GREMLIN Database
Q9HQH4 - Uncharacterized protein
UniProt: Q9HQH4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 315 (296)
Sequences: 4841 (2828)
Seq/√Len: 164.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_G26_P4.8221.00
261_D266_L3.6161.00
65_L126_L3.3251.00
40_A44_D3.0391.00
92_V130_A3.0191.00
34_V37_A2.9651.00
106_L160_V2.8861.00
107_A159_A2.8831.00
36_D40_A2.7581.00
36_D112_R2.6901.00
24_P28_V2.4501.00
137_D140_E2.4101.00
270_V286_T2.3851.00
52_E116_L2.3841.00
61_I121_P2.3521.00
262_A265_T2.2931.00
136_G141_F2.2781.00
150_A193_A2.1561.00
69_D97_T2.1261.00
143_A185_D2.0891.00
259_A265_T2.0771.00
28_V104_A2.0751.00
143_A189_T2.0731.00
278_P282_A2.0531.00
29_A33_A2.0291.00
39_L116_L2.0241.00
103_G159_A1.9851.00
154_A158_D1.9781.00
15_V19_D1.9741.00
26_P29_A1.9721.00
35_R108_A1.9691.00
68_H148_F1.9281.00
98_F155_A1.9221.00
153_L163_V1.9171.00
243_G246_D1.8851.00
39_L112_R1.8801.00
36_D108_A1.8771.00
230_A233_E1.8621.00
33_A37_A1.8401.00
56_G63_H1.8391.00
40_A43_R1.7741.00
22_G26_P1.7711.00
147_A189_T1.7271.00
106_L115_S1.7241.00
31_D57_W1.7231.00
208_L216_L1.7161.00
71_V126_L1.7101.00
8_P288_T1.7021.00
41_A301_V1.7021.00
121_P125_T1.6861.00
115_S161_A1.6561.00
267_R271_D1.6551.00
181_E185_D1.6501.00
214_A241_E1.6341.00
96_L148_F1.6081.00
189_T192_A1.5391.00
103_G152_E1.5211.00
298_S302_A1.4981.00
264_A268_E1.4931.00
184_S188_D1.4901.00
95_P144_A1.4881.00
104_A107_A1.4671.00
142_Q186_A1.4531.00
33_A36_D1.4521.00
278_P283_T1.4491.00
142_Q182_R1.4411.00
132_D136_G1.4321.00
69_D99_D1.4251.00
253_A261_D1.4201.00
277_T284_V1.4181.00
34_V38_H1.4131.00
263_P267_R1.4101.00
250_L273_F1.4081.00
49_R117_Q1.4061.00
271_D275_D1.3951.00
60_G121_P1.3941.00
16_A33_A1.3931.00
41_A44_D1.3921.00
165_V191_A1.3861.00
75_P131_T1.3801.00
277_T283_T1.3761.00
240_G276_R1.3721.00
245_A283_T1.3711.00
274_D284_V1.3681.00
155_A158_D1.3491.00
163_V197_A1.3491.00
224_V246_D1.3381.00
180_D215_H1.3341.00
144_A147_A1.3291.00
106_L116_L1.3211.00
29_A32_S1.3121.00
301_V305_R1.3101.00
108_A111_D1.3001.00
153_L165_V1.2921.00
16_A34_V1.2911.00
162_T200_V1.2831.00
200_V223_A1.2821.00
11_L41_A1.2791.00
299_R302_A1.2771.00
263_P306_A1.2701.00
146_A190_V1.2691.00
58_W86_V1.2631.00
188_D220_A1.2491.00
247_S285_Y1.2481.00
32_S108_A1.2481.00
8_P51_V1.2441.00
139_A182_R1.2431.00
39_L109_V1.2321.00
107_A110_A1.2281.00
103_G155_A1.2261.00
30_A33_A1.2161.00
175_P179_A1.2131.00
92_V141_F1.2101.00
43_R114_A1.2091.00
184_S218_D1.2071.00
279_N282_A1.1971.00
139_A143_A1.1921.00
11_L38_H1.1871.00
120_V152_E1.1821.00
154_A193_A1.1661.00
242_Y246_D1.1651.00
249_A287_T1.1581.00
223_A247_S1.1571.00
76_L79_S1.1501.00
25_T29_A1.1441.00
204_Y290_S1.1431.00
161_A198_D1.1381.00
157_P197_A1.1381.00
185_D189_T1.1271.00
146_A189_T1.1181.00
74_G88_R1.1161.00
253_A266_L1.1131.00
302_A305_R1.1091.00
70_N126_L1.1011.00
37_A41_A1.0991.00
178_G181_E1.0981.00
180_D212_V1.0901.00
150_A189_T1.0901.00
125_T169_S1.0821.00
235_A238_L1.0821.00
98_F151_D1.0801.00
249_A285_Y1.0791.00
64_P68_H1.0791.00
16_A37_A1.0760.99
101_G155_A1.0730.99
139_A185_D1.0710.99
28_V57_W1.0680.99
252_V270_V1.0660.99
28_V105_D1.0660.99
28_V32_S1.0570.99
84_R87_Y1.0410.99
216_L224_V1.0360.99
62_V88_R1.0300.99
30_A34_V1.0260.99
271_D274_D1.0160.99
148_F151_D1.0160.99
201_V216_L1.0080.99
150_A154_A1.0060.99
73_R76_L1.0050.99
155_A159_A1.0030.99
146_A150_A0.9850.99
191_A199_V0.9710.99
108_A112_R0.9690.99
45_A305_R0.9670.99
119_V166_L0.9670.99
97_T144_A0.9640.99
217_L245_A0.9630.99
152_E156_L0.9620.99
230_A254_N0.9600.99
269_R272_W0.9580.99
149_L168_P0.9560.99
106_L110_A0.9550.99
41_A45_A0.9540.99
110_A115_S0.9500.99
233_E269_R0.9490.99
194_V222_D0.9440.99
274_D279_N0.9440.99
202_H225_G0.9390.99
76_L80_T0.9320.99
44_D305_R0.9270.98
97_T151_D0.9250.98
273_F284_V0.9190.98
51_V119_V0.9170.98
231_D234_D0.9160.98
122_G167_E0.9130.98
171_I203_T0.9120.98
128_T179_A0.9080.98
150_A190_V0.9020.98
133_D136_G0.9010.98
252_V266_L0.8970.98
7_T117_Q0.8930.98
132_D141_F0.8930.98
214_A218_D0.8910.98
127_S142_Q0.8890.98
32_S56_G0.8880.98
228_L250_L0.8820.98
68_H152_E0.8780.98
301_V304_L0.8780.98
157_P195_T0.8760.98
9_G202_H0.8750.98
26_P30_A0.8750.98
141_F144_A0.8660.98
234_D237_Y0.8610.98
168_P219_A0.8580.97
128_T172_A0.8580.97
68_H145_I0.8540.97
265_T268_E0.8520.97
124_Y174_P0.8510.97
264_A267_R0.8510.97
37_A297_Q0.8490.97
128_T169_S0.8450.97
272_W275_D0.8420.97
201_V221_I0.8380.97
139_A178_G0.8370.97
181_E215_H0.8350.97
237_Y241_E0.8300.97
50_V114_A0.8260.97
266_L269_R0.8230.97
169_S172_A0.8220.97
117_Q285_Y0.8180.97
154_A194_V0.8090.96
136_G140_E0.8080.96
269_R273_F0.7960.96
103_G107_A0.7960.96
192_A220_A0.7940.96
107_A111_D0.7930.96
92_V96_L0.7900.96
157_P196_D0.7840.96
96_L100_G0.7830.96
125_T168_P0.7760.95
260_V296_P0.7760.95
46_D114_A0.7730.95
240_G272_W0.7720.95
38_H41_A0.7620.95
79_S85_G0.7610.95
38_H55_A0.7600.95
83_A89_R0.7600.95
132_D138_P0.7570.95
106_L159_A0.7560.95
147_A151_D0.7540.95
191_A222_D0.7520.95
117_Q164_F0.7520.95
87_Y90_P0.7510.95
32_S112_R0.7510.95
242_Y248_I0.7510.95
266_L286_T0.7500.95
127_S183_A0.7490.95
22_G30_A0.7470.94
75_P78_H0.7440.94
237_Y240_G0.7430.94
212_V216_L0.7390.94
27_V31_D0.7340.94
209_D238_L0.7330.94
25_T28_V0.7290.94
53_G105_D0.7290.94
49_R285_Y0.7290.94
235_A239_V0.7280.94
41_A297_Q0.7270.94
170_L201_V0.7250.94
150_A192_A0.7220.93
220_A246_D0.7220.93
113_T116_L0.7200.93
151_D154_A0.7180.93
154_A157_P0.7180.93
160_V163_V0.7140.93
14_P34_V0.7130.93
59_D86_V0.7130.93
152_E155_A0.7120.93
65_L130_A0.7090.93
73_R78_H0.7080.93
143_A147_A0.7080.93
213_H238_L0.7060.93
65_L74_G0.7060.93
44_D301_V0.7050.93
184_S215_H0.7040.93
77_A131_T0.6950.92
31_D35_R0.6880.92
80_T84_R0.6850.92
32_S111_D0.6850.92
49_R162_T0.6840.91
8_P287_T0.6840.91
174_P179_A0.6810.91
32_S104_A0.6810.91
254_N257_T0.6810.91
170_L183_A0.6780.91
109_V113_T0.6780.91
38_H42_Q0.6770.91
103_G156_L0.6760.91
94_G134_H0.6750.91
73_R79_S0.6740.91
14_P297_Q0.6740.91
191_A194_V0.6710.91
63_H105_D0.6710.91
85_G89_R0.6650.90
181_E184_S0.6630.90
53_G102_L0.6630.90
125_T128_T0.6630.90
86_V89_R0.6610.90
215_H218_D0.6600.90
296_P299_R0.6600.90
67_A102_L0.6590.90
124_Y183_A0.6560.90
78_H84_R0.6540.90
296_P302_A0.6530.89
76_L86_V0.6520.89
99_D151_D0.6490.89
224_V248_I0.6490.89
83_A86_V0.6480.89
217_L246_D0.6480.89
240_G275_D0.6470.89
96_L101_G0.6440.89
92_V126_L0.6410.89
228_L235_A0.6410.89
198_D222_D0.6390.88
297_Q301_V0.6340.88
205_G291_V0.6310.88
128_T138_P0.6300.88
203_T208_L0.6290.88
67_A105_D0.6280.88
14_P17_P0.6270.87
43_R113_T0.6250.87
47_L50_V0.6250.87
45_A304_L0.6240.87
138_P142_Q0.6230.87
225_G287_T0.6200.87
102_L105_D0.6190.87
117_Q162_T0.6190.87
128_T174_P0.6170.87
80_T86_V0.6160.87
64_P67_A0.6160.87
213_H242_Y0.6150.86
276_R284_V0.6110.86
67_A100_G0.6090.86
132_D137_D0.6090.86
80_T85_G0.6080.86
64_P121_P0.6070.86
36_D39_L0.6060.86
28_V31_D0.6060.86
39_L50_V0.6050.86
110_A116_L0.6050.86
93_A96_L0.6050.86
7_T49_R0.6030.85
76_L84_R0.6030.85
183_A187_I0.6030.85
154_A195_T0.6020.85
124_Y182_R0.6020.85
207_A234_D0.6010.85
236_A272_W0.6010.85
171_I206_G0.6000.85
170_L203_T0.6000.85
78_H89_R0.5990.85
239_V273_F0.5980.85
162_T223_A0.5950.85
83_A87_Y0.5950.85
7_T304_L0.5950.85
157_P194_V0.5950.85
50_V112_R0.5940.85
266_L306_A0.5930.84
124_Y169_S0.5920.84
73_R77_A0.5900.84
100_G152_E0.5900.84
51_V118_A0.5890.84
132_D135_Y0.5880.84
79_S84_R0.5880.84
32_S36_D0.5870.84
128_T175_P0.5860.84
65_L70_N0.5850.84
59_D85_G0.5810.83
223_A285_Y0.5810.83
73_R80_T0.5790.83
225_G249_A0.5750.83
38_H297_Q0.5740.83
110_A159_A0.5720.82
98_F101_G0.5720.82
32_S35_R0.5710.82
228_L273_F0.5690.82
236_A276_R0.5690.82
29_A40_A0.5690.82
124_Y142_Q0.5680.82
217_L241_E0.5680.82
196_D222_D0.5660.82
106_L161_A0.5650.82
162_T198_D0.5640.81
15_V296_P0.5640.81
122_G187_I0.5610.81
236_A250_L0.5600.81
59_D88_R0.5530.80
74_G77_A0.5530.80
54_Q57_W0.5530.80
6_T47_L0.5530.80
250_L270_V0.5520.80
213_H217_L0.5520.80
6_T286_T0.5510.80
169_S183_A0.5510.80
242_Y245_A0.5500.80
31_D56_G0.5500.80
72_A91_V0.5470.79
231_D235_A0.5440.79
143_A146_A0.5390.78
7_T47_L0.5380.78
7_T11_L0.5370.78
103_G106_L0.5370.78
16_A297_Q0.5370.78
78_H86_V0.5360.78
77_A89_R0.5360.78
156_L159_A0.5350.78
296_P300_L0.5340.78
17_P55_A0.5330.78
207_A211_K0.5310.77
273_F277_T0.5300.77
166_L290_S0.5300.77
141_F145_I0.5270.77
117_Q166_L0.5270.77
157_P161_A0.5260.77
94_G144_A0.5240.76
198_D247_S0.5230.76
61_I126_L0.5230.76
8_P42_Q0.5230.76
143_A186_A0.5220.76
57_W226_Y0.5210.76
59_D62_V0.5180.76
74_G78_H0.5170.76
229_I289_D0.5170.76
268_E272_W0.5150.75
156_L163_V0.5130.75
217_L243_G0.5110.75
47_L51_V0.5100.75
18_D59_D0.5100.75
13_S60_G0.5090.74
83_A91_V0.5080.74
77_A80_T0.5080.74
232_H269_R0.5070.74
40_A114_A0.5070.74
260_V299_R0.5060.74
184_S219_A0.5060.74
260_V264_A0.5040.74
78_H87_Y0.5030.74
53_G116_L0.5030.74
213_H239_V0.5030.74
208_L226_Y0.5020.73
204_Y227_D0.5020.73
123_P165_V0.5010.73
203_T224_V0.5000.73
51_V117_Q0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ypxA 1 0.9111 100 0.259 Contact Map
1u1jA 1 0.9714 100 0.261 Contact Map
1t7lA 1 0.981 100 0.265 Contact Map
2nq5A 1 0.8921 100 0.278 Contact Map
4l6hA 1 0.9587 100 0.284 Contact Map
3rpdA 1 0.9683 100 0.294 Contact Map
1j93A 2 0.9143 99.8 0.766 Contact Map
4exqA 2 0.9333 99.8 0.767 Contact Map
2ejaA 2 0.9143 99.8 0.767 Contact Map
4wshA 2 0.9333 99.7 0.779 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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