GREMLIN Database
Q9HQK5 - Uncharacterized protein
UniProt: Q9HQK5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 327 (265)
Sequences: 1071 (744)
Seq/√Len: 45.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
149_A214_A3.8061.00
207_T210_D3.6811.00
96_A130_D3.1991.00
86_V110_V3.0951.00
233_R259_E2.9441.00
179_F243_A2.8221.00
245_R272_H2.5341.00
137_T153_A2.5171.00
131_V137_T2.4991.00
182_F257_F2.4781.00
139_T150_L2.4541.00
181_M232_V2.4171.00
154_A207_T2.3841.00
180_D249_N2.3741.00
209_I213_Q2.3361.00
216_A227_G2.3221.00
80_A159_P2.3171.00
216_A225_V2.1991.00
198_R226_T2.1891.00
189_A201_A2.1691.00
309_R317_N2.1521.00
115_N130_D2.1351.00
287_E291_R2.0480.99
150_L211_Y2.0360.99
265_A269_C2.0100.99
209_I227_G2.0020.99
166_H170_E1.9790.99
161_L249_N1.8990.99
176_E245_R1.8920.99
292_A295_R1.8860.99
192_M247_V1.8670.99
111_E135_D1.8340.99
272_H321_D1.8300.99
140_V147_A1.8010.99
138_E211_Y1.8010.99
140_V149_A1.7910.99
156_Y161_L1.7670.98
147_A218_R1.7290.98
149_A218_R1.7150.98
289_A294_A1.7140.98
285_A289_A1.7030.98
210_D214_A1.6830.98
142_R147_A1.6630.98
100_A132_I1.6590.98
148_F191_P1.6510.97
307_T316_F1.6370.97
288_A292_A1.6270.97
156_Y160_R1.5960.97
164_E167_R1.5910.97
156_Y249_N1.5830.97
186_G212_L1.5590.96
301_T323_S1.5550.96
167_R319_V1.5490.96
114_L129_W1.5440.96
160_R187_P1.5420.96
214_A217_A1.5370.96
193_A248_M1.5300.96
69_P73_L1.5190.96
146_H194_S1.5140.96
85_I139_T1.4890.95
124_Q204_V1.4820.95
69_P72_I1.4740.95
200_V228_V1.4540.95
245_R321_D1.4460.95
281_G284_D1.4350.94
123_E204_V1.4280.94
176_E244_D1.4210.94
310_S316_F1.4180.94
86_V107_D1.4110.94
45_D48_A1.4070.94
146_H190_V1.4010.94
151_D154_A1.3910.93
180_D317_N1.3770.93
89_D116_R1.3750.93
161_L309_R1.3740.93
270_T323_S1.3640.93
86_V103_V1.3640.93
180_D309_R1.3610.93
217_A222_A1.3550.92
249_N317_N1.3500.92
156_Y187_P1.3380.92
171_Q304_T1.3310.92
187_P249_N1.3280.92
80_A160_R1.3140.91
150_L155_V1.3130.91
228_V235_V1.3030.91
172_V178_V1.2960.91
207_T211_Y1.2940.90
172_V192_M1.2920.90
100_A133_A1.2840.90
180_D212_L1.2710.90
104_V133_A1.2530.89
160_R249_N1.2370.88
161_L187_P1.2250.88
161_L251_P1.2210.88
161_L317_N1.2150.87
203_D249_N1.2050.87
193_A225_V1.2020.87
230_G235_V1.1930.86
160_R251_P1.1850.86
161_L203_D1.1840.86
274_Y306_H1.1820.86
290_I294_A1.1820.86
122_G126_V1.1780.86
183_A203_D1.1680.85
180_D203_D1.1680.85
183_A212_L1.1660.85
107_D110_V1.1660.85
172_V247_V1.1590.85
203_D209_I1.1540.85
156_Y251_P1.1500.84
291_R294_A1.1500.84
208_A274_Y1.1500.84
177_H243_A1.1410.84
141_H157_F1.1400.84
232_V235_V1.1200.83
270_T321_D1.1160.83
90_E99_I1.1130.82
190_V221_V1.1060.82
112_A136_S1.1050.82
249_N309_R1.1030.82
81_R108_I1.1030.82
286_G289_A1.0950.81
168_V247_V1.0880.81
178_V247_V1.0680.80
137_T151_D1.0550.79
201_A212_L1.0480.78
248_M257_F1.0460.78
111_E136_S1.0430.78
156_Y317_N1.0430.78
214_A218_R1.0410.78
122_G128_E1.0360.78
121_K128_E1.0280.77
178_V197_A1.0210.77
148_F190_V1.0200.76
122_G143_E1.0180.76
116_R119_K1.0180.76
182_F273_F1.0080.76
112_A134_G1.0000.75
311_Y315_E0.9970.75
179_F246_I0.9940.75
43_V47_A0.9890.74
160_R274_Y0.9870.74
209_I229_A0.9830.74
187_P317_N0.9670.72
114_L131_V0.9650.72
213_Q217_A0.9620.72
181_M261_A0.9590.72
158_S165_R0.9580.72
305_R320_L0.9470.71
111_E116_R0.9460.71
187_P251_P0.9430.71
168_V172_V0.9420.70
246_I265_A0.9400.70
180_D186_G0.9370.70
255_D275_D0.9350.70
179_F202_T0.9340.70
115_N132_I0.9330.70
276_I315_E0.9260.69
206_E229_A0.9260.69
103_V110_V0.9220.69
100_A113_V0.9180.68
248_M254_A0.9130.68
270_T303_A0.9120.68
165_R188_Y0.9060.67
165_R208_A0.9060.67
276_I311_Y0.9020.67
178_V199_V0.8910.66
156_Y274_Y0.8860.66
161_L274_Y0.8800.65
156_Y309_R0.8800.65
138_E151_D0.8780.65
144_Y166_H0.8740.65
132_I220_G0.8690.64
181_M271_L0.8640.64
104_V110_V0.8590.63
272_H319_V0.8550.63
203_D315_E0.8550.63
167_R272_H0.8510.63
160_R309_R0.8480.62
249_N276_I0.8440.62
162_A166_H0.8410.62
250_L254_A0.8410.62
43_V46_A0.8400.62
181_M248_M0.8370.61
165_R252_H0.8370.61
188_Y208_A0.8350.61
249_N274_Y0.8330.61
252_H276_I0.8290.61
81_R110_V0.8260.60
114_L152_V0.8260.60
82_L85_I0.8250.60
161_L180_D0.8150.59
317_N321_D0.8140.59
168_V192_M0.8120.59
311_Y317_N0.8100.59
96_A99_I0.8010.58
251_P274_Y0.7990.58
82_L274_Y0.7960.57
44_T48_A0.7880.57
281_G312_A0.7880.57
150_L208_A0.7850.56
213_Q227_G0.7840.56
79_Y103_V0.7770.56
306_H321_D0.7750.55
291_R295_R0.7750.55
181_M185_V0.7740.55
161_L276_I0.7730.55
209_I216_A0.7700.55
190_V215_N0.7690.55
178_V216_A0.7690.55
246_I261_A0.7670.55
287_E290_I0.7660.54
178_V192_M0.7660.54
92_D247_V0.7650.54
187_P309_R0.7650.54
203_D232_V0.7650.54
102_A105_E0.7620.54
101_D105_E0.7580.54
138_E149_A0.7580.54
114_L203_D0.7560.54
244_D266_G0.7460.53
96_A104_V0.7460.53
174_A222_A0.7450.52
217_A264_L0.7420.52
120_I126_V0.7390.52
163_T308_V0.7380.52
188_Y258_L0.7370.52
211_Y214_A0.7370.52
159_P192_M0.7360.52
173_T223_D0.7350.51
259_E271_L0.7330.51
175_G197_A0.7330.51
75_F79_Y0.7320.51
103_V107_D0.7280.51
68_T73_L0.7270.51
87_I152_V0.7230.50
286_G295_R0.7210.50
82_L159_P0.7200.50
248_M273_F0.7200.50
116_R276_I0.7170.50
160_R250_L0.7140.49
276_I312_A0.7130.49
246_I318_V0.7120.49
152_V204_V0.7030.48
122_G127_R0.7010.48
308_V317_N0.7000.48
155_V211_Y0.6990.48
189_A217_A0.6960.48
202_T230_G0.6940.47
148_F156_Y0.6900.47
312_A315_E0.6900.47
187_P276_I0.6900.47
203_D309_R0.6880.47
83_G100_A0.6870.47
179_F200_V0.6850.47
102_A106_S0.6840.46
148_F204_V0.6830.46
114_L137_T0.6830.46
187_P274_Y0.6820.46
70_A73_L0.6810.46
88_V132_I0.6810.46
277_Q281_G0.6800.46
125_R133_A0.6790.46
124_Q206_E0.6770.46
165_R187_P0.6750.46
297_A300_V0.6750.46
224_R246_I0.6740.46
117_A130_D0.6720.45
176_E321_D0.6720.45
160_R317_N0.6700.45
112_A116_R0.6680.45
143_E162_A0.6680.45
132_I233_R0.6670.45
249_N252_H0.6650.45
99_I130_D0.6650.45
193_A221_V0.6640.45
233_R256_E0.6630.44
121_K292_A0.6610.44
156_Y180_D0.6560.44
163_T278_H0.6550.44
175_G244_D0.6540.44
114_L215_N0.6520.43
156_Y203_D0.6520.43
160_R319_V0.6470.43
180_D250_L0.6470.43
44_T47_A0.6450.43
140_V220_G0.6420.42
122_G125_R0.6390.42
276_I317_N0.6380.42
143_E151_D0.6330.42
80_A200_V0.6320.41
127_R309_R0.6320.41
109_P168_V0.6280.41
180_D308_V0.6260.41
228_V232_V0.6260.41
82_L150_L0.6240.41
222_A301_T0.6230.41
191_P212_L0.6230.41
161_L165_R0.6220.41
317_N322_V0.6220.41
151_D195_A0.6190.40
169_V195_A0.6160.40
134_G151_D0.6150.40
274_Y309_R0.6140.40
283_F290_I0.6140.40
43_V288_A0.6130.40
111_E142_R0.6130.40
112_A131_V0.6080.39
143_E165_R0.6060.39
252_H309_R0.6060.39
141_H162_A0.6060.39
109_P267_D0.6060.39
78_S320_L0.6060.39
112_A137_T0.6050.39
78_S156_Y0.6030.39
155_V208_A0.6020.39
80_A127_R0.6020.39
150_L191_P0.6010.39
67_T75_F0.5990.38
310_S317_N0.5980.38
220_G223_D0.5970.38
68_T95_R0.5950.38
80_A211_Y0.5910.38
251_P276_I0.5900.38
123_E126_V0.5890.37
203_D250_L0.5880.37
99_I116_R0.5860.37
68_T90_E0.5860.37
177_H200_V0.5850.37
81_R144_Y0.5830.37
177_H197_A0.5830.37
82_L143_E0.5820.37
151_D183_A0.5810.37
156_Y162_A0.5800.37
180_D252_H0.5790.37
79_Y86_V0.5790.37
166_H185_V0.5770.36
142_R240_T0.5750.36
248_M258_L0.5710.36
113_V133_A0.5700.36
179_F321_D0.5700.36
271_L322_V0.5690.36
252_H311_Y0.5680.36
193_A250_L0.5670.35
191_P221_V0.5640.35
114_L120_I0.5640.35
127_R187_P0.5640.35
81_R97_H0.5630.35
183_A201_A0.5610.35
277_Q285_A0.5590.35
256_E322_V0.5570.35
208_A252_H0.5560.34
251_P254_A0.5550.34
190_V227_G0.5540.34
167_R306_H0.5510.34
188_Y191_P0.5510.34
120_I161_L0.5500.34
76_D79_Y0.5480.34
267_D298_Y0.5480.34
233_R260_T0.5460.34
152_V202_T0.5450.33
141_H151_D0.5450.33
118_S128_E0.5440.33
282_R285_A0.5440.33
83_G203_D0.5430.33
132_I241_G0.5420.33
87_I157_F0.5410.33
230_G234_E0.5400.33
126_V161_L0.5370.33
67_T94_D0.5360.33
305_R318_V0.5340.33
68_T71_D0.5340.33
179_F242_W0.5310.32
287_E292_A0.5300.32
233_R257_F0.5300.32
126_V274_Y0.5290.32
136_S150_L0.5280.32
188_Y253_T0.5270.32
175_G324_L0.5250.32
102_A228_V0.5240.32
143_E192_M0.5220.32
136_S190_V0.5210.31
169_V245_R0.5200.31
248_M271_L0.5180.31
250_L309_R0.5180.31
274_Y317_N0.5170.31
86_V267_D0.5160.31
181_M202_T0.5140.31
180_D276_I0.5120.31
183_A199_V0.5120.31
277_Q320_L0.5110.31
96_A100_A0.5080.30
209_I212_L0.5080.30
259_E263_A0.5030.30
125_R128_E0.5030.30
127_R191_P0.5010.30
315_E321_D0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yx1A 2 0.9174 100 0.475 Contact Map
3k6rA 1 0.7859 100 0.584 Contact Map
3a27A 1 0.6606 100 0.6 Contact Map
2b78A 1 0.9388 99.9 0.736 Contact Map
3vseA 1 0.9725 99.9 0.741 Contact Map
3v97A 1 0.8991 99.9 0.75 Contact Map
2as0A 2 0.9602 99.9 0.751 Contact Map
4dmgA 2 0.9572 99.9 0.757 Contact Map
1wxxA 2 0.948 99.9 0.758 Contact Map
3c0kA 2 0.9052 99.9 0.764 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0098 seconds.