GREMLIN Database
RL7A - 50S ribosomal protein L7Ae
UniProt: Q9HQH8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 120 (116)
Sequences: 649 (335)
Seq/√Len: 31.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_V61_V4.7001.00
17_A112_I2.9081.00
51_V64_L2.8821.00
21_L50_F2.5281.00
4_Y58_E2.4520.99
41_I73_I2.3750.99
49_V68_A2.2970.99
106_E110_E2.2680.99
14_Q79_E2.1890.99
38_T63_H1.9680.97
48_I99_V1.9510.97
110_E114_T1.9340.97
46_A98_A1.8840.96
68_A77_F1.8440.96
9_V53_E1.7940.95
17_A50_F1.6870.93
59_E62_M1.6860.93
82_D97_A1.6850.93
113_S116_V1.6480.92
22_E26_D1.6370.92
103_G109_I1.5920.91
49_V98_A1.5890.91
44_G81_Q1.5430.89
12_D19_E1.5390.89
32_K36_E1.5100.88
30_V54_D1.5090.88
18_L79_E1.5060.88
16_R115_K1.4530.86
73_I114_T1.4450.86
16_R111_D1.4400.86
54_D82_D1.4330.86
54_D80_T1.4190.85
105_A109_I1.4050.84
38_T67_L1.3720.83
40_A98_A1.3720.83
78_V84_L1.3260.81
11_A15_E1.3250.81
88_A94_S1.3080.80
41_I71_K1.2920.79
90_L95_A1.2470.76
35_N59_E1.2290.75
37_T49_V1.2250.75
20_S112_I1.2120.74
18_L88_A1.1820.72
30_V72_G1.1810.72
19_E23_V1.1440.70
69_A91_E1.1430.70
48_I116_V1.1340.69
34_T39_K1.1250.69
17_A76_V1.1190.68
82_D86_N1.1170.68
52_A81_Q1.0940.66
21_L97_A1.0810.65
53_E83_E1.0480.63
21_L84_L1.0380.62
36_E39_K1.0330.62
9_V13_L1.0260.61
36_E59_E1.0210.61
25_R28_G1.0110.60
48_I87_A1.0110.60
54_D85_G1.0020.59
20_S109_I0.9740.57
77_F109_I0.9680.57
85_G95_A0.9670.57
56_S108_E0.9640.56
6_D77_F0.9610.56
51_V62_M0.9450.55
9_V24_A0.9450.55
34_T95_A0.9310.54
17_A113_S0.9270.54
23_V107_D0.9240.53
111_D118_D0.9130.52
62_M66_E0.9100.52
64_L71_K0.8970.51
80_T106_E0.8940.51
30_V104_D0.8800.50
81_Q96_A0.8790.50
24_A79_E0.8780.50
60_I88_A0.8770.49
21_L78_V0.8700.49
99_V111_D0.8620.48
8_D41_I0.8580.48
5_V8_D0.8370.46
3_V18_L0.8290.46
56_S64_L0.7990.43
49_V70_E0.7950.43
101_A114_T0.7940.43
46_A71_K0.7770.41
30_V113_S0.7650.41
32_K96_A0.7580.40
14_Q76_V0.7570.40
31_K36_E0.7560.40
12_D16_R0.7550.40
56_S115_K0.7530.40
90_L97_A0.7520.40
37_T91_E0.7470.39
113_S117_E0.7460.39
16_R66_E0.7350.38
34_T67_L0.7350.38
14_Q17_A0.7320.38
14_Q73_I0.7300.38
32_K94_S0.7300.38
108_E111_D0.7280.38
34_T63_H0.7240.37
18_L80_T0.7230.37
62_M82_D0.7110.36
101_A104_D0.7060.36
40_A77_F0.7040.36
105_A108_E0.6910.35
44_G71_K0.6900.35
49_V77_F0.6890.35
10_P44_G0.6840.34
23_V104_D0.6830.34
88_A96_A0.6810.34
34_T93_G0.6730.34
3_V88_A0.6730.34
21_L48_I0.6720.34
108_E112_I0.6690.33
56_S59_E0.6680.33
78_V102_A0.6680.33
55_V76_V0.6670.33
18_L40_A0.6640.33
35_N38_T0.6600.33
10_P99_V0.6500.32
38_T62_M0.6450.32
31_K85_G0.6410.31
12_D75_V0.6300.31
17_A26_D0.6280.30
79_E111_D0.6250.30
14_Q18_L0.6180.30
20_S26_D0.6140.30
86_N107_D0.6120.29
53_E74_E0.6100.29
58_E92_V0.6100.29
46_A49_V0.6070.29
75_V81_Q0.6020.29
22_E86_N0.5960.28
78_V83_E0.5940.28
49_V100_V0.5940.28
101_A112_I0.5940.28
107_D116_V0.5930.28
64_L102_A0.5870.28
43_R67_L0.5780.27
114_T117_E0.5760.27
49_V61_V0.5730.27
38_T89_G0.5730.27
47_D53_E0.5710.27
38_T71_K0.5660.26
17_A116_V0.5660.26
11_A50_F0.5650.26
72_G114_T0.5610.26
51_V87_A0.5560.26
30_V88_A0.5540.26
42_E55_V0.5500.25
64_L84_L0.5500.25
4_Y7_Y0.5420.25
7_Y77_F0.5410.25
71_K108_E0.5390.25
10_P115_K0.5360.25
28_G83_E0.5330.24
45_N100_V0.5310.24
3_V8_D0.5310.24
15_E19_E0.5300.24
16_R40_A0.5270.24
84_L94_S0.5220.24
7_Y47_D0.5210.24
4_Y46_A0.5200.24
31_K100_V0.5200.24
36_E85_G0.5200.24
22_E81_Q0.5190.24
4_Y59_E0.5180.23
40_A100_V0.5050.23
50_F97_A0.5050.23
63_H75_V0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o85A 1 1 100 0.388 Contact Map
2aifA 1 0.9417 100 0.388 Contact Map
2jnbA 1 1 100 0.391 Contact Map
4nutA 1 1 100 0.394 Contact Map
1vq8F 1 0.9917 99.9 0.429 Contact Map
3j60M 1 0.9333 99.9 0.43 Contact Map
2fc3A 1 0.9917 99.9 0.435 Contact Map
4bw0B 1 0.975 99.9 0.438 Contact Map
2lbwA 1 0.9167 99.9 0.448 Contact Map
1xbiA 1 0.9667 99.9 0.46 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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