GREMLIN Database
Q9HQL6 - Uncharacterized protein
UniProt: Q9HQL6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 414 (399)
Sequences: 2496 (1631)
Seq/√Len: 81.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
184_A187_M7.5601.00
183_V187_M5.2611.00
105_R108_E5.2401.00
100_L276_R4.4201.00
180_L184_A3.2901.00
373_G377_G3.1751.00
129_V328_V3.1361.00
121_V331_A2.9211.00
112_V276_R2.8761.00
118_A335_A2.8461.00
180_L187_M2.7761.00
202_L404_V2.7481.00
239_P243_G2.7011.00
268_L271_D2.6661.00
180_L183_V2.6261.00
232_P235_E2.5991.00
177_S404_V2.5961.00
246_A268_L2.5531.00
112_V280_A2.5251.00
375_G378_V2.5191.00
214_A392_P2.4891.00
10_V325_A2.4801.00
265_A281_A2.4621.00
119_T240_G2.4511.00
127_F248_A2.4421.00
122_V328_V2.4341.00
236_V280_A2.3381.00
93_S279_V2.2201.00
173_A387_V2.1691.00
84_G94_V2.1601.00
12_P322_V2.1571.00
177_S400_H2.1541.00
103_G273_S2.1521.00
209_A362_C2.1291.00
116_G284_G2.1251.00
156_V171_V2.0921.00
170_A400_H2.0871.00
81_L97_G2.0851.00
99_R102_L2.0721.00
192_V376_T2.0521.00
197_D202_L2.0451.00
210_P214_A2.0441.00
231_V234_R2.0421.00
379_G383_A2.0371.00
231_V235_E2.0201.00
98_H102_L1.9631.00
18_V60_L1.9621.00
18_V63_A1.8861.00
63_A326_S1.8771.00
95_L99_R1.8671.00
391_P400_H1.8531.00
173_A400_H1.8421.00
123_V248_A1.8281.00
241_V245_L1.8261.00
123_V241_V1.8121.00
236_V239_P1.8081.00
131_A134_L1.8021.00
293_A305_T1.8011.00
375_G379_G1.7711.00
384_A388_G1.7701.00
117_S286_N1.7481.00
383_A387_V1.7321.00
230_A233_P1.7241.00
386_A390_I1.7221.00
77_V81_L1.6991.00
293_A308_L1.6911.00
100_L105_R1.6881.00
44_A307_V1.6771.00
59_H322_V1.6681.00
77_V113_S1.6541.00
100_L103_G1.6301.00
297_L312_E1.6281.00
47_L64_A1.6251.00
269_T281_A1.6131.00
245_L249_A1.6031.00
180_L185_L1.5891.00
209_A213_L1.5861.00
123_V127_F1.5721.00
21_A60_L1.5701.00
84_G392_P1.5621.00
23_A333_V1.5561.00
316_L319_T1.5471.00
376_T380_L1.5411.00
206_L388_G1.5340.99
8_V11_T1.5260.99
137_R141_V1.5140.99
391_P396_A1.5130.99
40_V72_H1.4910.99
190_D194_P1.4830.99
119_T123_V1.4770.99
65_L311_F1.4680.99
7_R11_T1.4680.99
57_P60_L1.4680.99
135_A252_Y1.4600.99
122_V126_A1.4530.99
170_A391_P1.4450.99
197_D380_L1.4250.99
138_A141_V1.4240.99
268_L272_D1.4210.99
160_R167_R1.4130.99
237_V241_V1.3980.99
112_V236_V1.3950.99
93_S283_S1.3910.99
71_T75_L1.3900.99
201_P380_L1.3870.99
23_A27_A1.3870.99
390_I394_F1.3780.99
212_L358_T1.3720.99
366_V381_L1.3700.99
25_G64_A1.3690.99
341_V345_Y1.3530.99
15_A18_V1.3510.99
342_G346_F1.3480.99
101_V106_G1.3270.98
250_V264_F1.3140.98
356_R360_G1.3120.98
111_R231_V1.2990.98
132_T299_A1.2910.98
242_A269_T1.2900.98
116_G240_G1.2880.98
238_R242_A1.2870.98
403_G407_V1.2820.98
66_L323_L1.2790.98
332_V336_A1.2790.98
230_A235_E1.2760.98
124_A290_T1.2700.98
171_V403_G1.2650.98
108_E235_E1.2610.98
201_P369_A1.2590.98
238_R241_V1.2520.98
178_G408_P1.2450.98
256_V402_M1.2440.98
206_L400_H1.2430.98
225_A228_R1.2330.98
210_P398_R1.2220.97
20_A24_A1.2140.97
9_L325_A1.2110.97
228_R232_P1.2110.97
391_P398_R1.2010.97
212_L362_C1.1990.97
242_A272_D1.1930.97
305_T308_L1.1920.97
23_A337_M1.1890.97
34_L88_A1.1860.97
129_V324_V1.1780.97
125_V129_V1.1770.97
98_H101_V1.1750.97
256_V260_I1.1740.97
229_I232_P1.1690.97
227_A230_A1.1670.97
379_G382_G1.1580.96
115_L280_A1.1570.96
84_G99_R1.1470.96
376_T379_G1.1430.96
114_A338_V1.1290.96
240_G280_A1.1280.96
175_A403_G1.1260.96
134_L138_A1.1230.96
211_V392_P1.1210.96
112_V279_V1.1160.96
210_P213_L1.1110.95
177_S197_D1.1100.95
92_V263_V1.1080.95
111_R229_I1.0960.95
366_V378_V1.0900.95
243_G265_A1.0880.95
21_A24_A1.0870.95
242_A268_L1.0830.95
70_V121_V1.0830.95
239_P269_T1.0790.95
208_G365_L1.0790.95
43_L68_A1.0770.95
328_V332_V1.0740.95
256_V304_H1.0710.94
34_L79_P1.0700.94
243_G269_T1.0670.94
227_A235_E1.0670.94
132_T136_V1.0650.94
228_R234_R1.0630.94
149_V152_V1.0480.94
265_A285_V1.0460.94
215_A358_T1.0440.94
230_A234_R1.0400.94
166_A396_A1.0370.93
74_I338_V1.0350.93
202_L384_A1.0280.93
162_R395_G1.0280.93
211_V215_A1.0180.93
58_P61_V1.0150.93
17_A20_A1.0140.93
243_G284_G1.0090.93
198_V373_G1.0090.93
227_A234_R1.0060.92
135_A138_A1.0060.92
169_G396_A1.0030.92
333_V337_M0.9960.92
221_I224_Q0.9950.92
95_L263_V0.9890.92
27_A337_M0.9890.92
261_A289_N0.9890.92
22_V333_V0.9880.92
31_C35_V0.9850.92
9_L13_M0.9760.91
107_R111_R0.9730.91
152_V253_V0.9730.91
202_L372_F0.9710.91
317_P322_V0.9700.91
74_I113_S0.9690.91
176_A179_T0.9670.91
355_R359_A0.9670.91
204_A365_L0.9650.91
214_A389_A0.9630.91
125_V328_V0.9600.91
100_L112_V0.9580.90
13_M325_A0.9560.90
236_V277_A0.9540.90
22_V63_A0.9530.90
90_L258_G0.9510.90
228_R235_E0.9500.90
111_R339_P0.9440.90
32_S43_L0.9430.90
183_V186_P0.9390.90
73_S91_A0.9360.89
178_G407_V0.9330.89
248_A292_F0.9310.89
244_S284_G0.9290.89
366_V382_G0.9290.89
165_R168_L0.9290.89
96_P279_V0.9270.89
127_F131_A0.9260.89
276_R279_V0.9240.89
123_V244_S0.9210.89
12_P15_A0.9180.88
405_L408_P0.9180.88
320_L397_R0.9160.88
30_T71_T0.9130.88
80_M93_S0.9070.88
239_P277_A0.9040.88
239_P242_A0.8990.87
198_V201_P0.8940.87
74_I114_A0.8940.87
70_V125_V0.8930.87
6_V129_V0.8910.87
81_L113_S0.8910.87
389_A393_V0.8890.87
387_V391_P0.8870.87
175_A178_G0.8850.87
173_A391_P0.8770.86
226_D231_V0.8770.86
237_V280_A0.8730.86
40_V73_S0.8720.86
62_G323_L0.8710.86
226_D233_P0.8700.86
84_G327_V0.8690.86
8_V318_R0.8650.85
261_A304_H0.8600.85
173_A177_S0.8590.85
250_V261_A0.8570.85
236_V240_G0.8560.85
239_P280_A0.8530.84
335_A339_P0.8500.84
365_L370_W0.8440.84
32_S38_V0.8420.84
79_P88_A0.8410.84
77_V263_V0.8390.84
292_F295_F0.8340.83
209_A385_T0.8330.83
346_F349_V0.8280.83
77_V338_V0.8240.82
261_A285_V0.8220.82
63_A74_I0.8160.82
262_A282_L0.8110.81
70_V330_A0.8110.81
170_A397_R0.8100.81
96_P99_R0.8090.81
74_I77_V0.8080.81
121_V287_T0.8040.81
228_R233_P0.8020.81
16_L20_A0.8000.80
106_G279_V0.8000.80
152_V260_I0.7990.80
39_H42_T0.7980.80
21_A64_A0.7980.80
160_R397_R0.7970.80
85_V208_G0.7960.80
84_G102_L0.7960.80
128_G294_L0.7930.80
90_L259_A0.7930.80
267_D271_D0.7920.80
77_V282_L0.7920.80
269_T272_D0.7920.80
99_R116_G0.7900.80
128_G132_T0.7900.80
22_V67_A0.7900.80
337_M341_V0.7870.79
277_A362_C0.7850.79
357_L361_V0.7850.79
47_L68_A0.7800.79
158_V267_D0.7800.79
22_V26_V0.7780.79
7_R10_V0.7770.79
6_V325_A0.7770.79
117_S287_T0.7720.78
10_V14_G0.7710.78
120_A244_S0.7590.77
115_L119_T0.7570.77
67_A71_T0.7540.76
238_R277_A0.7540.76
70_V290_T0.7520.76
384_A387_V0.7520.76
227_A231_V0.7490.76
77_V283_S0.7470.76
32_S72_H0.7460.76
120_A284_G0.7450.76
100_L275_D0.7440.75
26_V67_A0.7410.75
209_A381_L0.7410.75
367_V379_G0.7380.75
170_A396_A0.7370.75
42_T89_A0.7360.75
192_V374_G0.7350.75
14_G17_A0.7350.75
253_V288_A0.7350.75
391_P403_G0.7330.74
66_L83_L0.7310.74
15_A20_A0.7300.74
380_L383_A0.7280.74
154_V157_L0.7260.74
202_L387_V0.7250.74
32_S35_V0.7240.73
297_L308_L0.7210.73
43_L65_L0.7210.73
92_V95_L0.7180.73
198_V265_A0.7150.73
111_R230_A0.7150.73
295_F331_A0.7140.72
35_V310_A0.7130.72
341_V344_R0.7120.72
123_V245_L0.7120.72
108_E276_R0.7120.72
74_I85_V0.7100.72
252_Y304_H0.7090.72
149_V409_I0.7070.72
110_L342_G0.7050.72
153_L171_V0.7030.71
115_L335_A0.7010.71
134_L137_R0.7000.71
239_P281_A0.6990.71
124_A291_V0.6990.71
317_P320_L0.6960.71
354_H359_A0.6950.70
106_G112_V0.6950.70
20_A27_A0.6940.70
93_S286_N0.6940.70
256_V297_L0.6930.70
73_S262_A0.6930.70
108_E112_V0.6920.70
229_I233_P0.6920.70
288_A367_V0.6910.70
321_P324_V0.6900.70
206_L398_R0.6870.70
315_R319_T0.6860.69
275_D279_V0.6820.69
15_A382_G0.6820.69
100_L109_A0.6800.69
77_V114_A0.6780.69
320_L324_V0.6770.68
152_V402_M0.6770.68
157_L171_V0.6770.68
11_T14_G0.6760.68
99_R120_A0.6750.68
50_A311_F0.6740.68
66_L305_T0.6730.68
186_P189_P0.6720.68
358_T362_C0.6710.68
237_V240_G0.6700.68
210_P358_T0.6690.68
217_R222_P0.6660.67
391_P397_R0.6660.67
80_M91_A0.6660.67
225_A231_V0.6650.67
257_S304_H0.6650.67
88_A120_A0.6620.67
13_M19_L0.6610.67
76_D286_N0.6600.66
228_R231_V0.6590.66
66_L294_L0.6580.66
91_A262_A0.6570.66
274_G278_F0.6570.66
28_L32_S0.6550.66
30_T78_V0.6540.66
365_L381_L0.6540.66
103_G108_E0.6530.66
152_V407_V0.6530.66
256_V305_T0.6520.66
124_A289_N0.6510.65
59_H63_A0.6510.65
378_V381_L0.6480.65
240_G244_S0.6480.65
145_H253_V0.6470.65
326_S330_A0.6470.65
38_V144_A0.6460.65
382_G386_A0.6450.65
159_A167_R0.6450.65
70_V331_A0.6440.65
30_T338_V0.6440.65
17_A21_A0.6440.65
92_V208_G0.6430.64
107_R231_V0.6430.64
13_M22_V0.6430.64
219_D222_P0.6430.64
73_S258_G0.6420.64
269_T275_D0.6410.64
298_F305_T0.6410.64
10_V386_A0.6400.64
172_L176_A0.6400.64
199_L204_A0.6390.64
40_V79_P0.6370.64
250_V366_V0.6370.64
314_A371_L0.6360.64
81_L109_A0.6350.63
13_M18_V0.6350.63
84_G279_V0.6330.63
70_V327_V0.6330.63
73_S305_T0.6290.63
72_H291_V0.6280.63
226_D234_R0.6230.62
97_G109_A0.6200.62
207_F385_T0.6170.61
259_A405_L0.6160.61
250_V310_A0.6160.61
148_V363_L0.6150.61
154_V300_I0.6140.61
12_P59_H0.6130.61
298_F323_L0.6120.61
208_G319_T0.6100.60
151_A154_V0.6100.60
244_S288_A0.6100.60
201_P377_G0.6090.60
374_G377_G0.6080.60
14_G325_A0.6070.60
26_V365_L0.6070.60
229_I234_R0.6060.60
129_V325_A0.6050.60
16_L19_L0.6050.60
336_A340_A0.6040.60
8_V12_P0.6040.60
327_V330_A0.6020.59
100_L273_S0.6020.59
122_V340_A0.6020.59
112_V116_G0.5990.59
387_V390_I0.5990.59
39_H305_T0.5980.59
41_N405_L0.5980.59
260_I292_F0.5970.59
84_G211_V0.5950.59
217_R223_E0.5920.58
182_S187_M0.5920.58
71_T283_S0.5910.58
6_V279_V0.5910.58
262_A280_A0.5900.58
178_G405_L0.5880.58
214_A393_V0.5880.58
154_V158_V0.5830.57
282_L285_V0.5830.57
43_L320_L0.5820.57
400_H404_V0.5820.57
34_L39_H0.5820.57
198_V377_G0.5810.57
146_L170_A0.5770.56
210_P381_L0.5760.56
105_R276_R0.5730.56
118_A338_V0.5710.55
175_A179_T0.5700.55
30_T77_V0.5680.55
164_R167_R0.5670.55
67_A314_A0.5670.55
208_G399_V0.5670.55
206_L401_L0.5650.55
81_L84_G0.5640.55
208_G305_T0.5640.55
297_L304_H0.5630.54
243_G281_A0.5630.54
94_V200_S0.5630.54
265_A272_D0.5620.54
29_G33_G0.5620.54
152_V204_A0.5610.54
115_L240_G0.5610.54
344_R347_R0.5610.54
126_A130_P0.5580.54
42_T46_L0.5570.54
134_L159_A0.5560.53
227_A232_P0.5550.53
246_A264_F0.5540.53
289_N305_T0.5530.53
327_V357_L0.5530.53
71_T334_T0.5520.53
190_D227_A0.5520.53
79_P91_A0.5510.53
210_P365_L0.5500.53
226_D230_A0.5500.53
151_A302_D0.5480.52
75_L283_S0.5480.52
59_H79_P0.5470.52
120_A279_V0.5460.52
125_V327_V0.5460.52
175_A407_V0.5450.52
215_A354_H0.5450.52
297_L316_L0.5440.52
215_A365_L0.5430.52
96_P281_A0.5430.52
128_G136_V0.5430.52
250_V290_T0.5420.52
210_P384_A0.5420.52
236_V276_R0.5410.52
205_G384_A0.5400.51
35_V349_V0.5400.51
71_T74_I0.5390.51
149_V338_V0.5390.51
130_P179_T0.5390.51
41_N45_L0.5380.51
369_A381_L0.5380.51
392_P398_R0.5360.51
269_T277_A0.5360.51
53_L140_P0.5350.51
151_A155_V0.5350.51
124_A343_D0.5350.51
22_V330_A0.5340.51
198_V252_Y0.5330.50
237_V245_L0.5330.50
15_A24_A0.5330.50
195_T391_P0.5310.50
122_V129_V0.5300.50
12_P361_V0.5300.50
72_H88_A0.5290.50
239_P265_A0.5290.50
225_A232_P0.5290.50
189_P192_V0.5280.50
255_G295_F0.5270.50
241_V244_S0.5270.50
78_V81_L0.5270.50
238_R243_G0.5260.50
210_P392_P0.5260.50
123_V145_H0.5260.50
199_L306_G0.5260.50
19_L329_L0.5260.50
66_L69_G0.5260.50
6_V10_V0.5250.49
321_P334_T0.5250.49
89_A364_L0.5240.49
367_V384_A0.5240.49
46_L52_P0.5230.49
25_G67_A0.5230.49
334_T338_V0.5230.49
114_A118_A0.5220.49
226_D229_I0.5220.49
42_T208_G0.5210.49
80_M271_D0.5200.49
138_A219_D0.5190.49
72_H199_L0.5190.49
114_A339_P0.5190.49
51_A54_A0.5190.49
63_A67_A0.5180.48
79_P206_L0.5180.48
85_V212_L0.5160.48
327_V331_A0.5160.48
52_P140_P0.5140.48
186_P285_V0.5140.48
8_V325_A0.5140.48
79_P306_G0.5130.48
175_A369_A0.5120.48
202_L400_H0.5120.48
115_L339_P0.5120.48
39_H372_F0.5110.48
252_Y295_F0.5110.48
60_L64_A0.5110.48
173_A383_A0.5110.48
63_A330_A0.5100.47
53_L201_P0.5090.47
124_A313_R0.5090.47
208_G324_V0.5080.47
69_G75_L0.5080.47
197_D383_A0.5070.47
220_G223_E0.5070.47
259_A306_G0.5060.47
304_H312_E0.5060.47
297_L365_L0.5040.47
83_L349_V0.5030.47
66_L314_A0.5030.47
250_V304_H0.5030.47
42_T405_L0.5020.46
289_N308_L0.5020.46
162_R387_V0.5010.46
38_V90_L0.5010.46
160_R171_V0.5010.46
183_V194_P0.5010.46
338_V341_V0.5000.46
319_T332_V0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f35D 2 0.6667 20.5 0.974 Contact Map
4cz8A 2 0.6159 12.8 0.977 Contact Map
4rp9A 2 0.5048 11.7 0.977 Contact Map
4czbA 2 0.5942 9.9 0.978 Contact Map
1jb0K 1 0.1111 9.6 0.978 Contact Map
2ksfA 1 0.2536 3.3 0.982 Contact Map
4q65A 1 0.2101 2.5 0.983 Contact Map
3dh4A 3 0.2778 2.5 0.983 Contact Map
4ogqG 1 0.0845 2.5 0.983 Contact Map
1m56D 1 0.0797 2.4 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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