GREMLIN Database
Y1115 - Probable S-adenosyl-L-methionine-binding protein VNG_1115H
UniProt: Q9HQK7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 124 (119)
Sequences: 1764 (1238)
Seq/√Len: 113.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_E106_R3.4501.00
95_A104_A3.2551.00
10_D33_Q2.6071.00
31_N102_T2.6071.00
45_L96_V2.4471.00
94_L106_R2.3161.00
10_D112_H2.2011.00
19_A111_A2.1731.00
72_R77_T2.1261.00
54_V86_V2.0731.00
93_L103_L2.0321.00
32_V53_V1.9911.00
45_L51_V1.9451.00
32_V105_I1.9301.00
56_W117_L1.9101.00
14_E112_H1.8681.00
52_V90_P1.8531.00
3_A56_W1.8141.00
11_T30_A1.7641.00
105_I108_V1.7491.00
9_A116_V1.7271.00
33_Q102_T1.7181.00
29_A104_A1.7131.00
97_D104_A1.6871.00
29_A94_L1.6601.00
53_V116_V1.6161.00
91_C105_I1.6151.00
30_A108_V1.5931.00
86_V117_L1.5751.00
31_N104_A1.5741.00
3_A85_P1.5611.00
56_W85_P1.5381.00
51_V93_L1.4421.00
57_A87_C1.4151.00
59_D111_A1.3951.00
45_L93_L1.3581.00
4_T37_S1.3451.00
5_P8_Y1.3201.00
8_Y35_Y1.2930.99
52_V88_I1.2820.99
10_D31_N1.2760.99
53_V91_C1.2730.99
55_W87_C1.2530.99
7_G34_V1.2360.99
54_V117_L1.2320.99
94_L104_A1.1870.99
34_V119_L1.1690.99
39_R99_A1.1560.99
39_R98_A1.1360.99
54_V88_I1.1300.99
29_A106_R1.1220.98
68_R71_D1.1140.98
3_A117_L1.0820.98
44_G72_R1.0620.98
87_C114_S1.0360.97
6_I41_G1.0340.97
110_M116_V1.0110.97
11_T110_M1.0030.97
97_D102_T0.9910.97
36_E39_R0.9820.97
74_V79_S0.9570.96
55_W110_M0.9460.96
51_V91_C0.9400.96
55_W89_T0.9320.95
12_R28_Y0.9300.95
30_A110_M0.9200.95
21_R25_E0.9140.95
51_V119_L0.9140.95
72_R76_T0.9130.95
105_I116_V0.9070.95
15_T18_D0.9030.94
42_L103_L0.8920.94
51_V105_I0.8910.94
13_F28_Y0.8890.94
67_V77_T0.8870.94
43_V66_A0.8760.93
9_A30_A0.8720.93
58_D111_A0.8700.93
48_D93_L0.8670.93
96_V103_L0.8590.93
50_R122_A0.8410.92
50_R90_P0.8390.92
11_T108_V0.8330.92
42_L98_A0.8320.92
60_A63_D0.8250.91
53_V119_L0.8250.91
53_V110_M0.8220.91
62_R85_P0.8210.91
93_L96_V0.8160.91
41_G65_L0.8070.90
52_V122_A0.8020.90
99_A102_T0.7830.89
42_L93_L0.7710.88
32_V116_V0.7670.88
50_R92_E0.7670.88
38_F75_F0.7510.87
45_L103_L0.7510.87
3_A86_V0.7480.87
103_L119_L0.7450.86
13_F19_A0.7440.86
67_V114_S0.7380.86
77_T80_P0.7370.86
7_G35_Y0.7330.86
35_Y38_F0.7230.85
57_A114_S0.7200.85
64_V81_A0.7180.84
66_A71_D0.7180.84
33_Q99_A0.7160.84
8_Y33_Q0.7140.84
19_A74_V0.7120.84
14_E111_A0.7040.83
92_E107_G0.7020.83
40_G102_T0.6840.81
65_L68_R0.6800.81
61_D85_P0.6760.81
5_P117_L0.6740.80
34_V116_V0.6720.80
87_C115_P0.6660.80
22_Q78_R0.6600.79
44_G77_T0.6580.79
9_A108_V0.6440.77
55_W90_P0.6380.77
89_T114_S0.6320.76
32_V103_L0.6280.76
30_A91_C0.6220.75
15_T111_A0.6220.75
3_A63_D0.6160.74
42_L45_L0.6150.74
41_G74_V0.6140.74
69_D87_C0.6120.74
10_D113_G0.6120.74
61_D65_L0.6110.74
89_T109_D0.6100.74
19_A58_D0.6080.73
20_P78_R0.6020.73
9_A53_V0.6000.72
42_L119_L0.5990.72
49_D122_A0.5960.72
41_G75_F0.5950.72
16_A19_A0.5940.72
74_V77_T0.5940.72
28_Y107_G0.5910.71
29_A105_I0.5900.71
43_V68_R0.5890.71
25_E77_T0.5830.70
11_T112_H0.5820.70
60_A85_P0.5820.70
16_A57_A0.5800.70
22_Q25_E0.5800.70
13_F22_Q0.5790.70
9_A32_V0.5750.69
36_E88_I0.5710.69
62_R108_V0.5580.67
19_A25_E0.5560.67
89_T96_V0.5550.66
41_G52_V0.5530.66
78_R121_P0.5490.66
22_Q77_T0.5450.65
63_D81_A0.5410.64
27_P106_R0.5400.64
31_N97_D0.5390.64
52_V81_A0.5350.64
31_N95_A0.5320.63
57_A79_S0.5300.63
58_D115_P0.5300.63
62_R67_V0.5290.63
47_P72_R0.5260.62
110_M114_S0.5260.62
52_V89_T0.5250.62
65_L81_A0.5230.62
16_A22_Q0.5130.60
89_T107_G0.5110.60
34_V42_L0.5070.59
29_A92_E0.5050.59
79_S123_L0.5050.59
60_A64_V0.5040.59
50_R109_D0.5000.58
11_T20_P0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nv4A 2 0.9839 100 0.075 Contact Map
3okxA 2 0.9839 100 0.089 Contact Map
1xqbA 2 0.8871 100 0.097 Contact Map
2fj6A 1 0.5403 8.6 0.951 Contact Map
4qpiA 5 0.3306 6.2 0.954 Contact Map
2kzkA 1 0.6371 6 0.954 Contact Map
2q9kA 2 0.3548 5.7 0.954 Contact Map
4d9iA 2 0.4032 5.2 0.955 Contact Map
1tmoA 1 0.8952 4.2 0.957 Contact Map
4g4sP 1 0.7419 4.1 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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