GREMLIN Database
Q9HQI5 - Isopentenyl phosphate kinase
UniProt: Q9HQI5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 245 (240)
Sequences: 295 (237)
Seq/√Len: 15.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_A79_M5.9901.00
21_V26_L4.6681.00
95_V130_V3.9561.00
44_V150_G3.8451.00
173_P226_G3.6010.99
232_A237_D3.5830.99
18_P47_A3.4800.99
55_A147_I3.3360.99
148_L153_I2.8040.97
167_G225_F2.7090.96
167_G233_F2.7000.96
176_L182_V2.5600.95
137_I147_I2.5530.95
31_G93_A2.5330.94
32_A228_A2.5290.94
121_I133_L2.4750.94
176_L180_G2.4310.93
44_V151_D2.3200.91
27_A89_A2.2420.90
147_I205_T2.2070.89
4_V154_V2.1540.88
79_M151_D2.0110.84
97_A132_V1.9850.83
58_H71_A1.9840.83
158_A163_A1.9740.83
215_L222_A1.8640.79
75_I79_M1.7740.75
155_T214_A1.7530.74
55_A98_V1.6680.70
46_G136_D1.6490.70
101_H167_G1.6480.69
5_V100_V1.6160.68
154_V166_V1.5870.66
48_G52_H1.5860.66
79_M170_S1.5850.66
166_V218_L1.5190.63
6_K9_G1.5070.62
28_G32_A1.4940.62
7_L12_I1.4920.61
43_V56_A1.4770.61
234_V237_D1.4750.61
151_D154_V1.4670.60
166_V221_P1.4550.59
11_V230_I1.4500.59
121_I230_I1.4240.58
17_Q20_T1.4110.57
177_D180_G1.4060.57
225_F233_F1.4060.57
4_V151_D1.4060.57
163_A166_V1.3810.55
24_D187_T1.3590.54
49_S147_I1.3340.53
32_A226_G1.3260.52
102_P208_M1.3250.52
7_L18_P1.3210.52
168_L218_L1.3050.51
151_D170_S1.2950.51
12_I82_L1.2930.50
47_A151_D1.2890.50
123_T127_D1.2830.50
88_G164_D1.2830.50
101_H225_F1.2810.50
46_G52_H1.2790.50
71_A219_G1.2600.49
60_V146_T1.2600.49
7_L47_A1.2510.48
33_L41_L1.2500.48
5_V225_F1.2380.47
170_S212_V1.2250.47
51_G79_M1.2180.46
136_D151_D1.2180.46
63_T140_H1.2090.46
169_C222_A1.2030.45
12_I196_L1.1960.45
19_E78_T1.1920.45
48_G136_D1.1840.44
8_G15_K1.1800.44
9_G15_K1.1800.44
18_P79_M1.1790.44
150_G154_V1.1780.44
167_G180_G1.1690.43
53_P78_T1.1650.43
58_H121_I1.1600.43
170_S224_V1.1520.42
21_V85_A1.1520.42
87_V132_V1.1510.42
90_L97_A1.1420.42
80_E134_H1.1410.42
4_V150_G1.1390.42
102_P186_I1.1390.42
135_G149_S1.1340.41
92_D97_A1.1320.41
19_E81_A1.1320.41
108_R140_H1.1290.41
44_V154_V1.1270.41
60_V75_I1.1240.41
46_G151_D1.1010.40
28_G118_T1.1000.40
20_T86_V1.0980.39
9_G13_T1.0960.39
8_G13_T1.0960.39
221_P224_V1.0830.39
133_L150_G1.0820.39
47_A139_S1.0770.38
6_K15_K1.0750.38
168_L215_L1.0750.38
187_T190_S1.0700.38
183_I186_I1.0700.38
105_V232_A1.0630.38
112_G214_A1.0610.38
86_V159_R1.0600.37
79_M150_G1.0550.37
33_L237_D1.0410.36
49_S136_D1.0390.36
18_P53_P1.0360.36
87_V94_G1.0340.36
210_G215_L1.0310.36
32_A229_G1.0290.36
151_D174_G1.0160.35
101_H233_F1.0130.35
86_V125_L1.0110.35
104_S177_D1.0070.35
48_G135_G1.0000.34
30_A216_L0.9950.34
20_T184_P0.9850.34
105_V230_I0.9850.34
26_L85_A0.9810.33
14_E92_D0.9760.33
5_V167_G0.9760.33
78_T146_T0.9680.33
175_V225_F0.9540.32
39_D121_I0.9530.32
100_V124_L0.9460.32
58_H208_M0.9450.32
44_V220_S0.9310.31
46_G49_S0.9300.31
10_S76_A0.9200.30
143_A147_I0.9200.30
19_E43_V0.9150.30
56_A156_H0.9080.30
13_T20_T0.9050.30
27_A30_A0.9040.30
215_L225_F0.9010.29
217_A220_S0.8990.29
23_D85_A0.8950.29
212_V234_V0.8920.29
203_D206_G0.8870.29
103_A180_G0.8850.29
26_L31_G0.8830.29
101_H134_H0.8790.28
63_T147_I0.8710.28
208_M234_V0.8680.28
21_V159_R0.8680.28
112_G222_A0.8670.28
13_T82_L0.8640.28
69_A145_A0.8640.28
46_G135_G0.8630.28
6_K13_T0.8620.28
26_L172_V0.8580.27
48_G151_D0.8570.27
111_D140_H0.8530.27
151_D168_L0.8510.27
150_G174_G0.8500.27
105_V121_I0.8490.27
99_P169_C0.8470.27
46_G203_D0.8460.27
47_A53_P0.8460.27
76_A233_F0.8420.27
90_L95_V0.8360.26
134_H225_F0.8350.26
4_V96_A0.8350.26
44_V133_L0.8340.26
21_V93_A0.8160.26
186_I189_F0.8160.26
71_A75_I0.8100.25
118_T160_A0.8090.25
92_D144_G0.8080.25
21_V89_A0.7990.25
61_S181_T0.7960.25
136_D147_I0.7950.25
19_E53_P0.7910.25
52_H203_D0.7790.24
113_A140_H0.7750.24
136_D203_D0.7750.24
148_L232_A0.7740.24
49_S135_G0.7740.24
150_G170_S0.7680.24
80_E147_I0.7660.24
79_M240_G0.7660.24
26_L222_A0.7620.23
50_F207_G0.7610.23
104_S163_A0.7590.23
135_G203_D0.7530.23
4_V78_T0.7510.23
59_D62_A0.7500.23
48_G203_D0.7470.23
180_G242_R0.7460.23
151_D171_T0.7460.23
22_A87_V0.7450.23
180_G195_A0.7450.23
76_A179_D0.7450.23
47_A101_H0.7440.23
204_V207_G0.7410.23
163_A218_L0.7380.22
93_A212_V0.7380.22
55_A137_I0.7310.22
24_D94_G0.7300.22
21_V79_M0.7290.22
182_V225_F0.7260.22
58_H77_G0.7260.22
26_L209_A0.7250.22
231_E238_D0.7250.22
4_V163_A0.7240.22
76_A101_H0.7240.22
75_I134_H0.7230.22
28_G228_A0.7220.22
103_A182_V0.7220.22
45_H150_G0.7210.22
11_V242_R0.7200.22
119_G122_E0.7180.22
154_V163_A0.7170.22
152_E214_A0.7160.22
4_V153_I0.7140.21
183_I231_E0.7120.21
76_A103_A0.7110.21
18_P78_T0.7090.21
13_T128_G0.7060.21
157_L208_M0.7050.21
52_H136_D0.7040.21
36_G234_V0.7010.21
75_I78_T0.7000.21
89_A123_T0.6980.21
135_G151_D0.6980.21
26_L168_L0.6960.21
82_L135_G0.6960.21
94_G119_G0.6900.21
4_V133_L0.6850.20
45_H52_H0.6800.20
53_P202_T0.6750.20
136_D149_S0.6740.20
146_T224_V0.6730.20
161_V185_S0.6730.20
87_V120_A0.6720.20
72_I139_S0.6710.20
57_A219_G0.6680.20
22_A25_R0.6680.20
49_S82_L0.6650.20
128_G131_P0.6610.19
117_P171_T0.6590.19
86_V232_A0.6580.19
208_M240_G0.6580.19
42_V217_A0.6550.19
81_A84_T0.6540.19
229_G232_A0.6520.19
11_V227_P0.6510.19
48_G149_S0.6450.19
50_F212_V0.6450.19
50_F135_G0.6430.19
192_A235_A0.6420.19
149_S203_D0.6410.19
70_A74_D0.6410.19
11_V76_A0.6400.19
48_G82_L0.6400.19
69_A72_I0.6380.19
5_V95_V0.6380.19
137_I205_T0.6370.19
157_L163_A0.6350.19
33_L194_G0.6340.19
57_A96_A0.6330.19
19_E22_A0.6330.19
22_A60_V0.6320.18
55_A139_S0.6300.18
13_T219_G0.6290.18
98_V138_I0.6280.18
231_E235_A0.6270.18
97_A186_I0.6260.18
49_S52_H0.6240.18
212_V224_V0.6210.18
182_V185_S0.6200.18
138_I146_T0.6170.18
175_V216_L0.6160.18
158_A240_G0.6150.18
36_G147_I0.6150.18
113_A228_A0.6150.18
218_L222_A0.6100.18
86_V132_V0.6100.18
57_A223_Y0.6100.18
101_H104_S0.6080.18
78_T183_I0.6070.18
7_L26_L0.6030.18
79_M140_H0.6020.17
31_G34_A0.5990.17
24_D242_R0.5970.17
76_A100_V0.5920.17
99_P120_A0.5920.17
135_G147_I0.5910.17
122_E231_E0.5910.17
30_A90_L0.5910.17
98_V103_A0.5880.17
55_A226_G0.5880.17
110_A220_S0.5880.17
46_G150_G0.5860.17
75_I212_V0.5840.17
52_H82_L0.5830.17
80_E84_T0.5830.17
148_L213_R0.5810.17
169_C229_G0.5780.17
76_A167_G0.5700.16
180_G222_A0.5700.16
137_I148_L0.5670.16
28_G72_I0.5670.16
28_G113_A0.5650.16
11_V169_C0.5650.16
88_G198_G0.5640.16
16_D201_A0.5610.16
46_G82_L0.5610.16
177_D202_T0.5610.16
5_V33_L0.5590.16
126_D156_H0.5580.16
149_S205_T0.5550.16
71_A77_G0.5550.16
189_F195_A0.5530.16
52_H150_G0.5520.16
51_G207_G0.5510.16
120_A230_I0.5510.16
198_G202_T0.5510.16
71_A140_H0.5490.16
31_G35_D0.5490.16
29_L222_A0.5460.16
57_A105_V0.5460.16
176_L181_T0.5460.16
151_D203_D0.5430.16
46_G149_S0.5410.16
168_L205_T0.5380.15
74_D229_G0.5360.15
62_A242_R0.5330.15
19_E54_R0.5320.15
119_G130_V0.5320.15
45_H128_G0.5300.15
208_M214_A0.5300.15
169_C208_M0.5300.15
109_T142_G0.5270.15
63_T143_A0.5270.15
88_G106_A0.5200.15
167_G176_L0.5180.15
30_A43_V0.5170.15
150_G168_L0.5150.15
106_A165_R0.5140.15
43_V130_V0.5140.15
46_G50_F0.5110.15
34_A153_I0.5100.15
160_A185_S0.5090.15
24_D110_A0.5090.15
161_V174_G0.5090.15
84_T151_D0.5070.15
33_L88_G0.5070.15
183_I224_V0.5040.15
48_G150_G0.5020.14
136_D150_G0.5010.14
63_T144_G0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ll9A 2 0.9306 100 0.496 Contact Map
3k4oA 2 0.9837 100 0.496 Contact Map
3ll5A 2 0.9184 100 0.511 Contact Map
3d40A 2 0.8939 100 0.567 Contact Map
1gs5A 2 0.9429 100 0.589 Contact Map
3zzhA 3 0.9429 100 0.594 Contact Map
3wwnA 2 0.8939 100 0.6 Contact Map
2bufA 3 0.9306 100 0.603 Contact Map
2ap9A 3 0.9388 100 0.606 Contact Map
2akoA 2 0.898 100 0.607 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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