Q9HQH4 - HALSA - GREMLIN Contacts

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Q9HQH4 - Uncharacterized protein

UniProt:	Q9HQH4	Sequences: MSRIATTPGLLPSPVAPDDGGGGPTPVVAADSAVRDAHLAAQRDADLDRVVEGQAGWWDGIVHPLVAHDNVARGPLAHSTAVARGVYRRPVVAGPLTFDGGLGADLAAVADRTASLQAVVPGPYTLSTLATDDHYGDPAEFQAAIAAFLADELAALPDAVATVFVLEPSLIAAPPGDGADERASDAIDTVAAAVTDADVVVHTYGGALDEKVHAHLLDAAIDAVGYDLIADHEDAAYLVGEYGTADSIALGVANARTPAVDAPATLRERVDWFDDRTPNDFATVYTTTDSVLATLPQSRLVAQLRALGAATTPQS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	315 (296)
Sequences:	4841 (2828)
Seq/√Len:	164.4

ECOLI - METE
BACSU - YXJH YXJG METE
HALSA - Q9HQH4
SULSO - Q980B0 METE

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
23_G	26_P	4.822	1.00
261_D	266_L	3.616	1.00
65_L	126_L	3.325	1.00
40_A	44_D	3.039	1.00
92_V	130_A	3.019	1.00
34_V	37_A	2.965	1.00
106_L	160_V	2.886	1.00
107_A	159_A	2.883	1.00
36_D	40_A	2.758	1.00
36_D	112_R	2.690	1.00
24_P	28_V	2.450	1.00
137_D	140_E	2.410	1.00
270_V	286_T	2.385	1.00
52_E	116_L	2.384	1.00
61_I	121_P	2.352	1.00
262_A	265_T	2.293	1.00
136_G	141_F	2.278	1.00
150_A	193_A	2.156	1.00
69_D	97_T	2.126	1.00
143_A	185_D	2.089	1.00
259_A	265_T	2.077	1.00
28_V	104_A	2.075	1.00
143_A	189_T	2.073	1.00
278_P	282_A	2.053	1.00
29_A	33_A	2.029	1.00
39_L	116_L	2.024	1.00
103_G	159_A	1.985	1.00
154_A	158_D	1.978	1.00
15_V	19_D	1.974	1.00
26_P	29_A	1.972	1.00
35_R	108_A	1.969	1.00
68_H	148_F	1.928	1.00
98_F	155_A	1.922	1.00
153_L	163_V	1.917	1.00
243_G	246_D	1.885	1.00
39_L	112_R	1.880	1.00
36_D	108_A	1.877	1.00
230_A	233_E	1.862	1.00
33_A	37_A	1.840	1.00
56_G	63_H	1.839	1.00
40_A	43_R	1.774	1.00
22_G	26_P	1.771	1.00
147_A	189_T	1.727	1.00
106_L	115_S	1.724	1.00
31_D	57_W	1.723	1.00
208_L	216_L	1.716	1.00
71_V	126_L	1.710	1.00
8_P	288_T	1.702	1.00
41_A	301_V	1.702	1.00
121_P	125_T	1.686	1.00
115_S	161_A	1.656	1.00
267_R	271_D	1.655	1.00
181_E	185_D	1.650	1.00
214_A	241_E	1.634	1.00
96_L	148_F	1.608	1.00
189_T	192_A	1.539	1.00
103_G	152_E	1.521	1.00
298_S	302_A	1.498	1.00
264_A	268_E	1.493	1.00
184_S	188_D	1.490	1.00
95_P	144_A	1.488	1.00
104_A	107_A	1.467	1.00
142_Q	186_A	1.453	1.00
33_A	36_D	1.452	1.00
278_P	283_T	1.449	1.00
142_Q	182_R	1.441	1.00
132_D	136_G	1.432	1.00
69_D	99_D	1.425	1.00
253_A	261_D	1.420	1.00
277_T	284_V	1.418	1.00
34_V	38_H	1.413	1.00
263_P	267_R	1.410	1.00
250_L	273_F	1.408	1.00
49_R	117_Q	1.406	1.00
271_D	275_D	1.395	1.00
60_G	121_P	1.394	1.00
16_A	33_A	1.393	1.00
41_A	44_D	1.392	1.00
165_V	191_A	1.386	1.00
75_P	131_T	1.380	1.00
277_T	283_T	1.376	1.00
240_G	276_R	1.372	1.00
245_A	283_T	1.371	1.00
274_D	284_V	1.368	1.00
155_A	158_D	1.349	1.00
163_V	197_A	1.349	1.00
224_V	246_D	1.338	1.00
180_D	215_H	1.334	1.00
144_A	147_A	1.329	1.00
106_L	116_L	1.321	1.00
29_A	32_S	1.312	1.00
301_V	305_R	1.310	1.00
108_A	111_D	1.300	1.00
153_L	165_V	1.292	1.00
16_A	34_V	1.291	1.00
162_T	200_V	1.283	1.00
200_V	223_A	1.282	1.00
11_L	41_A	1.279	1.00
299_R	302_A	1.277	1.00
263_P	306_A	1.270	1.00
146_A	190_V	1.269	1.00
58_W	86_V	1.263	1.00
188_D	220_A	1.249	1.00
247_S	285_Y	1.248	1.00
32_S	108_A	1.248	1.00
8_P	51_V	1.244	1.00
139_A	182_R	1.243	1.00
39_L	109_V	1.232	1.00
107_A	110_A	1.228	1.00
103_G	155_A	1.226	1.00
30_A	33_A	1.216	1.00
175_P	179_A	1.213	1.00
92_V	141_F	1.210	1.00
43_R	114_A	1.209	1.00
184_S	218_D	1.207	1.00
279_N	282_A	1.197	1.00
139_A	143_A	1.192	1.00
11_L	38_H	1.187	1.00
120_V	152_E	1.182	1.00
154_A	193_A	1.166	1.00
242_Y	246_D	1.165	1.00
249_A	287_T	1.158	1.00
223_A	247_S	1.157	1.00
76_L	79_S	1.150	1.00
25_T	29_A	1.144	1.00
204_Y	290_S	1.143	1.00
161_A	198_D	1.138	1.00
157_P	197_A	1.138	1.00
185_D	189_T	1.127	1.00
146_A	189_T	1.118	1.00
74_G	88_R	1.116	1.00
253_A	266_L	1.113	1.00
302_A	305_R	1.109	1.00
70_N	126_L	1.101	1.00
37_A	41_A	1.099	1.00
178_G	181_E	1.098	1.00
180_D	212_V	1.090	1.00
150_A	189_T	1.090	1.00
125_T	169_S	1.082	1.00
235_A	238_L	1.082	1.00
98_F	151_D	1.080	1.00
249_A	285_Y	1.079	1.00
64_P	68_H	1.079	1.00
16_A	37_A	1.076	0.99
101_G	155_A	1.073	0.99
139_A	185_D	1.071	0.99
28_V	57_W	1.068	0.99
252_V	270_V	1.066	0.99
28_V	105_D	1.066	0.99
28_V	32_S	1.057	0.99
84_R	87_Y	1.041	0.99
216_L	224_V	1.036	0.99
62_V	88_R	1.030	0.99
30_A	34_V	1.026	0.99
271_D	274_D	1.016	0.99
148_F	151_D	1.016	0.99
201_V	216_L	1.008	0.99
150_A	154_A	1.006	0.99
73_R	76_L	1.005	0.99
155_A	159_A	1.003	0.99
146_A	150_A	0.985	0.99
191_A	199_V	0.971	0.99
108_A	112_R	0.969	0.99
45_A	305_R	0.967	0.99
119_V	166_L	0.967	0.99
97_T	144_A	0.964	0.99
217_L	245_A	0.963	0.99
152_E	156_L	0.962	0.99
230_A	254_N	0.960	0.99
269_R	272_W	0.958	0.99
149_L	168_P	0.956	0.99
106_L	110_A	0.955	0.99
41_A	45_A	0.954	0.99
110_A	115_S	0.950	0.99
233_E	269_R	0.949	0.99
194_V	222_D	0.944	0.99
274_D	279_N	0.944	0.99
202_H	225_G	0.939	0.99
76_L	80_T	0.932	0.99
44_D	305_R	0.927	0.98
97_T	151_D	0.925	0.98
273_F	284_V	0.919	0.98
51_V	119_V	0.917	0.98
231_D	234_D	0.916	0.98
122_G	167_E	0.913	0.98
171_I	203_T	0.912	0.98
128_T	179_A	0.908	0.98
150_A	190_V	0.902	0.98
133_D	136_G	0.901	0.98
252_V	266_L	0.897	0.98
7_T	117_Q	0.893	0.98
132_D	141_F	0.893	0.98
214_A	218_D	0.891	0.98
127_S	142_Q	0.889	0.98
32_S	56_G	0.888	0.98
228_L	250_L	0.882	0.98
68_H	152_E	0.878	0.98
301_V	304_L	0.878	0.98
157_P	195_T	0.876	0.98
9_G	202_H	0.875	0.98
26_P	30_A	0.875	0.98
141_F	144_A	0.866	0.98
234_D	237_Y	0.861	0.98
168_P	219_A	0.858	0.97
128_T	172_A	0.858	0.97
68_H	145_I	0.854	0.97
265_T	268_E	0.852	0.97
124_Y	174_P	0.851	0.97
264_A	267_R	0.851	0.97
37_A	297_Q	0.849	0.97
128_T	169_S	0.845	0.97
272_W	275_D	0.842	0.97
201_V	221_I	0.838	0.97
139_A	178_G	0.837	0.97
181_E	215_H	0.835	0.97
237_Y	241_E	0.830	0.97
50_V	114_A	0.826	0.97
266_L	269_R	0.823	0.97
169_S	172_A	0.822	0.97
117_Q	285_Y	0.818	0.97
154_A	194_V	0.809	0.96
136_G	140_E	0.808	0.96
269_R	273_F	0.796	0.96
103_G	107_A	0.796	0.96
192_A	220_A	0.794	0.96
107_A	111_D	0.793	0.96
92_V	96_L	0.790	0.96
157_P	196_D	0.784	0.96
96_L	100_G	0.783	0.96
125_T	168_P	0.776	0.95
260_V	296_P	0.776	0.95
46_D	114_A	0.773	0.95
240_G	272_W	0.772	0.95
38_H	41_A	0.762	0.95
79_S	85_G	0.761	0.95
38_H	55_A	0.760	0.95
83_A	89_R	0.760	0.95
132_D	138_P	0.757	0.95
106_L	159_A	0.756	0.95
147_A	151_D	0.754	0.95
191_A	222_D	0.752	0.95
117_Q	164_F	0.752	0.95
87_Y	90_P	0.751	0.95
32_S	112_R	0.751	0.95
242_Y	248_I	0.751	0.95
266_L	286_T	0.750	0.95
127_S	183_A	0.749	0.95
22_G	30_A	0.747	0.94
75_P	78_H	0.744	0.94
237_Y	240_G	0.743	0.94
212_V	216_L	0.739	0.94
27_V	31_D	0.734	0.94
209_D	238_L	0.733	0.94
25_T	28_V	0.729	0.94
53_G	105_D	0.729	0.94
49_R	285_Y	0.729	0.94
235_A	239_V	0.728	0.94
41_A	297_Q	0.727	0.94
170_L	201_V	0.725	0.94
150_A	192_A	0.722	0.93
220_A	246_D	0.722	0.93
113_T	116_L	0.720	0.93
151_D	154_A	0.718	0.93
154_A	157_P	0.718	0.93
160_V	163_V	0.714	0.93
14_P	34_V	0.713	0.93
59_D	86_V	0.713	0.93
152_E	155_A	0.712	0.93
65_L	130_A	0.709	0.93
73_R	78_H	0.708	0.93
143_A	147_A	0.708	0.93
213_H	238_L	0.706	0.93
65_L	74_G	0.706	0.93
44_D	301_V	0.705	0.93
184_S	215_H	0.704	0.93
77_A	131_T	0.695	0.92
31_D	35_R	0.688	0.92
80_T	84_R	0.685	0.92
32_S	111_D	0.685	0.92
49_R	162_T	0.684	0.91
8_P	287_T	0.684	0.91
174_P	179_A	0.681	0.91
32_S	104_A	0.681	0.91
254_N	257_T	0.681	0.91
170_L	183_A	0.678	0.91
109_V	113_T	0.678	0.91
38_H	42_Q	0.677	0.91
103_G	156_L	0.676	0.91
94_G	134_H	0.675	0.91
73_R	79_S	0.674	0.91
14_P	297_Q	0.674	0.91
191_A	194_V	0.671	0.91
63_H	105_D	0.671	0.91
85_G	89_R	0.665	0.90
181_E	184_S	0.663	0.90
53_G	102_L	0.663	0.90
125_T	128_T	0.663	0.90
86_V	89_R	0.661	0.90
215_H	218_D	0.660	0.90
296_P	299_R	0.660	0.90
67_A	102_L	0.659	0.90
124_Y	183_A	0.656	0.90
78_H	84_R	0.654	0.90
296_P	302_A	0.653	0.89
76_L	86_V	0.652	0.89
99_D	151_D	0.649	0.89
224_V	248_I	0.649	0.89
83_A	86_V	0.648	0.89
217_L	246_D	0.648	0.89
240_G	275_D	0.647	0.89
96_L	101_G	0.644	0.89
92_V	126_L	0.641	0.89
228_L	235_A	0.641	0.89
198_D	222_D	0.639	0.88
297_Q	301_V	0.634	0.88
205_G	291_V	0.631	0.88
128_T	138_P	0.630	0.88
203_T	208_L	0.629	0.88
67_A	105_D	0.628	0.88
14_P	17_P	0.627	0.87
43_R	113_T	0.625	0.87
47_L	50_V	0.625	0.87
45_A	304_L	0.624	0.87
138_P	142_Q	0.623	0.87
225_G	287_T	0.620	0.87
102_L	105_D	0.619	0.87
117_Q	162_T	0.619	0.87
128_T	174_P	0.617	0.87
80_T	86_V	0.616	0.87
64_P	67_A	0.616	0.87
213_H	242_Y	0.615	0.86
276_R	284_V	0.611	0.86
67_A	100_G	0.609	0.86
132_D	137_D	0.609	0.86
80_T	85_G	0.608	0.86
64_P	121_P	0.607	0.86
36_D	39_L	0.606	0.86
28_V	31_D	0.606	0.86
39_L	50_V	0.605	0.86
110_A	116_L	0.605	0.86
93_A	96_L	0.605	0.86
7_T	49_R	0.603	0.85
76_L	84_R	0.603	0.85
183_A	187_I	0.603	0.85
154_A	195_T	0.602	0.85
124_Y	182_R	0.602	0.85
207_A	234_D	0.601	0.85
236_A	272_W	0.601	0.85
171_I	206_G	0.600	0.85
170_L	203_T	0.600	0.85
78_H	89_R	0.599	0.85
239_V	273_F	0.598	0.85
162_T	223_A	0.595	0.85
83_A	87_Y	0.595	0.85
7_T	304_L	0.595	0.85
157_P	194_V	0.595	0.85
50_V	112_R	0.594	0.85
266_L	306_A	0.593	0.84
124_Y	169_S	0.592	0.84
73_R	77_A	0.590	0.84
100_G	152_E	0.590	0.84
51_V	118_A	0.589	0.84
132_D	135_Y	0.588	0.84
79_S	84_R	0.588	0.84
32_S	36_D	0.587	0.84
128_T	175_P	0.586	0.84
65_L	70_N	0.585	0.84
59_D	85_G	0.581	0.83
223_A	285_Y	0.581	0.83
73_R	80_T	0.579	0.83
225_G	249_A	0.575	0.83
38_H	297_Q	0.574	0.83
110_A	159_A	0.572	0.82
98_F	101_G	0.572	0.82
32_S	35_R	0.571	0.82
228_L	273_F	0.569	0.82
236_A	276_R	0.569	0.82
29_A	40_A	0.569	0.82
124_Y	142_Q	0.568	0.82
217_L	241_E	0.568	0.82
196_D	222_D	0.566	0.82
106_L	161_A	0.565	0.82
162_T	198_D	0.564	0.81
15_V	296_P	0.564	0.81
122_G	187_I	0.561	0.81
236_A	250_L	0.560	0.81
59_D	88_R	0.553	0.80
74_G	77_A	0.553	0.80
54_Q	57_W	0.553	0.80
6_T	47_L	0.553	0.80
250_L	270_V	0.552	0.80
213_H	217_L	0.552	0.80
6_T	286_T	0.551	0.80
169_S	183_A	0.551	0.80
242_Y	245_A	0.550	0.80
31_D	56_G	0.550	0.80
72_A	91_V	0.547	0.79
231_D	235_A	0.544	0.79
143_A	146_A	0.539	0.78
7_T	47_L	0.538	0.78
7_T	11_L	0.537	0.78
103_G	106_L	0.537	0.78
16_A	297_Q	0.537	0.78
78_H	86_V	0.536	0.78
77_A	89_R	0.536	0.78
156_L	159_A	0.535	0.78
296_P	300_L	0.534	0.78
17_P	55_A	0.533	0.78
207_A	211_K	0.531	0.77
273_F	277_T	0.530	0.77
166_L	290_S	0.530	0.77
141_F	145_I	0.527	0.77
117_Q	166_L	0.527	0.77
157_P	161_A	0.526	0.77
94_G	144_A	0.524	0.76
198_D	247_S	0.523	0.76
61_I	126_L	0.523	0.76
8_P	42_Q	0.523	0.76
143_A	186_A	0.522	0.76
57_W	226_Y	0.521	0.76
59_D	62_V	0.518	0.76
74_G	78_H	0.517	0.76
229_I	289_D	0.517	0.76
268_E	272_W	0.515	0.75
156_L	163_V	0.513	0.75
217_L	243_G	0.511	0.75
47_L	51_V	0.510	0.75
18_D	59_D	0.510	0.75
13_S	60_G	0.509	0.74
83_A	91_V	0.508	0.74
77_A	80_T	0.508	0.74
232_H	269_R	0.507	0.74
40_A	114_A	0.507	0.74
260_V	299_R	0.506	0.74
184_S	219_A	0.506	0.74
260_V	264_A	0.504	0.74
78_H	87_Y	0.503	0.74
53_G	116_L	0.503	0.74
213_H	239_V	0.503	0.74
208_L	226_Y	0.502	0.73
204_Y	227_D	0.502	0.73
123_P	165_V	0.501	0.73
203_T	224_V	0.500	0.73
51_V	117_Q	0.500	0.73

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ypxA	1	0.9111	100	0.259	Contact Map
1u1jA	1	0.9714	100	0.261	Contact Map
1t7lA	1	0.981	100	0.265	Contact Map
2nq5A	1	0.8921	100	0.278	Contact Map
4l6hA	1	0.9587	100	0.284	Contact Map
3rpdA	1	0.9683	100	0.294	Contact Map
1j93A	2	0.9143	99.8	0.766	Contact Map
4exqA	2	0.9333	99.8	0.767	Contact Map
2ejaA	2	0.9143	99.8	0.767	Contact Map
4wshA	2	0.9333	99.7	0.779	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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