DPHB - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

DPHB - Diphthine synthase

UniProt:	Q9HQK6	Sequences: MLTFVGLGLYDEASVTVAGRDAIAAADRVFAEFYTSRLIGTDVAALEAHHDTTIERRDRAGVEQHPEPILDAAADGDAVFLTAGDTMISTTHVDLRMRAADRGIDTRVIHAPTAASAAAGLTGLQNYRFGKATTLPFPWAHGADGVPGSVTDTIEANRERGLHTLVYLDIKVDHPRVDGDAYMTASQAADLLATNWDADALGVVVARAGAPDATVRADRLGALADADFGSPLHLLVVPGSLHHIERDALRELAGAPADAL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	260 (244)
Sequences:	529 (325)
Seq/√Len:	20.8

HALSA - DPHB
SULSO - DPHB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
26_A	79_V	8.110	1.00
13_A	21_D	6.182	1.00
135_L	166_V	4.472	1.00
15_V	23_I	4.243	1.00
27_D	76_G	3.948	1.00
185_A	204_V	3.414	1.00
161_G	239_G	3.323	1.00
94_D	98_R	3.053	0.99
198_A	221_G	2.866	0.99
107_R	211_P	2.810	0.99
189_A	220_L	2.808	0.99
25_A	77_D	2.803	0.99
189_A	228_F	2.771	0.99
70_L	104_I	2.756	0.99
17_V	49_H	2.591	0.98
114_A	208_A	2.410	0.97
28_R	72_A	2.214	0.95
115_A	132_A	2.206	0.95
156_A	160_R	2.178	0.95
27_D	77_D	2.167	0.94
22_A	109_I	2.159	0.94
99_A	106_T	2.113	0.94
57_R	61_G	2.112	0.94
2_L	80_F	2.095	0.93
4_F	96_R	2.094	0.93
11_D	18_A	2.009	0.92
29_V	52_T	2.001	0.92
122_T	236_V	1.986	0.91
62_V	80_F	1.976	0.91
131_K	153_T	1.926	0.90
135_L	188_A	1.903	0.89
122_T	205_V	1.861	0.88
155_E	159_E	1.808	0.87
88_I	116_S	1.795	0.86
137_F	187_Q	1.745	0.85
12_E	45_A	1.736	0.85
71_D	102_R	1.729	0.84
111_A	134_T	1.717	0.84
110_H	213_A	1.712	0.84
218_D	222_A	1.688	0.83
58_D	173_D	1.663	0.82
21_D	24_A	1.652	0.81
203_V	249_L	1.640	0.81
248_A	252_L	1.639	0.81
125_Q	242_H	1.609	0.80
223_L	228_F	1.580	0.78
30_F	72_A	1.564	0.78
201_L	217_A	1.562	0.78
28_R	74_A	1.546	0.77
21_D	25_A	1.522	0.76
132_A	167_Y	1.519	0.75
204_V	228_F	1.506	0.75
151_T	155_E	1.487	0.74
74_A	102_R	1.480	0.74
5_V	79_V	1.477	0.73
218_D	223_L	1.467	0.73
23_I	29_V	1.461	0.73
82_T	111_A	1.457	0.72
14_S	18_A	1.456	0.72
229_G	233_H	1.444	0.72
3_T	26_A	1.435	0.71
60_A	64_Q	1.433	0.71
22_A	52_T	1.389	0.69
205_V	208_A	1.360	0.67
135_L	150_V	1.350	0.66
93_V	248_A	1.344	0.66
65_H	162_L	1.325	0.65
121_L	208_A	1.307	0.64
58_D	61_G	1.298	0.63
189_A	224_A	1.297	0.63
3_T	22_A	1.294	0.63
146_V	194_T	1.286	0.62
15_V	32_E	1.283	0.62
28_R	76_G	1.267	0.61
2_L	99_A	1.238	0.59
167_Y	234_L	1.238	0.59
87_M	96_R	1.234	0.59
119_A	205_V	1.232	0.59
4_F	106_T	1.219	0.58
3_T	79_V	1.182	0.56
4_F	29_V	1.165	0.55
53_T	154_I	1.154	0.54
238_P	249_L	1.139	0.53
1_M	106_T	1.128	0.52
82_T	86_T	1.122	0.52
28_R	78_A	1.114	0.51
39_I	182_Y	1.107	0.51
30_F	78_A	1.106	0.51
80_F	94_D	1.104	0.51
61_G	65_H	1.100	0.50
15_V	19_G	1.072	0.49
2_L	5_V	1.066	0.48
96_R	106_T	1.065	0.48
158_R	240_S	1.065	0.48
138_P	150_V	1.064	0.48
93_V	100_A	1.061	0.48
246_R	250_R	1.049	0.47
135_L	154_I	1.047	0.47
121_L	213_A	1.045	0.47
61_G	69_I	1.035	0.46
160_R	238_P	1.023	0.45
72_A	76_G	1.023	0.45
23_I	50_H	1.020	0.45
15_V	20_R	1.017	0.45
137_F	183_M	1.015	0.45
86_T	136_P	1.009	0.44
148_G	195_N	0.992	0.43
23_I	79_V	0.992	0.43
65_H	68_P	0.987	0.43
219_R	222_A	0.983	0.43
89_S	167_Y	0.982	0.43
25_A	76_G	0.982	0.43
168_L	188_A	0.976	0.42
10_Y	39_I	0.972	0.42
45_A	48_A	0.972	0.42
202_G	223_L	0.967	0.42
198_A	212_D	0.961	0.41
26_A	29_V	0.960	0.41
171_K	174_H	0.959	0.41
184_T	187_Q	0.959	0.41
45_A	158_R	0.959	0.41
5_V	109_I	0.955	0.41
73_A	104_I	0.949	0.41
185_A	228_F	0.948	0.40
2_L	95_L	0.946	0.40
29_V	251_E	0.920	0.39
158_R	196_W	0.916	0.38
22_A	79_V	0.916	0.38
5_V	26_A	0.916	0.38
207_R	233_H	0.909	0.38
16_T	220_L	0.906	0.38
188_A	192_L	0.898	0.37
202_G	220_L	0.893	0.37
217_A	238_P	0.892	0.37
151_T	193_A	0.882	0.36
138_P	191_L	0.881	0.36
38_L	232_L	0.879	0.36
70_L	98_R	0.875	0.36
166_V	192_L	0.870	0.36
156_A	239_G	0.868	0.36
139_W	144_D	0.864	0.35
13_A	25_A	0.852	0.35
16_T	112_P	0.847	0.34
80_F	98_R	0.847	0.34
75_D	104_I	0.846	0.34
25_A	109_I	0.842	0.34
154_I	166_V	0.841	0.34
47_E	53_T	0.837	0.34
208_A	223_L	0.828	0.33
27_D	30_F	0.825	0.33
53_T	56_R	0.819	0.33
189_A	218_D	0.815	0.32
43_V	53_T	0.814	0.32
53_T	205_V	0.811	0.32
221_G	226_A	0.806	0.32
131_K	156_A	0.803	0.32
186_S	224_A	0.802	0.32
31_A	134_T	0.802	0.32
48_A	160_R	0.799	0.31
4_F	80_F	0.796	0.31
48_A	53_T	0.793	0.31
43_V	247_D	0.793	0.31
48_A	51_D	0.792	0.31
115_A	122_T	0.792	0.31
156_A	162_L	0.790	0.31
216_R	254_G	0.787	0.31
100_A	251_E	0.786	0.31
67_E	109_I	0.786	0.31
190_D	224_A	0.786	0.31
101_D	236_V	0.784	0.31
26_A	52_T	0.777	0.30
160_R	239_G	0.776	0.30
118_A	165_L	0.772	0.30
135_L	197_D	0.772	0.30
189_A	223_L	0.767	0.30
190_D	237_V	0.764	0.29
22_A	78_A	0.762	0.29
124_L	249_L	0.760	0.29
229_G	232_L	0.759	0.29
147_P	181_A	0.751	0.29
71_D	75_D	0.750	0.29
74_A	104_I	0.746	0.29
108_V	241_L	0.742	0.28
122_T	126_N	0.736	0.28
222_A	244_I	0.735	0.28
212_D	230_S	0.730	0.28
114_A	234_L	0.729	0.28
28_R	55_E	0.729	0.28
131_K	166_V	0.727	0.27
62_V	94_D	0.725	0.27
143_A	151_T	0.724	0.27
133_T	153_T	0.724	0.27
4_F	87_M	0.720	0.27
174_H	181_A	0.720	0.27
14_S	134_T	0.720	0.27
10_Y	16_T	0.718	0.27
28_R	77_D	0.715	0.27
184_T	230_S	0.713	0.27
19_G	110_H	0.712	0.27
207_R	229_G	0.711	0.27
111_A	153_T	0.711	0.27
31_A	83_A	0.708	0.27
125_Q	206_A	0.706	0.26
212_D	227_D	0.705	0.26
216_R	226_A	0.703	0.26
75_D	135_L	0.700	0.26
74_A	105_D	0.699	0.26
15_V	29_V	0.693	0.26
196_W	220_L	0.689	0.26
139_W	143_A	0.688	0.25
52_T	203_V	0.685	0.25
26_A	223_L	0.684	0.25
111_A	167_Y	0.683	0.25
57_R	150_V	0.682	0.25
135_L	192_L	0.682	0.25
74_A	203_V	0.682	0.25
90_T	127_Y	0.679	0.25
16_T	109_I	0.679	0.25
136_P	201_L	0.678	0.25
1_M	253_A	0.677	0.25
102_R	221_G	0.676	0.25
88_I	126_N	0.674	0.25
22_A	25_A	0.672	0.25
151_T	196_W	0.670	0.25
126_N	167_Y	0.669	0.25
29_V	64_Q	0.668	0.25
149_S	234_L	0.667	0.24
60_A	161_G	0.666	0.24
7_L	15_V	0.661	0.24
106_T	208_A	0.660	0.24
17_V	97_M	0.658	0.24
65_H	101_D	0.656	0.24
213_A	237_V	0.651	0.24
68_P	101_D	0.650	0.24
192_L	237_V	0.642	0.23
105_D	225_D	0.639	0.23
36_S	99_A	0.637	0.23
25_A	45_A	0.637	0.23
199_D	224_A	0.635	0.23
9_L	19_G	0.634	0.23
52_T	75_D	0.630	0.23
100_A	194_T	0.628	0.23
149_S	165_L	0.627	0.23
97_M	241_L	0.627	0.23
207_R	231_P	0.626	0.23
107_R	247_D	0.625	0.22
192_L	241_L	0.625	0.22
203_V	217_A	0.621	0.22
121_L	187_Q	0.619	0.22
145_G	149_S	0.618	0.22
206_A	249_L	0.617	0.22
5_V	19_G	0.616	0.22
85_D	125_Q	0.613	0.22
133_T	147_P	0.612	0.22
201_L	248_A	0.610	0.22
70_L	78_A	0.609	0.22
124_L	127_Y	0.608	0.22
33_F	56_R	0.607	0.22
134_T	232_L	0.605	0.22
5_V	23_I	0.604	0.22
97_M	220_L	0.603	0.21
72_A	189_A	0.602	0.21
172_V	182_Y	0.598	0.21
66_P	128_R	0.597	0.21
92_H	127_Y	0.596	0.21
80_F	99_A	0.594	0.21
193_A	247_D	0.593	0.21
60_A	80_F	0.592	0.21
76_G	155_E	0.592	0.21
31_A	43_V	0.592	0.21
23_I	81_L	0.591	0.21
37_R	185_A	0.591	0.21
135_L	186_S	0.591	0.21
12_E	41_T	0.588	0.21
1_M	238_P	0.583	0.21
241_L	246_R	0.583	0.21
32_E	232_L	0.582	0.21
2_L	70_L	0.579	0.20
36_S	188_A	0.578	0.20
132_A	234_L	0.576	0.20
87_M	121_L	0.575	0.20
95_L	102_R	0.573	0.20
101_D	235_L	0.573	0.20
36_S	234_L	0.573	0.20
217_A	236_V	0.571	0.20
201_L	216_R	0.570	0.20
206_A	233_H	0.569	0.20
133_T	154_I	0.569	0.20
183_M	188_A	0.568	0.20
82_T	174_H	0.568	0.20
114_A	134_T	0.566	0.20
202_G	237_V	0.566	0.20
64_Q	241_L	0.566	0.20
166_V	186_S	0.565	0.20
56_R	154_I	0.565	0.20
66_P	69_I	0.564	0.20
118_A	205_V	0.561	0.20
42_D	45_A	0.560	0.20
185_A	206_A	0.560	0.20
69_I	72_A	0.559	0.20
145_G	150_V	0.559	0.20
30_F	74_A	0.558	0.20
173_D	180_D	0.558	0.20
153_T	234_L	0.556	0.19
87_M	128_R	0.555	0.19
36_S	132_A	0.555	0.19
70_L	219_R	0.553	0.19
158_R	161_G	0.553	0.19
22_A	223_L	0.553	0.19
23_I	53_T	0.552	0.19
43_V	56_R	0.551	0.19
22_A	86_T	0.551	0.19
96_R	116_S	0.551	0.19
186_S	190_D	0.550	0.19
14_S	114_A	0.550	0.19
88_I	153_T	0.549	0.19
24_A	78_A	0.549	0.19
183_M	232_L	0.548	0.19
119_A	122_T	0.548	0.19
88_I	208_A	0.548	0.19
217_A	242_H	0.547	0.19
83_A	98_R	0.541	0.19
123_G	147_P	0.540	0.19
138_P	146_V	0.537	0.19
112_P	120_G	0.536	0.19
31_A	57_R	0.536	0.19
237_V	249_L	0.533	0.19
16_T	69_I	0.532	0.18
34_Y	46_L	0.532	0.18
184_T	206_A	0.531	0.18
87_M	108_V	0.531	0.18
58_D	126_N	0.531	0.18
111_A	173_D	0.530	0.18
158_R	203_V	0.530	0.18
171_K	183_M	0.530	0.18
190_D	230_S	0.529	0.18
115_A	167_Y	0.527	0.18
243_H	248_A	0.526	0.18
107_R	222_A	0.526	0.18
199_D	221_G	0.525	0.18
87_M	126_N	0.523	0.18
186_S	228_F	0.523	0.18
7_L	31_A	0.522	0.18
202_G	238_P	0.522	0.18
101_D	158_R	0.521	0.18
4_F	209_G	0.520	0.18
121_L	215_V	0.520	0.18
18_A	107_R	0.520	0.18
77_D	155_E	0.518	0.18
33_F	116_S	0.518	0.18
161_G	193_A	0.514	0.18
149_S	153_T	0.513	0.18
155_E	194_T	0.512	0.18
208_A	215_V	0.512	0.18
5_V	22_A	0.512	0.18
93_V	129_F	0.512	0.18
57_R	234_L	0.511	0.18
43_V	47_E	0.511	0.18
215_V	237_V	0.510	0.18
17_V	72_A	0.508	0.18
12_E	121_L	0.506	0.17
13_A	211_P	0.505	0.17
103_G	246_R	0.503	0.17
103_G	205_V	0.503	0.17
145_G	243_H	0.501	0.17
14_S	20_R	0.500	0.17

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3i4tA	2	0.9269	100	0.548	Contact Map
2z6rA	2	0.9654	100	0.579	Contact Map
1wdeA	2	0.9538	100	0.582	Contact Map
1vhvA	2	0.9385	100	0.61	Contact Map
1cbfA	2	0.8615	100	0.711	Contact Map
2yboA	2	0.8846	100	0.717	Contact Map
1s4dA	4	0.9038	100	0.723	Contact Map
1pjqA	2	0.8846	100	0.723	Contact Map
1va0A	2	0.8577	100	0.727	Contact Map
4e16A	2	0.8385	100	0.728	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0087 seconds.