GREMLIN Database
Q9HQH9 - tRNA(Met) cytidine acetyltransferase TmcA
UniProt: Q9HQH9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 768 (693)
Sequences: 719 (483)
Seq/√Len: 18.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
573_V610_M7.7261.00
561_R612_D7.6971.00
231_L257_V7.5291.00
488_S543_T6.2441.00
480_L552_L6.0221.00
517_I572_G5.0161.00
715_G726_L4.7831.00
557_L590_Y4.6011.00
538_V557_L4.5601.00
112_C117_L4.3381.00
554_S588_N4.1161.00
557_L588_N4.0401.00
256_S288_R3.7891.00
75_T78_A3.7751.00
494_R536_Y3.7721.00
274_V285_L3.6781.00
282_T285_L3.3421.00
535_G570_W3.3071.00
576_G581_L3.2991.00
517_I609_I3.1790.99
164_R438_A3.1530.99
262_A333_F3.0800.99
102_R125_D2.9780.99
561_R590_Y2.9460.99
368_R576_G2.9360.99
289_A314_I2.9330.99
576_G605_E2.9220.99
434_A476_T2.8900.99
593_V611_L2.8370.98
592_T608_A2.8090.98
230_A246_A2.7410.98
334_A356_F2.6870.98
721_R729_D2.6820.98
633_I652_A2.6570.98
277_P339_A2.6400.97
490_A556_L2.6270.97
454_L489_V2.6220.97
260_L292_L2.6200.97
117_L406_A2.5810.97
413_G448_R2.5560.97
516_M574_G2.5440.97
332_V348_L2.5350.97
239_D242_H2.5300.97
450_A469_L2.4900.96
628_W671_T2.4830.96
545_P548_R2.4740.96
44_R51_G2.4080.96
168_R444_E2.3970.96
115_N464_N2.3150.95
433_V481_V2.2950.94
591_S626_A2.2890.94
712_L730_L2.2880.94
44_R49_L2.2570.94
50_A486_V2.2510.94
276_A316_F2.2330.93
450_A477_M2.2260.93
726_L738_A2.2190.93
93_A119_R2.1570.92
450_A489_V2.1330.92
392_D398_G2.1240.92
449_E485_H2.1160.91
450_A486_V2.1000.91
345_L374_F2.0750.91
51_G56_G2.0100.89
527_D625_H2.0020.89
100_T126_G1.9790.88
520_V609_I1.9700.88
356_F374_F1.9680.88
262_A285_L1.9520.88
569_D615_S1.9520.88
245_V375_R1.9440.87
414_A452_G1.9340.87
637_L649_A1.9250.87
112_C449_E1.9160.87
430_A552_L1.8910.86
435_L479_A1.8870.86
246_A388_T1.8740.85
49_L131_V1.8490.84
521_L593_V1.8400.84
243_A383_Q1.8320.84
92_N281_N1.8320.84
475_L491_L1.8250.84
458_H540_R1.8240.84
52_D184_V1.8090.83
489_V607_S1.7850.82
166_R247_D1.7810.82
47_L131_V1.7710.82
222_C231_L1.7530.81
455_V592_T1.7410.81
637_L721_R1.7390.81
113_R464_N1.7370.80
145_G467_A1.7360.80
132_V358_T1.7350.80
340_I713_L1.7290.80
440_L444_E1.7170.80
520_V594_H1.6990.79
480_L488_S1.6720.78
55_A184_V1.6700.78
358_T370_F1.6660.78
34_L37_E1.6650.77
715_G729_D1.6570.77
43_E49_L1.6530.77
231_L260_L1.6480.77
561_R571_L1.6460.77
33_A393_P1.6430.77
234_F244_V1.6330.76
155_P474_N1.6280.76
595_L684_V1.6200.75
74_T78_A1.6130.75
715_G721_R1.6130.75
404_P742_L1.6050.75
231_L698_V1.6040.75
109_H553_G1.6000.75
631_D668_D1.5890.74
583_S587_A1.5860.74
376_D380_D1.5620.73
112_C472_A1.5580.73
168_R243_A1.5540.72
633_I641_L1.5340.71
107_D460_R1.5330.71
256_S284_E1.5140.70
258_A357_T1.5110.70
277_P340_I1.5080.70
368_R581_L1.5080.70
453_L516_M1.5020.70
490_A560_L1.4930.69
35_L44_R1.4880.69
510_Q596_S1.4790.68
682_Y723_W1.4780.68
215_P234_F1.4780.68
397_A401_P1.4760.68
569_D679_P1.4750.68
488_S556_L1.4710.68
244_V553_G1.4670.68
378_L400_D1.4660.68
106_I126_G1.4650.68
237_L244_V1.4640.68
460_R600_N1.4540.67
233_S386_H1.4480.67
276_A360_V1.4460.67
717_L742_L1.4450.67
261_A331_A1.4450.67
234_F242_H1.4380.66
327_G332_V1.4300.66
549_S580_A1.4250.65
368_R374_F1.4220.65
342_V374_F1.4170.65
50_A59_T1.4150.65
453_L548_R1.4140.65
53_R57_V1.4130.65
460_R535_G1.4130.65
332_V354_L1.4110.65
121_V406_A1.4100.65
488_S694_V1.4050.64
435_L450_A1.4010.64
131_V388_T1.3990.64
629_F633_I1.3870.63
274_V286_F1.3840.63
478_R563_E1.3830.63
734_S743_G1.3820.63
554_S587_A1.3820.63
473_P551_G1.3810.63
76_L79_T1.3710.62
118_G410_L1.3640.62
244_V402_I1.3640.62
234_F246_A1.3620.62
131_V557_L1.3530.61
709_E712_L1.3430.61
399_T538_V1.3310.60
48_V51_G1.3290.60
447_L470_L1.3240.60
135_P140_W1.3230.60
713_L738_A1.3170.59
169_L385_V1.3160.59
486_V655_A1.3160.59
581_L605_E1.3090.59
507_Y570_W1.3060.59
535_G548_R1.3050.58
446_L486_V1.3000.58
616_D619_R1.2990.58
364_E395_R1.2850.57
535_G572_G1.2850.57
400_D447_L1.2820.57
50_A73_E1.2790.57
682_Y716_A1.2790.57
244_V331_A1.2720.56
469_L677_H1.2680.56
258_A272_V1.2670.56
282_T731_G1.2640.56
401_P412_L1.2640.56
38_A43_E1.2610.56
575_Y674_G1.2600.56
274_V544_H1.2600.56
333_F469_L1.2530.55
165_F472_A1.2430.55
369_G374_F1.2410.55
402_I691_R1.2400.54
50_A58_R1.2350.54
570_W710_Q1.2350.54
364_E458_H1.2330.54
395_R458_H1.2330.54
168_R172_T1.2300.54
674_G684_V1.2270.54
519_D596_S1.2230.53
121_V246_A1.2170.53
246_A477_M1.2160.53
620_A695_H1.2150.53
364_E540_R1.2100.53
395_R540_R1.2100.53
393_P626_A1.2090.53
488_S615_S1.2070.52
122_G461_T1.2010.52
365_G395_R1.1910.51
331_A355_A1.1880.51
51_G55_A1.1800.51
272_V738_A1.1740.50
379_A387_E1.1730.50
257_V444_E1.1720.50
548_R553_G1.1700.50
716_A723_W1.1630.50
349_L565_N1.1620.50
57_V486_V1.1610.50
50_A56_G1.1560.49
434_A478_R1.1540.49
286_F469_L1.1530.49
183_D187_D1.1530.49
276_A485_H1.1450.49
226_D391_T1.1440.49
664_L668_D1.1440.49
602_T610_M1.1390.48
45_R48_V1.1380.48
594_H600_N1.1350.48
365_G458_H1.1330.48
277_P524_Q1.1320.48
440_L447_L1.1280.48
613_A622_H1.1280.48
101_Q553_G1.1270.47
493_A539_L1.1250.47
134_A140_W1.1220.47
469_L522_T1.1150.47
365_G540_R1.1130.47
565_N617_A1.1100.46
40_R44_R1.1090.46
105_V199_P1.1080.46
358_T750_V1.1060.46
467_A512_V1.1060.46
435_L440_L1.1050.46
141_P170_A1.1050.46
145_G530_A1.1020.46
40_R43_E1.1010.46
109_H133_L1.0990.46
487_A552_L1.0970.46
562_A567_H1.0930.45
600_N605_E1.0920.45
38_A489_V1.0900.45
358_T728_D1.0890.45
134_A166_R1.0830.45
524_Q598_T1.0830.45
133_L354_L1.0810.45
571_L575_Y1.0800.45
648_V685_D1.0780.44
425_A430_A1.0760.44
369_G603_S1.0710.44
140_W373_R1.0700.44
137_L170_A1.0700.44
334_A547_V1.0690.44
501_D598_T1.0680.44
345_L603_S1.0660.44
575_Y652_A1.0620.43
596_S601_D1.0600.43
598_T726_L1.0570.43
499_A502_R1.0550.43
404_P408_R1.0540.43
607_S727_A1.0540.43
460_R602_T1.0530.43
596_S600_N1.0530.43
129_L379_A1.0530.43
524_Q594_H1.0530.43
197_P202_P1.0510.43
122_G491_L1.0510.43
234_F355_A1.0450.42
135_P369_G1.0450.42
316_F322_A1.0440.42
496_G518_P1.0440.42
234_F239_D1.0430.42
318_K321_A1.0430.42
111_D596_S1.0410.42
258_A262_A1.0400.42
671_T687_R1.0400.42
63_L69_I1.0400.42
332_V512_V1.0380.42
102_R128_G1.0380.42
146_A151_L1.0360.42
712_L741_A1.0330.42
411_L606_Y1.0320.42
59_T63_L1.0320.42
60_A260_L1.0300.42
282_T286_F1.0290.41
164_R437_G1.0290.41
465_D496_G1.0260.41
112_C506_M1.0240.41
645_D664_L1.0240.41
38_A126_G1.0230.41
436_S439_D1.0230.41
262_A356_F1.0210.41
646_A729_D1.0200.41
455_V641_L1.0180.41
272_V554_S1.0180.41
472_A533_T1.0160.41
169_L334_A1.0150.41
346_E685_D1.0130.41
96_L328_D1.0120.40
606_Y641_L1.0120.40
664_L692_L1.0080.40
682_Y686_P1.0040.40
346_E377_R1.0030.40
256_S570_W1.0020.40
242_H353_R0.9970.40
238_R241_G0.9940.39
689_F742_L0.9930.39
524_Q564_F0.9920.39
152_A155_P0.9910.39
399_T404_P0.9910.39
547_V550_R0.9840.39
243_A385_V0.9840.39
555_R559_E0.9830.39
317_S538_V0.9770.38
112_C357_T0.9760.38
405_W409_A0.9750.38
461_T491_L0.9750.38
340_I456_S0.9730.38
616_D620_A0.9730.38
112_C256_S0.9720.38
244_V388_T0.9700.38
56_G60_A0.9700.38
394_I455_V0.9690.38
526_R596_S0.9660.38
145_G521_L0.9630.38
414_A455_V0.9630.38
69_I73_E0.9620.37
581_L629_F0.9610.37
290_G294_A0.9600.37
45_R51_G0.9600.37
98_G364_E0.9580.37
98_G395_R0.9580.37
238_R242_H0.9510.37
250_R363_Y0.9490.37
363_Y459_Y0.9490.37
363_Y537_R0.9490.37
440_L470_L0.9490.37
224_T469_L0.9480.37
498_L610_M0.9460.37
412_L582_L0.9420.36
88_V271_D0.9390.36
81_D84_A0.9380.36
582_L588_N0.9330.36
75_T79_T0.9330.36
475_L602_T0.9320.36
345_L369_G0.9320.36
222_C392_D0.9310.36
354_L435_L0.9300.36
412_L629_F0.9260.35
157_D567_H0.9250.35
34_L649_A0.9240.35
177_P567_H0.9240.35
570_W705_L0.9210.35
182_Y645_D0.9200.35
520_V524_Q0.9200.35
38_A462_E0.9200.35
520_V596_S0.9190.35
733_H740_R0.9170.35
262_A556_L0.9170.35
250_R459_Y0.9150.35
250_R537_R0.9150.35
459_Y537_R0.9150.35
131_V721_R0.9120.35
177_P562_A0.9120.35
293_L310_A0.9120.35
275_T278_R0.9110.35
100_T320_P0.9080.34
564_F567_H0.9080.34
672_V739_M0.9040.34
106_I594_H0.9030.34
615_S618_G0.9030.34
510_Q519_D0.9020.34
136_P633_I0.9010.34
511_R596_S0.9010.34
98_G458_H0.9000.34
150_G166_R0.8970.34
257_V261_A0.8970.34
665_S746_L0.8960.34
62_T73_E0.8950.34
468_R480_L0.8940.34
38_A42_N0.8940.34
423_A550_R0.8930.34
427_P430_A0.8920.34
257_V451_F0.8910.33
245_V262_A0.8900.33
39_E462_E0.8890.33
238_R243_A0.8890.33
262_A374_F0.8890.33
393_P656_C0.8860.33
342_V607_S0.8840.33
269_G595_L0.8840.33
518_P539_L0.8840.33
595_L685_D0.8840.33
432_Y478_R0.8820.33
517_I535_G0.8820.33
201_L204_P0.8800.33
161_V593_V0.8800.33
98_G540_R0.8770.33
749_L754_G0.8770.33
458_H514_G0.8740.33
326_P329_P0.8740.33
33_A185_D0.8720.32
343_R366_A0.8720.32
258_A515_N0.8700.32
182_Y293_L0.8700.32
665_S689_F0.8690.32
722_P731_G0.8680.32
224_T447_L0.8620.32
468_R472_A0.8620.32
285_L634_G0.8610.32
356_F470_L0.8600.32
351_C460_R0.8590.32
463_P604_G0.8580.32
166_R373_R0.8550.31
552_L612_D0.8550.31
388_T559_E0.8540.31
392_D555_R0.8530.31
510_Q549_S0.8530.31
332_V503_R0.8520.31
340_I614_L0.8520.31
98_G365_G0.8510.31
329_P538_V0.8500.31
671_T675_A0.8500.31
347_S500_D0.8490.31
160_D163_G0.8490.31
316_F493_A0.8490.31
139_E143_R0.8480.31
243_A515_N0.8460.31
520_V523_S0.8460.31
202_P595_L0.8460.31
514_G540_R0.8450.31
233_S314_I0.8430.31
479_A486_V0.8400.31
383_Q596_S0.8390.31
182_Y185_D0.8390.31
33_A61_D0.8370.31
238_R407_F0.8360.30
552_L672_V0.8340.30
511_R516_M0.8340.30
665_S712_L0.8340.30
122_G369_G0.8320.30
274_V360_V0.8300.30
228_A390_L0.8300.30
38_A45_R0.8290.30
363_Y395_R0.8290.30
283_T725_G0.8280.30
564_F571_L0.8280.30
315_R578_T0.8270.30
476_T494_R0.8270.30
414_A637_L0.8270.30
271_D315_R0.8270.30
297_G521_L0.8240.30
235_A664_L0.8230.30
114_P452_G0.8230.30
454_L602_T0.8200.30
234_F331_A0.8200.30
333_F503_R0.8190.30
354_L589_G0.8170.29
133_L581_L0.8170.29
391_T558_G0.8160.29
451_F603_S0.8150.29
112_C397_A0.8140.29
248_A571_L0.8130.29
548_R674_G0.8120.29
316_F451_F0.8120.29
117_L354_L0.8110.29
159_A388_T0.8100.29
499_A643_D0.8090.29
263_A333_F0.8070.29
607_S665_S0.8060.29
457_A693_A0.8060.29
363_Y540_R0.8040.29
597_T683_S0.8040.29
448_R478_R0.8040.29
286_F349_L0.8030.29
114_P730_L0.8030.29
132_V194_R0.8020.29
536_Y564_F0.8020.29
404_P660_P0.7990.29
250_R364_E0.7980.29
250_R395_R0.7980.29
364_E459_Y0.7980.29
364_E537_R0.7980.29
395_R459_Y0.7980.29
395_R537_R0.7980.29
266_A497_G0.7970.28
401_P613_A0.7970.28
60_A283_T0.7950.28
177_P614_L0.7950.28
652_A707_P0.7940.28
99_T278_R0.7940.28
200_R501_D0.7940.28
492_L536_Y0.7910.28
282_T578_T0.7910.28
91_R646_A0.7900.28
516_M596_S0.7890.28
363_Y458_H0.7880.28
222_C393_P0.7880.28
483_D541_I0.7860.28
472_A576_G0.7860.28
168_R572_G0.7850.28
448_R648_V0.7840.28
105_V506_M0.7840.28
661_S707_P0.7810.28
177_P616_D0.7810.28
46_M49_L0.7790.28
497_G661_S0.7780.28
692_L753_H0.7770.27
388_T413_G0.7770.27
250_R540_R0.7770.27
459_Y540_R0.7770.27
537_R540_R0.7770.27
234_F674_G0.7770.27
129_L509_G0.7740.27
404_P722_P0.7740.27
498_L531_A0.7730.27
486_V580_A0.7730.27
525_L530_A0.7720.27
503_R528_E0.7720.27
333_F372_V0.7700.27
114_P539_L0.7680.27
396_Y461_T0.7670.27
554_S557_L0.7660.27
35_L39_E0.7660.27
282_T409_A0.7660.27
319_P584_F0.7650.27
104_V237_L0.7640.27
37_E57_V0.7630.27
252_R403_E0.7630.27
250_R458_H0.7630.27
458_H537_R0.7630.27
453_L457_A0.7630.27
234_F237_L0.7630.27
446_L481_V0.7620.27
469_L477_M0.7610.27
451_F460_R0.7590.27
413_G487_A0.7580.27
415_R448_R0.7570.26
512_V523_S0.7570.26
316_F454_L0.7550.26
509_G512_V0.7540.26
277_P360_V0.7530.26
332_V613_A0.7530.26
52_D55_A0.7520.26
262_A316_F0.7520.26
396_Y596_S0.7500.26
416_P662_L0.7500.26
544_H548_R0.7500.26
320_P393_P0.7490.26
115_N412_L0.7490.26
50_A55_A0.7480.26
364_E465_D0.7470.26
395_R465_D0.7470.26
60_A173_M0.7470.26
450_A553_G0.7460.26
280_R387_E0.7460.26
469_L503_R0.7460.26
556_L744_D0.7450.26
174_R215_P0.7440.26
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124_V603_S0.5660.18
516_M540_R0.5650.18
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535_G625_H0.5610.18
164_R471_D0.5600.18
519_D594_H0.5600.18
562_A623_D0.5600.18
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429_T731_G0.5500.18
103_A120_V0.5500.18
489_V682_Y0.5500.18
161_V595_L0.5500.18
461_T530_A0.5490.18
658_T752_A0.5490.18
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337_A365_G0.5480.18
340_I533_T0.5480.18
152_A373_R0.5470.18
639_D682_Y0.5460.18
226_D518_P0.5460.18
686_P742_L0.5460.18
361_H412_L0.5460.18
271_D350_D0.5450.18
699_A746_L0.5450.18
539_L572_G0.5450.18
177_P225_P0.5440.18
364_E496_G0.5430.17
395_R496_G0.5430.17
223_V256_S0.5420.17
440_L641_L0.5420.17
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143_R515_N0.5410.17
244_V450_A0.5390.17
66_D546_A0.5390.17
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432_Y480_L0.5370.17
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380_D575_Y0.5300.17
475_L535_G0.5290.17
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213_D388_T0.5280.17
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340_I350_D0.5250.17
665_S725_G0.5250.17
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480_L557_L0.5250.17
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65_D80_Q0.5180.17
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180_A408_R0.5170.17
134_A410_L0.5170.17
89_P92_N0.5170.17
69_I195_T0.5170.17
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286_F452_G0.5160.17
114_P128_G0.5150.16
244_V577_A0.5150.16
299_L521_L0.5150.16
369_G608_A0.5150.16
48_V106_I0.5140.16
414_A599_R0.5140.16
414_A528_E0.5140.16
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444_E681_M0.5130.16
516_M519_D0.5120.16
293_L382_T0.5120.16
460_R594_H0.5120.16
552_L662_L0.5120.16
39_E565_N0.5120.16
406_A550_R0.5110.16
476_T492_L0.5100.16
130_L461_T0.5100.16
251_G359_T0.5100.16
253_G359_T0.5100.16
254_K359_T0.5100.16
518_P569_D0.5100.16
56_G622_H0.5090.16
332_V451_F0.5090.16
467_A594_H0.5090.16
246_A555_R0.5080.16
62_T712_L0.5080.16
419_E422_V0.5080.16
224_T400_D0.5070.16
230_A683_S0.5070.16
116_A346_E0.5060.16
260_L450_A0.5060.16
36_A105_V0.5050.16
115_N349_L0.5050.16
134_A633_I0.5050.16
165_F511_R0.5050.16
517_I538_V0.5040.16
369_G383_Q0.5040.16
608_A688_P0.5040.16
53_R56_G0.5040.16
528_E626_A0.5030.16
273_L326_P0.5030.16
34_L264_C0.5030.16
234_F238_R0.5020.16
239_D243_A0.5020.16
268_E299_L0.5020.16
251_G254_K0.5020.16
98_G363_Y0.5010.16
366_A739_M0.5010.16
224_T450_A0.5010.16
413_G464_N0.5010.16
393_P523_S0.5010.16
714_V718_L0.5010.16
62_T246_A0.5000.16
46_M90_T0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zpaA 1 0.8555 100 0.43 Contact Map
2reeA 1 0.2174 99.5 0.934 Contact Map
3c26A 2 0.3047 99.4 0.94 Contact Map
1z4rA 1 0.2005 99.3 0.942 Contact Map
1kzfA 1 0.2383 99.2 0.945 Contact Map
1m4iA 2 0.2279 99.2 0.946 Contact Map
1n71A 4 0.1927 99.2 0.946 Contact Map
3d8pA 1 0.1914 99.1 0.946 Contact Map
1yghA 1 0.2044 99.1 0.947 Contact Map
4znkA 1 0.2904 99.1 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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