GREMLIN Database
ENO - Enolase
UniProt: Q9HQI9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 398 (392)
Sequences: 3345 (1501)
Seq/√Len: 75.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
312_R316_A3.9781.00
12_I36_A3.6361.00
321_S348_D3.6221.00
23_A103_A3.4931.00
254_A286_E3.2601.00
91_T308_E3.1371.00
76_D79_G3.1041.00
63_R95_A3.0961.00
159_A230_G3.0561.00
261_A290_R3.0561.00
311_Q315_D2.9561.00
252_S255_A2.9291.00
46_H309_R2.9141.00
176_V227_V2.7131.00
163_A172_A2.6861.00
341_L345_N2.6821.00
58_A62_E2.6441.00
365_H390_E2.6091.00
29_D115_V2.5881.00
170_V392_I2.5641.00
186_D218_E2.5551.00
206_A266_E2.5481.00
140_V212_V2.5131.00
204_D207_T2.5111.00
80_V108_A2.4481.00
310_L322_I2.3851.00
222_E225_F2.3491.00
390_E393_R2.3351.00
209_F213_A2.2881.00
106_M332_L2.2651.00
166_V170_V2.2511.00
161_T228_R2.2351.00
78_R337_D2.2341.00
285_A289_D2.2271.00
187_D214_G2.2271.00
217_A222_E2.1861.00
336_V370_T2.1731.00
296_L374_F2.1251.00
351_V372_A2.1251.00
45_E279_N2.1071.00
303_F319_A2.0901.00
71_R83_A2.0871.00
259_Y263_L2.0581.00
82_A86_A2.0521.00
46_H279_N2.0291.00
62_E66_P2.0231.00
303_F313_G2.0041.00
110_K362_T1.9741.00
257_I276_L1.9441.00
27_T73_F1.9421.00
258_E290_R1.9351.00
177_H379_A1.9221.00
210_D267_Y1.9171.00
22_E393_R1.9011.00
168_Q171_F1.8891.00
213_A223_F1.8811.00
64_I87_A1.8661.00
138_G173_N1.8611.00
10_R396_D1.8581.00
34_R390_E1.8421.00
177_H380_V1.8291.00
279_N309_R1.8211.00
257_I286_E1.7881.00
7_V68_L1.7641.00
24_E34_R1.7241.00
11_P167_R1.7131.00
10_R22_E1.6961.00
216_A229_L1.6831.00
166_V392_I1.6621.00
265_S294_E1.6601.00
233_L260_V1.6561.00
262_G266_E1.6521.00
72_E75_G1.6511.00
172_A227_V1.6461.00
187_D211_V1.6411.00
275_P287_L1.6251.00
339_I351_V1.6221.00
45_E236_A1.5890.99
214_G217_A1.5820.99
8_R396_D1.5820.99
256_Q260_V1.5440.99
230_G271_Y1.5340.99
310_L338_A1.5300.99
49_V94_S1.5300.99
339_I370_T1.5170.99
71_R79_G1.5020.99
109_A332_L1.4880.99
261_A265_S1.4860.99
87_A96_V1.4760.99
228_R270_A1.4730.99
340_E344_R1.4700.99
253_T283_A1.4540.99
124_L369_A1.4510.99
240_D245_V1.4500.99
171_F175_A1.4460.99
36_A358_T1.4450.99
24_E393_R1.4360.99
285_A318_A1.4310.99
22_E390_E1.4290.99
340_E343_T1.3910.99
181_K199_W1.3860.99
362_T366_L1.3790.98
63_R66_P1.3560.98
101_A331_T1.3470.98
182_D185_D1.3430.98
206_A210_D1.3400.98
78_R333_T1.3350.98
119_H122_Q1.3300.98
359_E386_A1.3290.98
351_V367_A1.3270.98
311_Q341_L1.3140.98
255_A258_E1.3070.98
258_E261_A1.3050.98
156_F208_A1.3040.98
382_G385_T1.3030.98
275_P297_V1.3000.98
164_P172_A1.2940.98
216_A223_F1.2900.98
79_G83_A1.2770.98
3_R28_D1.2730.97
324_V339_I1.2720.97
318_A347_Y1.2710.97
25_V108_A1.2680.97
37_A103_A1.2570.97
64_I104_T1.2500.97
287_L291_V1.2480.97
303_F347_Y1.2480.97
137_L159_A1.2410.97
64_I96_V1.2410.97
12_I358_T1.2370.97
326_P332_L1.2350.97
124_L336_V1.2230.97
10_R24_E1.2050.96
284_F297_V1.2020.96
183_R211_V1.2000.96
307_T341_L1.1980.96
247_G251_R1.1970.96
379_A385_T1.1970.96
307_T338_A1.1970.96
246_F256_Q1.1860.96
34_R393_R1.1830.96
243_E250_R1.1800.96
211_V214_G1.1770.96
149_D202_S1.1760.96
291_V295_T1.1720.96
282_E316_A1.1700.96
78_R131_R1.1690.96
59_A63_R1.1580.96
317_G347_Y1.1580.96
60_G103_A1.1560.96
336_V366_L1.1470.95
84_L331_T1.1470.95
137_L350_V1.1460.95
280_D283_A1.1460.95
78_R82_A1.1430.95
6_A65_A1.1430.95
182_D186_D1.1380.95
75_G116_L1.1370.95
68_L71_R1.1340.95
326_P366_L1.1330.95
65_A69_E1.1240.95
289_D317_G1.1210.95
73_F108_A1.1110.94
236_A277_D1.1010.94
24_E396_D1.1000.94
256_Q276_L1.0990.94
22_E34_R1.0990.94
57_I61_R1.0910.94
245_V250_R1.0810.94
51_L59_A1.0770.93
286_E289_D1.0740.93
153_I233_L1.0670.93
77_Q123_H1.0660.93
287_L297_V1.0640.93
248_D251_R1.0610.93
179_R182_D1.0570.93
109_A124_L1.0510.93
26_T32_F1.0470.92
214_G218_E1.0460.92
93_F334_D1.0380.92
285_A316_A1.0380.92
258_E262_G1.0370.92
153_I263_L1.0340.92
262_G265_S1.0290.92
281_F318_A1.0290.92
141_L151_T1.0290.92
264_V291_V1.0280.92
31_G115_V1.0280.92
182_D218_E1.0270.92
126_G130_G1.0260.92
288_T347_Y1.0220.92
150_A202_S1.0220.92
309_R318_A1.0220.92
310_L347_Y1.0180.91
10_R393_R1.0120.91
172_A221_D1.0110.91
83_A86_A1.0110.91
118_V126_G1.0090.91
247_G250_R1.0080.91
307_T337_D1.0070.91
67_R87_A0.9980.91
150_A203_I0.9970.90
339_I343_T0.9950.90
164_P168_Q0.9940.90
8_R26_T0.9930.90
271_Y296_L0.9920.90
276_L283_A0.9860.90
84_L101_A0.9780.90
380_V385_T0.9760.90
179_R218_E0.9750.89
27_T30_G0.9700.89
206_A262_G0.9680.89
217_A223_F0.9620.89
159_A350_V0.9610.89
118_V123_H0.9590.89
35_A106_M0.9550.89
90_T95_A0.9490.88
68_L108_A0.9480.88
187_D207_T0.9460.88
349_A372_A0.9450.88
286_E290_R0.9440.88
343_T349_A0.9330.87
393_R396_D0.9320.87
73_F112_A0.9300.87
309_R312_R0.9290.87
313_G319_A0.9230.87
169_A173_N0.9230.87
9_Y60_G0.9180.86
116_L126_G0.9170.86
27_T31_G0.9080.86
319_A347_Y0.9070.86
25_V33_G0.9010.85
175_A221_D0.8990.85
106_M336_V0.8960.85
153_I259_Y0.8940.85
148_A185_D0.8930.85
177_H193_K0.8910.85
10_R34_R0.8910.85
339_I349_A0.8910.85
23_A60_G0.8880.85
124_L127_A0.8810.84
314_I345_N0.8770.84
110_K361_T0.8750.84
49_V92_D0.8740.84
24_E32_F0.8730.84
31_G114_D0.8720.84
359_E382_G0.8710.83
63_R67_R0.8700.83
46_H312_R0.8680.83
82_A337_D0.8670.83
67_R83_A0.8620.83
264_V295_T0.8590.83
148_A181_K0.8570.82
124_L362_T0.8570.82
18_N178_Q0.8560.82
125_G130_G0.8500.82
271_Y374_F0.8490.82
254_A257_I0.8490.82
263_L269_L0.8480.82
302_L309_R0.8470.82
164_P171_F0.8460.82
167_R395_A0.8460.82
235_A238_R0.8430.81
183_R214_G0.8430.81
165_S168_Q0.8410.81
246_F251_R0.8390.81
150_A153_I0.8360.81
189_V192_A0.8330.81
322_I342_A0.8320.81
129_R337_D0.8310.80
10_R390_E0.8310.80
163_A226_D0.8300.80
165_S395_A0.8290.80
310_L342_A0.8280.80
254_A258_E0.8220.80
6_A26_T0.8220.80
75_G115_V0.8210.80
5_E28_D0.8150.79
251_R256_Q0.8140.79
243_E252_S0.8120.79
189_V204_D0.8070.78
106_M110_K0.8070.78
159_A228_R0.8060.78
148_A151_T0.8050.78
172_A226_D0.8010.78
260_V272_V0.7990.78
361_T385_T0.7980.78
106_M362_T0.7980.78
312_R315_D0.7970.78
324_V335_A0.7960.78
61_R66_P0.7940.77
203_I211_V0.7920.77
13_L170_V0.7890.77
91_T94_S0.7880.77
157_L298_C0.7870.77
8_R61_R0.7860.77
332_L362_T0.7860.77
27_T32_F0.7850.77
151_T202_S0.7840.76
71_R80_V0.7810.76
367_A375_I0.7810.76
183_R218_E0.7790.76
276_L287_L0.7790.76
306_N329_I0.7750.76
210_D213_A0.7680.75
209_F231_L0.7670.75
332_L366_L0.7650.75
233_L272_V0.7620.74
98_A102_V0.7620.74
361_T382_G0.7600.74
129_R371_D0.7600.74
68_L80_V0.7600.74
153_I231_L0.7570.74
322_I338_A0.7560.74
140_V176_V0.7550.74
11_P174_A0.7490.73
213_A216_A0.7490.73
336_V372_A0.7480.73
257_I290_R0.7460.73
123_H126_G0.7440.73
7_V65_A0.7360.72
83_A87_A0.7350.72
85_H331_T0.7340.72
390_E396_D0.7340.72
222_E226_D0.7330.72
276_L291_V0.7300.71
145_A237_E0.7300.71
145_A233_L0.7280.71
229_L233_L0.7280.71
24_E390_E0.7270.71
257_I287_L0.7250.71
207_T210_D0.7240.71
27_T115_V0.7230.70
170_V174_A0.7220.70
33_G114_D0.7210.70
238_R260_V0.7210.70
257_I291_V0.7160.70
233_L238_R0.7150.70
349_A370_T0.7140.70
37_A102_V0.7130.69
158_V212_V0.7120.69
203_I208_A0.7120.69
261_A264_V0.7080.69
343_T371_D0.7060.69
213_A267_Y0.7050.69
7_V25_V0.7050.69
158_V227_V0.7030.68
59_A96_V0.7020.68
13_L171_F0.7010.68
233_L277_D0.6990.68
163_A169_A0.6980.68
176_V179_R0.6960.68
148_A191_A0.6960.68
127_A336_V0.6940.67
174_A380_V0.6940.67
150_A204_D0.6920.67
132_N371_D0.6910.67
239_Y242_D0.6910.67
167_R170_V0.6910.67
124_L351_V0.6910.67
253_T276_L0.6900.67
68_L83_A0.6870.67
223_F229_L0.6870.67
338_A349_A0.6830.66
140_V158_V0.6810.66
240_D243_E0.6780.66
167_R396_D0.6770.65
110_K114_D0.6770.65
261_A294_E0.6750.65
28_D73_F0.6750.65
275_P284_F0.6720.65
259_Y262_G0.6720.65
45_E278_E0.6700.65
31_G73_F0.6700.65
150_A205_D0.6690.65
24_E36_A0.6690.65
131_R371_D0.6660.64
49_V85_H0.6660.64
235_A277_D0.6650.64
308_E312_R0.6630.64
126_G371_D0.6630.64
321_S350_V0.6610.64
253_T257_I0.6610.64
282_E285_A0.6590.63
6_A69_E0.6570.63
148_A190_P0.6560.63
131_R337_D0.6540.63
141_L212_V0.6540.63
326_P335_A0.6540.63
95_A331_T0.6520.63
213_A229_L0.6520.63
233_L256_Q0.6520.63
21_V103_A0.6500.62
73_F115_V0.6460.62
260_V287_L0.6450.62
212_V229_L0.6440.62
351_V370_T0.6440.62
155_E353_H0.6430.61
206_A267_Y0.6420.61
285_A317_G0.6400.61
55_E171_F0.6380.61
260_V263_L0.6350.60
75_G112_A0.6350.60
148_A184_L0.6340.60
85_H93_F0.6330.60
296_L373_P0.6330.60
138_G380_V0.6330.60
45_E309_R0.6330.60
239_Y277_D0.6330.60
152_A245_V0.6310.60
189_V207_T0.6300.60
33_G111_A0.6300.60
145_A185_D0.6290.60
21_V60_G0.6280.60
246_F249_D0.6260.59
80_V85_H0.6260.59
314_I341_L0.6200.59
8_R24_E0.6200.59
24_E33_G0.6190.59
112_A123_H0.6170.58
126_G129_R0.6160.58
118_V122_Q0.6150.58
258_E286_E0.6150.58
237_E377_T0.6140.58
264_V287_L0.6140.58
158_V176_V0.6120.58
351_V366_L0.6120.58
194_G353_H0.6120.58
79_G82_A0.6100.57
337_D340_E0.6090.57
25_V107_A0.6080.57
109_A362_T0.6060.57
57_I60_G0.6060.57
307_T311_Q0.6040.57
241_G245_V0.6040.57
296_L350_V0.6040.57
177_H383_E0.6040.57
171_F221_D0.6030.57
229_L269_L0.6000.56
173_N227_V0.5990.56
297_V318_A0.5990.56
12_I34_R0.5990.56
150_A192_A0.5980.56
254_A282_E0.5980.56
13_L174_A0.5970.56
150_A211_V0.5970.56
13_L380_V0.5960.56
3_R117_G0.5960.56
45_E277_D0.5960.56
82_A333_T0.5960.56
29_D73_F0.5930.55
27_T111_A0.5920.55
108_A112_A0.5910.55
153_I208_A0.5900.55
125_G131_R0.5860.54
151_T211_V0.5850.54
109_A369_A0.5820.54
35_A107_A0.5810.54
302_L318_A0.5800.54
288_T317_G0.5790.54
7_V24_E0.5790.54
29_D117_G0.5780.53
150_A189_V0.5780.53
73_F80_V0.5780.53
186_D214_G0.5780.53
61_R65_A0.5750.53
23_A108_A0.5740.53
284_F319_A0.5740.53
78_R340_E0.5730.53
40_G44_G0.5730.53
137_L230_G0.5730.53
157_L230_G0.5730.53
235_A260_V0.5710.53
93_F101_A0.5700.52
22_E396_D0.5690.52
316_A347_Y0.5690.52
322_I347_Y0.5680.52
9_Y21_V0.5680.52
151_T169_A0.5680.52
67_R71_R0.5680.52
261_A291_V0.5660.52
149_D199_W0.5660.52
122_Q126_G0.5660.52
75_G108_A0.5650.52
141_L211_V0.5650.52
127_A344_R0.5640.52
12_I359_E0.5640.52
167_R392_I0.5630.52
59_A100_V0.5610.51
279_N312_R0.5610.51
131_R340_E0.5580.51
45_E241_G0.5570.51
161_T270_A0.5570.51
159_A173_N0.5560.51
32_F114_D0.5550.51
303_F318_A0.5530.50
326_P351_V0.5520.50
315_D341_L0.5510.50
3_R72_E0.5510.50
339_I372_A0.5510.50
163_A168_Q0.5510.50
139_N142_G0.5500.50
114_D117_G0.5500.50
190_P202_S0.5490.50
307_T310_L0.5490.50
156_F203_I0.5490.50
183_R187_D0.5490.50
184_L211_V0.5490.50
281_F312_R0.5490.50
241_G277_D0.5480.50
36_A396_D0.5460.49
159_A233_L0.5460.49
5_E26_T0.5460.49
149_D207_T0.5460.49
142_G194_G0.5430.49
366_L372_A0.5430.49
56_A100_V0.5420.49
78_R129_R0.5380.48
162_G172_A0.5380.48
183_R215_A0.5370.48
12_I21_V0.5360.48
146_H353_H0.5360.48
207_T211_V0.5350.48
145_A277_D0.5340.48
388_L391_L0.5340.48
238_R246_F0.5330.48
29_D32_F0.5330.48
222_E311_Q0.5320.48
189_V211_V0.5320.48
23_A104_T0.5320.48
11_P57_I0.5320.48
148_A192_A0.5290.47
236_A309_R0.5270.47
130_G371_D0.5270.47
237_E304_V0.5270.47
275_P318_A0.5270.47
28_D72_E0.5260.47
62_E67_R0.5240.47
77_Q331_T0.5230.47
260_V276_L0.5230.47
6_A61_R0.5220.46
145_A152_A0.5220.46
46_H277_D0.5210.46
173_N238_R0.5200.46
230_G233_L0.5200.46
238_R379_A0.5200.46
72_E112_A0.5190.46
153_I246_F0.5180.46
142_G155_E0.5180.46
151_T246_F0.5180.46
145_A238_R0.5160.46
41_A195_D0.5160.46
118_V127_A0.5150.46
359_E375_I0.5150.46
237_E366_L0.5150.46
341_L344_R0.5140.45
116_L127_A0.5140.45
163_A170_V0.5140.45
155_E194_G0.5120.45
22_E36_A0.5120.45
135_V159_A0.5110.45
245_V248_D0.5110.45
281_F309_R0.5110.45
109_A120_T0.5110.45
222_E243_E0.5100.45
180_V194_G0.5100.45
142_G353_H0.5080.45
283_A291_V0.5080.45
246_F260_V0.5080.45
338_A341_L0.5070.45
310_L324_V0.5060.44
200_A353_H0.5060.44
224_G228_R0.5050.44
84_L96_V0.5050.44
179_R212_V0.5050.44
3_R71_R0.5040.44
258_E265_S0.5040.44
332_L336_V0.5040.44
8_R252_S0.5040.44
64_I267_Y0.5040.44
21_V359_E0.5030.44
264_V294_E0.5030.44
149_D246_F0.5030.44
141_L153_I0.5020.44
276_L286_E0.5010.44
159_A270_A0.5010.44
186_D225_F0.5000.44
142_G180_V0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mksA 3 0.9372 100 0.29 Contact Map
1w6tA 3 0.9874 100 0.317 Contact Map
3tqpA 2 0.9799 100 0.324 Contact Map
3otrA 2 0.9899 100 0.335 Contact Map
2akzA 2 0.9799 100 0.34 Contact Map
4ywsA 2 0.9573 100 0.356 Contact Map
4ropA 3 0.9925 100 0.356 Contact Map
2pa6A 5 0.9849 100 0.359 Contact Map
3uj2A 3 0.9874 100 0.364 Contact Map
2fymA 3 0.995 100 0.366 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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