Q9HQK5 - HALSA - GREMLIN Contacts

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Q9HQK5 - Uncharacterized protein

UniProt:	Q9HQK5	Sequences: MAVPCVRVPVDDGEATRQRLADADLIDDTHAIAAADGALHIPVTDAAAVPDALSVVSFDAPPRRTQTTPADILGFDPSYARLGDIVIVDEDDSDRAHAIADAVVESDIPVEAVLNRASKIKGEQRVREWDVIAGDSTETVHREYGHAFALDVAAVYFSPRLATERHRVVEQVTAGEHVFDMFAGVGPYAVPMASAGARVVATDVNETAIDYLQANAARNGVADRVTGVAGDVREVAGEYTGWADRIVMNLPHTADEFLETAVALAGDECTLHFYDIQHEDGRFDAGEAAIRAAARPAYDVTVATRHTVRSYAPHEFNVVLDVSLSRR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	327 (265)
Sequences:	1071 (744)
Seq/√Len:	45.7

HALSA - Q9HQK5 Q9HMM2
SULSO - Q97W08 Q97WJ4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
149_A	214_A	3.806	1.00
207_T	210_D	3.681	1.00
96_A	130_D	3.199	1.00
86_V	110_V	3.095	1.00
233_R	259_E	2.944	1.00
179_F	243_A	2.822	1.00
245_R	272_H	2.534	1.00
137_T	153_A	2.517	1.00
131_V	137_T	2.499	1.00
182_F	257_F	2.478	1.00
139_T	150_L	2.454	1.00
181_M	232_V	2.417	1.00
154_A	207_T	2.384	1.00
180_D	249_N	2.374	1.00
209_I	213_Q	2.336	1.00
216_A	227_G	2.322	1.00
80_A	159_P	2.317	1.00
216_A	225_V	2.199	1.00
198_R	226_T	2.189	1.00
189_A	201_A	2.169	1.00
309_R	317_N	2.152	1.00
115_N	130_D	2.135	1.00
287_E	291_R	2.048	0.99
150_L	211_Y	2.036	0.99
265_A	269_C	2.010	0.99
209_I	227_G	2.002	0.99
166_H	170_E	1.979	0.99
161_L	249_N	1.899	0.99
176_E	245_R	1.892	0.99
292_A	295_R	1.886	0.99
192_M	247_V	1.867	0.99
111_E	135_D	1.834	0.99
272_H	321_D	1.830	0.99
140_V	147_A	1.801	0.99
138_E	211_Y	1.801	0.99
140_V	149_A	1.791	0.99
156_Y	161_L	1.767	0.98
147_A	218_R	1.729	0.98
149_A	218_R	1.715	0.98
289_A	294_A	1.714	0.98
285_A	289_A	1.703	0.98
210_D	214_A	1.683	0.98
142_R	147_A	1.663	0.98
100_A	132_I	1.659	0.98
148_F	191_P	1.651	0.97
307_T	316_F	1.637	0.97
288_A	292_A	1.627	0.97
156_Y	160_R	1.596	0.97
164_E	167_R	1.591	0.97
156_Y	249_N	1.583	0.97
186_G	212_L	1.559	0.96
301_T	323_S	1.555	0.96
167_R	319_V	1.549	0.96
114_L	129_W	1.544	0.96
160_R	187_P	1.542	0.96
214_A	217_A	1.537	0.96
193_A	248_M	1.530	0.96
69_P	73_L	1.519	0.96
146_H	194_S	1.514	0.96
85_I	139_T	1.489	0.95
124_Q	204_V	1.482	0.95
69_P	72_I	1.474	0.95
200_V	228_V	1.454	0.95
245_R	321_D	1.446	0.95
281_G	284_D	1.435	0.94
123_E	204_V	1.428	0.94
176_E	244_D	1.421	0.94
310_S	316_F	1.418	0.94
86_V	107_D	1.411	0.94
45_D	48_A	1.407	0.94
146_H	190_V	1.401	0.94
151_D	154_A	1.391	0.93
180_D	317_N	1.377	0.93
89_D	116_R	1.375	0.93
161_L	309_R	1.374	0.93
270_T	323_S	1.364	0.93
86_V	103_V	1.364	0.93
180_D	309_R	1.361	0.93
217_A	222_A	1.355	0.92
249_N	317_N	1.350	0.92
156_Y	187_P	1.338	0.92
171_Q	304_T	1.331	0.92
187_P	249_N	1.328	0.92
80_A	160_R	1.314	0.91
150_L	155_V	1.313	0.91
228_V	235_V	1.303	0.91
172_V	178_V	1.296	0.91
207_T	211_Y	1.294	0.90
172_V	192_M	1.292	0.90
100_A	133_A	1.284	0.90
180_D	212_L	1.271	0.90
104_V	133_A	1.253	0.89
160_R	249_N	1.237	0.88
161_L	187_P	1.225	0.88
161_L	251_P	1.221	0.88
161_L	317_N	1.215	0.87
203_D	249_N	1.205	0.87
193_A	225_V	1.202	0.87
230_G	235_V	1.193	0.86
160_R	251_P	1.185	0.86
161_L	203_D	1.184	0.86
274_Y	306_H	1.182	0.86
290_I	294_A	1.182	0.86
122_G	126_V	1.178	0.86
183_A	203_D	1.168	0.85
180_D	203_D	1.168	0.85
183_A	212_L	1.166	0.85
107_D	110_V	1.166	0.85
172_V	247_V	1.159	0.85
203_D	209_I	1.154	0.85
156_Y	251_P	1.150	0.84
291_R	294_A	1.150	0.84
208_A	274_Y	1.150	0.84
177_H	243_A	1.141	0.84
141_H	157_F	1.140	0.84
232_V	235_V	1.120	0.83
270_T	321_D	1.116	0.83
90_E	99_I	1.113	0.82
190_V	221_V	1.106	0.82
112_A	136_S	1.105	0.82
249_N	309_R	1.103	0.82
81_R	108_I	1.103	0.82
286_G	289_A	1.095	0.81
168_V	247_V	1.088	0.81
178_V	247_V	1.068	0.80
137_T	151_D	1.055	0.79
201_A	212_L	1.048	0.78
248_M	257_F	1.046	0.78
111_E	136_S	1.043	0.78
156_Y	317_N	1.043	0.78
214_A	218_R	1.041	0.78
122_G	128_E	1.036	0.78
121_K	128_E	1.028	0.77
178_V	197_A	1.021	0.77
148_F	190_V	1.020	0.76
122_G	143_E	1.018	0.76
116_R	119_K	1.018	0.76
182_F	273_F	1.008	0.76
112_A	134_G	1.000	0.75
311_Y	315_E	0.997	0.75
179_F	246_I	0.994	0.75
43_V	47_A	0.989	0.74
160_R	274_Y	0.987	0.74
209_I	229_A	0.983	0.74
187_P	317_N	0.967	0.72
114_L	131_V	0.965	0.72
213_Q	217_A	0.962	0.72
181_M	261_A	0.959	0.72
158_S	165_R	0.958	0.72
305_R	320_L	0.947	0.71
111_E	116_R	0.946	0.71
187_P	251_P	0.943	0.71
168_V	172_V	0.942	0.70
246_I	265_A	0.940	0.70
180_D	186_G	0.937	0.70
255_D	275_D	0.935	0.70
179_F	202_T	0.934	0.70
115_N	132_I	0.933	0.70
276_I	315_E	0.926	0.69
206_E	229_A	0.926	0.69
103_V	110_V	0.922	0.69
100_A	113_V	0.918	0.68
248_M	254_A	0.913	0.68
270_T	303_A	0.912	0.68
165_R	188_Y	0.906	0.67
165_R	208_A	0.906	0.67
276_I	311_Y	0.902	0.67
178_V	199_V	0.891	0.66
156_Y	274_Y	0.886	0.66
161_L	274_Y	0.880	0.65
156_Y	309_R	0.880	0.65
138_E	151_D	0.878	0.65
144_Y	166_H	0.874	0.65
132_I	220_G	0.869	0.64
181_M	271_L	0.864	0.64
104_V	110_V	0.859	0.63
272_H	319_V	0.855	0.63
203_D	315_E	0.855	0.63
167_R	272_H	0.851	0.63
160_R	309_R	0.848	0.62
249_N	276_I	0.844	0.62
162_A	166_H	0.841	0.62
250_L	254_A	0.841	0.62
43_V	46_A	0.840	0.62
181_M	248_M	0.837	0.61
165_R	252_H	0.837	0.61
188_Y	208_A	0.835	0.61
249_N	274_Y	0.833	0.61
252_H	276_I	0.829	0.61
81_R	110_V	0.826	0.60
114_L	152_V	0.826	0.60
82_L	85_I	0.825	0.60
161_L	180_D	0.815	0.59
317_N	321_D	0.814	0.59
168_V	192_M	0.812	0.59
311_Y	317_N	0.810	0.59
96_A	99_I	0.801	0.58
251_P	274_Y	0.799	0.58
82_L	274_Y	0.796	0.57
44_T	48_A	0.788	0.57
281_G	312_A	0.788	0.57
150_L	208_A	0.785	0.56
213_Q	227_G	0.784	0.56
79_Y	103_V	0.777	0.56
306_H	321_D	0.775	0.55
291_R	295_R	0.775	0.55
181_M	185_V	0.774	0.55
161_L	276_I	0.773	0.55
209_I	216_A	0.770	0.55
190_V	215_N	0.769	0.55
178_V	216_A	0.769	0.55
246_I	261_A	0.767	0.55
287_E	290_I	0.766	0.54
178_V	192_M	0.766	0.54
92_D	247_V	0.765	0.54
187_P	309_R	0.765	0.54
203_D	232_V	0.765	0.54
102_A	105_E	0.762	0.54
101_D	105_E	0.758	0.54
138_E	149_A	0.758	0.54
114_L	203_D	0.756	0.54
244_D	266_G	0.746	0.53
96_A	104_V	0.746	0.53
174_A	222_A	0.745	0.52
217_A	264_L	0.742	0.52
120_I	126_V	0.739	0.52
163_T	308_V	0.738	0.52
188_Y	258_L	0.737	0.52
211_Y	214_A	0.737	0.52
159_P	192_M	0.736	0.52
173_T	223_D	0.735	0.51
259_E	271_L	0.733	0.51
175_G	197_A	0.733	0.51
75_F	79_Y	0.732	0.51
103_V	107_D	0.728	0.51
68_T	73_L	0.727	0.51
87_I	152_V	0.723	0.50
286_G	295_R	0.721	0.50
82_L	159_P	0.720	0.50
248_M	273_F	0.720	0.50
116_R	276_I	0.717	0.50
160_R	250_L	0.714	0.49
276_I	312_A	0.713	0.49
246_I	318_V	0.712	0.49
152_V	204_V	0.703	0.48
122_G	127_R	0.701	0.48
308_V	317_N	0.700	0.48
155_V	211_Y	0.699	0.48
189_A	217_A	0.696	0.48
202_T	230_G	0.694	0.47
148_F	156_Y	0.690	0.47
312_A	315_E	0.690	0.47
187_P	276_I	0.690	0.47
203_D	309_R	0.688	0.47
83_G	100_A	0.687	0.47
179_F	200_V	0.685	0.47
102_A	106_S	0.684	0.46
148_F	204_V	0.683	0.46
114_L	137_T	0.683	0.46
187_P	274_Y	0.682	0.46
70_A	73_L	0.681	0.46
88_V	132_I	0.681	0.46
277_Q	281_G	0.680	0.46
125_R	133_A	0.679	0.46
124_Q	206_E	0.677	0.46
165_R	187_P	0.675	0.46
297_A	300_V	0.675	0.46
224_R	246_I	0.674	0.46
117_A	130_D	0.672	0.45
176_E	321_D	0.672	0.45
160_R	317_N	0.670	0.45
112_A	116_R	0.668	0.45
143_E	162_A	0.668	0.45
132_I	233_R	0.667	0.45
249_N	252_H	0.665	0.45
99_I	130_D	0.665	0.45
193_A	221_V	0.664	0.45
233_R	256_E	0.663	0.44
121_K	292_A	0.661	0.44
156_Y	180_D	0.656	0.44
163_T	278_H	0.655	0.44
175_G	244_D	0.654	0.44
114_L	215_N	0.652	0.43
156_Y	203_D	0.652	0.43
160_R	319_V	0.647	0.43
180_D	250_L	0.647	0.43
44_T	47_A	0.645	0.43
140_V	220_G	0.642	0.42
122_G	125_R	0.639	0.42
276_I	317_N	0.638	0.42
143_E	151_D	0.633	0.42
80_A	200_V	0.632	0.41
127_R	309_R	0.632	0.41
109_P	168_V	0.628	0.41
180_D	308_V	0.626	0.41
228_V	232_V	0.626	0.41
82_L	150_L	0.624	0.41
222_A	301_T	0.623	0.41
191_P	212_L	0.623	0.41
161_L	165_R	0.622	0.41
317_N	322_V	0.622	0.41
151_D	195_A	0.619	0.40
169_V	195_A	0.616	0.40
134_G	151_D	0.615	0.40
274_Y	309_R	0.614	0.40
283_F	290_I	0.614	0.40
43_V	288_A	0.613	0.40
111_E	142_R	0.613	0.40
112_A	131_V	0.608	0.39
143_E	165_R	0.606	0.39
252_H	309_R	0.606	0.39
141_H	162_A	0.606	0.39
109_P	267_D	0.606	0.39
78_S	320_L	0.606	0.39
112_A	137_T	0.605	0.39
78_S	156_Y	0.603	0.39
155_V	208_A	0.602	0.39
80_A	127_R	0.602	0.39
150_L	191_P	0.601	0.39
67_T	75_F	0.599	0.38
310_S	317_N	0.598	0.38
220_G	223_D	0.597	0.38
68_T	95_R	0.595	0.38
80_A	211_Y	0.591	0.38
251_P	276_I	0.590	0.38
123_E	126_V	0.589	0.37
203_D	250_L	0.588	0.37
99_I	116_R	0.586	0.37
68_T	90_E	0.586	0.37
177_H	200_V	0.585	0.37
81_R	144_Y	0.583	0.37
177_H	197_A	0.583	0.37
82_L	143_E	0.582	0.37
151_D	183_A	0.581	0.37
156_Y	162_A	0.580	0.37
180_D	252_H	0.579	0.37
79_Y	86_V	0.579	0.37
166_H	185_V	0.577	0.36
142_R	240_T	0.575	0.36
248_M	258_L	0.571	0.36
113_V	133_A	0.570	0.36
179_F	321_D	0.570	0.36
271_L	322_V	0.569	0.36
252_H	311_Y	0.568	0.36
193_A	250_L	0.567	0.35
191_P	221_V	0.564	0.35
114_L	120_I	0.564	0.35
127_R	187_P	0.564	0.35
81_R	97_H	0.563	0.35
183_A	201_A	0.561	0.35
277_Q	285_A	0.559	0.35
256_E	322_V	0.557	0.35
208_A	252_H	0.556	0.34
251_P	254_A	0.555	0.34
190_V	227_G	0.554	0.34
167_R	306_H	0.551	0.34
188_Y	191_P	0.551	0.34
120_I	161_L	0.550	0.34
76_D	79_Y	0.548	0.34
267_D	298_Y	0.548	0.34
233_R	260_T	0.546	0.34
152_V	202_T	0.545	0.33
141_H	151_D	0.545	0.33
118_S	128_E	0.544	0.33
282_R	285_A	0.544	0.33
83_G	203_D	0.543	0.33
132_I	241_G	0.542	0.33
87_I	157_F	0.541	0.33
230_G	234_E	0.540	0.33
126_V	161_L	0.537	0.33
67_T	94_D	0.536	0.33
305_R	318_V	0.534	0.33
68_T	71_D	0.534	0.33
179_F	242_W	0.531	0.32
287_E	292_A	0.530	0.32
233_R	257_F	0.530	0.32
126_V	274_Y	0.529	0.32
136_S	150_L	0.528	0.32
188_Y	253_T	0.527	0.32
175_G	324_L	0.525	0.32
102_A	228_V	0.524	0.32
143_E	192_M	0.522	0.32
136_S	190_V	0.521	0.31
169_V	245_R	0.520	0.31
248_M	271_L	0.518	0.31
250_L	309_R	0.518	0.31
274_Y	317_N	0.517	0.31
86_V	267_D	0.516	0.31
181_M	202_T	0.514	0.31
180_D	276_I	0.512	0.31
183_A	199_V	0.512	0.31
277_Q	320_L	0.511	0.31
96_A	100_A	0.508	0.30
209_I	212_L	0.508	0.30
259_E	263_A	0.503	0.30
125_R	128_E	0.503	0.30
127_R	191_P	0.501	0.30
315_E	321_D	0.500	0.30

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2yx1A	2	0.9174	100	0.475	Contact Map
3k6rA	1	0.7859	100	0.584	Contact Map
3a27A	1	0.6606	100	0.6	Contact Map
2b78A	1	0.9388	99.9	0.736	Contact Map
3vseA	1	0.9725	99.9	0.741	Contact Map
3v97A	1	0.8991	99.9	0.75	Contact Map
2as0A	2	0.9602	99.9	0.751	Contact Map
4dmgA	2	0.9572	99.9	0.757	Contact Map
1wxxA	2	0.948	99.9	0.758	Contact Map
3c0kA	2	0.9052	99.9	0.764	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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