1.3010.58
124_S142_T1.2890.57
52_F161_R1.2800.57
99_F111_S1.2460.54
49_P235_Q1.2440.54
172_S213_Y1.2430.54
110_F114_D1.2400.54
114_D143_D1.2380.54
216_Q242_D1.2340.54
138_V150_C1.2280.53
183_F192_I1.2180.53
41_G47_P1.2150.53
33_E41_G1.1870.51
127_H216_Q1.1830.51
128_V251_A1.1830.51
39_V47_P1.1780.50
133_P212_E1.1730.50
176_P206_I1.1680.50
202_A229_G1.1650.49
79_F101_T1.1440.48
203_R232_E1.1410.48
203_R206_I1.1400.48
41_G174_Y1.1390.48
48_F195_D1.1380.48
170_R217_C1.1340.48
113_A246_P1.1230.47
74_D149_F1.1210.47
244_Q247_T1.1200.47
137_D155_P1.1060.46
135_P185_P1.0990.45
71_T106_P1.0960.45
48_F56_S1.0960.45
87_L152_G1.0880.45
65_T101_T1.0840.44
155_P192_I1.0710.44
28_V187_G1.0700.44
128_V203_R1.0700.44
182_T223_G1.0650.43
219_H241_D1.0620.43
232_E236_Y1.0590.43
133_P152_G1.0590.43
147_W238_F1.0580.43
25_P199_G1.0580.43
159_T199_G1.0550.43
184_Q199_G1.0540.43
148_E160_C1.0520.43
102_F248_E1.0470.42
134_W207_Q1.0370.42
89_E93_R1.0360.42
143_D231_R1.0240.41
35_F154_E1.0070.40
130_D163_P1.0040.40
35_F100_V0.9950.39
51_H54_A0.9930.39
230_D251_A0.9930.39
67_V99_F0.9770.38
101_T200_Q0.9690.38
186_A233_W0.9680.38
29_R33_E0.9580.37
186_A235_Q0.9580.37
73_P77_L0.9580.37
65_T252_T0.9510.37
52_F202_A0.9440.36
51_H108_D0.9410.36
159_T238_F0.9350.36
79_F111_S0.9160.35
97_V225_L0.9140.34
169_D172_S0.9080.34
53_G183_F0.8970.34
209_R226_G0.8950.33
210_I238_F0.8930.33
117_E140_T0.8900.33
75_A176_P0.8890.33
237_L240_E0.8870.33
160_C188_L0.8830.33
26_D30_S0.8810.33
92_D133_P0.8810.33
48_F161_R0.8800.33
24_Y152_G0.8720.32
197_D217_C0.8710.32
23_D145_P0.8690.32
225_L232_E0.8680.32
103_W179_L0.8560.31
66_V185_P0.8500.31
157_F172_S0.8480.31
135_P165_Y0.8420.31
80_R214_D0.8370.30
100_V248_E0.8320.30
148_E186_A0.8300.30
84_L131_P0.8250.30
186_A232_E0.8240.30
161_R186_A0.8230.30
192_I202_A0.8200.29
171_Y213_Y0.8150.29
141_D164_F0.8110.29
142_T233_W0.8080.29
193_T219_H0.8060.29
108_D121_H0.8020.29
80_R151_F0.8000.28
81_D204_A0.7990.28
69_S114_D0.7980.28
170_R216_Q0.7940.28
35_F208_N0.7930.28
73_P125_V0.7930.28
87_L202_A0.7890.28
129_H181_I0.7880.28
36_S124_S0.7870.28
96_R165_Y0.7840.28
147_W210_I0.7830.28
148_E182_T0.7820.28
148_E188_L0.7770.27
165_Y219_H0.7770.27
48_F210_I0.7760.27
51_H61_E0.7750.27
56_S195_D0.7750.27
188_L237_L0.7750.27
68_P245_A0.7740.27
185_P232_E0.7740.27
189_F235_Q0.7740.27
170_R219_H0.7730.27
103_W142_T0.7690.27
102_F219_H0.7680.27
52_F157_F0.7680.27
34_T37_E0.7680.27
191_G242_D0.7660.27
98_S183_F0.7630.27
185_P203_R0.7550.26
206_I237_L0.7540.26
210_I214_D0.7530.26
151_F240_E0.7480.26
40_T212_E0.7450.26
97_V210_I0.7440.26
83_L99_F0.7440.26
56_S157_F0.7440.26
189_F192_I0.7430.26
119_L240_E0.7420.26
85_E101_T0.7410.26
103_W206_I0.7400.25
49_P210_I0.7370.25
91_G94_D0.7330.25
104_K212_E0.7290.25
138_V236_Y0.7240.25
98_S252_T0.7230.25
179_L231_R0.7230.25
219_H233_W0.7220.25
170_R214_D0.7160.24
66_V172_S0.7160.24
123_L214_D0.7130.24
185_P226_G0.7110.24
112_E215_G0.7100.24
131_P152_G0.7020.24
112_E237_L0.7000.24
215_G229_G0.6950.23
158_P183_F0.6950.23
83_L86_Y0.6950.23
69_S101_T0.6910.23
189_F249_C0.6820.23
102_F149_F0.6800.23
64_Y102_F0.6770.23
99_F157_F0.6740.23
49_P226_G0.6730.22
30_S88_T0.6710.22
239_R244_Q0.6700.22
165_Y222_L0.6700.22
159_T183_F0.6670.22
147_W225_L0.6660.22
179_L188_L0.6660.22
53_G97_V0.6640.22
140_T234_V0.6620.22
183_F231_R0.6610.22
122_I239_R0.6610.22
163_P235_Q0.6600.22
50_C173_R0.6600.22
213_Y236_Y0.6600.22
116_H190_E0.6570.22
169_D210_I0.6540.22
194_A201_R0.6530.22
25_P28_V0.6510.22
62_P249_C0.6430.21
119_L188_L0.6430.21
48_F159_T0.6320.21
138_V225_L0.6320.21
148_E236_Y0.6290.21
148_E231_R0.6270.21
37_E118_A0.6260.21
219_H237_L0.6240.20
39_V46_T0.6190.20
184_Q191_G0.6160.20
52_F176_P0.6150.20
119_L220_A0.6150.20
111_S215_G0.6120.20
123_L129_H0.6090.20
31_H165_Y0.6080.20
228_D234_V0.6060.20
166_A169_D0.6040.20
90_H210_I0.6030.20
34_T53_G0.6010.20
151_F185_P0.6000.19
186_A199_G0.5990.19
153_G189_F0.5960.19
184_Q219_H0.5950.19
68_P72_D0.5950.19
119_L210_I0.5950.19
184_Q196_T0.5950.19
145_P229_G0.5940.19
116_H221_D0.5940.19
86_Y131_P0.5940.19
117_E190_E0.5930.19
161_R182_T0.5890.19
148_E184_Q0.5890.19
65_T99_F0.5880.19
24_Y166_A0.5850.19
150_C183_F0.5850.19
234_V251_A0.5840.19
69_S106_P0.5830.19
214_D219_H0.5830.19
185_P225_L0.5810.19
94_D185_P0.5800.19
52_F56_S0.5780.19
85_E141_D0.5760.19
68_P84_L0.5750.19
102_F241_D0.5750.19
132_E136_A0.5730.18
155_P183_F0.5720.18
85_E117_E0.5710.18
79_F122_I0.5710.18
115_Y170_R0.5700.18
79_F126_L0.5660.18
182_T189_F0.5640.18
94_D187_G0.5640.18
48_F52_F0.5620.18
55_E158_P0.5610.18
47_P148_E0.5600.18
83_L194_A0.5590.18
100_V180_E0.5580.18
73_P158_P0.5580.18
66_V162_A0.5560.18
124_S203_R0.5510.18
160_C237_L0.5490.18
30_S85_E0.5480.18
111_S241_D0.5450.17
149_F210_I0.5410.17
102_F122_I0.5410.17
122_I125_V0.5380.17
165_Y225_L0.5360.17
29_R78_G0.5350.17
37_E117_E0.5350.17
192_I209_R0.5340.17
41_G217_C0.5340.17
113_A164_F0.5310.17
194_A198_A0.5300.17
41_G133_P0.5300.17
72_D136_A0.5290.17
153_G183_F0.5260.17
78_G205_A0.5240.17
60_G68_P0.5230.17
41_G208_N0.5220.17
203_R209_R0.5190.17
120_W226_G0.5180.16
159_T175_C0.5170.16
117_E121_H0.5160.16
89_E140_T0.5150.16
120_W209_R0.5120.16
195_D205_A0.5110.16
150_C236_Y0.5110.16
172_S221_D0.5040.16
30_S74_D0.5040.16
33_E73_P0.5030.16
86_Y93_R0.5030.16
55_E150_C0.5020.16
125_V149_F0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ucvA 1 0.2698 3.9 0.978 Contact Map
1vsrA 1 0.3777 3.9 0.978 Contact Map
2q2kA 3 0.1619 3.4 0.978 Contact Map
4gxbB 1 0.054 3.2 0.978 Contact Map
2kwaA 1 0.3094 3.1 0.979 Contact Map
2b4rO 4 0.3165 2.9 0.979 Contact Map
1jogA 2 0.4388 2.5 0.98 Contact Map
4hneA 6 0.3058 2.5 0.98 Contact Map
1cw0A 1 0.4604 2.4 0.98 Contact Map
1wtyA 4 0.4173 2.2 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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