GREMLIN Database
Q9HQK3 - Uncharacterized protein
UniProt: Q9HQK3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 158 (141)
Sequences: 882 (708)
Seq/√Len: 59.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_P16_S3.1491.00
80_T94_T2.8171.00
21_H109_F2.7531.00
12_A17_V2.6941.00
63_A72_R2.6301.00
83_A89_A2.5961.00
7_D117_V2.4961.00
95_M98_G2.3381.00
7_D119_R2.3101.00
78_V96_E2.2911.00
14_L111_A2.2111.00
10_V17_V2.1511.00
122_V144_F2.1201.00
11_D115_Q1.9611.00
108_S121_R1.8931.00
15_E19_A1.8661.00
126_P136_A1.8621.00
9_R115_Q1.8541.00
129_G132_G1.8421.00
5_K121_R1.8261.00
110_Y119_R1.7590.99
94_T104_E1.7490.99
106_T123_A1.7190.99
9_R112_D1.6680.99
33_E146_F1.6650.99
20_F26_G1.6630.99
124_Y136_A1.6280.99
150_Q153_A1.6030.99
14_L88_H1.5430.98
118_L151_T1.4990.98
150_Q154_T1.4860.98
5_K119_R1.4720.98
17_V116_T1.4690.98
92_V106_T1.4600.98
149_R153_A1.4550.98
110_Y117_V1.4540.98
9_R117_V1.4500.98
13_P17_V1.4390.97
10_V118_L1.3990.97
112_D117_V1.3870.97
18_W82_R1.3830.97
25_D29_A1.3620.96
112_D115_Q1.3330.96
131_L135_G1.3320.96
11_D152_R1.3260.96
83_A90_Y1.3260.96
6_R145_R1.3160.96
65_E72_R1.3070.95
21_H148_H1.2990.95
8_L148_H1.2790.95
63_A74_T1.2680.95
29_A154_T1.2620.95
20_F154_T1.2570.94
18_W88_H1.2440.94
90_Y108_S1.2300.94
24_V54_L1.2170.93
141_W145_R1.1940.93
19_A22_S1.1830.92
3_T123_A1.1800.92
75_W99_P1.1800.92
101_P125_E1.1760.92
81_E92_V1.1720.92
59_R78_V1.1690.92
31_T143_M1.1540.91
146_F150_Q1.1480.91
93_D107_H1.1480.91
61_N76_T1.1350.91
24_V58_T1.1250.90
64_V73_Q1.1210.90
15_E111_A1.1200.90
19_A53_E1.1110.90
22_S82_R1.1100.90
75_W122_V1.0990.89
102_E123_A1.0860.89
130_G134_V1.0010.84
148_H152_R0.9950.84
75_W103_W0.9900.84
12_A155_F0.9850.83
64_V75_W0.9820.83
107_H120_D0.9780.83
54_L58_T0.9650.82
95_M99_P0.9600.82
102_E125_E0.9550.81
21_H151_T0.9540.81
12_A116_T0.9330.80
10_V152_R0.9260.79
103_W124_Y0.9240.79
32_P144_F0.9170.79
26_G29_A0.9160.79
56_A81_E0.9130.78
145_R149_R0.9080.78
90_Y106_T0.8980.77
68_G71_P0.8970.77
64_V67_F0.8800.76
95_M100_F0.8780.76
108_S119_R0.8600.74
22_S53_E0.8560.74
27_L31_T0.8510.73
73_Q99_P0.8390.72
10_V151_T0.8320.72
91_F107_H0.8210.71
21_H62_M0.8190.70
15_E87_D0.8180.70
30_L79_I0.8100.70
11_D74_T0.8000.69
20_F25_D0.7980.68
20_F29_A0.7870.67
130_G137_P0.7850.67
60_I100_F0.7810.67
81_E96_E0.7730.66
8_L152_R0.7710.66
104_E123_A0.7680.65
128_L132_G0.7660.65
55_V87_D0.7490.63
99_P103_W0.7430.63
25_D154_T0.7380.62
23_T30_L0.7310.62
40_E61_N0.7270.61
132_G135_G0.7260.61
14_L89_A0.7250.61
112_D145_R0.7250.61
18_W22_S0.7220.61
20_F144_F0.7090.59
106_T121_R0.7020.58
32_P146_F0.6930.57
15_E88_H0.6900.57
132_G136_A0.6880.57
19_A87_D0.6840.56
111_A114_D0.6830.56
83_A88_H0.6820.56
81_E90_Y0.6770.56
6_R148_H0.6750.55
57_G151_T0.6690.55
91_F105_H0.6690.55
133_A137_P0.6680.55
133_A136_A0.6620.54
37_L62_M0.6620.54
4_F122_V0.6620.54
3_T121_R0.6580.54
4_F144_F0.6570.54
63_A133_A0.6530.53
26_G77_S0.6510.53
16_S101_P0.6500.53
20_F27_L0.6390.51
131_L141_W0.6370.51
23_T154_T0.6360.51
83_A149_R0.6350.51
11_D117_V0.6270.50
31_T144_F0.6240.50
91_F98_G0.6230.50
99_P122_V0.6230.50
26_G79_I0.6140.49
126_P140_L0.6120.48
35_A143_M0.6010.47
14_L39_V0.6010.47
13_P116_T0.6000.47
128_L139_V0.6000.47
52_D122_V0.6000.47
25_D79_I0.5990.47
35_A100_F0.5990.47
111_A115_Q0.5940.46
73_Q95_M0.5900.46
122_V140_L0.5850.45
145_R148_H0.5830.45
27_L60_I0.5830.45
75_W140_L0.5820.45
41_D61_N0.5780.45
8_L143_M0.5740.44
19_A139_V0.5740.44
32_P103_W0.5720.44
62_M77_S0.5720.44
148_H151_T0.5710.44
6_R141_W0.5690.44
37_L143_M0.5640.43
76_T97_N0.5640.43
78_V124_Y0.5630.43
26_G30_L0.5630.43
75_W143_M0.5630.43
6_R144_F0.5620.43
39_V95_M0.5620.43
62_M100_F0.5610.43
54_L77_S0.5590.43
18_W66_P0.5590.43
20_F23_T0.5570.42
82_R87_D0.5570.42
27_L39_V0.5560.42
43_V51_G0.5540.42
145_R152_R0.5530.42
128_L152_R0.5530.42
29_A150_Q0.5520.42
103_W122_V0.5490.42
92_V104_E0.5440.41
79_I154_T0.5430.41
18_W87_D0.5400.41
74_T125_E0.5380.40
43_V52_D0.5380.40
96_E102_E0.5360.40
20_F79_I0.5310.40
75_W144_F0.5250.39
90_Y125_E0.5230.39
132_G137_P0.5220.39
9_R13_P0.5210.38
18_W27_L0.5190.38
67_F72_R0.5150.38
51_G58_T0.5150.38
124_Y129_G0.5120.38
4_F58_T0.5110.37
15_E153_A0.5090.37
121_R126_P0.5080.37
22_S60_I0.5040.37
113_G133_A0.5010.36
60_I64_V0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3oh8A 1 0.8228 100 0.358 Contact Map
2d4rA 4 0.8924 99.5 0.683 Contact Map
1t17A 1 0.9177 99.5 0.694 Contact Map
3ggnA 2 0.8101 99.4 0.709 Contact Map
3tfzA 2 0.8987 99.4 0.712 Contact Map
3tl1A 1 0.8987 99.3 0.728 Contact Map
3p9vA 2 0.8861 99.1 0.743 Contact Map
3ijtA 2 0.8671 99.1 0.746 Contact Map
2le1A 1 0.8797 99 0.758 Contact Map
3tvqA 1 0.8924 99 0.759 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0065 seconds.