Q9HQI7 - HALSA - GREMLIN Contacts

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Q9HQI7 - Uncharacterized protein

UniProt:	Q9HQI7	Sequences: MTAYRLRGDMRPVIDHVPFAGASLDVLVERFETAGFDPEYGGEHPGVGTEMSMLVFPDGSYLQLVAPAREDPGWWREFFANADPIAGPSGWCVETGSVHGECQRAIDHDVEVHGPRRGFRDRPDGVTVEWDAAALGPRDHHLLPFLITDRTPREYRVPDATNFGAPISGVDCIVLAVPDLSDAIDCFTQLYRLPTPDHDYDDDFGELVSFPGQDVILAEPTTGWAADRVDTYGPVPAAVFLTADVDDARHRHPLDGGREWFGRRVRMIEGFDGYLGVISR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	280 (235)
Sequences:	534 (439)
Seq/√Len:	28.6

HALSA - Q9HQI7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
37_D	164_G	6.556	1.00
167_I	241_L	5.461	1.00
36_F	165_A	3.678	1.00
163_F	166_P	3.089	1.00
118_G	130_W	3.028	1.00
179_D	182_D	2.906	1.00
44_H	49_T	2.829	1.00
23_S	26_V	2.506	0.99
72_P	77_E	2.454	0.99
61_Y	149_D	2.408	0.99
35_G	165_A	2.363	0.99
119_F	129_E	2.355	0.99
131_D	150_R	2.328	0.99
18_P	90_G	2.302	0.99
117_R	131_D	2.245	0.98
247_D	250_H	2.224	0.98
36_F	163_F	2.135	0.98
56_F	169_G	2.129	0.98
61_Y	151_T	2.119	0.98
41_G	149_D	2.070	0.97
73_G	77_E	2.057	0.97
72_P	76_R	2.037	0.97
17_V	88_P	2.005	0.97
172_C	216_I	1.984	0.96
98_V	148_T	1.967	0.96
41_G	130_W	1.934	0.96
130_W	156_R	1.896	0.95
210_F	213_Q	1.859	0.95
95_T	101_E	1.835	0.94
130_W	149_D	1.788	0.94
25_D	41_G	1.760	0.93
118_G	156_R	1.748	0.93
38_P	54_L	1.718	0.92
49_T	134_A	1.707	0.92
34_A	165_A	1.634	0.90
58_D	157_V	1.608	0.89
130_W	144_P	1.597	0.89
181_S	219_E	1.561	0.88
149_D	156_R	1.534	0.87
246_D	249_R	1.529	0.87
14_I	45_P	1.492	0.85
41_G	52_S	1.473	0.85
97_S	100_G	1.456	0.84
164_G	192_R	1.448	0.84
41_G	156_R	1.445	0.83
51_M	61_Y	1.437	0.83
99_H	117_R	1.437	0.83
47_V	153_R	1.435	0.83
43_E	50_E	1.430	0.83
28_V	52_S	1.426	0.83
72_P	75_W	1.413	0.82
130_W	147_I	1.404	0.82
246_D	250_H	1.404	0.82
226_A	231_T	1.403	0.82
20_A	89_S	1.398	0.81
41_G	144_P	1.386	0.81
248_A	251_R	1.384	0.81
149_D	153_R	1.370	0.80
36_F	167_I	1.362	0.80
39_E	53_M	1.359	0.79
19_F	62_L	1.353	0.79
180_L	184_I	1.330	0.78
118_G	132_A	1.328	0.78
170_V	239_V	1.304	0.77
71_D	76_R	1.294	0.76
21_G	27_L	1.294	0.76
96_G	106_I	1.289	0.76
118_G	147_I	1.288	0.76
27_L	35_G	1.267	0.74
177_V	187_F	1.263	0.74
58_D	149_D	1.260	0.74
47_V	132_A	1.258	0.74
204_F	222_T	1.257	0.74
245_V	248_A	1.254	0.74
247_D	251_R	1.249	0.73
24_L	65_V	1.242	0.73
144_P	156_R	1.231	0.72
149_D	157_V	1.228	0.72
38_P	163_F	1.222	0.72
118_G	145_F	1.219	0.71
50_E	228_R	1.218	0.71
59_G	149_D	1.203	0.70
21_G	31_F	1.195	0.70
105_A	146_L	1.193	0.70
91_W	215_V	1.191	0.70
45_P	133_A	1.189	0.70
45_P	49_T	1.189	0.70
38_P	64_L	1.187	0.69
22_A	93_V	1.170	0.68
42_G	156_R	1.156	0.67
47_V	118_G	1.154	0.67
92_C	145_F	1.152	0.67
90_G	149_D	1.147	0.67
177_V	183_A	1.146	0.67
181_S	231_T	1.144	0.66
15_D	145_F	1.139	0.66
116_R	151_T	1.135	0.66
188_T	193_L	1.133	0.66
74_W	77_E	1.129	0.65
148_T	170_V	1.127	0.65
18_P	44_H	1.115	0.64
47_V	149_D	1.106	0.64
163_F	167_I	1.105	0.64
55_V	149_D	1.096	0.63
79_F	132_A	1.095	0.63
27_L	34_A	1.092	0.63
44_H	145_F	1.091	0.63
20_A	47_V	1.084	0.62
59_G	153_R	1.080	0.62
42_G	62_L	1.075	0.62
128_V	156_R	1.069	0.61
61_Y	128_V	1.064	0.61
167_I	242_T	1.063	0.61
18_P	118_G	1.062	0.61
126_V	243_A	1.060	0.60
110_V	135_L	1.060	0.60
41_G	118_G	1.059	0.60
209_S	229_V	1.057	0.60
47_V	143_L	1.041	0.59
164_G	167_I	1.040	0.59
15_D	18_P	1.038	0.59
18_P	51_M	1.034	0.59
58_D	169_G	1.029	0.58
131_D	211_P	1.028	0.58
43_E	68_A	1.019	0.57
175_L	187_F	1.011	0.57
19_F	42_G	1.010	0.57
29_E	35_G	1.007	0.56
128_V	149_D	1.007	0.56
71_D	75_W	0.998	0.56
49_T	52_S	0.993	0.55
21_G	215_V	0.991	0.55
14_I	17_V	0.988	0.55
83_D	217_L	0.983	0.55
61_Y	130_W	0.978	0.54
56_F	60_S	0.969	0.54
32_E	218_A	0.968	0.53
64_L	128_V	0.958	0.53
28_V	53_M	0.956	0.53
132_A	147_I	0.946	0.52
95_T	148_T	0.940	0.51
90_G	118_G	0.931	0.51
53_M	90_G	0.919	0.50
31_F	36_F	0.909	0.49
168_S	244_D	0.907	0.49
62_L	167_I	0.899	0.48
15_D	147_I	0.896	0.48
55_V	160_A	0.893	0.48
44_H	118_G	0.892	0.48
50_E	68_A	0.892	0.48
12_P	187_F	0.890	0.47
76_R	79_F	0.887	0.47
115_P	144_P	0.886	0.47
27_L	48_G	0.881	0.47
51_M	163_F	0.879	0.47
33_T	62_L	0.877	0.46
181_S	222_T	0.876	0.46
49_T	118_G	0.873	0.46
90_G	160_A	0.868	0.46
225_A	228_R	0.865	0.46
67_P	191_Y	0.864	0.45
71_D	77_E	0.856	0.45
118_G	128_V	0.853	0.45
101_E	105_A	0.852	0.45
170_V	191_Y	0.847	0.44
15_D	130_W	0.843	0.44
14_I	170_V	0.842	0.44
143_L	149_D	0.833	0.43
49_T	111_E	0.832	0.43
15_D	92_C	0.830	0.43
101_E	187_F	0.830	0.43
20_A	90_G	0.824	0.42
118_G	149_D	0.816	0.42
83_D	215_V	0.815	0.42
151_T	155_Y	0.812	0.41
40_Y	184_I	0.810	0.41
62_L	65_V	0.797	0.40
192_R	199_D	0.795	0.40
182_D	193_L	0.791	0.40
177_V	180_L	0.790	0.40
104_R	169_G	0.789	0.40
55_V	118_G	0.786	0.40
47_V	55_V	0.779	0.39
28_V	38_P	0.778	0.39
24_L	52_S	0.777	0.39
49_T	67_P	0.773	0.39
131_D	148_T	0.772	0.38
65_V	174_V	0.765	0.38
13_V	213_Q	0.764	0.38
103_Q	124_D	0.763	0.38
35_G	52_S	0.760	0.38
168_S	171_D	0.757	0.37
56_F	250_H	0.754	0.37
73_G	76_R	0.754	0.37
100_G	247_D	0.749	0.37
91_W	153_R	0.740	0.36
90_G	186_C	0.733	0.36
128_V	155_Y	0.731	0.36
137_P	213_Q	0.730	0.35
119_F	147_I	0.729	0.35
196_P	219_E	0.727	0.35
41_G	47_V	0.726	0.35
55_V	156_R	0.723	0.35
176_A	236_P	0.719	0.35
121_D	127_T	0.717	0.35
53_M	144_P	0.715	0.34
99_H	104_R	0.713	0.34
110_V	190_L	0.713	0.34
116_R	132_A	0.709	0.34
45_P	48_G	0.708	0.34
155_Y	187_F	0.705	0.34
39_E	62_L	0.700	0.33
138_R	208_V	0.699	0.33
18_P	141_H	0.693	0.33
184_I	205_G	0.693	0.33
221_T	224_W	0.690	0.33
44_H	120_R	0.689	0.33
238_A	241_L	0.688	0.33
242_T	245_V	0.688	0.33
248_A	252_H	0.688	0.33
170_V	243_A	0.687	0.32
33_T	198_H	0.686	0.32
19_F	211_P	0.683	0.32
40_Y	163_F	0.680	0.32
28_V	177_V	0.676	0.32
18_P	91_W	0.675	0.32
181_S	185_D	0.673	0.32
47_V	58_D	0.672	0.31
147_I	165_A	0.671	0.31
12_P	50_E	0.668	0.31
110_V	242_T	0.665	0.31
123_P	180_L	0.664	0.31
36_F	87_G	0.663	0.31
95_T	234_P	0.661	0.31
128_V	143_L	0.661	0.31
171_D	240_F	0.660	0.31
95_T	235_V	0.655	0.30
45_P	79_F	0.648	0.30
185_D	194_P	0.648	0.30
123_P	182_D	0.647	0.30
181_S	198_H	0.646	0.30
56_F	95_T	0.644	0.30
39_E	156_R	0.643	0.30
66_A	190_L	0.641	0.29
105_A	186_C	0.641	0.29
74_W	96_G	0.636	0.29
19_F	175_L	0.634	0.29
182_D	244_D	0.634	0.29
23_S	97_S	0.634	0.29
121_D	170_V	0.632	0.29
55_V	61_Y	0.631	0.29
85_I	159_D	0.631	0.29
99_H	210_F	0.630	0.29
172_C	241_L	0.629	0.29
20_A	24_L	0.628	0.29
18_P	145_F	0.623	0.28
38_P	51_M	0.622	0.28
71_D	78_F	0.621	0.28
40_Y	167_I	0.620	0.28
108_H	178_P	0.619	0.28
59_G	169_G	0.619	0.28
185_D	196_P	0.613	0.28
15_D	53_M	0.613	0.28
98_V	128_V	0.611	0.28
75_W	78_F	0.611	0.28
102_C	106_I	0.610	0.27
157_V	160_A	0.609	0.27
149_D	160_A	0.605	0.27
99_H	114_G	0.604	0.27
60_S	122_R	0.603	0.27
56_F	138_R	0.601	0.27
18_P	132_A	0.599	0.27
188_T	211_P	0.598	0.27
225_A	229_V	0.597	0.27
100_G	219_E	0.597	0.27
110_V	176_A	0.596	0.27
53_M	130_W	0.596	0.27
54_L	59_G	0.595	0.27
87_G	165_A	0.592	0.26
90_G	153_R	0.584	0.26
181_S	194_P	0.584	0.26
106_I	117_R	0.581	0.26
115_P	145_F	0.578	0.26
44_H	147_I	0.574	0.25
122_R	173_I	0.573	0.25
56_F	166_P	0.573	0.25
52_S	155_Y	0.572	0.25
90_G	157_V	0.570	0.25
53_M	149_D	0.568	0.25
13_V	23_S	0.566	0.25
113_H	193_L	0.564	0.25
99_H	162_N	0.563	0.25
231_T	251_R	0.561	0.25
28_V	32_E	0.561	0.25
45_P	78_F	0.559	0.24
174_V	240_F	0.558	0.24
177_V	186_C	0.558	0.24
23_S	222_T	0.556	0.24
58_D	240_F	0.556	0.24
153_R	156_R	0.556	0.24
149_D	155_Y	0.553	0.24
17_V	215_V	0.552	0.24
181_S	188_T	0.552	0.24
103_Q	106_I	0.552	0.24
176_A	225_A	0.550	0.24
65_V	156_R	0.549	0.24
90_G	116_R	0.549	0.24
116_R	143_L	0.547	0.24
153_R	169_G	0.546	0.24
107_D	230_D	0.546	0.24
227_D	231_T	0.545	0.24
137_P	217_L	0.542	0.23
183_A	191_Y	0.541	0.23
114_G	139_D	0.541	0.23
99_H	159_D	0.541	0.23
47_V	90_G	0.538	0.23
134_A	175_L	0.537	0.23
24_L	174_V	0.537	0.23
229_V	245_V	0.536	0.23
113_H	217_L	0.536	0.23
161_T	172_C	0.535	0.23
53_M	118_G	0.534	0.23
58_D	156_R	0.532	0.23
20_A	45_P	0.531	0.23
39_E	52_S	0.531	0.23
31_F	88_P	0.531	0.23
89_S	133_A	0.530	0.23
18_P	27_L	0.529	0.23
184_I	188_T	0.529	0.23
50_E	66_A	0.528	0.23
65_V	145_F	0.527	0.23
69_R	76_R	0.523	0.22
208_V	211_P	0.523	0.22
27_L	165_A	0.522	0.22
26_V	213_Q	0.522	0.22
223_G	229_V	0.521	0.22
39_E	98_V	0.520	0.22
22_A	251_R	0.520	0.22
82_A	85_I	0.520	0.22
142_L	236_P	0.519	0.22
45_P	132_A	0.517	0.22
207_L	216_I	0.511	0.22
107_D	195_T	0.510	0.22
115_P	151_T	0.509	0.22
16_H	125_G	0.508	0.22
38_P	236_P	0.507	0.22
127_T	204_F	0.506	0.22
36_F	147_I	0.506	0.22
121_D	221_T	0.505	0.21
94_E	149_D	0.502	0.21
54_L	100_G	0.500	0.21
139_D	177_V	0.500	0.21

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3p8aA	1	0.8571	100	0.472	Contact Map
1t47A	2	0.9357	99.8	0.727	Contact Map
3zgjA	1	0.9179	99.8	0.739	Contact Map
2r5vA	1	0.9179	99.8	0.746	Contact Map
3isqA	2	0.9643	99.8	0.747	Contact Map
1sp8A	2	0.9536	99.7	0.756	Contact Map
1cjxA	2	0.9179	99.7	0.763	Contact Map
1sqdA	2	0.9357	99.7	0.764	Contact Map
1zswA	1	0.8929	99.7	0.766	Contact Map
3oajA	2	0.8821	99.6	0.781	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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