GREMLIN Database
Q9HQI6 - Mevalonate kinase
UniProt: Q9HQI6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 330 (297)
Sequences: 5064 (3731)
Seq/√Len: 216.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_S33_R4.7721.00
253_D277_R4.4791.00
47_R107_D3.6611.00
39_S107_D3.5361.00
244_D247_T3.4541.00
143_D146_E3.2831.00
36_V129_A3.2451.00
236_G248_L2.9941.00
284_A297_A2.9771.00
34_A125_A2.8571.00
231_D235_R2.7911.00
185_T241_A2.7661.00
193_P301_G2.6541.00
178_R237_E2.6431.00
259_L264_V2.6341.00
249_G283_G2.6261.00
41_R107_D2.5501.00
44_S63_S2.4551.00
38_V133_A2.4221.00
238_A242_D2.4211.00
247_T250_R2.2811.00
269_L295_I2.2771.00
309_S313_D2.2271.00
239_A247_T2.1311.00
47_R59_T2.1191.00
299_D307_A2.1151.00
235_R247_T2.0931.00
14_F236_G2.0531.00
135_T141_E2.0511.00
128_V172_A2.0211.00
239_A244_D2.0091.00
131_I147_V1.9751.00
7_A129_A1.9711.00
191_A301_G1.9341.00
237_E241_A1.9231.00
274_W278_D1.9231.00
211_G215_L1.8891.00
212_V215_L1.8621.00
197_G297_A1.8311.00
303_G306_T1.7891.00
45_R59_T1.7591.00
145_R149_D1.7191.00
40_E104_A1.6901.00
257_G277_R1.6891.00
257_G260_S1.6681.00
310_L314_C1.6591.00
203_H289_A1.6451.00
5_S136_R1.6051.00
305_E308_L1.5901.00
211_G214_A1.5771.00
195_V307_A1.5751.00
300_A303_G1.5561.00
153_Q157_T1.5541.00
110_I126_V1.5421.00
148_A172_A1.5411.00
93_E97_A1.5221.00
24_P234_R1.5211.00
250_R254_I1.5191.00
104_A138_L1.4841.00
275_A279_G1.4821.00
135_T140_V1.4821.00
52_D111_D1.4741.00
128_V151_A1.4691.00
212_V216_R1.4571.00
305_E309_S1.4521.00
271_A275_A1.4491.00
61_E64_G1.4481.00
265_S270_D1.4441.00
213_R216_R1.4251.00
201_T266_G1.4171.00
273_V284_A1.4141.00
279_G310_L1.4001.00
50_S53_L1.3921.00
213_R217_E1.3781.00
38_V106_F1.3661.00
37_T109_T1.3621.00
24_P178_R1.3611.00
17_H20_V1.3381.00
132_D144_A1.3301.00
193_P304_A1.3291.00
225_T258_L1.3211.00
304_A308_L1.3131.00
18_A230_G1.3101.00
38_V137_E1.3011.00
46_L106_F1.2961.00
256_H273_V1.2911.00
235_R238_A1.2911.00
46_L105_G1.2881.00
197_G295_I1.2811.00
135_T147_V1.2801.00
248_L298_L1.2611.00
238_A241_A1.2571.00
278_D314_C1.2511.00
144_A172_A1.2491.00
204_D207_E1.2391.00
91_A131_I1.2381.00
84_A87_Y1.2361.00
306_T309_S1.2301.00
4_T37_T1.2021.00
135_T142_L1.1981.00
275_A314_C1.1791.00
91_A95_A1.1761.00
308_L312_P1.1721.00
48_V88_V1.1711.00
228_A254_I1.1631.00
246_A300_A1.1551.00
12_Y27_P1.1481.00
27_P170_C1.1461.00
272_M295_I1.1431.00
145_R173_M1.1431.00
254_I257_G1.1411.00
229_I255_N1.1271.00
306_T310_L1.1251.00
266_G269_L1.1191.00
222_V263_G1.1161.00
45_R61_E1.1141.00
108_V130_G1.1141.00
239_A251_L1.1121.00
92_V134_A1.1121.00
40_E137_E1.1111.00
19_V164_S1.0991.00
94_Q97_A1.0911.00
24_P230_G1.0901.00
265_S286_L1.0841.00
38_V108_V1.0821.00
88_V130_G1.0811.00
44_S61_E1.0761.00
41_R105_G1.0751.00
201_T268_T1.0671.00
10_K164_S1.0611.00
269_L286_L1.0601.00
231_D234_R1.0591.00
94_Q153_Q1.0561.00
16_E259_L1.0551.00
10_K19_V1.0531.00
178_R234_R1.0501.00
110_I130_G1.0491.00
162_E213_R1.0471.00
49_C109_T1.0411.00
252_M283_G1.0391.00
214_A217_E1.0361.00
36_V110_I1.0351.00
210_A215_L1.0341.00
199_D272_M1.0231.00
220_G224_D1.0221.00
48_V60_V1.0191.00
36_V108_V1.0181.00
51_G109_T1.0171.00
284_A295_I1.0131.00
270_D274_W1.0101.00
185_T237_E1.0091.00
222_V225_T1.0071.00
128_V171_S1.0061.00
155_E293_G1.0041.00
18_A229_I1.0041.00
214_A218_E1.0031.00
9_G114_I1.0001.00
221_F263_G0.9971.00
25_A166_A0.9871.00
86_G89_D0.9851.00
125_A171_S0.9801.00
12_Y16_E0.9721.00
229_I232_L0.9721.00
156_H163_A0.9701.00
310_L313_D0.9691.00
18_A21_Y0.9681.00
197_G276_A0.9621.00
205_T211_G0.9511.00
152_Y163_A0.9501.00
229_I233_V0.9491.00
246_A250_R0.9461.00
307_A311_T0.9340.99
165_R181_G0.9340.99
275_A278_D0.9330.99
125_A129_A0.9280.99
36_V133_A0.9260.99
205_T210_A0.9250.99
282_D300_A0.9210.99
210_A213_R0.9190.99
100_D103_T0.9160.99
233_V236_G0.9110.99
257_G261_G0.9110.99
35_H111_D0.9070.99
205_T215_L0.9050.99
132_D147_V0.9040.99
197_G272_M0.9020.99
49_C107_D0.8990.99
23_E230_G0.8960.99
112_S125_A0.8960.99
218_E221_F0.8900.99
267_R271_A0.8900.99
7_A171_S0.8890.99
11_V296_V0.8890.99
144_A147_V0.8880.99
18_A23_E0.8780.99
205_T213_R0.8760.99
27_P166_A0.8750.99
82_D89_D0.8670.99
148_A152_Y0.8660.99
11_V287_T0.8650.99
82_D85_M0.8610.99
253_D257_G0.8600.99
161_G205_T0.8570.99
46_L60_V0.8550.99
260_S270_D0.8530.99
22_G182_D0.8510.99
28_C176_V0.8480.99
131_I150_R0.8460.99
164_S168_T0.8440.99
199_D292_G0.8440.99
232_L251_L0.8390.99
309_S312_P0.8330.99
26_V233_V0.8330.99
14_F251_L0.8310.99
6_S35_H0.8290.99
131_I151_A0.8280.99
169_F173_M0.8250.99
197_G284_A0.8230.99
26_V236_G0.8230.99
124_A163_A0.8220.99
225_T228_A0.8110.99
252_M296_V0.8040.98
155_E168_T0.8020.98
256_H260_S0.7990.98
281_A303_G0.7980.98
276_A307_A0.7950.98
146_E150_R0.7930.98
95_A140_V0.7910.98
270_D273_V0.7910.98
127_V154_V0.7900.98
273_V277_R0.7870.98
276_A284_A0.7850.98
24_P233_V0.7840.98
235_R254_I0.7830.98
11_V28_C0.7810.98
19_V23_E0.7780.98
205_T212_V0.7760.98
37_T111_D0.7760.98
82_D86_G0.7690.98
146_E149_D0.7690.98
228_A231_D0.7680.98
197_G311_T0.7640.98
51_G111_D0.7590.98
41_R44_S0.7590.98
287_T294_S0.7560.98
93_E96_R0.7560.98
170_C177_V0.7520.98
85_M88_V0.7500.98
10_K121_G0.7460.98
234_R238_A0.7450.97
235_R251_L0.7430.97
165_R169_F0.7430.97
12_Y17_H0.7420.97
11_V30_I0.7370.97
147_V172_A0.7360.97
195_V276_A0.7340.97
41_R46_L0.7330.97
12_Y166_A0.7260.97
85_M89_D0.7260.97
251_L255_N0.7250.97
267_R270_D0.7210.97
178_R233_V0.7200.97
191_A300_A0.7170.97
224_D228_A0.7150.97
230_G234_R0.7100.97
5_S129_A0.7070.97
229_I258_L0.7060.97
44_S62_Y0.7060.97
252_M298_L0.7050.97
152_Y156_H0.7050.97
41_R47_R0.7040.96
247_T251_L0.7040.96
205_T216_R0.7040.96
161_G289_A0.7030.96
128_V147_V0.7030.96
253_D283_G0.6990.96
87_Y90_A0.6970.96
279_G307_A0.6970.96
271_A274_W0.6950.96
64_G67_D0.6950.96
12_Y287_T0.6900.96
34_A129_A0.6900.96
81_V85_M0.6900.96
126_V130_G0.6870.96
233_V237_E0.6840.96
228_A261_G0.6820.96
26_V237_E0.6820.96
279_G306_T0.6810.96
118_A198_Y0.6790.96
124_A161_G0.6770.96
169_F179_V0.6770.96
255_N258_L0.6730.95
87_Y91_A0.6730.95
228_A258_L0.6590.95
273_V295_I0.6550.95
28_C194_F0.6540.95
43_D105_G0.6490.94
224_D262_L0.6490.94
229_I262_L0.6410.94
192_L282_D0.6390.94
275_A310_L0.6390.94
23_E227_T0.6390.94
256_H286_L0.6380.94
95_A134_A0.6380.94
155_E164_S0.6370.94
251_L254_I0.6360.94
221_F225_T0.6360.94
13_L176_V0.6360.94
268_T271_A0.6350.94
19_V25_A0.6340.94
236_G240_L0.6340.94
39_S109_T0.6330.94
10_K25_A0.6320.94
288_G292_G0.6310.94
127_V151_A0.6310.94
29_A171_S0.6300.94
91_A94_Q0.6300.94
151_A172_A0.6240.93
206_G213_R0.6210.93
127_V163_A0.6210.93
274_W277_R0.6200.93
33_R114_I0.6200.93
276_A297_A0.6170.93
249_G252_M0.6160.93
149_D153_Q0.6150.93
152_Y165_R0.6150.93
132_D135_T0.6140.93
81_V86_G0.6140.93
236_G252_M0.6130.93
129_A133_A0.6120.93
121_G164_S0.6100.92
88_V126_V0.6100.92
256_H265_S0.6090.92
224_D227_T0.6080.92
148_A168_T0.6080.92
163_A168_T0.6080.92
235_R239_A0.6070.92
223_A226_V0.6070.92
276_A311_T0.6070.92
259_L269_L0.6060.92
271_A314_C0.6040.92
156_H162_E0.6020.92
19_V168_T0.6000.92
258_L261_G0.5980.92
12_Y25_A0.5970.92
124_A151_A0.5970.92
25_A164_S0.5910.91
14_F248_L0.5900.91
50_S55_I0.5900.91
199_D295_I0.5890.91
149_D152_Y0.5880.91
175_G186_T0.5860.91
8_P29_A0.5860.91
259_L289_A0.5860.91
130_G134_A0.5860.91
10_K167_D0.5850.91
132_D172_A0.5850.91
224_D261_G0.5830.91
10_K168_T0.5820.91
108_V133_A0.5800.91
12_Y19_V0.5800.91
127_V168_T0.5800.91
276_A295_I0.5790.90
90_A94_Q0.5780.90
89_D92_V0.5760.90
25_A165_R0.5760.90
276_A280_G0.5760.90
265_S269_L0.5750.90
195_V299_D0.5740.90
135_T138_L0.5710.90
232_L258_L0.5700.90
287_T296_V0.5690.90
188_D241_A0.5680.90
148_A166_A0.5680.90
196_I287_T0.5660.89
17_H166_A0.5650.89
249_G253_D0.5630.89
281_A307_A0.5620.89
135_T146_E0.5620.89
81_V84_A0.5600.89
224_D260_S0.5580.89
142_L146_E0.5570.89
18_A233_V0.5560.89
79_P83_A0.5560.89
12_Y164_S0.5550.89
266_G291_G0.5530.88
66_R158_V0.5530.88
80_I83_A0.5510.88
9_G34_A0.5510.88
18_A24_P0.5500.88
106_F138_L0.5500.88
97_A153_Q0.5480.88
304_A307_A0.5480.88
30_I120_L0.5460.88
275_A307_A0.5460.88
40_E138_L0.5430.87
99_A153_Q0.5410.87
10_K166_A0.5390.87
124_A289_A0.5380.87
307_A310_L0.5380.87
148_A169_F0.5370.87
12_Y121_G0.5340.87
281_A300_A0.5320.86
195_V308_L0.5310.86
49_C55_I0.5310.86
202_S205_T0.5300.86
80_I86_G0.5290.86
60_V65_D0.5290.86
79_P82_D0.5290.86
94_Q157_T0.5280.86
256_H259_L0.5260.86
228_A260_S0.5260.86
180_S234_R0.5250.86
34_A114_I0.5250.86
17_H259_L0.5240.86
88_V110_I0.5230.85
193_P302_S0.5230.85
29_A175_G0.5220.85
103_T138_L0.5220.85
227_T231_D0.5170.85
168_T293_G0.5170.85
184_C187_L0.5140.84
12_Y259_L0.5140.84
92_V96_R0.5130.84
270_D276_A0.5120.84
90_A93_E0.5110.84
264_V286_L0.5100.84
101_A142_L0.5100.84
159_Q163_A0.5090.84
206_G212_V0.5090.84
152_Y168_T0.5090.84
244_D250_R0.5080.84
148_A173_M0.5080.84
253_D273_V0.5080.84
16_E296_V0.5080.84
42_E104_A0.5080.84
123_S288_G0.5070.84
199_D269_L0.5060.84
226_V264_V0.5050.83
95_A150_R0.5030.83
131_I154_V0.5020.83
7_A128_V0.5020.83
154_V163_A0.5020.83
135_T144_A0.5010.83
11_V27_P0.5000.83
163_A166_A0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pieA 1 0.9636 100 0.282 Contact Map
2a2cA 1 0.9545 100 0.294 Contact Map
3v2uC 2 0.9667 100 0.304 Contact Map
4n3oA 2 0.9121 100 0.313 Contact Map
1kvkA 2 0.9667 100 0.316 Contact Map
1wuuA 2 0.9667 100 0.32 Contact Map
3k85A 3 0.8545 100 0.323 Contact Map
2cz9A 1 0.9273 100 0.324 Contact Map
4hacA 2 0.9091 100 0.327 Contact Map
1kkhA 1 0.9273 100 0.347 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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