GREMLIN Database
Q9HQI7 - Uncharacterized protein
UniProt: Q9HQI7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 280 (235)
Sequences: 534 (439)
Seq/√Len: 28.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_D164_G6.5561.00
167_I241_L5.4611.00
36_F165_A3.6781.00
163_F166_P3.0891.00
118_G130_W3.0281.00
179_D182_D2.9061.00
44_H49_T2.8291.00
23_S26_V2.5060.99
72_P77_E2.4540.99
61_Y149_D2.4080.99
35_G165_A2.3630.99
119_F129_E2.3550.99
131_D150_R2.3280.99
18_P90_G2.3020.99
117_R131_D2.2450.98
247_D250_H2.2240.98
36_F163_F2.1350.98
56_F169_G2.1290.98
61_Y151_T2.1190.98
41_G149_D2.0700.97
73_G77_E2.0570.97
72_P76_R2.0370.97
17_V88_P2.0050.97
172_C216_I1.9840.96
98_V148_T1.9670.96
41_G130_W1.9340.96
130_W156_R1.8960.95
210_F213_Q1.8590.95
95_T101_E1.8350.94
130_W149_D1.7880.94
25_D41_G1.7600.93
118_G156_R1.7480.93
38_P54_L1.7180.92
49_T134_A1.7070.92
34_A165_A1.6340.90
58_D157_V1.6080.89
130_W144_P1.5970.89
181_S219_E1.5610.88
149_D156_R1.5340.87
246_D249_R1.5290.87
14_I45_P1.4920.85
41_G52_S1.4730.85
97_S100_G1.4560.84
164_G192_R1.4480.84
41_G156_R1.4450.83
51_M61_Y1.4370.83
99_H117_R1.4370.83
47_V153_R1.4350.83
43_E50_E1.4300.83
28_V52_S1.4260.83
72_P75_W1.4130.82
130_W147_I1.4040.82
246_D250_H1.4040.82
226_A231_T1.4030.82
20_A89_S1.3980.81
41_G144_P1.3860.81
248_A251_R1.3840.81
149_D153_R1.3700.80
36_F167_I1.3620.80
39_E53_M1.3590.79
19_F62_L1.3530.79
180_L184_I1.3300.78
118_G132_A1.3280.78
170_V239_V1.3040.77
71_D76_R1.2940.76
21_G27_L1.2940.76
96_G106_I1.2890.76
118_G147_I1.2880.76
27_L35_G1.2670.74
177_V187_F1.2630.74
58_D149_D1.2600.74
47_V132_A1.2580.74
204_F222_T1.2570.74
245_V248_A1.2540.74
247_D251_R1.2490.73
24_L65_V1.2420.73
144_P156_R1.2310.72
149_D157_V1.2280.72
38_P163_F1.2220.72
118_G145_F1.2190.71
50_E228_R1.2180.71
59_G149_D1.2030.70
21_G31_F1.1950.70
105_A146_L1.1930.70
91_W215_V1.1910.70
45_P133_A1.1890.70
45_P49_T1.1890.70
38_P64_L1.1870.69
22_A93_V1.1700.68
42_G156_R1.1560.67
47_V118_G1.1540.67
92_C145_F1.1520.67
90_G149_D1.1470.67
177_V183_A1.1460.67
181_S231_T1.1440.66
15_D145_F1.1390.66
116_R151_T1.1350.66
188_T193_L1.1330.66
74_W77_E1.1290.65
148_T170_V1.1270.65
18_P44_H1.1150.64
47_V149_D1.1060.64
163_F167_I1.1050.64
55_V149_D1.0960.63
79_F132_A1.0950.63
27_L34_A1.0920.63
44_H145_F1.0910.63
20_A47_V1.0840.62
59_G153_R1.0800.62
42_G62_L1.0750.62
128_V156_R1.0690.61
61_Y128_V1.0640.61
167_I242_T1.0630.61
18_P118_G1.0620.61
126_V243_A1.0600.60
110_V135_L1.0600.60
41_G118_G1.0590.60
209_S229_V1.0570.60
47_V143_L1.0410.59
164_G167_I1.0400.59
15_D18_P1.0380.59
18_P51_M1.0340.59
58_D169_G1.0290.58
131_D211_P1.0280.58
43_E68_A1.0190.57
175_L187_F1.0110.57
19_F42_G1.0100.57
29_E35_G1.0070.56
128_V149_D1.0070.56
71_D75_W0.9980.56
49_T52_S0.9930.55
21_G215_V0.9910.55
14_I17_V0.9880.55
83_D217_L0.9830.55
61_Y130_W0.9780.54
56_F60_S0.9690.54
32_E218_A0.9680.53
64_L128_V0.9580.53
28_V53_M0.9560.53
132_A147_I0.9460.52
95_T148_T0.9400.51
90_G118_G0.9310.51
53_M90_G0.9190.50
31_F36_F0.9090.49
168_S244_D0.9070.49
62_L167_I0.8990.48
15_D147_I0.8960.48
55_V160_A0.8930.48
44_H118_G0.8920.48
50_E68_A0.8920.48
12_P187_F0.8900.47
76_R79_F0.8870.47
115_P144_P0.8860.47
27_L48_G0.8810.47
51_M163_F0.8790.47
33_T62_L0.8770.46
181_S222_T0.8760.46
49_T118_G0.8730.46
90_G160_A0.8680.46
225_A228_R0.8650.46
67_P191_Y0.8640.45
71_D77_E0.8560.45
118_G128_V0.8530.45
101_E105_A0.8520.45
170_V191_Y0.8470.44
15_D130_W0.8430.44
14_I170_V0.8420.44
143_L149_D0.8330.43
49_T111_E0.8320.43
15_D92_C0.8300.43
101_E187_F0.8300.43
20_A90_G0.8240.42
118_G149_D0.8160.42
83_D215_V0.8150.42
151_T155_Y0.8120.41
40_Y184_I0.8100.41
62_L65_V0.7970.40
192_R199_D0.7950.40
182_D193_L0.7910.40
177_V180_L0.7900.40
104_R169_G0.7890.40
55_V118_G0.7860.40
47_V55_V0.7790.39
28_V38_P0.7780.39
24_L52_S0.7770.39
49_T67_P0.7730.39
131_D148_T0.7720.38
65_V174_V0.7650.38
13_V213_Q0.7640.38
103_Q124_D0.7630.38
35_G52_S0.7600.38
168_S171_D0.7570.37
56_F250_H0.7540.37
73_G76_R0.7540.37
100_G247_D0.7490.37
91_W153_R0.7400.36
90_G186_C0.7330.36
128_V155_Y0.7310.36
137_P213_Q0.7300.35
119_F147_I0.7290.35
196_P219_E0.7270.35
41_G47_V0.7260.35
55_V156_R0.7230.35
176_A236_P0.7190.35
121_D127_T0.7170.35
53_M144_P0.7150.34
99_H104_R0.7130.34
110_V190_L0.7130.34
116_R132_A0.7090.34
45_P48_G0.7080.34
155_Y187_F0.7050.34
39_E62_L0.7000.33
138_R208_V0.6990.33
18_P141_H0.6930.33
184_I205_G0.6930.33
221_T224_W0.6900.33
44_H120_R0.6890.33
238_A241_L0.6880.33
242_T245_V0.6880.33
248_A252_H0.6880.33
170_V243_A0.6870.32
33_T198_H0.6860.32
19_F211_P0.6830.32
40_Y163_F0.6800.32
28_V177_V0.6760.32
18_P91_W0.6750.32
181_S185_D0.6730.32
47_V58_D0.6720.31
147_I165_A0.6710.31
12_P50_E0.6680.31
110_V242_T0.6650.31
123_P180_L0.6640.31
36_F87_G0.6630.31
95_T234_P0.6610.31
128_V143_L0.6610.31
171_D240_F0.6600.31
95_T235_V0.6550.30
45_P79_F0.6480.30
185_D194_P0.6480.30
123_P182_D0.6470.30
181_S198_H0.6460.30
56_F95_T0.6440.30
39_E156_R0.6430.30
66_A190_L0.6410.29
105_A186_C0.6410.29
74_W96_G0.6360.29
19_F175_L0.6340.29
182_D244_D0.6340.29
23_S97_S0.6340.29
121_D170_V0.6320.29
55_V61_Y0.6310.29
85_I159_D0.6310.29
99_H210_F0.6300.29
172_C241_L0.6290.29
20_A24_L0.6280.29
18_P145_F0.6230.28
38_P51_M0.6220.28
71_D78_F0.6210.28
40_Y167_I0.6200.28
108_H178_P0.6190.28
59_G169_G0.6190.28
185_D196_P0.6130.28
15_D53_M0.6130.28
98_V128_V0.6110.28
75_W78_F0.6110.28
102_C106_I0.6100.27
157_V160_A0.6090.27
149_D160_A0.6050.27
99_H114_G0.6040.27
60_S122_R0.6030.27
56_F138_R0.6010.27
18_P132_A0.5990.27
188_T211_P0.5980.27
225_A229_V0.5970.27
100_G219_E0.5970.27
110_V176_A0.5960.27
53_M130_W0.5960.27
54_L59_G0.5950.27
87_G165_A0.5920.26
90_G153_R0.5840.26
181_S194_P0.5840.26
106_I117_R0.5810.26
115_P145_F0.5780.26
44_H147_I0.5740.25
122_R173_I0.5730.25
56_F166_P0.5730.25
52_S155_Y0.5720.25
90_G157_V0.5700.25
53_M149_D0.5680.25
13_V23_S0.5660.25
113_H193_L0.5640.25
99_H162_N0.5630.25
231_T251_R0.5610.25
28_V32_E0.5610.25
45_P78_F0.5590.24
174_V240_F0.5580.24
177_V186_C0.5580.24
23_S222_T0.5560.24
58_D240_F0.5560.24
153_R156_R0.5560.24
149_D155_Y0.5530.24
17_V215_V0.5520.24
181_S188_T0.5520.24
103_Q106_I0.5520.24
176_A225_A0.5500.24
65_V156_R0.5490.24
90_G116_R0.5490.24
116_R143_L0.5470.24
153_R169_G0.5460.24
107_D230_D0.5460.24
227_D231_T0.5450.24
137_P217_L0.5420.23
183_A191_Y0.5410.23
114_G139_D0.5410.23
99_H159_D0.5410.23
47_V90_G0.5380.23
134_A175_L0.5370.23
24_L174_V0.5370.23
229_V245_V0.5360.23
113_H217_L0.5360.23
161_T172_C0.5350.23
53_M118_G0.5340.23
58_D156_R0.5320.23
20_A45_P0.5310.23
39_E52_S0.5310.23
31_F88_P0.5310.23
89_S133_A0.5300.23
18_P27_L0.5290.23
184_I188_T0.5290.23
50_E66_A0.5280.23
65_V145_F0.5270.23
69_R76_R0.5230.22
208_V211_P0.5230.22
27_L165_A0.5220.22
26_V213_Q0.5220.22
223_G229_V0.5210.22
39_E98_V0.5200.22
22_A251_R0.5200.22
82_A85_I0.5200.22
142_L236_P0.5190.22
45_P132_A0.5170.22
207_L216_I0.5110.22
107_D195_T0.5100.22
115_P151_T0.5090.22
16_H125_G0.5080.22
38_P236_P0.5070.22
127_T204_F0.5060.22
36_F147_I0.5060.22
121_D221_T0.5050.21
94_E149_D0.5020.21
54_L100_G0.5000.21
139_D177_V0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3p8aA 1 0.8571 100 0.472 Contact Map
1t47A 2 0.9357 99.8 0.727 Contact Map
3zgjA 1 0.9179 99.8 0.739 Contact Map
2r5vA 1 0.9179 99.8 0.746 Contact Map
3isqA 2 0.9643 99.8 0.747 Contact Map
1sp8A 2 0.9536 99.7 0.756 Contact Map
1cjxA 2 0.9179 99.7 0.763 Contact Map
1sqdA 2 0.9357 99.7 0.764 Contact Map
1zswA 1 0.8929 99.7 0.766 Contact Map
3oajA 2 0.8821 99.6 0.781 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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