GREMLIN Database
Q9HQK2 - Aspartate aminotransferase
UniProt: Q9HQK2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 391 (347)
Sequences: 43438 (29809)
Seq/√Len: 1600.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_V61_R3.0961.00
120_A141_V2.9691.00
344_A382_A2.9071.00
100_T106_A2.8921.00
161_D198_R2.7671.00
301_I374_R2.7521.00
296_R300_D2.7461.00
79_A282_R2.7071.00
186_G190_S2.7011.00
297_T370_T2.5351.00
115_V140_G2.5321.00
119_S169_A2.5241.00
375_E379_R2.4711.00
85_A91_S2.4601.00
50_A54_E2.3501.00
75_S278_E2.3441.00
250_C255_V2.2951.00
185_D188_S2.1011.00
108_L112_L2.0981.00
305_A377_V2.0321.00
190_S194_A1.9961.00
245_L277_A1.9881.00
120_A143_R1.9701.00
305_A308_R1.9351.00
375_E378_A1.9141.00
332_A335_A1.8971.00
78_D94_A1.8851.00
303_C307_E1.8811.00
54_E58_D1.8801.00
82_G282_R1.8361.00
135_V140_G1.8121.00
158_S191_A1.8001.00
159_D163_A1.7951.00
154_Q188_S1.7881.00
304_A308_R1.7861.00
161_D191_A1.7701.00
78_D82_G1.7651.00
125_D144_T1.7601.00
204_V231_I1.7321.00
338_D342_E1.7171.00
74_R78_D1.7101.00
81_S94_A1.7081.00
156_A159_D1.7041.00
301_I305_A1.6991.00
300_D304_A1.6871.00
305_A381_D1.6711.00
148_A188_S1.6621.00
196_A203_V1.6601.00
305_A378_A1.6551.00
313_P326_D1.6491.00
305_A309_W1.6491.00
110_V229_F1.6411.00
39_M376_A1.6401.00
369_S372_A1.6351.00
79_A82_G1.6291.00
58_D279_A1.6201.00
303_C316_T1.6121.00
208_I233_G1.6101.00
96_R252_R1.6051.00
159_D162_A1.5971.00
120_A167_D1.5931.00
132_P136_R1.5871.00
120_A165_G1.5551.00
339_A383_V1.5411.00
120_A168_T1.5381.00
302_L323_M1.5271.00
121_V135_V1.5231.00
170_A204_V1.5211.00
191_A194_A1.5211.00
110_V204_V1.5151.00
80_I247_W1.5091.00
53_T57_V1.5081.00
111_L135_V1.4851.00
103_S231_I1.4821.00
301_I370_T1.4791.00
248_V258_I1.4641.00
200_D227_D1.4631.00
344_A379_R1.4621.00
270_P273_V1.4591.00
79_A278_E1.4451.00
84_Y249_V1.4421.00
348_V362_V1.4411.00
289_D293_A1.4321.00
92_V249_V1.4321.00
95_E252_R1.4161.00
335_A339_A1.4151.00
333_A352_P1.4111.00
308_R381_D1.4051.00
194_A198_R1.3871.00
75_S282_R1.3861.00
303_C323_M1.3811.00
125_D146_G1.3791.00
157_V195_L1.3731.00
164_I195_L1.3701.00
187_E190_S1.3681.00
157_V191_A1.3611.00
309_W381_D1.3581.00
161_D199_T1.3551.00
122_V168_T1.3471.00
294_D297_T1.3401.00
302_L377_V1.3291.00
53_T61_R1.3271.00
234_V277_A1.3271.00
196_A201_T1.3191.00
73_R275_A1.3161.00
132_P144_T1.3081.00
195_L199_T1.3061.00
56_A276_G1.3051.00
56_A60_L1.3041.00
54_E57_V1.2971.00
294_D370_T1.2951.00
55_A279_A1.2931.00
188_S191_A1.2891.00
71_R259_N1.2801.00
324_L351_G1.2761.00
98_V255_V1.2741.00
335_A338_D1.2721.00
312_D326_D1.2711.00
378_A382_A1.2641.00
146_G159_D1.2621.00
165_G168_T1.2591.00
374_R378_A1.2451.00
326_D361_Y1.2421.00
278_E282_R1.2401.00
123_L142_V1.2391.00
194_A197_D1.2321.00
325_L364_A1.2161.00
307_E313_P1.2121.00
229_F250_C1.2091.00
257_T260_A1.2081.00
111_L172_L1.2031.00
58_D62_A1.2021.00
293_A296_R1.2001.00
326_D360_E1.2001.00
305_A374_R1.1991.00
195_L201_T1.1971.00
74_R94_A1.1971.00
289_D292_R1.1951.00
34_A345_G1.1921.00
117_P139_D1.1881.00
75_S275_A1.1751.00
71_R77_R1.1691.00
80_I99_V1.1661.00
187_E191_A1.1621.00
161_D165_G1.1611.00
112_L138_A1.1561.00
122_V145_V1.1541.00
162_A166_D1.1471.00
93_P96_R1.1461.00
256_D260_A1.1421.00
232_D247_W1.1411.00
299_R303_C1.1381.00
161_D195_L1.1381.00
332_A359_T1.1371.00
285_T289_D1.1371.00
77_R81_S1.1341.00
105_P262_A1.1341.00
111_L115_V1.1331.00
339_A342_E1.1271.00
84_Y247_W1.1261.00
334_P352_P1.1261.00
370_T374_R1.1181.00
113_A261_I1.1121.00
368_V372_A1.1111.00
293_A297_T1.1101.00
101_P105_P1.1101.00
294_D298_R1.1091.00
279_A282_R1.1011.00
115_V121_V1.0981.00
55_A58_D1.0951.00
215_D318_A1.0921.00
337_A348_V1.0901.00
106_A248_V1.0821.00
299_R366_F1.0801.00
171_M201_T1.0791.00
229_F248_V1.0761.00
328_S360_E1.0671.00
93_P252_R1.0661.00
148_A156_A1.0631.00
83_Y285_T1.0621.00
372_A375_E1.0611.00
51_A283_H1.0611.00
50_A53_T1.0591.00
197_D226_D1.0581.00
135_V142_V1.0541.00
309_W378_A1.0501.00
116_D119_S1.0481.00
310_G313_P1.0461.00
226_D251_P1.0421.00
202_A229_F1.0421.00
75_S78_D1.0321.00
262_A266_L1.0311.00
114_T170_A1.0291.00
307_E316_T1.0291.00
193_V224_Y1.0281.00
53_T60_L1.0271.00
80_I97_I1.0261.00
298_R301_I1.0171.00
145_V163_A1.0131.00
333_A360_E1.0121.00
279_A283_H1.0071.00
81_S93_P1.0031.00
81_S97_I1.0021.00
340_L348_V1.0001.00
220_S223_E0.9951.00
164_I201_T0.9891.00
76_L99_V0.9891.00
301_I304_A0.9851.00
87_E285_T0.9801.00
96_R255_V0.9801.00
190_S224_Y0.9801.00
304_A307_E0.9781.00
364_A376_A0.9691.00
193_V228_A0.9691.00
35_D345_G0.9651.00
109_T262_A0.9571.00
158_S162_A0.9521.00
58_D61_R0.9471.00
197_D225_T0.9461.00
286_D290_G0.9461.00
114_T202_A0.9421.00
121_V170_A0.9361.00
290_G294_D0.9341.00
74_R77_R0.9321.00
197_D227_D0.9301.00
339_A344_A0.9261.00
98_V258_I0.9231.00
148_A159_D0.9171.00
165_G199_T0.9151.00
127_H174_N0.9151.00
106_A231_I0.9141.00
97_I249_V0.9131.00
46_F294_D0.9131.00
113_A258_I0.9111.00
334_P338_D0.9071.00
252_R256_D0.9071.00
340_L380_I0.8981.00
158_S161_D0.8971.00
101_P270_P0.8951.00
202_A254_Y0.8931.00
290_G293_A0.8921.00
275_A278_E0.8891.00
136_R142_V0.8861.00
193_V203_V0.8821.00
304_A374_R0.8811.00
336_V362_V0.8781.00
157_V161_D0.8781.00
51_A54_E0.8751.00
122_V163_A0.8741.00
309_W377_V0.8731.00
255_V259_N0.8721.00
35_D375_E0.8651.00
229_F254_Y0.8621.00
231_I248_V0.8591.00
164_I168_T0.8551.00
110_V258_I0.8551.00
73_R278_E0.8521.00
157_V192_L0.8511.00
103_S233_G0.8511.00
302_L305_A0.8471.00
103_S208_I0.8451.00
168_T201_T0.8451.00
131_Y172_L0.8441.00
96_R225_T0.8431.00
54_E61_R0.8401.00
250_C258_I0.8361.00
224_Y227_D0.8351.00
83_Y211_G0.8331.00
39_M373_V0.8321.00
124_S155_P0.8311.00
300_D316_T0.8271.00
286_D289_D0.8261.00
157_V188_S0.8231.00
213_A216_A0.8191.00
155_P188_S0.8181.00
287_W290_G0.8181.00
245_L269_A0.8161.00
299_R317_P0.8161.00
221_V228_A0.8131.00
202_A227_D0.8091.00
186_G223_E0.8061.00
344_A383_V0.8061.00
327_V362_V0.8031.00
331_G336_V0.8011.00
115_V170_A0.7991.00
245_L273_V0.7981.00
51_A279_A0.7951.00
302_L373_V0.7941.00
83_Y87_E0.7931.00
104_S130_C0.7871.00
348_V364_A0.7861.00
105_P266_L0.7851.00
122_V160_Y0.7851.00
33_R345_G0.7821.00
55_A59_A0.7781.00
44_P295_Y0.7771.00
82_G85_A0.7761.00
124_S145_V0.7751.00
331_G335_A0.7701.00
133_N136_R0.7691.00
334_P350_P0.7691.00
346_V380_I0.7661.00
47_A53_T0.7631.00
297_T300_D0.7621.00
301_I377_V0.7591.00
56_A272_F0.7591.00
332_A336_V0.7581.00
298_R369_S0.7571.00
83_Y238_Y0.7571.00
214_F296_R0.7561.00
125_D357_N0.7561.00
287_W291_V0.7531.00
302_L366_F0.7531.00
147_L177_G0.7511.00
122_V171_M0.7511.00
73_R274_Q0.7511.00
207_E230_V0.7501.00
211_G237_R0.7471.00
100_T248_V0.7461.00
346_V379_R0.7461.00
222_L230_V0.7421.00
333_A350_P0.7411.00
105_P109_T0.7381.00
111_L170_A0.7381.00
87_E211_G0.7351.00
300_D303_C0.7351.00
154_Q185_D0.7341.00
150_D154_Q0.7311.00
83_Y88_Y0.7271.00
35_D372_A0.7261.00
297_T301_I0.7251.00
125_D355_G0.7241.00
237_R288_L0.7201.00
121_V140_G0.7191.00
313_P328_S0.7181.00
115_V119_S0.7181.00
143_R165_G0.7181.00
148_A154_Q0.7131.00
371_D374_R0.7131.00
336_V383_V0.7111.00
98_V248_V0.7091.00
160_Y171_M0.7091.00
336_V340_L0.7061.00
215_D296_R0.7051.00
337_A350_P0.7051.00
77_R94_A0.7051.00
183_V319_G0.7041.00
109_T258_I0.7031.00
177_G180_T0.7011.00
79_A281_I0.6981.00
203_V221_V0.6951.00
59_A276_G0.6941.00
379_R382_A0.6911.00
123_L135_V0.6911.00
143_R168_T0.6901.00
145_V159_D0.6871.00
209_Y322_Y0.6871.00
333_A337_A0.6851.00
143_R163_A0.6851.00
76_L80_I0.6831.00
102_G244_R0.6811.00
160_Y195_L0.6801.00
197_D224_Y0.6771.00
164_I199_T0.6761.00
288_L292_R0.6761.00
331_G339_A0.6761.00
224_Y228_A0.6731.00
51_A287_W0.6721.00
324_L361_Y0.6721.00
346_V376_A0.6721.00
81_S92_V0.6721.00
131_Y135_V0.6711.00
262_A269_A0.6701.00
234_V247_W0.6691.00
104_S128_Y0.6671.00
48_P51_A0.6671.00
108_L138_A0.6671.00
186_G218_A0.6611.00
124_S177_G0.6611.00
238_Y285_T0.6571.00
215_D299_R0.6561.00
57_V60_L0.6541.00
226_D253_R0.6511.00
173_L189_L0.6511.00
99_V245_L0.6501.00
341_L347_A0.6461.00
49_P52_A0.6451.00
291_V295_Y0.6441.00
120_A169_A0.6431.00
72_G77_R0.6431.00
351_G354_F0.6411.00
325_L361_Y0.6401.00
45_D298_R0.6391.00
146_G163_A0.6391.00
118_G141_V0.6371.00
378_A381_D0.6371.00
48_P52_A0.6361.00
271_S275_A0.6361.00
253_R256_D0.6351.00
172_L204_V0.6301.00
306_A325_L0.6301.00
301_I373_V0.6281.00
64_D275_A0.6261.00
171_M196_A0.6261.00
88_Y210_H0.6241.00
98_V259_N0.6231.00
168_T171_M0.6231.00
250_C254_Y0.6201.00
112_L261_I0.6191.00
38_H43_E0.6191.00
62_A279_A0.6181.00
111_L140_G0.6141.00
225_T228_A0.6111.00
108_L134_F0.6101.00
184_I188_S0.6091.00
37_I375_E0.6091.00
298_R370_T0.6071.00
48_P53_T0.6071.00
214_F299_R0.6041.00
92_V96_R0.6031.00
308_R374_R0.6021.00
299_R316_T0.6021.00
175_S207_E0.6011.00
184_I189_L0.5991.00
123_L132_P0.5981.00
36_V347_A0.5981.00
68_T73_R0.5971.00
123_L144_T0.5961.00
154_Q182_A0.5931.00
55_A276_G0.5901.00
84_Y230_V0.5891.00
162_A165_G0.5891.00
110_V231_I0.5871.00
312_D325_L0.5861.00
351_G361_Y0.5861.00
212_L292_R0.5861.00
98_V250_C0.5841.00
251_P254_Y0.5841.00
210_H232_D0.5831.00
333_A336_V0.5831.00
107_L134_F0.5831.00
296_R299_R0.5831.00
51_A286_D0.5821.00
146_G156_A0.5821.00
52_A280_A0.5811.00
111_L138_A0.5801.00
276_G279_A0.5781.00
33_R36_V0.5781.00
337_A362_V0.5771.00
337_A340_L0.5761.00
340_L383_V0.5741.00
259_N262_A0.5731.00
156_A188_S0.5721.00
275_A279_A0.5721.00
76_L277_A0.5721.00
149_P326_D0.5701.00
292_R296_R0.5691.00
256_D259_N0.5681.00
52_A240_M0.5631.00
302_L364_A0.5611.00
119_S167_D0.5611.00
150_D188_S0.5611.00
78_D81_S0.5611.00
212_L295_Y0.5601.00
369_S374_R0.5601.00
77_R259_N0.5591.00
155_P160_Y0.5591.00
375_E382_A0.5571.00
111_L134_F0.5561.00
175_S183_V0.5541.00
205_S230_V0.5531.00
176_P319_G0.5531.00
48_P287_W0.5521.00
234_V281_I0.5511.00
109_T261_I0.5511.00
78_D282_R0.5511.00
83_Y210_H0.5491.00
285_T288_L0.5491.00
116_D169_A0.5491.00
108_L265_T0.5491.00
101_P269_A0.5481.00
214_F366_F0.5471.00
42_G209_Y0.5471.00
40_E347_A0.5451.00
337_A341_L0.5431.00
46_F49_P0.5421.00
69_T74_R0.5421.00
203_V224_Y0.5391.00
182_A318_A0.5371.00
333_A359_T0.5371.00
213_A219_H0.5361.00
106_A246_G0.5341.00
196_A199_T0.5321.00
326_D329_R0.5311.00
165_G198_R0.5301.00
104_S267_I0.5281.00
170_A202_A0.5261.00
99_V274_Q0.5261.00
68_T268_C0.5251.00
196_A200_D0.5241.00
68_T271_S0.5211.00
115_V169_A0.5201.00
178_N209_Y0.5201.00
274_Q278_E0.5191.00
207_E220_S0.5181.00
59_A62_A0.5171.00
155_P171_M0.5151.00
85_A90_V0.5151.00
332_A352_P0.5111.00
338_D341_L0.5091.00
145_V155_P0.5071.00
38_H41_V0.5071.00
236_K244_R0.5041.00
75_S79_A0.5031.00
193_V225_T0.5021.00
171_M195_L0.5021.00
183_V213_A0.5021.00
73_R271_S0.5021.00
129_A353_D0.5001.00
191_A195_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3h14A 2 0.9309 100 0.294 Contact Map
1gd9A 2 0.9719 100 0.298 Contact Map
4my5A 2 0.977 100 0.299 Contact Map
1xi9A 4 0.977 100 0.302 Contact Map
2x5dA 3 0.9463 100 0.306 Contact Map
3piuA 2 0.9309 100 0.309 Contact Map
1yizA 2 0.9591 100 0.31 Contact Map
2o1bA 2 0.9412 100 0.31 Contact Map
3dydA 2 0.9361 100 0.311 Contact Map
1b5pA 2 0.9616 100 0.315 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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