GREMLIN Database
Q9HQJ7 - Mrp protein homolog
UniProt: Q9HQJ7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 343 (324)
Sequences: 3430 (2043)
Seq/√Len: 113.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
264_C267_C5.3551.00
107_A201_V5.2081.00
280_E284_T4.8991.00
21_D24_S4.4061.00
117_R327_A3.7581.00
292_G325_F3.7031.00
107_A123_L3.6941.00
266_D269_G3.6521.00
262_F271_H3.3541.00
161_L166_F3.3221.00
160_K195_G3.1411.00
106_V322_F3.1141.00
261_S270_T2.9981.00
289_P332_M2.9291.00
119_A199_Y2.8381.00
137_V161_L2.8031.00
290_F293_S2.6771.00
56_A60_R2.6761.00
280_E293_S2.6111.00
228_T279_G2.6031.00
117_R323_R2.5041.00
122_G197_L2.4991.00
134_P165_A2.4631.00
108_V137_V2.4481.00
262_F265_P2.3451.00
108_V133_V2.2651.00
29_N43_A2.2171.00
11_A21_D2.2151.00
90_N222_T2.0781.00
60_R64_E2.0431.00
30_D41_S2.0401.00
136_M233_V2.0381.00
139_A161_L2.0371.00
272_D276_A2.0301.00
94_V201_V2.0251.00
33_V38_V2.0191.00
299_S302_A1.9861.00
22_I28_V1.9671.00
137_V159_M1.9591.00
173_P243_R1.9301.00
181_V211_T1.9151.00
316_N319_G1.9011.00
54_E58_H1.8961.00
267_C271_H1.8611.00
281_E284_T1.8501.00
152_V193_E1.8351.00
256_V325_F1.8341.00
266_D271_H1.8321.00
53_T56_A1.7961.00
116_D323_R1.7771.00
113_A326_A1.7731.00
243_R246_G1.7351.00
162_M192_V1.7281.00
37_T67_G1.6751.00
135_R236_D1.6721.00
280_E290_F1.6561.00
186_T190_E1.6421.00
40_I59_V1.6391.00
155_E160_K1.6361.00
263_V270_T1.6261.00
36_G66_E1.6031.00
110_L329_T1.5921.00
129_Y209_G1.5491.00
114_L199_Y1.5411.00
108_V136_M1.5391.00
289_P328_E1.5311.00
264_C271_H1.4931.00
14_T19_G1.4921.00
34_D37_T1.4881.00
11_A23_V1.4791.00
41_S71_D1.4381.00
57_A61_E1.4351.00
139_A154_P1.4291.00
314_P319_G1.4241.00
141_D154_P1.3931.00
119_A330_A1.3681.00
115_S159_M1.3641.00
94_V110_L1.3621.00
9_L63_L1.3571.00
95_A241_G1.3401.00
147_E150_T1.3331.00
150_T193_E1.3321.00
92_V253_L1.3291.00
187_Q191_D1.3221.00
114_L201_V1.3091.00
140_D143_P1.3010.99
32_S39_T1.2960.99
239_R285_A1.2940.99
45_G49_S1.2900.99
93_A221_L1.2820.99
15_D25_L1.2780.99
10_L23_V1.2710.99
20_D24_S1.2680.99
31_L40_I1.2660.99
169_G172_D1.2650.99
42_L59_V1.2600.99
328_E331_D1.2430.99
265_P271_H1.2420.99
279_G290_F1.2410.99
317_E320_A1.2390.99
223_G251_T1.2290.99
176_W184_V1.2280.99
299_S313_D1.2240.99
222_T333_L1.2240.99
123_L161_L1.2190.99
145_A148_T1.2130.99
112_A159_M1.2000.99
106_V227_V1.1920.99
53_T57_A1.1780.99
95_A226_V1.1780.99
17_A25_L1.1760.99
20_D25_L1.1710.99
261_S272_D1.1590.99
324_T327_A1.1590.99
273_I296_L1.1580.99
132_N237_D1.1560.99
106_V294_I1.1560.99
182_H214_T1.1530.99
309_P312_L1.1440.99
324_T328_E1.1400.99
294_I325_F1.1370.99
204_L241_G1.1200.98
160_K197_L1.1100.98
157_H308_Q1.1090.98
52_E56_A1.1060.98
15_D19_G1.1020.98
35_D66_E1.0950.98
310_V316_N1.0910.98
12_S21_D1.0910.98
44_L48_Y1.0890.98
201_V329_T1.0860.98
282_F285_A1.0830.98
216_L248_H1.0820.98
277_G280_E1.0820.98
202_V215_L1.0820.98
260_S293_S1.0800.98
325_F329_T1.0680.98
27_L51_A1.0680.98
94_V225_V1.0670.98
13_V59_V1.0650.98
255_V288_L1.0570.98
109_N309_P1.0550.98
104_S132_N1.0540.98
182_H218_T1.0410.98
30_D39_T1.0340.97
39_T69_E1.0330.97
40_I63_L1.0280.97
294_I321_S1.0210.97
233_V304_G1.0150.97
108_V161_L1.0150.97
104_S133_V1.0130.97
17_A27_L1.0110.97
242_L286_N1.0090.97
112_A116_D1.0090.97
139_A166_F1.0050.97
37_T69_E0.9980.97
297_D318_T0.9910.97
133_V161_L0.9840.97
12_S62_T0.9760.96
180_M183_K0.9750.96
58_H61_E0.9690.96
27_L50_P0.9680.96
61_E65_A0.9580.96
43_A73_T0.9470.96
182_H211_T0.9460.96
279_G283_A0.9440.96
313_D316_N0.9420.96
17_A51_A0.9420.96
62_T65_A0.9410.96
281_E285_A0.9380.95
224_S245_F0.9370.95
63_L68_L0.9320.95
38_V63_L0.9270.95
264_C269_G0.9270.95
321_S324_T0.9270.95
15_D46_A0.9220.95
9_L62_T0.9210.95
103_K206_P0.9160.95
135_R170_E0.9130.95
262_F273_I0.9090.95
327_A331_D0.9070.95
199_Y228_T0.9010.94
37_T66_E0.8990.94
301_R305_D0.8980.94
303_G310_V0.8980.94
155_E158_G0.8910.94
223_G253_L0.8900.94
9_L13_V0.8900.94
14_T20_D0.8900.94
168_V174_V0.8840.94
113_A311_A0.8810.94
46_A49_S0.8770.94
216_L250_T0.8770.94
13_V58_H0.8760.93
14_T17_A0.8730.93
138_D157_H0.8710.93
55_I59_V0.8710.93
23_V27_L0.8650.93
304_G310_V0.8640.93
44_L49_S0.8580.93
172_D247_R0.8560.93
123_L133_V0.8500.92
30_D40_I0.8440.92
27_L45_G0.8370.92
232_D235_V0.8370.92
15_D26_G0.8360.92
17_A49_S0.8330.92
29_N41_S0.8320.92
73_T76_I0.8320.92
320_A324_T0.8300.92
13_V26_G0.8270.91
294_I318_T0.8270.91
120_R196_Y0.8270.91
49_S52_E0.8250.91
45_G48_Y0.8240.91
112_A311_A0.8230.91
302_A306_N0.8230.91
197_L200_L0.8220.91
109_N112_A0.8220.91
151_I162_M0.8200.91
162_M166_F0.8190.91
320_A323_R0.8160.91
23_V28_V0.8140.91
150_T191_D0.8120.91
135_R140_D0.8100.91
11_A20_D0.8030.90
317_E321_S0.7930.90
58_H62_T0.7920.90
25_L55_I0.7870.89
22_I27_L0.7850.89
174_V181_V0.7840.89
226_V238_A0.7810.89
87_G196_Y0.7780.89
126_A202_V0.7740.88
107_A117_R0.7710.88
60_R67_G0.7710.88
263_V317_E0.7710.88
126_A185_L0.7700.88
311_A319_G0.7700.88
21_D26_G0.7690.88
212_Q241_G0.7690.88
261_S293_S0.7680.88
28_V42_L0.7600.88
189_I219_L0.7590.87
21_D25_L0.7580.87
186_T218_T0.7530.87
225_V325_F0.7500.87
33_V36_G0.7490.87
315_D320_A0.7490.87
236_D240_K0.7480.87
300_V304_G0.7420.86
79_R82_T0.7410.86
204_L212_Q0.7390.86
259_M296_L0.7350.86
175_I213_L0.7350.86
74_A77_P0.7350.86
93_A204_L0.7350.86
132_N233_V0.7330.86
95_A204_L0.7260.85
27_L49_S0.7190.84
226_V242_L0.7160.84
17_A45_G0.7150.84
56_A64_E0.7150.84
34_D39_T0.7130.84
17_A22_I0.7060.83
15_D49_S0.7060.83
9_L12_S0.7060.83
237_D245_F0.7050.83
146_T150_T0.7050.83
124_F200_L0.7040.83
264_C268_G0.7010.83
13_V22_I0.7000.83
114_L330_A0.6960.83
85_L91_V0.6950.82
323_R327_A0.6950.82
55_I58_H0.6940.82
246_G287_E0.6890.82
282_F286_N0.6880.82
171_D282_F0.6860.82
11_A14_T0.6850.82
104_S136_M0.6830.81
231_E305_D0.6820.81
31_L38_V0.6820.81
134_P163_S0.6800.81
151_I192_V0.6780.81
85_L88_V0.6770.81
185_L211_T0.6770.81
224_S237_D0.6760.81
90_N199_Y0.6760.81
204_L245_F0.6750.81
106_V256_V0.6730.80
269_G272_D0.6720.80
45_G50_P0.6720.80
68_L72_L0.6710.80
51_A55_I0.6690.80
13_V62_T0.6690.80
14_T58_H0.6680.80
112_A312_L0.6680.80
46_A50_P0.6670.80
262_F269_G0.6670.80
14_T22_I0.6660.80
179_P257_E0.6650.80
90_N119_A0.6620.79
138_D156_K0.6590.79
44_L50_P0.6590.79
23_V26_G0.6590.79
22_I42_L0.6590.79
184_V188_L0.6550.79
121_V199_Y0.6540.78
180_M184_V0.6520.78
12_S23_V0.6520.78
181_V188_L0.6510.78
31_L36_G0.6490.78
188_L192_V0.6490.78
256_V329_T0.6490.78
328_E332_M0.6460.78
89_K120_R0.6460.78
32_S36_G0.6400.77
233_V237_D0.6400.77
105_T300_V0.6390.77
278_G283_A0.6390.77
40_I43_A0.6390.77
17_A50_P0.6380.77
129_Y212_Q0.6380.77
41_S73_T0.6360.77
129_Y241_G0.6340.76
10_L13_V0.6340.76
27_L46_A0.6320.76
144_Q147_E0.6320.76
17_A46_A0.6300.76
298_P302_A0.6290.76
182_H192_V0.6290.76
132_N211_T0.6270.76
96_S103_K0.6250.75
126_A204_L0.6240.75
172_D243_R0.6230.75
212_Q245_F0.6200.75
298_P301_R0.6180.74
122_G200_L0.6170.74
271_H296_L0.6150.74
131_P223_G0.6130.74
15_D50_P0.6120.74
39_T71_D0.6120.74
175_I179_P0.6120.74
90_N223_G0.6110.74
199_Y330_A0.6110.74
112_A201_V0.6100.74
48_Y52_E0.6100.74
171_D285_A0.6100.74
178_G210_D0.6090.73
242_L255_V0.6080.73
22_I26_G0.6070.73
102_G258_N0.6070.73
170_E239_R0.6060.73
11_A22_I0.6040.73
157_H309_P0.6040.73
11_A32_S0.6010.72
20_D45_G0.6010.72
214_T218_T0.6010.72
117_R330_A0.6000.72
242_L252_V0.5970.72
260_S263_V0.5970.72
19_G25_L0.5960.72
45_G52_E0.5950.72
274_F296_L0.5940.72
255_V279_G0.5910.71
12_S31_L0.5910.71
44_L52_E0.5900.71
145_A150_T0.5900.71
25_L28_V0.5900.71
145_A149_E0.5900.71
242_L282_F0.5890.71
14_T27_L0.5890.71
134_P164_M0.5880.71
21_D28_V0.5880.71
121_V159_M0.5860.71
313_D319_G0.5860.71
109_N311_A0.5850.70
130_G206_P0.5850.70
202_V219_L0.5820.70
37_T64_E0.5810.70
25_L49_S0.5790.70
238_A296_L0.5790.70
47_P50_P0.5780.70
114_L121_V0.5780.70
124_F189_I0.5770.69
28_V31_L0.5760.69
94_V199_Y0.5750.69
278_G301_R0.5750.69
124_F202_V0.5740.69
13_V17_A0.5730.69
168_V213_L0.5710.69
146_T152_V0.5690.68
303_G308_Q0.5690.68
209_G212_Q0.5650.68
130_G259_M0.5650.68
72_L77_P0.5630.68
275_G301_R0.5610.67
48_Y51_A0.5600.67
54_E57_A0.5600.67
177_R210_D0.5590.67
329_T333_L0.5590.67
80_S85_L0.5570.67
95_A245_F0.5550.66
17_A52_E0.5520.66
206_P254_G0.5510.66
229_T259_M0.5510.66
223_G250_T0.5510.66
95_A181_V0.5490.66
15_D27_L0.5470.65
71_D74_A0.5460.65
96_S207_G0.5440.65
124_F188_L0.5440.65
131_P237_D0.5430.65
51_A58_H0.5430.65
123_L137_V0.5420.65
49_S55_I0.5410.64
29_N40_I0.5410.64
119_A228_T0.5410.64
51_A54_E0.5410.64
310_V314_P0.5400.64
127_D206_P0.5390.64
270_T276_A0.5380.64
221_L250_T0.5370.64
295_P307_G0.5370.64
178_G207_G0.5350.64
270_T293_S0.5350.64
148_T152_V0.5350.64
132_N231_E0.5340.63
15_D20_D0.5320.63
179_P210_D0.5310.63
30_D67_G0.5310.63
113_A117_R0.5280.63
115_S158_G0.5270.62
93_A250_T0.5260.62
113_A201_V0.5260.62
108_V159_M0.5240.62
46_A51_A0.5240.62
13_V27_L0.5220.62
92_V199_Y0.5220.62
92_V225_V0.5220.62
260_S278_G0.5220.62
125_D203_D0.5220.62
91_V216_L0.5200.61
9_L41_S0.5200.61
123_L201_V0.5190.61
67_G70_T0.5190.61
311_A323_R0.5160.61
295_P321_S0.5160.61
32_S57_A0.5150.61
239_R286_N0.5130.60
37_T57_A0.5130.60
134_P166_F0.5120.60
272_D293_S0.5120.60
181_V192_V0.5120.60
271_H275_G0.5120.60
25_L50_P0.5100.60
322_F325_F0.5090.60
15_D52_E0.5090.60
43_A75_A0.5090.60
266_D270_T0.5090.60
141_D156_K0.5090.60
188_L248_H0.5090.60
185_L215_L0.5090.60
45_G51_A0.5090.60
319_G322_F0.5070.60
95_A211_T0.5070.60
113_A323_R0.5070.60
213_L247_R0.5070.60
89_K196_Y0.5060.59
268_G271_H0.5060.59
9_L58_H0.5050.59
310_V313_D0.5050.59
226_V252_V0.5040.59
36_G67_G0.5040.59
132_N182_H0.5040.59
260_S270_T0.5030.59
25_L51_A0.5030.59
11_A29_N0.5020.59
27_L48_Y0.5020.59
10_L27_L0.5010.59
207_G230_P0.5010.59
15_D44_L0.5010.59
182_H186_T0.5010.59
50_P55_I0.5000.58
57_A64_E0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pfsA 1 0.6618 100 0.458 Contact Map
1g3qA 1 0.6618 100 0.473 Contact Map
5aunB 2 0.6997 100 0.475 Contact Map
3pg5A 2 0.6268 100 0.477 Contact Map
1hyqA 1 0.6472 100 0.479 Contact Map
3ea0A 2 0.656 100 0.484 Contact Map
4v03A 2 0.6531 100 0.484 Contact Map
3q9lA 2 0.691 100 0.487 Contact Map
2ph1A 2 0.7114 100 0.492 Contact Map
3ez2A 2 0.93 100 0.495 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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