Q9HQL8 - HALSA - GREMLIN Contacts

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Q9HQL8 - Uncharacterized protein

UniProt:	Q9HQL8	Sequences: MNEPELQAVVDQQTLADRVAAGDYPDWVRSHWETFSESVTGDRDGTPFPCHFGAESVANGEPLYTVVPSLTDPDALLGFRDALLEYLTEHGDRDARVSFVTFWKPPEDEFSEADYHEALWHILSVLHVHDPEPWPADVPTDTDSPGWEFCFGGEPLFPTCRAPFYAAHDRYSRYCPVGLEITFQPAGLFEGITADTDAGQRARAAIQNRIEEYDGQCPHADLGDLGVDGDREWVQYLFREDDAQAPTECPATFTREHPKATAGIDPVVGSQPPASGDD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	278 (224)
Sequences:	385 (272)
Seq/√Len:	18.2

BACSU - YQCI YCGG
HALSA - Q9HQL8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
116_H	239_R	4.792	1.00
65_T	82_A	4.239	1.00
183_F	189_F	3.882	1.00
87_L	156_L	3.823	1.00
158_P	181_I	3.158	0.99
226_G	232_E	2.859	0.98
172_S	210_I	2.719	0.98
124_S	128_V	2.558	0.97
196_T	199_G	2.525	0.97
83_L	151_F	2.281	0.94
48_F	157_F	2.261	0.94
159_T	184_Q	2.248	0.93
35_F	102_F	2.206	0.93
93_R	97_V	2.178	0.92
166_A	216_Q	2.115	0.91
52_F	223_G	2.059	0.90
84_L	152_G	2.041	0.90
33_E	37_E	2.013	0.89
68_P	104_K	1.990	0.88
232_E	235_Q	1.966	0.88
123_L	134_W	1.943	0.87
53_G	192_I	1.916	0.86
52_F	175_C	1.890	0.85
226_G	235_Q	1.853	0.84
138_V	148_E	1.853	0.84
32_W	36_S	1.840	0.84
67_V	79_F	1.827	0.83
111_S	114_D	1.804	0.83
162_A	165_Y	1.801	0.83
69_S	206_I	1.797	0.82
124_S	127_H	1.790	0.82
184_Q	189_F	1.760	0.81
127_H	253_F	1.736	0.80
189_F	199_G	1.716	0.79
67_V	82_A	1.709	0.79
71_T	105_P	1.695	0.78
123_L	207_Q	1.692	0.78
188_L	210_I	1.683	0.78
55_E	190_E	1.658	0.77
127_H	251_A	1.623	0.75
132_E	152_G	1.622	0.75
184_Q	192_I	1.620	0.75
116_H	244_Q	1.617	0.75
199_G	233_W	1.606	0.74
142_T	219_H	1.558	0.72
222_L	249_C	1.555	0.72
53_G	189_F	1.528	0.71
56_S	62_P	1.456	0.67
74_D	129_H	1.453	0.67
52_F	165_Y	1.428	0.65
32_W	57_V	1.417	0.65
136_A	252_T	1.399	0.64
126_L	246_P	1.399	0.64
67_V	103_W	1.360	0.61
67_V	101_T	1.357	0.61
51_H	222_L	1.356	0.61
53_G	184_Q	1.354	0.61
56_S	98_S	1.352	0.61
188_L	230_D	1.343	0.60
183_F	190_E	1.338	0.60
140_T	228_D	1.335	0.60
171_Y	214_D	1.334	0.60
86_Y	196_T	1.326	0.59
129_H	151_F	1.316	0.59
111_S	132_E	1.304	0.58
76_L	122_I	1.301	0.58
124_S	142_T	1.289	0.57
52_F	161_R	1.280	0.57
99_F	111_S	1.246	0.54
49_P	235_Q	1.244	0.54
172_S	213_Y	1.243	0.54
110_F	114_D	1.240	0.54
114_D	143_D	1.238	0.54
216_Q	242_D	1.234	0.54
138_V	150_C	1.228	0.53
183_F	192_I	1.218	0.53
41_G	47_P	1.215	0.53
33_E	41_G	1.187	0.51
127_H	216_Q	1.183	0.51
128_V	251_A	1.183	0.51
39_V	47_P	1.178	0.50
133_P	212_E	1.173	0.50
176_P	206_I	1.168	0.50
202_A	229_G	1.165	0.49
79_F	101_T	1.144	0.48
203_R	232_E	1.141	0.48
203_R	206_I	1.140	0.48
41_G	174_Y	1.139	0.48
48_F	195_D	1.138	0.48
170_R	217_C	1.134	0.48
113_A	246_P	1.123	0.47
74_D	149_F	1.121	0.47
244_Q	247_T	1.120	0.47
137_D	155_P	1.106	0.46
135_P	185_P	1.099	0.45
71_T	106_P	1.096	0.45
48_F	56_S	1.096	0.45
87_L	152_G	1.088	0.45
65_T	101_T	1.084	0.44
155_P	192_I	1.071	0.44
28_V	187_G	1.070	0.44
128_V	203_R	1.070	0.44
182_T	223_G	1.065	0.43
219_H	241_D	1.062	0.43
232_E	236_Y	1.059	0.43
133_P	152_G	1.059	0.43
147_W	238_F	1.058	0.43
25_P	199_G	1.058	0.43
159_T	199_G	1.055	0.43
184_Q	199_G	1.054	0.43
148_E	160_C	1.052	0.43
102_F	248_E	1.047	0.42
134_W	207_Q	1.037	0.42
89_E	93_R	1.036	0.42
143_D	231_R	1.024	0.41
35_F	154_E	1.007	0.40
130_D	163_P	1.004	0.40
35_F	100_V	0.995	0.39
51_H	54_A	0.993	0.39
230_D	251_A	0.993	0.39
67_V	99_F	0.977	0.38
101_T	200_Q	0.969	0.38
186_A	233_W	0.968	0.38
29_R	33_E	0.958	0.37
186_A	235_Q	0.958	0.37
73_P	77_L	0.958	0.37
65_T	252_T	0.951	0.37
52_F	202_A	0.944	0.36
51_H	108_D	0.941	0.36
159_T	238_F	0.935	0.36
79_F	111_S	0.916	0.35
97_V	225_L	0.914	0.34
169_D	172_S	0.908	0.34
53_G	183_F	0.897	0.34
209_R	226_G	0.895	0.33
210_I	238_F	0.893	0.33
117_E	140_T	0.890	0.33
75_A	176_P	0.889	0.33
237_L	240_E	0.887	0.33
160_C	188_L	0.883	0.33
26_D	30_S	0.881	0.33
92_D	133_P	0.881	0.33
48_F	161_R	0.880	0.33
24_Y	152_G	0.872	0.32
197_D	217_C	0.871	0.32
23_D	145_P	0.869	0.32
225_L	232_E	0.868	0.32
103_W	179_L	0.856	0.31
66_V	185_P	0.850	0.31
157_F	172_S	0.848	0.31
135_P	165_Y	0.842	0.31
80_R	214_D	0.837	0.30
100_V	248_E	0.832	0.30
148_E	186_A	0.830	0.30
84_L	131_P	0.825	0.30
186_A	232_E	0.824	0.30
161_R	186_A	0.823	0.30
192_I	202_A	0.820	0.29
171_Y	213_Y	0.815	0.29
141_D	164_F	0.811	0.29
142_T	233_W	0.808	0.29
193_T	219_H	0.806	0.29
108_D	121_H	0.802	0.29
80_R	151_F	0.800	0.28
81_D	204_A	0.799	0.28
69_S	114_D	0.798	0.28
170_R	216_Q	0.794	0.28
35_F	208_N	0.793	0.28
73_P	125_V	0.793	0.28
87_L	202_A	0.789	0.28
129_H	181_I	0.788	0.28
36_S	124_S	0.787	0.28
96_R	165_Y	0.784	0.28
147_W	210_I	0.783	0.28
148_E	182_T	0.782	0.28
148_E	188_L	0.777	0.27
165_Y	219_H	0.777	0.27
48_F	210_I	0.776	0.27
51_H	61_E	0.775	0.27
56_S	195_D	0.775	0.27
188_L	237_L	0.775	0.27
68_P	245_A	0.774	0.27
185_P	232_E	0.774	0.27
189_F	235_Q	0.774	0.27
170_R	219_H	0.773	0.27
103_W	142_T	0.769	0.27
102_F	219_H	0.768	0.27
52_F	157_F	0.768	0.27
34_T	37_E	0.768	0.27
191_G	242_D	0.766	0.27
98_S	183_F	0.763	0.27
185_P	203_R	0.755	0.26
206_I	237_L	0.754	0.26
210_I	214_D	0.753	0.26
151_F	240_E	0.748	0.26
40_T	212_E	0.745	0.26
97_V	210_I	0.744	0.26
83_L	99_F	0.744	0.26
56_S	157_F	0.744	0.26
189_F	192_I	0.743	0.26
119_L	240_E	0.742	0.26
85_E	101_T	0.741	0.26
103_W	206_I	0.740	0.25
49_P	210_I	0.737	0.25
91_G	94_D	0.733	0.25
104_K	212_E	0.729	0.25
138_V	236_Y	0.724	0.25
98_S	252_T	0.723	0.25
179_L	231_R	0.723	0.25
219_H	233_W	0.722	0.25
170_R	214_D	0.716	0.24
66_V	172_S	0.716	0.24
123_L	214_D	0.713	0.24
185_P	226_G	0.711	0.24
112_E	215_G	0.710	0.24
131_P	152_G	0.702	0.24
112_E	237_L	0.700	0.24
215_G	229_G	0.695	0.23
158_P	183_F	0.695	0.23
83_L	86_Y	0.695	0.23
69_S	101_T	0.691	0.23
189_F	249_C	0.682	0.23
102_F	149_F	0.680	0.23
64_Y	102_F	0.677	0.23
99_F	157_F	0.674	0.23
49_P	226_G	0.673	0.22
30_S	88_T	0.671	0.22
239_R	244_Q	0.670	0.22
165_Y	222_L	0.670	0.22
159_T	183_F	0.667	0.22
147_W	225_L	0.666	0.22
179_L	188_L	0.666	0.22
53_G	97_V	0.664	0.22
140_T	234_V	0.662	0.22
183_F	231_R	0.661	0.22
122_I	239_R	0.661	0.22
163_P	235_Q	0.660	0.22
50_C	173_R	0.660	0.22
213_Y	236_Y	0.660	0.22
116_H	190_E	0.657	0.22
169_D	210_I	0.654	0.22
194_A	201_R	0.653	0.22
25_P	28_V	0.651	0.22
62_P	249_C	0.643	0.21
119_L	188_L	0.643	0.21
48_F	159_T	0.632	0.21
138_V	225_L	0.632	0.21
148_E	236_Y	0.629	0.21
148_E	231_R	0.627	0.21
37_E	118_A	0.626	0.21
219_H	237_L	0.624	0.20
39_V	46_T	0.619	0.20
184_Q	191_G	0.616	0.20
52_F	176_P	0.615	0.20
119_L	220_A	0.615	0.20
111_S	215_G	0.612	0.20
123_L	129_H	0.609	0.20
31_H	165_Y	0.608	0.20
228_D	234_V	0.606	0.20
166_A	169_D	0.604	0.20
90_H	210_I	0.603	0.20
34_T	53_G	0.601	0.20
151_F	185_P	0.600	0.19
186_A	199_G	0.599	0.19
153_G	189_F	0.596	0.19
184_Q	219_H	0.595	0.19
68_P	72_D	0.595	0.19
119_L	210_I	0.595	0.19
184_Q	196_T	0.595	0.19
145_P	229_G	0.594	0.19
116_H	221_D	0.594	0.19
86_Y	131_P	0.594	0.19
117_E	190_E	0.593	0.19
161_R	182_T	0.589	0.19
148_E	184_Q	0.589	0.19
65_T	99_F	0.588	0.19
24_Y	166_A	0.585	0.19
150_C	183_F	0.585	0.19
234_V	251_A	0.584	0.19
69_S	106_P	0.583	0.19
214_D	219_H	0.583	0.19
185_P	225_L	0.581	0.19
94_D	185_P	0.580	0.19
52_F	56_S	0.578	0.19
85_E	141_D	0.576	0.19
68_P	84_L	0.575	0.19
102_F	241_D	0.575	0.19
132_E	136_A	0.573	0.18
155_P	183_F	0.572	0.18
85_E	117_E	0.571	0.18
79_F	122_I	0.571	0.18
115_Y	170_R	0.570	0.18
79_F	126_L	0.566	0.18
182_T	189_F	0.564	0.18
94_D	187_G	0.564	0.18
48_F	52_F	0.562	0.18
55_E	158_P	0.561	0.18
47_P	148_E	0.560	0.18
83_L	194_A	0.559	0.18
100_V	180_E	0.558	0.18
73_P	158_P	0.558	0.18
66_V	162_A	0.556	0.18
124_S	203_R	0.551	0.18
160_C	237_L	0.549	0.18
30_S	85_E	0.548	0.18
111_S	241_D	0.545	0.17
149_F	210_I	0.541	0.17
102_F	122_I	0.541	0.17
122_I	125_V	0.538	0.17
165_Y	225_L	0.536	0.17
29_R	78_G	0.535	0.17
37_E	117_E	0.535	0.17
192_I	209_R	0.534	0.17
41_G	217_C	0.534	0.17
113_A	164_F	0.531	0.17
194_A	198_A	0.530	0.17
41_G	133_P	0.530	0.17
72_D	136_A	0.529	0.17
153_G	183_F	0.526	0.17
78_G	205_A	0.524	0.17
60_G	68_P	0.523	0.17
41_G	208_N	0.522	0.17
203_R	209_R	0.519	0.17
120_W	226_G	0.518	0.16
159_T	175_C	0.517	0.16
117_E	121_H	0.516	0.16
89_E	140_T	0.515	0.16
120_W	209_R	0.512	0.16
195_D	205_A	0.511	0.16
150_C	236_Y	0.511	0.16
172_S	221_D	0.504	0.16
30_S	74_D	0.504	0.16
33_E	73_P	0.503	0.16
86_Y	93_R	0.503	0.16
55_E	150_C	0.502	0.16
125_V	149_F	0.500	0.16

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ucvA	1	0.2698	3.9	0.978	Contact Map
1vsrA	1	0.3777	3.9	0.978	Contact Map
2q2kA	3	0.1619	3.4	0.978	Contact Map
4gxbB	1	0.054	3.2	0.978	Contact Map
2kwaA	1	0.3094	3.1	0.979	Contact Map
2b4rO	4	0.3165	2.9	0.979	Contact Map
1jogA	2	0.4388	2.5	0.98	Contact Map
4hneA	6	0.3058	2.5	0.98	Contact Map
1cw0A	1	0.4604	2.4	0.98	Contact Map
1wtyA	4	0.4173	2.2	0.98	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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