Q9HQK3 - HALSA - GREMLIN Contacts

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Q9HQK3 - Uncharacterized protein

UniProt:	Q9HQK3	Sequences: MQTFKRDLRVDAPLESVWAFHSTVDGLLALTPEWANLTVEDVVWPQGQRDGDELVAGTRINMAVEPFGVGPRQTWTSVITERATEDDHAYFVDTMENGPFPEWEHTHSFYADGDQTVLRDRVAYEPPLGGLGAVGAPPVLWGMFRFRHRQTRATFGEA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	158 (141)
Sequences:	882 (708)
Seq/√Len:	59.6

HALSA - Q9HQK3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
13_P	16_S	3.149	1.00
80_T	94_T	2.817	1.00
21_H	109_F	2.753	1.00
12_A	17_V	2.694	1.00
63_A	72_R	2.630	1.00
83_A	89_A	2.596	1.00
7_D	117_V	2.496	1.00
95_M	98_G	2.338	1.00
7_D	119_R	2.310	1.00
78_V	96_E	2.291	1.00
14_L	111_A	2.211	1.00
10_V	17_V	2.151	1.00
122_V	144_F	2.120	1.00
11_D	115_Q	1.961	1.00
108_S	121_R	1.893	1.00
15_E	19_A	1.866	1.00
126_P	136_A	1.862	1.00
9_R	115_Q	1.854	1.00
129_G	132_G	1.842	1.00
5_K	121_R	1.826	1.00
110_Y	119_R	1.759	0.99
94_T	104_E	1.749	0.99
106_T	123_A	1.719	0.99
9_R	112_D	1.668	0.99
33_E	146_F	1.665	0.99
20_F	26_G	1.663	0.99
124_Y	136_A	1.628	0.99
150_Q	153_A	1.603	0.99
14_L	88_H	1.543	0.98
118_L	151_T	1.499	0.98
150_Q	154_T	1.486	0.98
5_K	119_R	1.472	0.98
17_V	116_T	1.469	0.98
92_V	106_T	1.460	0.98
149_R	153_A	1.455	0.98
110_Y	117_V	1.454	0.98
9_R	117_V	1.450	0.98
13_P	17_V	1.439	0.97
10_V	118_L	1.399	0.97
112_D	117_V	1.387	0.97
18_W	82_R	1.383	0.97
25_D	29_A	1.362	0.96
112_D	115_Q	1.333	0.96
131_L	135_G	1.332	0.96
11_D	152_R	1.326	0.96
83_A	90_Y	1.326	0.96
6_R	145_R	1.316	0.96
65_E	72_R	1.307	0.95
21_H	148_H	1.299	0.95
8_L	148_H	1.279	0.95
63_A	74_T	1.268	0.95
29_A	154_T	1.262	0.95
20_F	154_T	1.257	0.94
18_W	88_H	1.244	0.94
90_Y	108_S	1.230	0.94
24_V	54_L	1.217	0.93
141_W	145_R	1.194	0.93
19_A	22_S	1.183	0.92
3_T	123_A	1.180	0.92
75_W	99_P	1.180	0.92
101_P	125_E	1.176	0.92
81_E	92_V	1.172	0.92
59_R	78_V	1.169	0.92
31_T	143_M	1.154	0.91
146_F	150_Q	1.148	0.91
93_D	107_H	1.148	0.91
61_N	76_T	1.135	0.91
24_V	58_T	1.125	0.90
64_V	73_Q	1.121	0.90
15_E	111_A	1.120	0.90
19_A	53_E	1.111	0.90
22_S	82_R	1.110	0.90
75_W	122_V	1.099	0.89
102_E	123_A	1.086	0.89
130_G	134_V	1.001	0.84
148_H	152_R	0.995	0.84
75_W	103_W	0.990	0.84
12_A	155_F	0.985	0.83
64_V	75_W	0.982	0.83
107_H	120_D	0.978	0.83
54_L	58_T	0.965	0.82
95_M	99_P	0.960	0.82
102_E	125_E	0.955	0.81
21_H	151_T	0.954	0.81
12_A	116_T	0.933	0.80
10_V	152_R	0.926	0.79
103_W	124_Y	0.924	0.79
32_P	144_F	0.917	0.79
26_G	29_A	0.916	0.79
56_A	81_E	0.913	0.78
145_R	149_R	0.908	0.78
90_Y	106_T	0.898	0.77
68_G	71_P	0.897	0.77
64_V	67_F	0.880	0.76
95_M	100_F	0.878	0.76
108_S	119_R	0.860	0.74
22_S	53_E	0.856	0.74
27_L	31_T	0.851	0.73
73_Q	99_P	0.839	0.72
10_V	151_T	0.832	0.72
91_F	107_H	0.821	0.71
21_H	62_M	0.819	0.70
15_E	87_D	0.818	0.70
30_L	79_I	0.810	0.70
11_D	74_T	0.800	0.69
20_F	25_D	0.798	0.68
20_F	29_A	0.787	0.67
130_G	137_P	0.785	0.67
60_I	100_F	0.781	0.67
81_E	96_E	0.773	0.66
8_L	152_R	0.771	0.66
104_E	123_A	0.768	0.65
128_L	132_G	0.766	0.65
55_V	87_D	0.749	0.63
99_P	103_W	0.743	0.63
25_D	154_T	0.738	0.62
23_T	30_L	0.731	0.62
40_E	61_N	0.727	0.61
132_G	135_G	0.726	0.61
14_L	89_A	0.725	0.61
112_D	145_R	0.725	0.61
18_W	22_S	0.722	0.61
20_F	144_F	0.709	0.59
106_T	121_R	0.702	0.58
32_P	146_F	0.693	0.57
15_E	88_H	0.690	0.57
132_G	136_A	0.688	0.57
19_A	87_D	0.684	0.56
111_A	114_D	0.683	0.56
83_A	88_H	0.682	0.56
81_E	90_Y	0.677	0.56
6_R	148_H	0.675	0.55
57_G	151_T	0.669	0.55
91_F	105_H	0.669	0.55
133_A	137_P	0.668	0.55
133_A	136_A	0.662	0.54
37_L	62_M	0.662	0.54
4_F	122_V	0.662	0.54
3_T	121_R	0.658	0.54
4_F	144_F	0.657	0.54
63_A	133_A	0.653	0.53
26_G	77_S	0.651	0.53
16_S	101_P	0.650	0.53
20_F	27_L	0.639	0.51
131_L	141_W	0.637	0.51
23_T	154_T	0.636	0.51
83_A	149_R	0.635	0.51
11_D	117_V	0.627	0.50
31_T	144_F	0.624	0.50
91_F	98_G	0.623	0.50
99_P	122_V	0.623	0.50
26_G	79_I	0.614	0.49
126_P	140_L	0.612	0.48
35_A	143_M	0.601	0.47
14_L	39_V	0.601	0.47
13_P	116_T	0.600	0.47
128_L	139_V	0.600	0.47
52_D	122_V	0.600	0.47
25_D	79_I	0.599	0.47
35_A	100_F	0.599	0.47
111_A	115_Q	0.594	0.46
73_Q	95_M	0.590	0.46
122_V	140_L	0.585	0.45
145_R	148_H	0.583	0.45
27_L	60_I	0.583	0.45
75_W	140_L	0.582	0.45
41_D	61_N	0.578	0.45
8_L	143_M	0.574	0.44
19_A	139_V	0.574	0.44
32_P	103_W	0.572	0.44
62_M	77_S	0.572	0.44
148_H	151_T	0.571	0.44
6_R	141_W	0.569	0.44
37_L	143_M	0.564	0.43
76_T	97_N	0.564	0.43
78_V	124_Y	0.563	0.43
26_G	30_L	0.563	0.43
75_W	143_M	0.563	0.43
6_R	144_F	0.562	0.43
39_V	95_M	0.562	0.43
62_M	100_F	0.561	0.43
54_L	77_S	0.559	0.43
18_W	66_P	0.559	0.43
20_F	23_T	0.557	0.42
82_R	87_D	0.557	0.42
27_L	39_V	0.556	0.42
43_V	51_G	0.554	0.42
145_R	152_R	0.553	0.42
128_L	152_R	0.553	0.42
29_A	150_Q	0.552	0.42
103_W	122_V	0.549	0.42
92_V	104_E	0.544	0.41
79_I	154_T	0.543	0.41
18_W	87_D	0.540	0.41
74_T	125_E	0.538	0.40
43_V	52_D	0.538	0.40
96_E	102_E	0.536	0.40
20_F	79_I	0.531	0.40
75_W	144_F	0.525	0.39
90_Y	125_E	0.523	0.39
132_G	137_P	0.522	0.39
9_R	13_P	0.521	0.38
18_W	27_L	0.519	0.38
67_F	72_R	0.515	0.38
51_G	58_T	0.515	0.38
124_Y	129_G	0.512	0.38
4_F	58_T	0.511	0.37
15_E	153_A	0.509	0.37
121_R	126_P	0.508	0.37
22_S	60_I	0.504	0.37
113_G	133_A	0.501	0.36
60_I	64_V	0.500	0.36

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3oh8A	1	0.8228	100	0.358	Contact Map
2d4rA	4	0.8924	99.5	0.683	Contact Map
1t17A	1	0.9177	99.5	0.694	Contact Map
3ggnA	2	0.8101	99.4	0.709	Contact Map
3tfzA	2	0.8987	99.4	0.712	Contact Map
3tl1A	1	0.8987	99.3	0.728	Contact Map
3p9vA	2	0.8861	99.1	0.743	Contact Map
3ijtA	2	0.8671	99.1	0.746	Contact Map
2le1A	1	0.8797	99	0.758	Contact Map
3tvqA	1	0.8924	99	0.759	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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