GREMLIN Database
DPHB - Diphthine synthase
UniProt: Q9HQK6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 260 (244)
Sequences: 529 (325)
Seq/√Len: 20.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_A79_V8.1101.00
13_A21_D6.1821.00
135_L166_V4.4721.00
15_V23_I4.2431.00
27_D76_G3.9481.00
185_A204_V3.4141.00
161_G239_G3.3231.00
94_D98_R3.0530.99
198_A221_G2.8660.99
107_R211_P2.8100.99
189_A220_L2.8080.99
25_A77_D2.8030.99
189_A228_F2.7710.99
70_L104_I2.7560.99
17_V49_H2.5910.98
114_A208_A2.4100.97
28_R72_A2.2140.95
115_A132_A2.2060.95
156_A160_R2.1780.95
27_D77_D2.1670.94
22_A109_I2.1590.94
99_A106_T2.1130.94
57_R61_G2.1120.94
2_L80_F2.0950.93
4_F96_R2.0940.93
11_D18_A2.0090.92
29_V52_T2.0010.92
122_T236_V1.9860.91
62_V80_F1.9760.91
131_K153_T1.9260.90
135_L188_A1.9030.89
122_T205_V1.8610.88
155_E159_E1.8080.87
88_I116_S1.7950.86
137_F187_Q1.7450.85
12_E45_A1.7360.85
71_D102_R1.7290.84
111_A134_T1.7170.84
110_H213_A1.7120.84
218_D222_A1.6880.83
58_D173_D1.6630.82
21_D24_A1.6520.81
203_V249_L1.6400.81
248_A252_L1.6390.81
125_Q242_H1.6090.80
223_L228_F1.5800.78
30_F72_A1.5640.78
201_L217_A1.5620.78
28_R74_A1.5460.77
21_D25_A1.5220.76
132_A167_Y1.5190.75
204_V228_F1.5060.75
151_T155_E1.4870.74
74_A102_R1.4800.74
5_V79_V1.4770.73
218_D223_L1.4670.73
23_I29_V1.4610.73
82_T111_A1.4570.72
14_S18_A1.4560.72
229_G233_H1.4440.72
3_T26_A1.4350.71
60_A64_Q1.4330.71
22_A52_T1.3890.69
205_V208_A1.3600.67
135_L150_V1.3500.66
93_V248_A1.3440.66
65_H162_L1.3250.65
121_L208_A1.3070.64
58_D61_G1.2980.63
189_A224_A1.2970.63
3_T22_A1.2940.63
146_V194_T1.2860.62
15_V32_E1.2830.62
28_R76_G1.2670.61
2_L99_A1.2380.59
167_Y234_L1.2380.59
87_M96_R1.2340.59
119_A205_V1.2320.59
4_F106_T1.2190.58
3_T79_V1.1820.56
4_F29_V1.1650.55
53_T154_I1.1540.54
238_P249_L1.1390.53
1_M106_T1.1280.52
82_T86_T1.1220.52
28_R78_A1.1140.51
39_I182_Y1.1070.51
30_F78_A1.1060.51
80_F94_D1.1040.51
61_G65_H1.1000.50
15_V19_G1.0720.49
2_L5_V1.0660.48
96_R106_T1.0650.48
158_R240_S1.0650.48
138_P150_V1.0640.48
93_V100_A1.0610.48
246_R250_R1.0490.47
135_L154_I1.0470.47
121_L213_A1.0450.47
61_G69_I1.0350.46
160_R238_P1.0230.45
72_A76_G1.0230.45
23_I50_H1.0200.45
15_V20_R1.0170.45
137_F183_M1.0150.45
86_T136_P1.0090.44
148_G195_N0.9920.43
23_I79_V0.9920.43
65_H68_P0.9870.43
219_R222_A0.9830.43
89_S167_Y0.9820.43
25_A76_G0.9820.43
168_L188_A0.9760.42
10_Y39_I0.9720.42
45_A48_A0.9720.42
202_G223_L0.9670.42
198_A212_D0.9610.41
26_A29_V0.9600.41
171_K174_H0.9590.41
184_T187_Q0.9590.41
45_A158_R0.9590.41
5_V109_I0.9550.41
73_A104_I0.9490.41
185_A228_F0.9480.40
2_L95_L0.9460.40
29_V251_E0.9200.39
158_R196_W0.9160.38
22_A79_V0.9160.38
5_V26_A0.9160.38
207_R233_H0.9090.38
16_T220_L0.9060.38
188_A192_L0.8980.37
202_G220_L0.8930.37
217_A238_P0.8920.37
151_T193_A0.8820.36
138_P191_L0.8810.36
38_L232_L0.8790.36
70_L98_R0.8750.36
166_V192_L0.8700.36
156_A239_G0.8680.36
139_W144_D0.8640.35
13_A25_A0.8520.35
16_T112_P0.8470.34
80_F98_R0.8470.34
75_D104_I0.8460.34
25_A109_I0.8420.34
154_I166_V0.8410.34
47_E53_T0.8370.34
208_A223_L0.8280.33
27_D30_F0.8250.33
53_T56_R0.8190.33
189_A218_D0.8150.32
43_V53_T0.8140.32
53_T205_V0.8110.32
221_G226_A0.8060.32
131_K156_A0.8030.32
186_S224_A0.8020.32
31_A134_T0.8020.32
48_A160_R0.7990.31
4_F80_F0.7960.31
48_A53_T0.7930.31
43_V247_D0.7930.31
48_A51_D0.7920.31
115_A122_T0.7920.31
156_A162_L0.7900.31
216_R254_G0.7870.31
100_A251_E0.7860.31
67_E109_I0.7860.31
190_D224_A0.7860.31
101_D236_V0.7840.31
26_A52_T0.7770.30
160_R239_G0.7760.30
118_A165_L0.7720.30
135_L197_D0.7720.30
189_A223_L0.7670.30
190_D237_V0.7640.29
22_A78_A0.7620.29
124_L249_L0.7600.29
229_G232_L0.7590.29
147_P181_A0.7510.29
71_D75_D0.7500.29
74_A104_I0.7460.29
108_V241_L0.7420.28
122_T126_N0.7360.28
222_A244_I0.7350.28
212_D230_S0.7300.28
114_A234_L0.7290.28
28_R55_E0.7290.28
131_K166_V0.7270.27
62_V94_D0.7250.27
143_A151_T0.7240.27
133_T153_T0.7240.27
4_F87_M0.7200.27
174_H181_A0.7200.27
14_S134_T0.7200.27
10_Y16_T0.7180.27
28_R77_D0.7150.27
184_T230_S0.7130.27
19_G110_H0.7120.27
207_R229_G0.7110.27
111_A153_T0.7110.27
31_A83_A0.7080.27
125_Q206_A0.7060.26
212_D227_D0.7050.26
216_R226_A0.7030.26
75_D135_L0.7000.26
74_A105_D0.6990.26
15_V29_V0.6930.26
196_W220_L0.6890.26
139_W143_A0.6880.25
52_T203_V0.6850.25
26_A223_L0.6840.25
111_A167_Y0.6830.25
57_R150_V0.6820.25
135_L192_L0.6820.25
74_A203_V0.6820.25
90_T127_Y0.6790.25
16_T109_I0.6790.25
136_P201_L0.6780.25
1_M253_A0.6770.25
102_R221_G0.6760.25
88_I126_N0.6740.25
22_A25_A0.6720.25
151_T196_W0.6700.25
126_N167_Y0.6690.25
29_V64_Q0.6680.25
149_S234_L0.6670.24
60_A161_G0.6660.24
7_L15_V0.6610.24
106_T208_A0.6600.24
17_V97_M0.6580.24
65_H101_D0.6560.24
213_A237_V0.6510.24
68_P101_D0.6500.24
192_L237_V0.6420.23
105_D225_D0.6390.23
36_S99_A0.6370.23
25_A45_A0.6370.23
199_D224_A0.6350.23
9_L19_G0.6340.23
52_T75_D0.6300.23
100_A194_T0.6280.23
149_S165_L0.6270.23
97_M241_L0.6270.23
207_R231_P0.6260.23
107_R247_D0.6250.22
192_L241_L0.6250.22
203_V217_A0.6210.22
121_L187_Q0.6190.22
145_G149_S0.6180.22
206_A249_L0.6170.22
5_V19_G0.6160.22
85_D125_Q0.6130.22
133_T147_P0.6120.22
201_L248_A0.6100.22
70_L78_A0.6090.22
124_L127_Y0.6080.22
33_F56_R0.6070.22
134_T232_L0.6050.22
5_V23_I0.6040.22
97_M220_L0.6030.21
72_A189_A0.6020.21
172_V182_Y0.5980.21
66_P128_R0.5970.21
92_H127_Y0.5960.21
80_F99_A0.5940.21
193_A247_D0.5930.21
60_A80_F0.5920.21
76_G155_E0.5920.21
31_A43_V0.5920.21
23_I81_L0.5910.21
37_R185_A0.5910.21
135_L186_S0.5910.21
12_E41_T0.5880.21
1_M238_P0.5830.21
241_L246_R0.5830.21
32_E232_L0.5820.21
2_L70_L0.5790.20
36_S188_A0.5780.20
132_A234_L0.5760.20
87_M121_L0.5750.20
95_L102_R0.5730.20
101_D235_L0.5730.20
36_S234_L0.5730.20
217_A236_V0.5710.20
201_L216_R0.5700.20
206_A233_H0.5690.20
133_T154_I0.5690.20
183_M188_A0.5680.20
82_T174_H0.5680.20
114_A134_T0.5660.20
202_G237_V0.5660.20
64_Q241_L0.5660.20
166_V186_S0.5650.20
56_R154_I0.5650.20
66_P69_I0.5640.20
118_A205_V0.5610.20
42_D45_A0.5600.20
185_A206_A0.5600.20
69_I72_A0.5590.20
145_G150_V0.5590.20
30_F74_A0.5580.20
173_D180_D0.5580.20
153_T234_L0.5560.19
87_M128_R0.5550.19
36_S132_A0.5550.19
70_L219_R0.5530.19
158_R161_G0.5530.19
22_A223_L0.5530.19
23_I53_T0.5520.19
43_V56_R0.5510.19
22_A86_T0.5510.19
96_R116_S0.5510.19
186_S190_D0.5500.19
14_S114_A0.5500.19
88_I153_T0.5490.19
24_A78_A0.5490.19
183_M232_L0.5480.19
119_A122_T0.5480.19
88_I208_A0.5480.19
217_A242_H0.5470.19
83_A98_R0.5410.19
123_G147_P0.5400.19
138_P146_V0.5370.19
112_P120_G0.5360.19
31_A57_R0.5360.19
237_V249_L0.5330.19
16_T69_I0.5320.18
34_Y46_L0.5320.18
184_T206_A0.5310.18
87_M108_V0.5310.18
58_D126_N0.5310.18
111_A173_D0.5300.18
158_R203_V0.5300.18
171_K183_M0.5300.18
190_D230_S0.5290.18
115_A167_Y0.5270.18
243_H248_A0.5260.18
107_R222_A0.5260.18
199_D221_G0.5250.18
87_M126_N0.5230.18
186_S228_F0.5230.18
7_L31_A0.5220.18
202_G238_P0.5220.18
101_D158_R0.5210.18
4_F209_G0.5200.18
121_L215_V0.5200.18
18_A107_R0.5200.18
77_D155_E0.5180.18
33_F116_S0.5180.18
161_G193_A0.5140.18
149_S153_T0.5130.18
155_E194_T0.5120.18
208_A215_V0.5120.18
5_V22_A0.5120.18
93_V129_F0.5120.18
57_R234_L0.5110.18
43_V47_E0.5110.18
215_V237_V0.5100.18
17_V72_A0.5080.18
12_E121_L0.5060.17
13_A211_P0.5050.17
103_G246_R0.5030.17
103_G205_V0.5030.17
145_G243_H0.5010.17
14_S20_R0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i4tA 2 0.9269 100 0.548 Contact Map
2z6rA 2 0.9654 100 0.579 Contact Map
1wdeA 2 0.9538 100 0.582 Contact Map
1vhvA 2 0.9385 100 0.61 Contact Map
1cbfA 2 0.8615 100 0.711 Contact Map
2yboA 2 0.8846 100 0.717 Contact Map
1s4dA 4 0.9038 100 0.723 Contact Map
1pjqA 2 0.8846 100 0.723 Contact Map
1va0A 2 0.8577 100 0.727 Contact Map
4e16A 2 0.8385 100 0.728 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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