Q9HQI5 - HALSA - GREMLIN Contacts

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Q9HQI5 - Isopentenyl phosphate kinase

UniProt:	Q9HQI5	Sequences: MTVVVKLGGSVITEKDQPETVADDRLAGLAGALADGDIDDLVVVHGAGSFGHPRAAAHDVSATDGVQDAAAIRDIAGTMEALNTAVVGALADAGVAAVPVHPASVAHRTADGALEFPTGAIETLLDDGFVPVLHGDIISHAGAGATILSGDEIVTHLARAVDADRVGLCSTVPGVLDDDGTVIPSITAFSDAAGALGGSDATDVTGGMAGKVRALLALGSPAYVFGPAGIEAFVAGDDVGTRING	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	245 (240)
Sequences:	295 (237)
Seq/√Len:	15.3

HALSA - Q9HQI5
SULSO - Q7LY02

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
47_A	79_M	5.990	1.00
21_V	26_L	4.668	1.00
95_V	130_V	3.956	1.00
44_V	150_G	3.845	1.00
173_P	226_G	3.601	0.99
232_A	237_D	3.583	0.99
18_P	47_A	3.480	0.99
55_A	147_I	3.336	0.99
148_L	153_I	2.804	0.97
167_G	225_F	2.709	0.96
167_G	233_F	2.700	0.96
176_L	182_V	2.560	0.95
137_I	147_I	2.553	0.95
31_G	93_A	2.533	0.94
32_A	228_A	2.529	0.94
121_I	133_L	2.475	0.94
176_L	180_G	2.431	0.93
44_V	151_D	2.320	0.91
27_A	89_A	2.242	0.90
147_I	205_T	2.207	0.89
4_V	154_V	2.154	0.88
79_M	151_D	2.011	0.84
97_A	132_V	1.985	0.83
58_H	71_A	1.984	0.83
158_A	163_A	1.974	0.83
215_L	222_A	1.864	0.79
75_I	79_M	1.774	0.75
155_T	214_A	1.753	0.74
55_A	98_V	1.668	0.70
46_G	136_D	1.649	0.70
101_H	167_G	1.648	0.69
5_V	100_V	1.616	0.68
154_V	166_V	1.587	0.66
48_G	52_H	1.586	0.66
79_M	170_S	1.585	0.66
166_V	218_L	1.519	0.63
6_K	9_G	1.507	0.62
28_G	32_A	1.494	0.62
7_L	12_I	1.492	0.61
43_V	56_A	1.477	0.61
234_V	237_D	1.475	0.61
151_D	154_V	1.467	0.60
166_V	221_P	1.455	0.59
11_V	230_I	1.450	0.59
121_I	230_I	1.424	0.58
17_Q	20_T	1.411	0.57
177_D	180_G	1.406	0.57
225_F	233_F	1.406	0.57
4_V	151_D	1.406	0.57
163_A	166_V	1.381	0.55
24_D	187_T	1.359	0.54
49_S	147_I	1.334	0.53
32_A	226_G	1.326	0.52
102_P	208_M	1.325	0.52
7_L	18_P	1.321	0.52
168_L	218_L	1.305	0.51
151_D	170_S	1.295	0.51
12_I	82_L	1.293	0.50
47_A	151_D	1.289	0.50
123_T	127_D	1.283	0.50
88_G	164_D	1.283	0.50
101_H	225_F	1.281	0.50
46_G	52_H	1.279	0.50
71_A	219_G	1.260	0.49
60_V	146_T	1.260	0.49
7_L	47_A	1.251	0.48
33_L	41_L	1.250	0.48
5_V	225_F	1.238	0.47
170_S	212_V	1.225	0.47
51_G	79_M	1.218	0.46
136_D	151_D	1.218	0.46
63_T	140_H	1.209	0.46
169_C	222_A	1.203	0.45
12_I	196_L	1.196	0.45
19_E	78_T	1.192	0.45
48_G	136_D	1.184	0.44
8_G	15_K	1.180	0.44
9_G	15_K	1.180	0.44
18_P	79_M	1.179	0.44
150_G	154_V	1.178	0.44
167_G	180_G	1.169	0.43
53_P	78_T	1.165	0.43
58_H	121_I	1.160	0.43
170_S	224_V	1.152	0.42
21_V	85_A	1.152	0.42
87_V	132_V	1.151	0.42
90_L	97_A	1.142	0.42
80_E	134_H	1.141	0.42
4_V	150_G	1.139	0.42
102_P	186_I	1.139	0.42
135_G	149_S	1.134	0.41
92_D	97_A	1.132	0.41
19_E	81_A	1.132	0.41
108_R	140_H	1.129	0.41
44_V	154_V	1.127	0.41
60_V	75_I	1.124	0.41
46_G	151_D	1.101	0.40
28_G	118_T	1.100	0.40
20_T	86_V	1.098	0.39
9_G	13_T	1.096	0.39
8_G	13_T	1.096	0.39
221_P	224_V	1.083	0.39
133_L	150_G	1.082	0.39
47_A	139_S	1.077	0.38
6_K	15_K	1.075	0.38
168_L	215_L	1.075	0.38
187_T	190_S	1.070	0.38
183_I	186_I	1.070	0.38
105_V	232_A	1.063	0.38
112_G	214_A	1.061	0.38
86_V	159_R	1.060	0.37
79_M	150_G	1.055	0.37
33_L	237_D	1.041	0.36
49_S	136_D	1.039	0.36
18_P	53_P	1.036	0.36
87_V	94_G	1.034	0.36
210_G	215_L	1.031	0.36
32_A	229_G	1.029	0.36
151_D	174_G	1.016	0.35
101_H	233_F	1.013	0.35
86_V	125_L	1.011	0.35
104_S	177_D	1.007	0.35
48_G	135_G	1.000	0.34
30_A	216_L	0.995	0.34
20_T	184_P	0.985	0.34
105_V	230_I	0.985	0.34
26_L	85_A	0.981	0.33
14_E	92_D	0.976	0.33
5_V	167_G	0.976	0.33
78_T	146_T	0.968	0.33
175_V	225_F	0.954	0.32
39_D	121_I	0.953	0.32
100_V	124_L	0.946	0.32
58_H	208_M	0.945	0.32
44_V	220_S	0.931	0.31
46_G	49_S	0.930	0.31
10_S	76_A	0.920	0.30
143_A	147_I	0.920	0.30
19_E	43_V	0.915	0.30
56_A	156_H	0.908	0.30
13_T	20_T	0.905	0.30
27_A	30_A	0.904	0.30
215_L	225_F	0.901	0.29
217_A	220_S	0.899	0.29
23_D	85_A	0.895	0.29
212_V	234_V	0.892	0.29
203_D	206_G	0.887	0.29
103_A	180_G	0.885	0.29
26_L	31_G	0.883	0.29
101_H	134_H	0.879	0.28
63_T	147_I	0.871	0.28
208_M	234_V	0.868	0.28
21_V	159_R	0.868	0.28
112_G	222_A	0.867	0.28
13_T	82_L	0.864	0.28
69_A	145_A	0.864	0.28
46_G	135_G	0.863	0.28
6_K	13_T	0.862	0.28
26_L	172_V	0.858	0.27
48_G	151_D	0.857	0.27
111_D	140_H	0.853	0.27
151_D	168_L	0.851	0.27
150_G	174_G	0.850	0.27
105_V	121_I	0.849	0.27
99_P	169_C	0.847	0.27
46_G	203_D	0.846	0.27
47_A	53_P	0.846	0.27
76_A	233_F	0.842	0.27
90_L	95_V	0.836	0.26
134_H	225_F	0.835	0.26
4_V	96_A	0.835	0.26
44_V	133_L	0.834	0.26
21_V	93_A	0.816	0.26
186_I	189_F	0.816	0.26
71_A	75_I	0.810	0.25
118_T	160_A	0.809	0.25
92_D	144_G	0.808	0.25
21_V	89_A	0.799	0.25
61_S	181_T	0.796	0.25
136_D	147_I	0.795	0.25
19_E	53_P	0.791	0.25
52_H	203_D	0.779	0.24
113_A	140_H	0.775	0.24
136_D	203_D	0.775	0.24
148_L	232_A	0.774	0.24
49_S	135_G	0.774	0.24
150_G	170_S	0.768	0.24
80_E	147_I	0.766	0.24
79_M	240_G	0.766	0.24
26_L	222_A	0.762	0.23
50_F	207_G	0.761	0.23
104_S	163_A	0.759	0.23
135_G	203_D	0.753	0.23
4_V	78_T	0.751	0.23
59_D	62_A	0.750	0.23
48_G	203_D	0.747	0.23
180_G	242_R	0.746	0.23
151_D	171_T	0.746	0.23
22_A	87_V	0.745	0.23
180_G	195_A	0.745	0.23
76_A	179_D	0.745	0.23
47_A	101_H	0.744	0.23
204_V	207_G	0.741	0.23
163_A	218_L	0.738	0.22
93_A	212_V	0.738	0.22
55_A	137_I	0.731	0.22
24_D	94_G	0.730	0.22
21_V	79_M	0.729	0.22
182_V	225_F	0.726	0.22
58_H	77_G	0.726	0.22
26_L	209_A	0.725	0.22
231_E	238_D	0.725	0.22
4_V	163_A	0.724	0.22
76_A	101_H	0.724	0.22
75_I	134_H	0.723	0.22
28_G	228_A	0.722	0.22
103_A	182_V	0.722	0.22
45_H	150_G	0.721	0.22
11_V	242_R	0.720	0.22
119_G	122_E	0.718	0.22
154_V	163_A	0.717	0.22
152_E	214_A	0.716	0.22
4_V	153_I	0.714	0.21
183_I	231_E	0.712	0.21
76_A	103_A	0.711	0.21
18_P	78_T	0.709	0.21
13_T	128_G	0.706	0.21
157_L	208_M	0.705	0.21
52_H	136_D	0.704	0.21
36_G	234_V	0.701	0.21
75_I	78_T	0.700	0.21
89_A	123_T	0.698	0.21
135_G	151_D	0.698	0.21
26_L	168_L	0.696	0.21
82_L	135_G	0.696	0.21
94_G	119_G	0.690	0.21
4_V	133_L	0.685	0.20
45_H	52_H	0.680	0.20
53_P	202_T	0.675	0.20
136_D	149_S	0.674	0.20
146_T	224_V	0.673	0.20
161_V	185_S	0.673	0.20
87_V	120_A	0.672	0.20
72_I	139_S	0.671	0.20
57_A	219_G	0.668	0.20
22_A	25_R	0.668	0.20
49_S	82_L	0.665	0.20
128_G	131_P	0.661	0.19
117_P	171_T	0.659	0.19
86_V	232_A	0.658	0.19
208_M	240_G	0.658	0.19
42_V	217_A	0.655	0.19
81_A	84_T	0.654	0.19
229_G	232_A	0.652	0.19
11_V	227_P	0.651	0.19
48_G	149_S	0.645	0.19
50_F	212_V	0.645	0.19
50_F	135_G	0.643	0.19
192_A	235_A	0.642	0.19
149_S	203_D	0.641	0.19
70_A	74_D	0.641	0.19
11_V	76_A	0.640	0.19
48_G	82_L	0.640	0.19
69_A	72_I	0.638	0.19
5_V	95_V	0.638	0.19
137_I	205_T	0.637	0.19
157_L	163_A	0.635	0.19
33_L	194_G	0.634	0.19
57_A	96_A	0.633	0.19
19_E	22_A	0.633	0.19
22_A	60_V	0.632	0.18
55_A	139_S	0.630	0.18
13_T	219_G	0.629	0.18
98_V	138_I	0.628	0.18
231_E	235_A	0.627	0.18
97_A	186_I	0.626	0.18
49_S	52_H	0.624	0.18
212_V	224_V	0.621	0.18
182_V	185_S	0.620	0.18
138_I	146_T	0.617	0.18
175_V	216_L	0.616	0.18
158_A	240_G	0.615	0.18
36_G	147_I	0.615	0.18
113_A	228_A	0.615	0.18
218_L	222_A	0.610	0.18
86_V	132_V	0.610	0.18
57_A	223_Y	0.610	0.18
101_H	104_S	0.608	0.18
78_T	183_I	0.607	0.18
7_L	26_L	0.603	0.18
79_M	140_H	0.602	0.17
31_G	34_A	0.599	0.17
24_D	242_R	0.597	0.17
76_A	100_V	0.592	0.17
99_P	120_A	0.592	0.17
135_G	147_I	0.591	0.17
122_E	231_E	0.591	0.17
30_A	90_L	0.591	0.17
98_V	103_A	0.588	0.17
55_A	226_G	0.588	0.17
110_A	220_S	0.588	0.17
46_G	150_G	0.586	0.17
75_I	212_V	0.584	0.17
52_H	82_L	0.583	0.17
80_E	84_T	0.583	0.17
148_L	213_R	0.581	0.17
169_C	229_G	0.578	0.17
76_A	167_G	0.570	0.16
180_G	222_A	0.570	0.16
137_I	148_L	0.567	0.16
28_G	72_I	0.567	0.16
28_G	113_A	0.565	0.16
11_V	169_C	0.565	0.16
88_G	198_G	0.564	0.16
16_D	201_A	0.561	0.16
46_G	82_L	0.561	0.16
177_D	202_T	0.561	0.16
5_V	33_L	0.559	0.16
126_D	156_H	0.558	0.16
149_S	205_T	0.555	0.16
71_A	77_G	0.555	0.16
189_F	195_A	0.553	0.16
52_H	150_G	0.552	0.16
51_G	207_G	0.551	0.16
120_A	230_I	0.551	0.16
198_G	202_T	0.551	0.16
71_A	140_H	0.549	0.16
31_G	35_D	0.549	0.16
29_L	222_A	0.546	0.16
57_A	105_V	0.546	0.16
176_L	181_T	0.546	0.16
151_D	203_D	0.543	0.16
46_G	149_S	0.541	0.16
168_L	205_T	0.538	0.15
74_D	229_G	0.536	0.15
62_A	242_R	0.533	0.15
19_E	54_R	0.532	0.15
119_G	130_V	0.532	0.15
45_H	128_G	0.530	0.15
208_M	214_A	0.530	0.15
169_C	208_M	0.530	0.15
109_T	142_G	0.527	0.15
63_T	143_A	0.527	0.15
88_G	106_A	0.520	0.15
167_G	176_L	0.518	0.15
30_A	43_V	0.517	0.15
150_G	168_L	0.515	0.15
106_A	165_R	0.514	0.15
43_V	130_V	0.514	0.15
46_G	50_F	0.511	0.15
34_A	153_I	0.510	0.15
160_A	185_S	0.509	0.15
24_D	110_A	0.509	0.15
161_V	174_G	0.509	0.15
84_T	151_D	0.507	0.15
33_L	88_G	0.507	0.15
183_I	224_V	0.504	0.15
48_G	150_G	0.502	0.14
136_D	150_G	0.501	0.14
63_T	144_G	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ll9A	2	0.9306	100	0.496	Contact Map
3k4oA	2	0.9837	100	0.496	Contact Map
3ll5A	2	0.9184	100	0.511	Contact Map
3d40A	2	0.8939	100	0.567	Contact Map
1gs5A	2	0.9429	100	0.589	Contact Map
3zzhA	3	0.9429	100	0.594	Contact Map
3wwnA	2	0.8939	100	0.6	Contact Map
2bufA	3	0.9306	100	0.603	Contact Map
2ap9A	3	0.9388	100	0.606	Contact Map
2akoA	2	0.898	100	0.607	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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