Q9HQJ7 - HALSA - GREMLIN Contacts

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Q9HQJ7 - Mrp protein homolog

UniProt:	Q9HQJ7	Sequences: MNDDDVMELLASVTDPALGDDIVSLGLVNDLSVDDGTVTISLALGAPYSPAETEIAAHVRETLEAEGLETDLTAAIPDRSETEVLPGVKNVVAVASGKGGVGKSTVAVNLAAALSDRGARVGLFDADIYGPNVPRMVDADDHPQATETETIVPPEKHGMKLMSMAFMVGEDDPVIWRGPMVHKVLTQLIEDVEWGYLDYLVVDLPPGTGDTQLTLLQTLPLTGSVVVTTPEDVAVDDARKGLRMFGRHDTTVLGVVENMSSFVCPDCGGTHDIFGAGGGEEFATANELPFLGSIPLDPSVRAGGDNGQPVALDPDNETGASFRTFAAETADMLGLVQRRGVGE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	343 (324)
Sequences:	3430 (2043)
Seq/√Len:	113.5

ECOLI - MRP MIND BCSQ
BACSU - SALA MIND SOJ YLXH
HALSA - Q9HQJ7 Q9HHZ7 Q9HQY5 Q9HNF1 Q9HHU2 O54573 O51969 Q9HHL5 O51991
SULSO - Q97ZW4 Q97YM8 Q97VX7 Q981B3 Q97WA2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
264_C	267_C	5.355	1.00
107_A	201_V	5.208	1.00
280_E	284_T	4.899	1.00
21_D	24_S	4.406	1.00
117_R	327_A	3.758	1.00
292_G	325_F	3.703	1.00
107_A	123_L	3.694	1.00
266_D	269_G	3.652	1.00
262_F	271_H	3.354	1.00
161_L	166_F	3.322	1.00
160_K	195_G	3.141	1.00
106_V	322_F	3.114	1.00
261_S	270_T	2.998	1.00
289_P	332_M	2.929	1.00
119_A	199_Y	2.838	1.00
137_V	161_L	2.803	1.00
290_F	293_S	2.677	1.00
56_A	60_R	2.676	1.00
280_E	293_S	2.611	1.00
228_T	279_G	2.603	1.00
117_R	323_R	2.504	1.00
122_G	197_L	2.499	1.00
134_P	165_A	2.463	1.00
108_V	137_V	2.448	1.00
262_F	265_P	2.345	1.00
108_V	133_V	2.265	1.00
29_N	43_A	2.217	1.00
11_A	21_D	2.215	1.00
90_N	222_T	2.078	1.00
60_R	64_E	2.043	1.00
30_D	41_S	2.040	1.00
136_M	233_V	2.038	1.00
139_A	161_L	2.037	1.00
272_D	276_A	2.030	1.00
94_V	201_V	2.025	1.00
33_V	38_V	2.019	1.00
299_S	302_A	1.986	1.00
22_I	28_V	1.967	1.00
137_V	159_M	1.959	1.00
173_P	243_R	1.930	1.00
181_V	211_T	1.915	1.00
316_N	319_G	1.901	1.00
54_E	58_H	1.896	1.00
267_C	271_H	1.861	1.00
281_E	284_T	1.850	1.00
152_V	193_E	1.835	1.00
256_V	325_F	1.834	1.00
266_D	271_H	1.832	1.00
53_T	56_A	1.796	1.00
116_D	323_R	1.777	1.00
113_A	326_A	1.773	1.00
243_R	246_G	1.735	1.00
162_M	192_V	1.728	1.00
37_T	67_G	1.675	1.00
135_R	236_D	1.672	1.00
280_E	290_F	1.656	1.00
186_T	190_E	1.642	1.00
40_I	59_V	1.639	1.00
155_E	160_K	1.636	1.00
263_V	270_T	1.626	1.00
36_G	66_E	1.603	1.00
110_L	329_T	1.592	1.00
129_Y	209_G	1.549	1.00
114_L	199_Y	1.541	1.00
108_V	136_M	1.539	1.00
289_P	328_E	1.531	1.00
264_C	271_H	1.493	1.00
14_T	19_G	1.492	1.00
34_D	37_T	1.488	1.00
11_A	23_V	1.479	1.00
41_S	71_D	1.438	1.00
57_A	61_E	1.435	1.00
139_A	154_P	1.429	1.00
314_P	319_G	1.424	1.00
141_D	154_P	1.393	1.00
119_A	330_A	1.368	1.00
115_S	159_M	1.364	1.00
94_V	110_L	1.362	1.00
9_L	63_L	1.357	1.00
95_A	241_G	1.340	1.00
147_E	150_T	1.333	1.00
150_T	193_E	1.332	1.00
92_V	253_L	1.329	1.00
187_Q	191_D	1.322	1.00
114_L	201_V	1.309	1.00
140_D	143_P	1.301	0.99
32_S	39_T	1.296	0.99
239_R	285_A	1.294	0.99
45_G	49_S	1.290	0.99
93_A	221_L	1.282	0.99
15_D	25_L	1.278	0.99
10_L	23_V	1.271	0.99
20_D	24_S	1.268	0.99
31_L	40_I	1.266	0.99
169_G	172_D	1.265	0.99
42_L	59_V	1.260	0.99
328_E	331_D	1.243	0.99
265_P	271_H	1.242	0.99
279_G	290_F	1.241	0.99
317_E	320_A	1.239	0.99
223_G	251_T	1.229	0.99
176_W	184_V	1.228	0.99
299_S	313_D	1.224	0.99
222_T	333_L	1.224	0.99
123_L	161_L	1.219	0.99
145_A	148_T	1.213	0.99
112_A	159_M	1.200	0.99
106_V	227_V	1.192	0.99
53_T	57_A	1.178	0.99
95_A	226_V	1.178	0.99
17_A	25_L	1.176	0.99
20_D	25_L	1.171	0.99
261_S	272_D	1.159	0.99
324_T	327_A	1.159	0.99
273_I	296_L	1.158	0.99
132_N	237_D	1.156	0.99
106_V	294_I	1.156	0.99
182_H	214_T	1.153	0.99
309_P	312_L	1.144	0.99
324_T	328_E	1.140	0.99
294_I	325_F	1.137	0.99
204_L	241_G	1.120	0.98
160_K	197_L	1.110	0.98
157_H	308_Q	1.109	0.98
52_E	56_A	1.106	0.98
15_D	19_G	1.102	0.98
35_D	66_E	1.095	0.98
310_V	316_N	1.091	0.98
12_S	21_D	1.091	0.98
44_L	48_Y	1.089	0.98
201_V	329_T	1.086	0.98
282_F	285_A	1.083	0.98
216_L	248_H	1.082	0.98
277_G	280_E	1.082	0.98
202_V	215_L	1.082	0.98
260_S	293_S	1.080	0.98
325_F	329_T	1.068	0.98
27_L	51_A	1.068	0.98
94_V	225_V	1.067	0.98
13_V	59_V	1.065	0.98
255_V	288_L	1.057	0.98
109_N	309_P	1.055	0.98
104_S	132_N	1.054	0.98
182_H	218_T	1.041	0.98
30_D	39_T	1.034	0.97
39_T	69_E	1.033	0.97
40_I	63_L	1.028	0.97
294_I	321_S	1.021	0.97
233_V	304_G	1.015	0.97
108_V	161_L	1.015	0.97
104_S	133_V	1.013	0.97
17_A	27_L	1.011	0.97
242_L	286_N	1.009	0.97
112_A	116_D	1.009	0.97
139_A	166_F	1.005	0.97
37_T	69_E	0.998	0.97
297_D	318_T	0.991	0.97
133_V	161_L	0.984	0.97
12_S	62_T	0.976	0.96
180_M	183_K	0.975	0.96
58_H	61_E	0.969	0.96
27_L	50_P	0.968	0.96
61_E	65_A	0.958	0.96
43_A	73_T	0.947	0.96
182_H	211_T	0.946	0.96
279_G	283_A	0.944	0.96
313_D	316_N	0.942	0.96
17_A	51_A	0.942	0.96
62_T	65_A	0.941	0.96
281_E	285_A	0.938	0.95
224_S	245_F	0.937	0.95
63_L	68_L	0.932	0.95
38_V	63_L	0.927	0.95
264_C	269_G	0.927	0.95
321_S	324_T	0.927	0.95
15_D	46_A	0.922	0.95
9_L	62_T	0.921	0.95
103_K	206_P	0.916	0.95
135_R	170_E	0.913	0.95
262_F	273_I	0.909	0.95
327_A	331_D	0.907	0.95
199_Y	228_T	0.901	0.94
37_T	66_E	0.899	0.94
301_R	305_D	0.898	0.94
303_G	310_V	0.898	0.94
155_E	158_G	0.891	0.94
223_G	253_L	0.890	0.94
9_L	13_V	0.890	0.94
14_T	20_D	0.890	0.94
168_V	174_V	0.884	0.94
113_A	311_A	0.881	0.94
46_A	49_S	0.877	0.94
216_L	250_T	0.877	0.94
13_V	58_H	0.876	0.93
14_T	17_A	0.873	0.93
138_D	157_H	0.871	0.93
55_I	59_V	0.871	0.93
23_V	27_L	0.865	0.93
304_G	310_V	0.864	0.93
44_L	49_S	0.858	0.93
172_D	247_R	0.856	0.93
123_L	133_V	0.850	0.92
30_D	40_I	0.844	0.92
27_L	45_G	0.837	0.92
232_D	235_V	0.837	0.92
15_D	26_G	0.836	0.92
17_A	49_S	0.833	0.92
29_N	41_S	0.832	0.92
73_T	76_I	0.832	0.92
320_A	324_T	0.830	0.92
13_V	26_G	0.827	0.91
294_I	318_T	0.827	0.91
120_R	196_Y	0.827	0.91
49_S	52_E	0.825	0.91
45_G	48_Y	0.824	0.91
112_A	311_A	0.823	0.91
302_A	306_N	0.823	0.91
197_L	200_L	0.822	0.91
109_N	112_A	0.822	0.91
151_I	162_M	0.820	0.91
162_M	166_F	0.819	0.91
320_A	323_R	0.816	0.91
23_V	28_V	0.814	0.91
150_T	191_D	0.812	0.91
135_R	140_D	0.810	0.91
11_A	20_D	0.803	0.90
317_E	321_S	0.793	0.90
58_H	62_T	0.792	0.90
25_L	55_I	0.787	0.89
22_I	27_L	0.785	0.89
174_V	181_V	0.784	0.89
226_V	238_A	0.781	0.89
87_G	196_Y	0.778	0.89
126_A	202_V	0.774	0.88
107_A	117_R	0.771	0.88
60_R	67_G	0.771	0.88
263_V	317_E	0.771	0.88
126_A	185_L	0.770	0.88
311_A	319_G	0.770	0.88
21_D	26_G	0.769	0.88
212_Q	241_G	0.769	0.88
261_S	293_S	0.768	0.88
28_V	42_L	0.760	0.88
189_I	219_L	0.759	0.87
21_D	25_L	0.758	0.87
186_T	218_T	0.753	0.87
225_V	325_F	0.750	0.87
33_V	36_G	0.749	0.87
315_D	320_A	0.749	0.87
236_D	240_K	0.748	0.87
300_V	304_G	0.742	0.86
79_R	82_T	0.741	0.86
204_L	212_Q	0.739	0.86
259_M	296_L	0.735	0.86
175_I	213_L	0.735	0.86
74_A	77_P	0.735	0.86
93_A	204_L	0.735	0.86
132_N	233_V	0.733	0.86
95_A	204_L	0.726	0.85
27_L	49_S	0.719	0.84
226_V	242_L	0.716	0.84
17_A	45_G	0.715	0.84
56_A	64_E	0.715	0.84
34_D	39_T	0.713	0.84
17_A	22_I	0.706	0.83
15_D	49_S	0.706	0.83
9_L	12_S	0.706	0.83
237_D	245_F	0.705	0.83
146_T	150_T	0.705	0.83
124_F	200_L	0.704	0.83
264_C	268_G	0.701	0.83
13_V	22_I	0.700	0.83
114_L	330_A	0.696	0.83
85_L	91_V	0.695	0.82
323_R	327_A	0.695	0.82
55_I	58_H	0.694	0.82
246_G	287_E	0.689	0.82
282_F	286_N	0.688	0.82
171_D	282_F	0.686	0.82
11_A	14_T	0.685	0.82
104_S	136_M	0.683	0.81
231_E	305_D	0.682	0.81
31_L	38_V	0.682	0.81
134_P	163_S	0.680	0.81
151_I	192_V	0.678	0.81
85_L	88_V	0.677	0.81
185_L	211_T	0.677	0.81
224_S	237_D	0.676	0.81
90_N	199_Y	0.676	0.81
204_L	245_F	0.675	0.81
106_V	256_V	0.673	0.80
269_G	272_D	0.672	0.80
45_G	50_P	0.672	0.80
68_L	72_L	0.671	0.80
51_A	55_I	0.669	0.80
13_V	62_T	0.669	0.80
14_T	58_H	0.668	0.80
112_A	312_L	0.668	0.80
46_A	50_P	0.667	0.80
262_F	269_G	0.667	0.80
14_T	22_I	0.666	0.80
179_P	257_E	0.665	0.80
90_N	119_A	0.662	0.79
138_D	156_K	0.659	0.79
44_L	50_P	0.659	0.79
23_V	26_G	0.659	0.79
22_I	42_L	0.659	0.79
184_V	188_L	0.655	0.79
121_V	199_Y	0.654	0.78
180_M	184_V	0.652	0.78
12_S	23_V	0.652	0.78
181_V	188_L	0.651	0.78
31_L	36_G	0.649	0.78
188_L	192_V	0.649	0.78
256_V	329_T	0.649	0.78
328_E	332_M	0.646	0.78
89_K	120_R	0.646	0.78
32_S	36_G	0.640	0.77
233_V	237_D	0.640	0.77
105_T	300_V	0.639	0.77
278_G	283_A	0.639	0.77
40_I	43_A	0.639	0.77
17_A	50_P	0.638	0.77
129_Y	212_Q	0.638	0.77
41_S	73_T	0.636	0.77
129_Y	241_G	0.634	0.76
10_L	13_V	0.634	0.76
27_L	46_A	0.632	0.76
144_Q	147_E	0.632	0.76
17_A	46_A	0.630	0.76
298_P	302_A	0.629	0.76
182_H	192_V	0.629	0.76
132_N	211_T	0.627	0.76
96_S	103_K	0.625	0.75
126_A	204_L	0.624	0.75
172_D	243_R	0.623	0.75
212_Q	245_F	0.620	0.75
298_P	301_R	0.618	0.74
122_G	200_L	0.617	0.74
271_H	296_L	0.615	0.74
131_P	223_G	0.613	0.74
15_D	50_P	0.612	0.74
39_T	71_D	0.612	0.74
175_I	179_P	0.612	0.74
90_N	223_G	0.611	0.74
199_Y	330_A	0.611	0.74
112_A	201_V	0.610	0.74
48_Y	52_E	0.610	0.74
171_D	285_A	0.610	0.74
178_G	210_D	0.609	0.73
242_L	255_V	0.608	0.73
22_I	26_G	0.607	0.73
102_G	258_N	0.607	0.73
170_E	239_R	0.606	0.73
11_A	22_I	0.604	0.73
157_H	309_P	0.604	0.73
11_A	32_S	0.601	0.72
20_D	45_G	0.601	0.72
214_T	218_T	0.601	0.72
117_R	330_A	0.600	0.72
242_L	252_V	0.597	0.72
260_S	263_V	0.597	0.72
19_G	25_L	0.596	0.72
45_G	52_E	0.595	0.72
274_F	296_L	0.594	0.72
255_V	279_G	0.591	0.71
12_S	31_L	0.591	0.71
44_L	52_E	0.590	0.71
145_A	150_T	0.590	0.71
25_L	28_V	0.590	0.71
145_A	149_E	0.590	0.71
242_L	282_F	0.589	0.71
14_T	27_L	0.589	0.71
134_P	164_M	0.588	0.71
21_D	28_V	0.588	0.71
121_V	159_M	0.586	0.71
313_D	319_G	0.586	0.71
109_N	311_A	0.585	0.70
130_G	206_P	0.585	0.70
202_V	219_L	0.582	0.70
37_T	64_E	0.581	0.70
25_L	49_S	0.579	0.70
238_A	296_L	0.579	0.70
47_P	50_P	0.578	0.70
114_L	121_V	0.578	0.70
124_F	189_I	0.577	0.69
28_V	31_L	0.576	0.69
94_V	199_Y	0.575	0.69
278_G	301_R	0.575	0.69
124_F	202_V	0.574	0.69
13_V	17_A	0.573	0.69
168_V	213_L	0.571	0.69
146_T	152_V	0.569	0.68
303_G	308_Q	0.569	0.68
209_G	212_Q	0.565	0.68
130_G	259_M	0.565	0.68
72_L	77_P	0.563	0.68
275_G	301_R	0.561	0.67
48_Y	51_A	0.560	0.67
54_E	57_A	0.560	0.67
177_R	210_D	0.559	0.67
329_T	333_L	0.559	0.67
80_S	85_L	0.557	0.67
95_A	245_F	0.555	0.66
17_A	52_E	0.552	0.66
206_P	254_G	0.551	0.66
229_T	259_M	0.551	0.66
223_G	250_T	0.551	0.66
95_A	181_V	0.549	0.66
15_D	27_L	0.547	0.65
71_D	74_A	0.546	0.65
96_S	207_G	0.544	0.65
124_F	188_L	0.544	0.65
131_P	237_D	0.543	0.65
51_A	58_H	0.543	0.65
123_L	137_V	0.542	0.65
49_S	55_I	0.541	0.64
29_N	40_I	0.541	0.64
119_A	228_T	0.541	0.64
51_A	54_E	0.541	0.64
310_V	314_P	0.540	0.64
127_D	206_P	0.539	0.64
270_T	276_A	0.538	0.64
221_L	250_T	0.537	0.64
295_P	307_G	0.537	0.64
178_G	207_G	0.535	0.64
270_T	293_S	0.535	0.64
148_T	152_V	0.535	0.64
132_N	231_E	0.534	0.63
15_D	20_D	0.532	0.63
179_P	210_D	0.531	0.63
30_D	67_G	0.531	0.63
113_A	117_R	0.528	0.63
115_S	158_G	0.527	0.62
93_A	250_T	0.526	0.62
113_A	201_V	0.526	0.62
108_V	159_M	0.524	0.62
46_A	51_A	0.524	0.62
13_V	27_L	0.522	0.62
92_V	199_Y	0.522	0.62
92_V	225_V	0.522	0.62
260_S	278_G	0.522	0.62
125_D	203_D	0.522	0.62
91_V	216_L	0.520	0.61
9_L	41_S	0.520	0.61
123_L	201_V	0.519	0.61
67_G	70_T	0.519	0.61
311_A	323_R	0.516	0.61
295_P	321_S	0.516	0.61
32_S	57_A	0.515	0.61
239_R	286_N	0.513	0.60
37_T	57_A	0.513	0.60
134_P	166_F	0.512	0.60
272_D	293_S	0.512	0.60
181_V	192_V	0.512	0.60
271_H	275_G	0.512	0.60
25_L	50_P	0.510	0.60
322_F	325_F	0.509	0.60
15_D	52_E	0.509	0.60
43_A	75_A	0.509	0.60
266_D	270_T	0.509	0.60
141_D	156_K	0.509	0.60
188_L	248_H	0.509	0.60
185_L	215_L	0.509	0.60
45_G	51_A	0.509	0.60
319_G	322_F	0.507	0.60
95_A	211_T	0.507	0.60
113_A	323_R	0.507	0.60
213_L	247_R	0.507	0.60
89_K	196_Y	0.506	0.59
268_G	271_H	0.506	0.59
9_L	58_H	0.505	0.59
310_V	313_D	0.505	0.59
226_V	252_V	0.504	0.59
36_G	67_G	0.504	0.59
132_N	182_H	0.504	0.59
260_S	270_T	0.503	0.59
25_L	51_A	0.503	0.59
11_A	29_N	0.502	0.59
27_L	48_Y	0.502	0.59
10_L	27_L	0.501	0.59
207_G	230_P	0.501	0.59
15_D	44_L	0.501	0.59
182_H	186_T	0.501	0.59
50_P	55_I	0.500	0.58
57_A	64_E	0.500	0.58

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4pfsA	1	0.6618	100	0.458	Contact Map
1g3qA	1	0.6618	100	0.473	Contact Map
5aunB	2	0.6997	100	0.475	Contact Map
3pg5A	2	0.6268	100	0.477	Contact Map
1hyqA	1	0.6472	100	0.479	Contact Map
3ea0A	2	0.656	100	0.484	Contact Map
4v03A	2	0.6531	100	0.484	Contact Map
3q9lA	2	0.691	100	0.487	Contact Map
2ph1A	2	0.7114	100	0.492	Contact Map
3ez2A	2	0.93	100	0.495	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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